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异麦芽糖铁对伴有缺铁的慢性心力衰竭患者骨骼肌耐力的影响:一项三价铁-心力衰竭Ⅱ期的随机动态研究

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中华高血压杂志(中英文) 2019年第8期 799-799页

作者： Charles-Edwards G Amaral N Sleigh A Ayis S Catibog N McDonagh T Monaghan M Amin-Youssef G kemp gj Shah AM Okonko DO 曾文飞余惠珍

慢性心力衰竭(chronic heart failure, CHF)患者补充铁元素后,尽管血红蛋白增加不多,却能够增强运动耐力。铁离子如何增强骨骼肌运动强度,目前仍缺乏相关研究来阐明其中的机制。铁离子为血红蛋白的重要组分,也是线粒体酶中的重要组分之... 详细信息

慢性心力衰竭(chronic heart failure, CHF)患者补充铁元素后,尽管血红蛋白增加不多,却能够增强运动耐力。铁离子如何增强骨骼肌运动强度,目前仍缺乏相关研究来阐明其中的机制。铁离子为血红蛋白的重要组分,也是线粒体酶中的重要组分之一,线粒体酶以三磷酸腺苷和磷酸肌酸的形式产生细胞能量代谢。动态31P磁共振波谱学(31PMRS)是一种非侵入性技术,通过测定肌肉磷酸肌酸的代谢动力学参数来定量体内肌肉的能量变化。该文企图验证这

关键词：慢性心力衰竭骨骼肌心功能分级终点事件三价铁异麦芽糖随机动态

VERIFYING THE IMPLICITIZATION FOR MULAE FORDEGREE n RATIONAL BEZIER CURVES

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Journal of Computational Mathematics 1999年第1期17卷 33-40页

作者： Wang, gj Sederberg, TW Brigham Young Univ Dept Comp Sci Provo UT 84602 USA Zhejiang Univ Dept Appl Math Hangzhou 310027 Peoples R China

This is a continuation of short communication([1]). In [1] a verification of the implicitization equation for degree two rational Bezier curves is presented which does not require the use of resultants. This paper presents these verifications in the general cases, i.e., for degree n rational Bezier curves. Thus some interesting interplay between the structure of the n x n implicitization matrix and the de Casteljau algorithm is revealed.

关键词： rational Bezier curve implicitization resultant de Casteljau algorithm

Understanding the health and social care needs of people living with IBD: A meta-synthesis of the evidence

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World Journal of Gastroenterology 2012年第43期18卷 6240-6249页

作者： Karen kemp Jane Griffiths Karina Lovell School of Nursing Midwifery and Social Work University of Manchester Manchester M13 9PL United Kingdom Department of Gastroenterology Manchester Royal Infirmary Manchester M13 9WL United Kingdom

AIM:To undertake a metasynthesis of qualitative studies to understand the health and social needs of people living with inflammatory bowel disease (IBD). METHODS:A systematic search strategy identified qualitative studies exploring the phenomenon of living with inflammatory bowel disease. Databases included MEDLINE, PsychInfo, EMBASE, CINAHL and the British Nursing Index via the OVID platform. Qualitative search filters were adapted from Hedges database (http://***/hslt/miner/ digital_library/tip_sheets/Cinahl_eb_***). Qualitative empirical studies exploring the health and social needs of people living with inflammatory bowel disease were selected. Study eligibility and data extraction were independently completed using the Critical Appraisal Skills Programme for qualitative studies. The studies were analysed and synthesised using metasynthesis methodology. The themes from the studies allowed for common translations into a new interpretation of the impact of living with inflammatory bowel disease. RESULTS:Of 1395 studies, six published studies and one unpublished thesis fulfilled the inclusion criteria. First iteration of synthesis identified 16 themes, 2nd iteration synthesised these into three main 2nd order constructs:"detained by the disease"; "living in a world of disease" and "wrestling with life". "Detained by the disease" is the fear of incontinence, the behaviour the patients display due to the fear, and the impact this has on the individual, such as social isolation and missing out on life events. All of these serve to "pull" the patient back from normal living. "Living in a world of disease" is the long term effects of living with a long term condition and the fear of these effects. "Wrestling with life" is the continued fight to thrive, the "push" to continue normal living. CONCLUSION:The metasynthesis provides a comprehensive representation of living with IBD. The unmistakeable burden of incontinence is exposed and its ongoing

关键词： Inflammatory bowel disease Metasynthesis Qualitative Incontinence

Understanding and reducing the fear of COVID-19

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2020年第9期21卷 752-754页

作者： Kwan Hoong NG Ray kemp Department of Biomedical Imaging University of MalayaKuala Lumpur 50603Malaysia Ray kemp Consulting BarringtonCambridgeCB227RRUK

The world is now plagued by a pandemic of unprecedented nature caused by a novel,emerging,and still poorly understood infectious disease,coronavirus disease 2019(COVID-19)(Wu and Mc Googan,2020).In addition to the rap... 详细信息

关键词： COV understood emerging

ROLLING DEFORMATION LAW OF ALUMINIUM ALLOY CLAD SHEET

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中国有色金属学会会刊：英文版 1999年第2期9卷 77-81页

作者： Zhou, HZ Wang, LY Huang, gj SW Aluminium Fabricat Plant Chongqing 401326 Peoples R China Chongqing Univ Dept Met & Mat Engn Chongqing 400044 Peoples R China

１ＩＮＴＲＯＤＵＣＴＩＯＮＡｌＳｉ／ＡｌＭｎｔｒｉｌａｙｅｒｂｒａｚｅｄｃｌａｄａｌｕｍｉｎｉｕｍｓｈｅｅｔｉｓｔｈｅｍａｉｎｍａｔｅｒｉａｌｆｏｒｍａｋｉｎｇｅｖａｐｏｒａｔｏｒａｎｄｃｏｏｌｅｒｉｎｔｈ... 详细信息

１ＩＮＴＲＯＤＵＣＴＩＯＮＡｌＳｉ／ＡｌＭｎｔｒｉｌａｙｅｒｂｒａｚｅｄｃｌａｄａｌｕｍｉｎｉｕｍｓｈｅｅｔｉｓｔｈｅｍａｉｎｍａｔｅｒｉａｌｆｏｒｍａｋｉｎｇｅｖａｐｏｒａｔｏｒａｎｄｃｏｏｌｅｒｉｎｔｈｅａｉｒｃｏｎｄｉｔｉｏｎｅｒｏｆ...

关键词： aluminium alloyclad sheetrolling deformationdeformation lawcan be divided into 3 stages: free (slip or nonrestraining) deformation stage partial restraining (partial clad) deformation stage full restraining (full clad) deformation stage.

Autoantibodies against MMP-7 as a novel diagnostic biomarker in esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2011年第10期17卷 1373-1378页

作者： Jing-Hua Zhou Bin Zhang kemp H Kernstine Li Zhong Department of CellBiology College of Life Sciences Hebei University Baoding071400 Hebei Province China Department of Thoracic Surgery City of Hope Medical Center Duarte CA 91766 United States Department of Basic Medical Sciences College of Osteopathic Medicine Western University of Health SciencesPomona CA 91766 United States

AIM： To evaluate the diagnostic values of serum autoan tibodies against matrix metalloproteinase-7 （MMP-7） in patients with esophageal squamous cell carcinoma （ESCC）. METHODS： The MMP-7 cDNA was cloned from ESCC tissues, and MMP-7 was expressed and purified from a prokaryotic system. MMP-7 autoanUbodies were then measured in sera from 50 patients with primary ESCC and 58 risk-matched controls, using a reverse capture enzyme-linked immunosorbent assay （ELISA） in which autoantibodies to MMP-7 bound to the purified MMP-7 proteins. In addition, MMP-7 autoantibody levels in sera from 38 gastric cancer patients and from control serum samples were also tested. RESULTS： The optimum conditions for recombinant MMP-7 protein expression were determined as 0.04 mmol/L Isopropyl-13-D-Thiogalactopyranoside （IPTG）induction at 37℃ for four hours. The levels of serum autoantibodies against MMP-7 were significantly higher in patients with ESCC than in the matched-control samples （OD450 = 1.69 ±0.08 vs OD450 = 1.55 ± 0.10, P 〈 0.001）. The area under the receiver operating character- istic （ROC） curve was 0.87. The sensitivity and specificity for detection of ESCC were 78.0% and 81.0%, respectively, when the OD450 value was greater than 1.65. Although the levels of autoantibodies against MMP-7 were also significantly higher in patients with gastric cancer compared to control samples （OD450 = 1.62± 0.06 vs OD450 = 1.55±0.10, P 〈 0.001）, the diagnostic accuracy was less significant than in ESCC patients. The area of ROC curve was 0.75, whereas the sensitivity and specificity were 60.5% and 71.7%, respectively, when the cut-off value of OD450 was set at 1.60. CONCLUSION： Serum autoantibody levels of MMP-7 may be a good diagnostic biomarker for esophageal squamous cell carcinoma,

关键词： Matrix metalloproteinase-7 Serum autoantibody Esophageal squamous cell carcinoma Gastriccancer Biomarker

The　Electrochemistry　of　Cytochrome　c　at　a　Viologen-thiol　Self-Assembled　Monolayer

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Chemical Research in Chinese Universities 1998年第1期14卷 17-24页

作者： Li, JH Cheng, gj Dong, SJ Chinese Acad Sci Changchun Inst Appl Chem Electroanalyt Chem Lab Changchun 130022 Peoples R China

ＴｈｅＥｌｅｃｔｒｏｃｈｅｍｉｓｔｒｙｏｆＣｙｔｏｃｈｒｏｍｅｃａｔａＶｉｏｌｏｇｅｎ－ｔｈｉｏｌＳｅｌｆ－ＡｓｓｅｍｂｌｅｄＭｏｎｏｌａｙｅｒＬＩＪｉｎｇ－ｈｏｎｇ，ＣＨＥＮＧＧｕａｎｇ－ｊｉｎ，ＤＯＮＧＳｈａｏ－... 详细信息

ＴｈｅＥｌｅｃｔｒｏｃｈｅｍｉｓｔｒｙｏｆＣｙｔｏｃｈｒｏｍｅｃａｔａＶｉｏｌｏｇｅｎ－ｔｈｉｏｌＳｅｌｆ－ＡｓｓｅｍｂｌｅｄＭｏｎｏｌａｙｅｒＬＩＪｉｎｇ－ｈｏｎｇ，ＣＨＥＮＧＧｕａｎｇ－ｊｉｎ，ＤＯＮＧＳｈａｏ－ｊｕｎ（ＬａｂｏｒａｔｏｒｙｏｆＥ...

关键词： at Viologen-thiol Monolayer Self-Assembled The Cytochrome Electrochemistry

27-Ald-triterpenoid saponins from Adina rubella

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Chinese Journal of Chemistry 1997年第5期15卷 431-437页

作者： Fan, gj He, ZS Wu, HM Xu, JF Chinese Acad Sci Shanghai Inst Mat Med Shanghai 200031 Peoples R China Chinese Acad Sci Shanghai Inst Organ Chem State Key Lab Bioorgan & Nat Prod Chem Shanghai 200032 Peoples R China

Four new triterpenoid saponins were isolated from the roots of Adina rubella Hance. They were characterized as adinaic acid 3 beta-O-[alpha-L-rhamnopyranosyl(1-->2)-beta-D-glucopyranosyl(1-->2)-beta-D-glucurono-pyranoside-6-O-methyl ester]-28-O-beta-D-glucopyranoside, adinaic acid 3 beta-O-[alpha-L-rhamnopyranosyl(1-->2)-beta-D-glucopyranosyl(1-->2)-beta-D-glucuronopyranoside-6-O-butyl ester]-28-O-beta-D-glucopyranoside, adinaic acid 3 beta-O-[beta-D-glucopyranosyl(1-->2)-beta-D-glucopyrnaosyl]-(28-->1)-beta-D-glucopyranosyl(1-->6)-beta-D-glucopyranosyl ester, 27-hydroxyursolic acid 3 beta-O-[alpha-L-rhamnopyranosyl (1-->2)-beta-D-glucopyranosyl(1-->2)-beta-D-glucuronopyranoside-6-O-methyl ester]-28-O-beta-D-glycopyranoside. Their structures were elucidated by spectral methods, especially with the aid of 2D NMR techniques. Their complete assignments of the H-1 and C-13 NMR signals were carried out.

关键词： Adina rubella Hance Rubiaceae adinaic acid glycosides 27-ald-terpenoids

Current Therapeutics in Primary Sclerosing Cholangitis

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Journal of Clinical and Translational Hepatology 2023年第5期11卷 1267-1281页

作者： Natassia Tan John Lubel William kemp Stuart Roberts Ammar Majeed Department of Gastroenterology and Hepatology Alfred HealthCentral Clinical SchoolMonash UniversityMelbourneAustralia

Primary sclerosing cholangitis(PSC)is an orphan,cholestatic liver disease that is characterized by inflammatory biliary strictures with variable progression to end-stage liver *** pathophysiology is poorly *** biliary inflammation is likely driven by immune dysregulation,gut dysbiosis,and environmental exposures resulting in gutliver crosstalk and bile acid metabolism *** is no proven medical therapy that alters disease progression in PSC,with the commonly prescribed ursodeoxycholic acid being shown to improve liver biochemistry at low-moderate doses(15–23 mg/kg/day)but not alter transplant-free survival or liver-related *** transplantation is the only option for patients who develop end-stage liver disease or refractory complications of *** and antifibrotic agents have not proven to be effective,but there is promise for manipulation of the gut microbiome with fecal microbiota transplantation and *** acid manipulation via alternate synthetic bile acids such as norursodeoxycholic acid,or interaction at a transcriptional level via nuclear receptor agonists and fibrates have shown potential in phase II trials in PSC with several leading to larger phase III *** view of the enhanced malignancy risk,statins,and aspirin show potential for reducing the risk of colorectal cancer and cholangiocarcinoma in PSC *** patients who develop clinically relevant strictures with cholestatic symptoms and worsening liver function,balloon dilatation is safer compared with biliary stent insertion with equivalent clinical efficacy.

关键词： Primary sclerosing cholangitis Bile acid Microbiome 24-Norursodeoxycholic acid Farnesoid X receptor agonists Liver transplant