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Research in Astronomy and Astrophysics 2023年第1期23卷 153-160页

作者： Wenyu Xin ken’ichi nomoto Gang Zhao Xianfei Zhang CAS Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China Kavli Institute for the Physics and Mathematics of the Universe(WPI) The University of Tokyo Institutes for Advanced StudyThe University of TokyoKashiwaChiba 277-8583Japan Department of Astronomy Beijing Normal UniversityBeijing 100875China

Motivated by the determination of black hole masses with gravitational-wave observations,we calculate the evolution of massive stars through presupernova stages and obtain the mass distribution of black *** the first part,we calculate the evolution of He stars with masses of 30-120 M_(⊙).We study in detail how convective carbon shell burning controls pair-instability pulsations before and during oxygen burning and determine their final *** the second part,we calculate the evolution of H-rich stars with initial masses of 13-80 M_(⊙) until Fe core collapse and obtain the possible black hole mass range by applying the criterion of the compactness *** these models,we predict the mass distribution of black holes for stars that undergo Fe core collapse and pair-instability *** predicted masses for black holes range from 4.2 to 46 M_(⊙),which are consistent with the gravitational-wave observations.

关键词： gravitational waves-stars black holes-stars evolution-stars massive-(stars:)supernovae general

Impact of the new ^(12)C+^(12)C reaction rate on presupernova nucleosynthesis

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Chinese Physics C 2023年第3期47卷 206-217页

作者：辛文宇野本憲一赵刚吴文博 CAS Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBejing 10o101China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China Kavli Institute for the Physics and Mathematics of the Universe(WPI) The University of Tokyo Institutes for Advanced StudyThe University of TokyoKashiwaChiba277-8583Japan

The ^(12)C+^(12)C reaction rate plays an essential role in stellar evolution and ***,the uncertainties of this reaction rate are still *** calculate a series of stellar evolution models with the near solar abundance from the zero-age main-sequence through presupernova stages for initial masses of 20 M_(⊙) to 40 M_(⊙).The ^(12)C+^(12)C reaction rates from two different studies are used in our *** is the rate obtained using the Trojan Horse Method(THM)by Tumino et al.[Nature 557(7707),687(2018)],and the other was obtained by Mukhamedzhanov et al.[Physical Review C 99(6),064618(2019)](Muk19).Then,comparisons of the nucleosynthesis and presupernova isotopic abundances are *** particular,we find that in the C burning shell,models with the THM produce a smaller amount of ^(23)Na and some neutron-rich isotopes than *** difference in the abundance ratios of Na/Mg,S/Mg,Ar/Mg,and K/Mg between the two models are *** compare Na/Mg obtained from our theoretical presupernovae models with Na/Mg in stellar atmospheres observed with high-resolution spectra as well as from the latest galactic chemical evolution *** Na/Mg obtained using the THM is within 2σ of the observed stellar ratio,the theoretical uncertainty on Na/Mg introduced by the uncertainty of the ^(12)C+^(12)C reaction rate is almost equivalent to the standard deviation of astronomical ***,a more accurate ^(12)C+^(12)C reaction rate is crucial.

关键词： reaction rate presupernova nucleosynthesis massive stars

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World Journal of Gastroenterology 2006年第11期12卷 1805-1809页

作者： Yoshimi Nakajima Hitoshi Takagi Naondo Sohara ken Sato Satoru Kakizaki kenichi nomoto Hideki Suzuki Taketoshi Suehiro Tatsuo Shimura Takayuki Asao Hiroyuki Kuwano Masatomo Mori ken Nishikura Department of Medicine and Molecular Science Gunma University Graduate School of Medicine MaebashiGunma 371-8511Japan Department of Surgery Gunma University Graduate School of Medicine MaebashiGunma 371-8511Japan Division of Molecular and Functional Pathology Department of Cellular Function Niigata University Graduate School of Medicine and Dental SciencesNiigataNiigata 951-8510Japan

A 42-year-old woman was admitted to our hospital because of multiple liver tumors detected by ultrasonography. Colonoscopy revealed submucosal tumor in the rectum, which was considered the primary lesion. Endoscopic mucosal resection followed by histopathological examination revealed that the tumor was carcinoid. The resected margin of the tumor was positive for malignant cells. Two courses to transcatheter arterial chemotherapy for liver metastasis were ineffective. Accordingly, the rectal tumor and metastatic lymph nodes were surgically resected. One month after the operation, she received liver transplantation （left lateral segment and caudate lobe） from her son. No recurrent lesion has been observed at two years after the liver transplantation. Liver transplantation should be considered as a treatment option even in advanced case of carcinoid metastasis to the liver. We also discuss the literature on liver transplantation for metastatic carcinoid tumor.

关键词： Carcinoid Liver metastasis Living related liver transplantation

Fixed-ratio combinations of basal insulin and glucagon-like peptide-1 receptor agonists as a promising strategy for treating diabetes

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World Journal of Diabetes 2023年第3期14卷 188-197页

作者： Hiroshi nomoto Department of Rheumatology Endocrinology and NephrologyFaculty of Medicine and Graduate School of MedicineHokkaido UniversitySapporo 060-8638HokkaidoJapan

The maintenance of appropriate glycemic control is important for the prevention of diabetic complications in people with type 2 diabetes(T2D). Numerous oral antidiabetic drugs are now clinically available, but in particular, the introduction of injection regimens using insulin and/or glucagon-like peptide-1 receptor agonist(GLP-1RA)s represents promising step-up options for oral antidiabetic drug treatment. The recently licensed fixed-ratio combination(FRC) products,which comprise basal insulin and a GLP-1RA, have potent anti-hyperglycemic effects and reduce the undesirable side-effects of each component, such as body weight gain, hypoglycemia, and gastrointestinal symptoms. Two FRCs-insulin degludec/Liraglutide and insulin glargine/Lixisenatide-are now clinically available and, to date, several phase Ⅱ/Ⅲ trials have been conducted in particular groups of subjects with T2D. However, their utility in real-world clinical settings is of interest for most clinicians. Recently reported real-world clinical trials of these two FRCs in various situations have demonstrated their efficacy regarding glycemic control and the quality of life of people with T2D. Their long-term safety and efficacy require confirmation, but a treatment strategy that includes an FRC may be compatible with the concept of “well-balanced” therapy in certain groups of patients with T2D who have inadequate glycemic control.

关键词： Clinical trial Diabetes mellitus,type 2 Glucagon-like peptide-1 receptor Glycemic control Insulin,long-acting Quality of life

Small sphincterotomy combined with papillary dilation with large balloon permits retrieval of large stones without mechanical lithotripsy

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World Journal of Gastroenterology 2007年第15期13卷 2179-2182页

作者： Atsushi Minami Shinji Hirose Tomohiro nomoto Shoichiro Hayakawa Internal Medicine Kawasaki Kyodo Hospital 2-1-5 Sakuramoto Kawasaki City 210-0833Japan

AIM： TO introduce a new method： small endoscopic sphincterotomy （ES） combined with endoscopic papillary large balloon dilation （SES ＋ EPLBD） to treat patients with large biliary stones.METHODS： Retrieval of large biliary stones was performed in 88 patients. Mean stone size was 14 ± 3 mm and mean number of stones was 2.5 ± 3.5. Firstly, ES with a small incision was performed. Next, endoscopic papillary dilation was performed with a large balloon to slowly match the size of the bile duct. Stones were then retrieved from the biliary duct with a balloon and a basket.RESULTS： Stone retrieval was successful in all cases except one cystic duct stone case without the need to crush large stones. Mean procedure time was 30 ± 5 min. Dilating the papillary orifice with a large balloon made it possible to remove large stones smoothly without crushing them. After dilation with the large balloon, there were some instances of oozing, but no perforations. One instance of post-procedural pancreatitis （1%） occurred. CONCLUSION： SES ＋ EPLBD was effective for the retrieval of large biliary stones without the use of mechanical lithotripsy.

关键词： Endoscopic sphincterotomy Endoscopic papillary dilation Bile duct stone

Dynamic Multi-Wavelength Assignment with Link Aggregation on SLAMNet Test System

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光学学报 2003年第S1期23卷 695-696页

作者： Hiroyuki Yokoyama Hajime Nakamura Shinichi nomoto KDDI R&D Laboratories Inc. 2-1-15 Ohara Kamifukuoka-shi Saitama 356-8502 JapanKDDI R&D Laboratories Inc. 2-1-15 Ohara Kamifukuoka-shi Saitama 356-8502 JapanKDDI R&D Laboratories Inc. 2-1-15 Ohara Kamifukuoka-shi Saitama 356-8502 Japan

This paper presents the implementation and performance of the best-effort multi-wavelength assignment with link aggregation on the SLAMNet (Statistical Lambda Multiplexing Network) test system.

关键词： link of than Test Dynamic Multi-Wavelength Assignment with Link Aggregation on SLAMNet Test System with

Gastrointestinal stromal tumor presenting with prominent calcification

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World Journal of Gastroenterology 2012年第39期18卷 5645-5648页

作者： Naoki Izawa Takeshi Sawada Ryuichi Abiko Daisuke Kumon Mami Hirakawa Mika Kobayashi Nobuyuki Obinata Masahito nomoto Tadateru Maehata Shun-ichi Yamauchi Takefumi Kouro Takashi Tsuda Satoshi Kitajima Hiroshi Yasuda Keiichi Tanaka ichiro Tanaka Masahiro Hoshikawa Masayuki Takagi Fumio Itoh Division of Gastroenterology and Hepatology St.Marianna University School of MedicineKawasaki 216-8511Japan Division of Gastroenterological and General Surgery St.Marianna University School of MedicineKawasaki 216-8511Japan Department of Pathology St.Marianna University School of MedicineKawasak 216-8511Japan

We present a rare case of a gastrointestinal stromal tumor (GIST) in the stomach with prominent calcifica-tion at presentation. A 61-year-old woman visited our hospital because of epigastric discomfort. A spherical calcified lesion with a diameter of about 30 mm was incidentally shown in the left upper quadrant on an abdominal X-ray. Computed tomography demonstrated that the tumor was growing from the upper gastric body, with calcification in the peripheral ring area. A laparoscopic partial gastrectomy was performed, and the resected specimen revealed a well-circumscribed tumor with exophytic growth from the gastric muscularis propria. Microscopic examination revealed spindle- shaped tumor cells with calcification and hemorrhage. Additionally, positive immunoreactivity of the tumor to KIT and CD34 and a low mitotic index resulted in the diagnosis of very low risk GIST. There are a few case reports of heavily calcified GIST, although solitary or punctate calcification of primary GIST has been reported in several case series. Dystrophic calcification of necrotic or degenerative tissue is the supposed cause of primary calcified GISTs. In contrast, appearance of calcification after administration of imatinib mesylate, which may be one indicator of disease response, is possibly caused by a different mechanism.

关键词： Gastrointestinal stromal tumor Calcifica-tion Stomach Computed tomography Imatinib me-sylate

Risk factors of gastric cancer specific for tumor location and histology in Cali,Colombia

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World Journal of Gastroenterology 2006年第36期12卷 5772-5779页

作者： Francia Campos Gabriel Carrasquilla Chihaya Koriyama Mauricio Serra Edwin Carrascal Tetsuhiko Itoh Mitsuharu nomoto Suminori Akiba Depart-ment of Epidemiology and Preventive Medicine Kagoshima Uni-versity Graduate School of Medical and Dental Sciences 8-35-1 Sakuragaoka Kagoshima 890-8544 Japan Department of Microbiology Faculty of Health Sciences Universidad del Valle San Fernando Cali Co-lombia Health Division FES Foundation Cali Colom-bia Department of Pathology Faculty of Health Sciences Universidad del Valle San Fernando Cali Colombia Kaisei-en Geriatric Health Services Facility 551 Akasegawa Akune Kagoshima Japan Department of Human Pathology Kagoshi-ma University Graduate School of Medical and Dental Sciences 8-35-1 Sakuragaoka Kagoshima 890-8544 Japan

AIM- To examine histology- and tumor-location specific risk factors of gastric cancer （GC）.METHODS： This was subjects were 216 GC the period 2000-2002 non-cancer patients hospital. We obtained habits, and others by a a case-control study. The study patients newly diagnosed during and 431 controls selected from matching in age, gender, and information on lifestyles, dietary ***： The subjects who were not eldest among his/her siblings were at a slightly elevated GC risk （OR 1.3; 95% CI 0.8-2.0）. Salting meals before tasting was related to an increased GC risk （OR 3.5; 95% CI 1.6- 7.3）. Frequent consumptions of fruits （OR 0.3; 95% CI 0.1-1.0） and vegetables （OR 0.3; 95% CI 0.1-1.0） were related to decreased GC risks. On the other hand, frying foods （OR 1.9; 95% CI 1.0-3.6） and cooking with coal （OR 1.8; 95% CI 1.3-2.6） were related to increased GC risks. Neither Lauren＇s histological classification （intestinal and diffuse types） nor tumor location significantly affected those associations except birth order. The subjects who were not eldest among his/her siblings had an increased risk of GCs in the distal and middle thirds, and their ORs were 1.7 （95% CI 1.0-2.8） and 1.9 （95% CI 0.8-4.3）, respectively. The corresponding OR in the upper third stomach was 0.3 （95% CI 0.1-0.9）. The differences of those three ORs were statistically significant （P = 0.010）.CONCLUSION： The present study shows that birth order, salt intake, consumption of fruits and vegetables, the type of cooking, and cigarette smoking are related to GC risk. In histology and tumor-location specific analyses, non-eldest person among their siblings is related to an increased GC risk in the distal and middle thirds of the stomach, and is related to a decreased GC risk in the cardia.

关键词： Gastric cancer Risk factor Tumor location Histological type Colombia

Oncological problems in pancreatic cancer surgery

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World Journal of Gastroenterology 2006年第28期12卷 4466-4472页

作者： Akimasa Nakao Tsutomu Fujii Hiroyuki Sugimoto Naohito Kanazumi Shuji nomoto Yasuhiro Kodera Soichiro Inoue Shin Takeda Department of Surgery Ⅱ Nagoya University Graduate School of MedicineNagoyaJapan

Despite the development of more sophisticated diagnostic techniques, pancreatic carcinoma has not yet been detected in the early stage. Surgical resection provides the only chance for cure or long-term survival. The resection rate has increased due to recent advances in surgical techniques and the application of extensive surgery. However, the postoperative prognosis has been poor due to commonly occurring liver metastasis, local recurrence and peritoneal dissemination. Recent molecular-biological studies have clarified occult metastasis, micrometastasis and systemic disease in pancreatic cancer. Several oncological problems in pancreatic cancer surgery are discussed in the present review.

关键词： Pancreatic cancer Extended resection Molecular diagnosis Micrometastasis Adjuvant therapy

Extended cancer-free survival after palliative chemoradiation for metastatic esophageal cancer

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World Journal of Gastrointestinal Oncology 2014年第2期6卷 52-54页

作者： Hideomi Yamashita Kae Okuma Akihiro nomoto Mami Yamashita Hiroshi Igaki Keiichi Nakagawa Departments of Radiology University of Tokyo Hospital Departments of Palliative Care Unit University of Tokyo Hospital

We report on a patient who remained cancer-free for an extended time after palliative radiotherapy(RT) and chemotherapy(nedaplatin plus 5-fluorouracil) treatment for stage Ⅳ(cT3N3M1) esophageal squamous cell carcinoma. Although multiple lymph nodes outside the RT field recurred, the local primary tumor within the RT field did not recur, even 17 mo after palliative RT of 30 Gy in 10 fractions. In this case, acute toxicity, such as myelosuppression or esophagitis, was not enhanced by increasing the fraction dose from 1.8-2.0 Gy to 3.0 Gy. Because 30 Gy in 10 fractions can be completed within a shorter time and is less expensive than 50.4 Gy in 28 fractions, we think that 30 Gy without oblique beams is a more favorable RT method for patients.

关键词： Radiotherapy Chemotherapy Esophageal cancer Esophageal stenosis Metastatic esophageal cancer