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Potential mechanism of corpus-predominant gastritis after PPI therapy in Helicobacter pylori-positive patients with GERD

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World Journal of Gastroenterology 2014年第34期20卷 11962-11965页

作者： ken-ichi Mukaisho Tadashi hagiwara Takahisa Nakayama Takanori Hattori Hiroyuki Sugihara Department of Pathology Division of Molecular Diagnostic PathologyShiga University of Medical ScienceSeta-tsukinowa-choOtsuShiga 520-2192Japan

The long-term use of proton pump inhibitors(PPIs)exacerbates corpus atrophic gastritis in patients with Helicobacter pylori(***)*** identify a potential mechanism for this change,we discuss interactions between pH,bile acids,and *** reflux,which includes bile,occurs in healthy individuals,and bile reflux is increased in patients with gastroesophageal reflux disease(GERD).Diluted human plasma and bile acids have been found to be significant chemoattractants and chemorepellents,respectively,for the bacillus *** only taurine conjugates,with a pKa of 1.8-1.9,are soluble in an acidic environment,glycine conjugates,with a pKa of 4.3-5.2,as well as taurine-conjugated bile acids are soluble in the presence of PPI ***,the soluble bile acid concentrations in the gastric contents of patients with GERD after continuous PPI therapy are considerably higher than that in those with intact acid *** the distal stomach,the high concentration of soluble bile acids is likely to act as a bactericide or chemorepellent for *** contrast,the mucous layer in the proximal stomach has an optimal bile concentration that forms chemotactic gradients with plasma components required to direct *** to the epithelial *** may then colonize in the stomach body rather than in the pyloric antrum,which may explain the occurrence of corpus-predominant gastritis after PPI therapy in ***-positive patients with GERD.

关键词： Helicobacter pylori Proton pump inhibitor Corpus-predominant gastritis Bile acids Gastroesophageal reflux disease Chemotactic gradient

CONVERGENCE ANALYSIS FOR A NONCONFORMING MEMBRANE ELEMENT ON ANISOTROPIC MESHES

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Journal of Computational Mathematics 2005年第4期23卷 373-382页

作者： Dong-yang Shi Shao-chun Chen ichiro hagiwara Department of Mathematics Zhengzhou University Zhengzhou 450052 China Tokyo Institute of Technology 2-12-1 Ohokayama Megro Tokyo 152-8552 Japan

Regular assumption of finite element meshes is a basic condition of most analysis of finite element approximations both for conventional conforming elements and nonconforming elements. The aim of this paper is to present a novel approach of dealing with the approximation of a four-degree nonconforming finite element for the second order elliptic problems on the anisotropic meshes. The optimal error estimates of energy norm and L^2-norm without the regular assumption or quasi-uniform assumption are obtained based on some new special features of this element discovered herein. Numerical results are given to demonstrate validity of our theoretical analysis.

关键词： Anisotropic mesh Nonconforming finite element Optimal estimate

Biomimetic Drag Reduction Study on Herringbone Riblets of Bird Feather

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Journal of Bionic Engineering 2013年第3期10卷 341-349页

作者： Huawei Chen Fugang Rao Xiaopeng Shang Deyuan Zhang ichiro hagiwara School of Mechanical Engineering and Automation Beihang University Beijing 100191 P. R. China Department of Mechanical Science and Engineering Tokyo Institute of Technology Tokyo 152-8550 Japan

Birds have gradually formed various excellent structures such as streamlined shape and hollow shaft of feather to improve their flying performance by millions of years of natural selection. As typical property of bird feather, herringbone riblets align along the shaft of each feather, which is caused by perfect link of barbs, especially for the primary and secondary feathers of wings. Such herringbone riblets of feather are assumed to have great impact on drag reduction. In this paper, microstructures of secondary feathers of adult pigeons are investigated by SEM, and their structural parameters are statistically obtained. Based on quantitative analysis of feather structure, novel biomimetic herringbone riblets with narrow smooth edge are proposed to reduce surface drag. In comparison with traditional microgroove riblets and other drag reduction structures, the drag reduction rate of the proposed biomimetic herringbone riblets is experimentally clarified up to 16%, much higher than others. Moreover, the drag reduction mechanism of herringbone riblets are also confirmed and exploited by CFD.

关键词： biomimetic surface drag reduction herringbone riblets bird feather

Prediction of Anisotropy Affected Fatigue Crack Growth Paths on Pure Aluminum Sheets

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Prediction of Anisotropy Affected Fatigue Crack Growth Paths...

MOTION ERROR ESTIMATION OF 5-AXIS MACHINING CENTER USING DBB METHOD

The Sixth World Congress on Computational Mechanics in Conjunction with the Second Asian-Pacific Congress on Computational Mechanics

作者： Yudy Surya Irawan Yoshihiko hagiwara Shin-ichi Ohya Department of Mechanical System Engineering Musashi Institute of Technology 1-28-1 Tamazutsumi Setagaya-ku Tokyo 158-8557 Japan Department of Mechanical System Engineering Musashi Institute of Technology 1-28-1 Tamazutsumi Setagaya-ku Tokyo 158-8557 Japan Department of Mechanical System Engineering Musashi Institute of Technology 1-28-1 Tamazutsumi Setagaya-ku Tokyo 158-8557 Japan

It is common that the anisotropy of rolling plate does not affect the fatigue crack propagation paths. Thus, when CCT-specimens of rolled plate with any rolling direction are applied by tensile fatigue load, the cracks propagate to mode Ⅰdirection. However, in case of CCT specimens of pure aluminum sheets A100P with rolling direction 30 degrees towards loading direction, the fatigue crack does not grow to mode Ⅰdirection but to rolling direction as a mixed mode Ⅰ-Ⅱcrack [1]. In order to understand the behavior of this anisotropy affected fatigue crack and improve the previous estimation technique [2, 3], basic experimental data was obtained from fatigue test using no-holed CCT-specimens with 30 degrees of rolling direction. The stress intensity factors and energy release rates were calculated using two-dimensional finite element analysis. Based on the basic experimental results, the anisotropy affected cracks were simulated as follow: 1) an initial mode Ⅰcrack grows in the direction with maximum energy release rate and the crack starts to gradually change its direction to rolling direction in the certain value of mode Ⅰstress intensity factor;2) On rolling direction, the crack continues to propagate to rolling direction in the certain value of total stress intensity factor and the ratio of mode Ⅱand mode Ⅰenergy release rate, GⅡ/GⅠis higher than 2.0;and 3) The crack change the direction from rolling direction to mode Ⅰdirection, when maximum mode Ⅱstress intensity factor is reached. This purposed method can predict crack propagation paths in no-hole specimens and 6-type holed specimens with 0, 30, 45 and 60 degrees of rolling direction. The simulation results were confirmed well to be coincided with experimental results.

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Chinese Journal of Mechanical Engineering 2006年第2期19卷 276-281页

作者： CHEN Huawei ZHANG Dawei TIAN Yanling ichiR0 hagiwara School of Mechanical Engineering Tianjin UniversityTianjin 300072 China Graduate School of Science and Engineering Tokyo Institute of TechnologyTokyo JAPAN

In order to estimate the motion errors of 5-axis machine center, the double ball bar （DBB） method is adopted to realize the diagnosis procedure. The motion error sources of rotary axes in 5-axis machining center comprise of the alignment error of rotary axes and the angular error due to various factors, e.g. the inclination of rotary axes. From sensitive viewpoints, each motion error is possible to have a particular sensitive direction in which deviation of DBB error trace arises from only some specific error sources. The model of the DBB error trace is established according to the spatial geometry theory. Accordingly, the sensitive direction of each motion error source is made clear through numerical simulation, which is used as the reference patterns for rotational error estimation. The estimation method is proposed to easily estimate the motion error sources of rotary axes in quantitative manner. To verify the proposed DBB method for rotational error estimation, the experimental tests are carried out on a 5-axis machining center M-400 （MORISEIKI）. The effect of the mismatch of the DBB is also studied to guarantee the estimation accuracy. From the experimental data, it is noted that the proposed estimation method for 5-axis machining center is feasible and effective.

关键词： 5-axis NC machine tool Double ball bar(DBB) Motion errors of rotary axes

Clothing skirt designed on conical truss model

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Advances in Manufacturing 2013年第2期1卷 130-135页

作者： Eri Nakayama Sachiko Ishida Yu-Jing Liao ichiro hagiwara Organization for the Strategic Coordination of Research and Intellectual Property Meiji University8114-21-1NakanoNakano-kuTokyo 164-8525Japan

Several applications of Origami have been tested in industrial area. However, Origami based design is found only in lamp shade and wrapping in design area, and has not been practically applied especially in clothing. In this paper, the conical truss model is applied in the clothing skirt, and the simulation software from 2D to 3D is developed by parametric Origami module （POM）. Finally, the pattern is copied on felt clothing, and the scaled model of skirt on the basis of conical reverse truss model design is made.

关键词： Origami Conical truss model ParametricOrigami module (POM)

Modified simultaneous integrated boost radiotherapy for an unresectable huge refractory pelvic tumor diagnosed as a rectal adenocarcinoma

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World Journal of Gastroenterology 2014年第48期20卷 18480-18486页

作者： Takuma Nomiya Hiroko Akamatsu Mayumi Harada Ibuki Ota Yasuhito hagiwara Mayumi ichikawa Misako Miwa Shouhei Kawashiro Motohisa hagiwara Masahiro Chin Eiji Hashizume kenji Nemoto Department of Radiation Oncology National Institute of Radiological Sciences Chiba 263-8555 Japan Department of Radiation Oncology Yamagata University Hospital Yamagata 990-8560 Japan Department of Surgery Nihonkai General Hospital Yamagata 990-8560 Japan

A clinical trial of radiotherapy with modified simultaneous integrated boost(SIB)technique against huge tumors was conducted.A 58-year-old male patient who had a huge pelvic tumor diagnosed as a rectal adenocarcinoma due to familial adenomatous polyposis was enrolled in this *** total dose of 77 Gy(equivalent dose in 2Gy/fraction)and 64.5 Gy was delivered to the center of the tumor and the surrounding area respectively,andapproximately 20%dose escalation was achieved with the modified SIB *** tumor with an initial maximum size of 15 cm disappeared 120 d after the start of the *** status of the patient improved from 4 to *** with modified SIB may be effective for patients with a huge tumor in terms of tumor shrinkage/disappearance,improvement of QOL,and prolongation of survival.

关键词： Clinical trial Image-guided radiotherapy Rectal neoplasms Quality of life Neoplasm recurrence

Antiviral therapy for chronic hepatitis B: Combination of nucleoside analogs and interferon

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World Journal of Hepatology 2015年第23期7卷 2427-2431页

作者： Satoru hagiwara Naoshi Nishida Masatoshi Kudo Depart-ment of Gastroenterology and Hepatology Kinki University School of Medicine

The ideal goal of chronic hepatitis B(CHB) treatment should be suppression of emergence of hepatocellular carcinoma through the disappearance of hepatitis B s antigen(HBs Ag) rather than the control of serum hepatitis B virus-DNA level. For this purpose, various types of combination therapies using nucleoside analogs(NAs) and interferon(IFN) have been conducted. The therapeutic effects of combination of two different kinds of agents are better than those of the monotherapy using NAs or IFN alone, probably because different pharmaceutical properties might act in a coordinated manner. Recently, combination therapies with NAs and IFN and sequential therapies with NAs administration followed by IFN therapy have been routinely employed. We previously reported that combination therapy using entecavir(ETV) and pegylated(PEG)-IFN showed antiviral effects in 71% of CHB patients; the effect of this combination was better than that using lamivudine(LAM) and PEG-IFN. This is partially explained by the better antiviral effects of ETV than those of LAM. In our analysis, the cohort of CHB consisted of the patients who showed a flare-up of hepatitis before antiviral therapy, and their baseline HBs Ag levels were relatively low. Therefore, in addition to the combination of the agents, the appropriate selection of patients is critical to achieve a good viral response.

关键词： Hepatitis B virus Interferon Sequential therapy Co

Can endoscopic submucosal dissection be safely performed in a smaller specialized clinic?

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World Journal of Gastroenterology 2013年第4期19卷 528-535页

作者： Naondo Sohara Satoshi hagiwara Riki Arai Haruhisa Iizuka Yasuhiro Onozato Satoru Kakizaki Department of Endoscopy and Endoscopic Surgery Shirakawa ClinicMaebashiGunma 371-0051Japan Department of Medicine and Molecular Science Gunma University Graduate School of MedicineMaebashiGunma 371-8511Japan

AIM:To investigate whether endoscopic submucosal dissection(ESD) can be safely performed at small clinics,such as the Shirakawa ***:One thousand forty-seven ESDs to treat gastrointestinal tumors were performed at the Shirakawa Clinic from April 2006 to March *** efficacy,technical feasibility and associated complications of the procedures were *** ESD procedures were performed by five *** was induced with propofol for esophagogastorduodenal ***:One thousand forty-seven ESDs were performed to treat 64 patients with esophageal cancer(E),850 patients with gastric tumors(G:764 patients with cancer,82 patients with adenomas and four others),four patients with duodenal cancer(D) and 129 patients with colorectal tumors(C:94 patients with cancer,21 patients with adenomas and 14 others).The en bloc resection rate was 94.3%(E:96.9%,G:95.8%,D:100%,C:79.8%).The median operation time was 46 min(range:4-360 min) and the mean size of the resected specimens was 18 mm(range:2-150 mm).No mortal complications were observed in association with the ESD *** occurred in 12 cases(1.1%,E:1 case,G:9 cases,D:1 case,C:1 case) and postoperative bleeding occurred in 53 cases(5.1%,G:51 cases,D:1 case,C:1 case);however,no case required either emergency surgery or blood *** of the perforations and postperative bleedings were resolved by endoscopic clipping or *** other problematic complication observed was pneumonia,which was treated with conservative ***:ESD can be safely performed in a clinic with established therapeutic methods and medical services to address potential complications.

关键词： Endoscopic submucosal dissection Complication Perforation Clinic