检索结果-南通市图书馆

Research in Astronomy and Astrophysics 2023年第1期23卷 153-160页

作者： Wenyu Xin ken’ichi Nomoto Gang Zhao Xianfei Zhang CAS Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China Kavli Institute for the Physics and Mathematics of the Universe(WPI) The University of Tokyo Institutes for Advanced StudyThe University of TokyoKashiwaChiba 277-8583Japan Department of Astronomy Beijing Normal UniversityBeijing 100875China

Motivated by the determination of black hole masses with gravitational-wave observations,we calculate the evolution of massive stars through presupernova stages and obtain the mass distribution of black *** the first part,we calculate the evolution of He stars with masses of 30-120 M_(⊙).We study in detail how convective carbon shell burning controls pair-instability pulsations before and during oxygen burning and determine their final *** the second part,we calculate the evolution of H-rich stars with initial masses of 13-80 M_(⊙) until Fe core collapse and obtain the possible black hole mass range by applying the criterion of the compactness *** these models,we predict the mass distribution of black holes for stars that undergo Fe core collapse and pair-instability *** predicted masses for black holes range from 4.2 to 46 M_(⊙),which are consistent with the gravitational-wave observations.

关键词： gravitational waves-stars black holes-stars evolution-stars massive-(stars:)supernovae general

Characteristics structure analysis on debris cloud in the hypervelocity impact of disk projectile on thin plate

在线全文

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2020年第2期16卷 299-307页

作者： Chun-bo Zhang De-ning Di Xiao-wei Chen ken Wen State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081China Institute of Systems Engineering China Academy of Engineering PhysicsMianyangSichuan621999China Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing100081China

In this paper,the gauge points setting is introduced in the SPH simulation to analyze the debris cloud structure generated by the hypervelocity impact of disk projectile on thin *** with the experiments,more detailed information of the debris cloud structure can be classified from the numerical ***,due to the solitary dispersion and overlap display of the particles in the SPH simulation,accurate comparison between numerical and experimental results is difficult to be *** track the velocity and spatial distribution of the particles in the debris cloud induced from disk and plate,gauge points are locally set in the single-layer profile in the SPH *** analyzing the gauge points’spatial coordinate and velocity,the location and velocity of characteristic points in the debris cloud are *** boundary of debris cloud is achieved,as well as the fragments distribution outside the main structure of debris cloud.

关键词： Hypervelocity impact Debris cloud SPH method Particle gauge points Motion characteristics

Seismic Policy, Operations, and Research Uses for a Building Inventory in an Earthquake-Prone City

在线全文

学校读者我要写书评

暂无评论

International Journal of Disaster Risk Science 2020年第6期11卷 709-718页

作者： ken Elwood Olga Filippova Ilan Noy Jacob Pastor Paz School of Engineering The University of AucklandAuckland 1142New Zealand Business School The University of AucklandAuckland 1142New Zealand School of Economics Victoria University of WellingtonWellington 6140New Zealand

After the 2016 New Zealand Kaikoura Earthquake,the absence of information about the state of buildings in Wellington proved to be a source of significant policy *** did not know what damages to expect and therefore how to react,and policies needed to be formulated without a clear quantification of the ***,without detailed knowledge of the existing buildings,it was difficult to assess what the available legal and regulatory tools can achieve and choose among *** describe the creation of a building inventory database for Wellington initiated by the *** database aims to assist the generation of research on the risks,impacts,and viable solutions for reducing future seismic risk in Wellington’s central business district(CBD).The database includes structural,economic,and market information on virtually every significant building in the *** primary purposes are:to collate and provide the best available information about the expected seismic performance of the existing building stock;to assess the impact of possible multiple building failures due to a seismic event;to describe a viable cost-effective path for seismic retrofitting;and to inform the design of a regulatory structure that can facilitate this resilience-building agenda.

关键词： Building inventory Building standards Disaster risk assessment Earthquake-prone city Retrofit

Exercise in the management of metabolic dysfunction-associated fatty liver disease-is more the answer, or is it just one piece of the puzzle?

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary Surgery and Nutrition 2024年第2期13卷 329-332页

作者： Emily Nash ken Liu AW Morrow Gastroenterology and Liver Centre Royal Prince Alfred HospitalSydneyNSWAustralia Faculty of Medicine and Health University of SydneySydneyNSWAustralia Liver Injury and Cancer Program Centenary InstituteSydneyNSWAustralia

Metabolic dysfunction-associated fatty liver disease(MAFLD)is the liver manifestation of metabolic syndrome,a rapidly growing clinical and public health issue mirrored by epidemic rates of obesity,type 2 diabetes mellitus,hypertension and cardiovascular disease(CVD).Besides MAFLD,nomenclature used to capture fatty liver disease not primarily due to alcohol excess include non-alcoholic fatty liver disease(NAFLD)and metabolic dysfunction-associated steatotic liver disease(MASLD).Regardless of the terminology used,these diagnoses describe the most common cause of chronic liver disease ***,MAFLD is poised to become the leading cause of hepatocellular carcinoma(HCC)and end-stage liver disease requiring liver transplantation around the world(1,2).In addition to this,CVD and extra-hepatic cancers are the two main causes of death in the MAFLD ***,MAFLD poses a severe clinical burden which is projected to worsen in the future and intervention is urgently needed.

关键词： Exercise metabolic dysfunction-associated liver disease(MAFLD) diet obesity weight loss

Cetuximab and panitumumab in a patient with colon cancer and concomitant chronic skin disease:A potential beneficial effect on psoriasis vulgaris

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2015年第12期21卷 3746-3749页

作者： ken Okamoto Hiromichi Maeda Takeo Shiga Mai Shiga ken Dabanaka Kazuhiro Hanazaki Michiya Kobayashi Department of Human Health and Medical Sciences Kochi Medical School Hospital Cancer Treatment Center Kochi Medical School Hospital Department of Dermatology Kochi Medical School Department of Surgery Kochi Medical School

Monoclonal antibodies against epidermal growth factor receptor(EGFR) are used in the treatment of advanced colorectal cancer. However, these agents can induce severe dermatological side effects that discourage their administration in patients with chronic dermatological disease. EGFR plays a key role in normal skin development and immunological function, and is expressed in various tissues and organs, although contrarily, it is overexpressed in psoriasis-related skin lesions. Thus, discussion is ongoing regarding the putative pathological role and therapeutic potential of this protein. We herein report on a patient with advanced colon cancer and concomitant long-standing psoriasis vulgaris who received antiEGFR antibody monotherapy as a third-line treatment for metastatic disease. One week after the initiation of treatment, the patient's skin lesions dramatically subsided and the improvement was sustained during therapy. Based on this case, we propose that anti-EGFR antibody therapy is not necessarily contraindicated in patients with psoriasis vulgaris. Moreover, the findings reaffirmed that EGFR is an important molecule in the pathology of psoriasis.

关键词： Psoriasis Cetuximab Panitumumab Epidermal growth f

Cigarette smoke‑induced malignant transformation via STAT3 signalling in pulmonary epithelial cells in a lung‑on‑a‑chip model

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bio-Design and Manufacturing 2020年第4期3卷 383-395页

作者： Wei Hou Siyi Hu ken‑tye Yong Jie Zhang Hanbin Ma CAS Key Laboratory of Bio‑Medical Diagnostics Suzhou Institute of Biomedical Engineering and TechnologyChinese Academy of SciencesNo.88 Keling RoadHuqiu DistrictSuzhou 215163JiangsuPeople’s Republic of China Department of Respiratory and Critical Care Medicine The Second Hospital of Jilin UniversityNo.218 Ziqiang StreetNanguan DistrictChangchun 130041JilinPeople’s Republic of China School of Electrical and Electronic Engineering Nanyang Technological UniversitySingapore 639798Singapore

Background Chronic obstructive pulmonary disease(COPD)is a severe public health *** smoke(CS)is a risk factor for COPD and lung *** underlying molecular mechanisms of CS-induced malignant transformation of bronchial epithelial cells remain *** this study,we describe a lung-on-a-chip to explore the possible mechanistic link between cigarette smoke extract(CSE)-associated COPD and lung *** An in vitro lung-on-a-chip model was used to simulate pulmonary epithelial cells and vascular endothelial cells with *** levels of IL-6 and TNF-αwere tested as indicators of inflammation using an enzyme-linked immune sorbent *** junction complex mRNA expression was detected with qRT-PCR as the index of epithelial-to-mesenchymal transition(EMT).The effects of CSE on the phosphorylation of signal transduction and transcriptional activator 3(STAT3)were detected by Western *** cytometry was performed to investigate the effects of this proto-oncogene on cell cycle *** Inflammation caused by CSE was achieved in a lung-on-a-chip model with a mimetic *** exposure induced the degradation of intercellular connections and triggered the EMT *** exposure also activated the phosphorylation of proto-oncogene STAT3,while these effects were inhibited with *** CSE exposure in the lung-on-a-chip model caused activation of STAT3 in epithelial cells and endothelial ***0152,an inhibitor of activated STAT3,could be a potential treatment for CS-associated COPD and lung cancer.

关键词： Cigarette smoke Microfluidic chips STAT3 Chronic obstructive pulmonary disease

A radical scavenger edaravone and oligodendrocyte protection/regeneration

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2018年第9期13卷 1550-1551页

作者： Hajime Takase Josephine Lok ken Arai Neuroprotection Research Laboratory Departments of Radiology and NeurologyMassachusetts General Hospital and Harvard Medical School

Cerebral white matter is vulnerable to oxidative stress： Oxidative stress is one of the major harmful conditions for the central ner- vous system （CNS）. Oxidative stress is a state from an imbalance between free radical production and their removal by antioxidants, resulting in an excessive amount of reactive oxygen species （ROS） in cells and tissues. ROS causes cell damage due to oxidation of cellular components, including DNAs, proteins, and lipids. During physiological conditions, small amounts of ROS are generated in the process of normal biological activity, and ROS at physiological levels play important roles in maintaining cellular homeostasis （Chen et al., 2018）. However, during pathological conditions, ROS levels are increased and excessive ROS can lead to deleterious ef- fects on many kinds of cells.

关键词：

Strategy for the control of drug-induced liver injury due to investigational treatments/drugs for COVID-19

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2021年第48期27卷 8370-8373页

作者： ken Sato Yuichi Yamazaki Toshio Uraoka Department of Gastroenterology and Hepatology Gunma University Graduate School of MedicineMaebashi 371-8511GunmaJapan

Investigational treatments/drugs for coronavirus disease 2019(COVID-19)have been applied,with repurposed or newly developed drugs,and their effectiveness has been *** of these drugs may be hepatotoxic,and each monotherapy or combination therapy may increase the risk of drug-induced liver injury(DILI).We should aim to control dysregulation of liver function,as well as the progression of COVID-19,as much as *** discussed the potential risks of investigational treatments/drugs and promising drugs for both COVID-19 and DILI due to investigational treatments/drugs.

关键词： Coronavirus disease 2019 Drug-induced liver injury Cytochrome P450 Drug-drug interaction Drug-disease interaction Cytokine

Indigenous peoples, heritage and landscape in the Asia-Pacifc: Knowledge co-production and empowerment, edited by Stephen Acabado and Da-Wei Kuan. Routledge, Abingdon and New York, 2021. 213pp. $201.00 (hardcover). ISBN9780367648718

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Built Heritage 2022年第2期6卷 106-109页

作者： ken Taylor Centre for Heritage&Museum Studies The Australian National UniversityCanberraAustralia

Collaborative academic scholarly and professional discourse on the links between landscape and heritage has burgeoned over the last two or three *** has emerged,in efect,is a manifesto for a move to a refreshed way of thinking and acting where we understand heritage and landscape as philosophically *** links exist between landscape and heritage is quite clear and we may,therefore,ask where and how does the concept of cultural landscapes slot into thinking on changing perspectives in heritage.

关键词： discourse landscape has

Arabidopsis Roots and Light:Complex Interactions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular Plant 2019年第11期12卷 1428-1430页

作者： Yinglang Wan ken Yokawa Frantisek Baluska Hainan Key Laboratory for Sustainable Utilization of Tropical Bioresources College of Tropical CropsHainan UniversityHaikou 570228China Research Center for Okhotsk Agriculture- Forestry-and Fisheries-Engineering CollaborationKitami Institute of TechnologyHokkaido 090-8507Japan lnstitute of Cellular and Molecular Botany University of Bonn53115 BonnGermany

Unlike actively moving animals,plants actively change their body architecture via growth of their diverse organs in response to environmental clues and *** example,changes in Arabidopsis thaliana root apex zonation under phosphate(Pi)deficiency is considered to be such an active response,including inhibition of primary root elongation and increasing densities of lateral roots and root hairs(Abel,2017).However,a recent study by Zheng et al.(2019)modifies this hypothesis,which is based on the transparent Petri dish-based culture method of young Arabidopsis seedlings causing illumination of *** this issue,Zheng et al.(2019)report that Pi deficiency not only increases malate secretion from Arabidopsis root apices via the ALMT1 transporter but also that blue light(BL)triggers a malate-mediated photo-Fenton reaction in the rhizosphere,increasing the OH radical levels.

关键词： Arabidopsis roots illumination