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Long-term efficacy and safety of Huangqi(Radix Astragali Mongolici)-based Traditional Chinese Medicine in diabetic peripheral neuropathy:a Meta-analysis of randomized controlled trials

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Journal of Traditional Chinese Medicine 2024年第2期44卷 229-242页

作者： PING Jing HAO Hongzheng WU Zhenqi ZOU Meijuan li Zuojing CHENG Gang School of life Sciences and Biopharmaceutics Shenyang Pharmaceutical UniversityShenyang 110000China Department of Endocrinology Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang 110000China Department of Research Administration Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang 110000China School of Pharmacy Shenyang Pharmaceutical UniversityShenyang 110000China

OBJECTIVE:To assess the long-term effectiveness of Huangqi(Radix Astragali Mongolici,HQ)-based Traditional Chinese Medicine(TCM)in the treatment of diabetic peripheral neuropathy(DPN).METHODS:Nine databases were searched to retrieve available randomized controlled trials that compared HQbased TCM and Western Medicines in the treatment of *** methodological quality of the included studies was assessed using the Cochrane bias risk tool,and RevMan 5.4 was used for data *** effect estimates of interest were risk ratio(RR),mean difference(MD)or standardized mean difference(SMD)with 95%confidence interval(CI).RESULTS:The results from 48 available studies assessing 3759 patients demonstrated that cases administered HQ-based TCM[RR=1.30,95%CI(1.21,1.40),Plinical Scoring System scores[MD=-1.50,95%CI(-1.83,-1.17),Plipids,oxidative stress and adverse drug reactions,there were no significant differences between the HQ-based TCM groups and the Western Medicine control ***:The current Meta-analysis revealed that HQ-based TCM yields higher efficacy and safety than Western Medicine alone for the treatment of DPN,although further well-designed RCTs are required to validate these findings.

关键词： Huangqi(Radix Astragali Mongolici) medicine Chinese traditional diabetic peripheral neuropathy Meta-analysis

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Responses of runoff to changes in climate and human activities in the liuhe River Basin, China

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Journal of Arid Land 2024年第8期16卷 1023-1043页

作者： li Mingqian WANG He DU Wei GU Hongbiao ZHOU Fanchao CHI Baoming School of Ecology and Environment Institute of Disaster PreventionLangfang 065201China Hebei Key Laboratory of Resource and Environmental Disaster Mechanism and Risk Monitoring Sanhe 065201China Suzhou Qianxing Environmental Engineering Co. Ltd.Suzhou 215000China College of Transportation Engineering Nanjing Tech UniversityNanjing 210000China Tianjin North China Geological Exploration General Institute Tianjin 300000China

Since the 1950s,numerous soil and water conservation measures have been implemented to control severe soil erosion in the liuhe River Basin(LRB),*** these measures have protected the upstream soil and water ecological environment,they have led to a sharp reduction in the downstream flow and the deterioration of the river ecological ***,it is important to evaluate the impact of soil and water conservation measures on hydrological processes to assess long-term runoff *** the Soil and Water Assessment Tool(SWAT)models and sensitivity analyses based on the Budyko hypothesis,this study quantitatively evaluated the effects of climate change,direct water withdrawal,and soil and water conservation measures on runoff in the LRB during different periods,including different responses to runoff discharge,hydrological regime,and flood *** runoff series were divided into a baseline period(1956-1969)and two altered periods,i.e.,period 1(1970-1999)and period 2(2000-2020).Human activities were the main cause of the decrease in runoff during the altered periods,contributing 86.03%(-29.61 mm),while the contribution of climate change was only 13.70%(-4.70 mm).The impact of climate change manifests as a decrease in flood volume caused by a reduction in precipitation during the flood *** of two flood cases indicated a 66.00%-84.00%reduction in basin runoff capacity due to soil and water conservation measures in the upstream *** and water conservation measures reduced the peak flow and total flood volume in the upstream runoff area by 77.98%and 55.16%,respectively,even with nearly double the *** runoff coefficient in the reservoir area without soil and water conservation measures was 4.0 times that in the conservation *** results contribute to the re-evaluation of soil and water conservation hydrological effects and provide important guidance for water resource planning and water conservation policy formu

关键词： runoff soil and water conservation climate variability flood human activities liuhe River Basin

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Paradigm for Determining the Optimal Ultradeep and Superthick Saline Aquifer for High-TDS Mine Water Geological Storage

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Acta Geologica Sinica(English Edition) 2024年第3期98卷 771-785页

作者： li Xin CHEN Ge XU Zhimin liU Qi CHEN Tianci SUN Yajun School of Resources and Geosciences China University of Mining and TechnologyXuzhouJiangsu 221116China National Professional Central Laboratory of Basic Research on Mine Water Disaster Prevention and Control Technology XuzhouJiangsu 221116China

Saline aquifers are the most popular waste and CO_(2)injection and storage reservoirs *** project proposes that several optimal injection positions should be investigated as hydraulic pressure-focused positions,in order to relieve the high demands of pump *** comprehensive indices(F_(i))representing the injectivity of different burial depths were obtained by using information entropy,based on the mercury injection experimental data of 13 rock *** results demonstrated that the burial depths of No.4,No.1 and No.2 in the liujiagou Formation were the most suitable positions for hydraulic focused injection,which means the upper 30 m thickness could be regarded as the hydraulic focused range in the saline aquifer with an average thickness of 400 *** addition,some laboratory experiments and in situ tests were carried out for the purpose of certifying and analyzing results,including SEM,XRD,brittleness index and *** results suggested that the rock samples at the No.4,No.1 and No.2 burial depth ranges have loose microstructure,weak cementation,as well as dual pores and *** lithology is mainly quartz and feldspar,but the clay mineral content is high(10%-25%),which is positive for *** lithology is suitable for hydraulic fracturing to form extended cracks and micro-fissures during high-TDS(total dissolved solids)mine water injection,because of the high brittleness ***,a theoretical and technical framework for high-TDS mine water injection was established,based on operating pilot *** theoretical defects and drawbacks learned from the field practices were summarized and solutions *** research in this study could provide guidance and a paradigm for the inexpensive treatment of high-TDS mine water by injection and storage.

关键词： ultradeep liujiagou Formation high-TDS mine water optimal hydraulic injection positions information entropy reservoir spatial characteristics

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A DNA tetrahedron-based ferroptosis-suppressing nanoparticle: superior delivery of curcumin and alleviation of diabetic osteoporosis

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Bone Research 2024年第1期12卷 227-239页

作者： Yong li Zhengwen Cai Wenjuan Ma Long Bai En Luo Yunfeng lin State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases West China Hospital of StomatologySichuan UniversityChengduSichuan 610041PR China Department of Oral and Maxillofacial Surgery Affiliated Stomatological HospitalSouthwest Medical UniversityLuzhouSichuan 646000PR China Sichuan Provincial Engineering Research Center of Oral Biomaterials ChengduSichuan 610041China

Diabetic osteoporosis(DOP)is a significant complication that poses continuous threat to the bone health of patients with diabetes;however,currently,there are no effective treatment *** patients with diabetes,the increased levels of ferroptosis affect the osteogenic commitment and differentiation of bone mesenchymal stem cells(BMSCs),leading to significant skeletal *** address this issue,we aimed to target ferroptosis and propose a novel therapeutic approach for the treatment of *** synthesized ferroptosis-suppressing nanoparticles,which could deliver curcumin,a natural compound,to the bone marrow using tetrahedral framework nucleic acid(tFNA).This delivery system demonstrated excellent curcumin bioavailability and stability,as well as synergistic properties with *** in vitro and in vivo experiments revealed that nanoparticles could enhance mitochondrial function by activating the nuclear factor E2-related factor 2(NRF2)/glutathione peroxidase 4(GPX4)pathway,inhibiting ferroptosis,promoting the osteogenic differentiation of BMSCs in the diabetic microenvironment,reducing trabecular loss,and increasing bone *** findings suggest that curcumin-containing DNA tetrahedron-based ferroptosissuppressing nanoparticles have a promising potential for the treatment of DOP and other ferroptosis-related diseases.

关键词： curcumin osteoporosis diabetic

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Bioactive citrate-based polyurethane tissue adhesive for fast sealing and promoted wound healing

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Regenerative Biomaterials 2024年第1期3卷 69-81页

作者： Yan li Jiawei liu Chenxi lian He Yang Mingjiang Zhang Youfa Wang Honglian Dai State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Biomedical Materials and Engineering Research Center of Hubei ProvinceWuhan University of TechnologyWuhan 430070China Chaozhou Branch of Chemistry and Chemical Engineering Guangdong Laboratory Chaozhou 521000China Shenzhen Research Institute of Wuhan University of Technology Shenzhen 518000China

As a superior alternative to sutures,tissue adhesives have been developed significantly in recent ***,existing tissue adhesives struggle to form fast and stable adhesion between tissue interfaces,bond weakly in wet environments and lack *** this study,a degradable and bioactive citrate-based polyurethane adhesive is constructed to achieve rapid and strong tissue *** hydrophobic layer was created with polycaprolactone to overcome the bonding failure between tissue and adhesion layer in wet environments,which can effectively improve the wet bonding *** citrate-based polyurethane adhesive provides rapid,non-invasive,liquid-tight and seamless closure of skin incisions,overcoming the limitations of sutures and commercial tissue *** addition,it exhibits biocompatibility,biodegradability and hemostatic *** degradation product citrate could promote the process of angiogenesis and accelerate wound *** study provides a novel approach to the development of a fast-adhering wet tissue adhesive and provides a valuable contribution to the development of polyurethane-based tissue adhesives.

关键词： tissue adhesive polyurethane citrate wet adhesion

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Development review and the prospect of oil shale in-situ catalysis conversion technology

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Petroleum Science 2024年第2期21卷 1385-1395页

作者： li Wang Chen-Hao Gao Rui-Ying Xiong Xiao-Jun Zhang Ji-Xiang Guo The Unconventional Oil and Gas Institute China University of Petroleum-BeijingBeijing102200China

As an unconventional resource, oil shale possesses abundant reserves and significant potential for industrial applications. The rational and efficient development of oil shale resources holds immense importance in reducing national energy demand. In-situ catalytic technology, characterized by its high efficiency, low pollution, and minimal energy consumption, represents a key direction for future oil shale development. This paper provides a comprehensive review of research progress in in-situ oil shale mining technology, oil shale pyrolysis catalysts, the pyrolysis mechanism of kerogen, and the compatibility of different heating processes and catalysts. Furthermore, the paper proposes future research directions and prospects for oil shale in-situ catalytic technology, including reservoir modification, highefficiency catalyst synthesis, injection processes, and high-efficiency heating technology. These insights serve as valuable technical references for the advancement of oil shale in-situ catalytic technology.

关键词： Oil shale In-situ catalytic technology Pyrolysis catalyst Kerogen pyrolysis mechanism

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Reinforcement Learning-Based Energy Management for Hybrid Power Systems:State-of-the-Art Survey,Review,and Perspectives

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Chinese Journal of Mechanical Engineering 2024年第3期37卷 1-25页

作者： Xiaolin Tang Jiaxin Chen Yechen Qin Teng liu Kai Yang Amir Khajepour Shen li College of Mechanical and Vehicle Engineering Chongqing UniversityChongqing 400044China School of Mechanical Engineering Beijing Institute of TechnologyBeijing 100081China Department of Mechanical and Mechatronics Engineering University of WaterlooWaterlooON N2L 3G1Canada School of Civil Engineering Tsinghua UniversityBeijing 100084China

The new energy vehicle plays a crucial role in green transportation,and the energy management strategy of hybrid power systems is essential for ensuring energy-efficient *** paper presents a state-of-the-art survey and review of reinforcement learning-based energy management strategies for hybrid power ***,it envisions the outlook for autonomous intelligent hybrid electric vehicles,with reinforcement learning as the foundational *** of all,to provide a macro view of historical development,the brief history of deep learning,reinforcement learning,and deep reinforcement learning is presented in the form of a ***,the comprehensive survey and review are conducted by collecting papers from mainstream academic *** most of the contributions based on three main directions—algorithm innovation,powertrain innovation,and environment innovation—provides an objective review of the research ***,to advance the application of reinforcement learning in autonomous intelligent hybrid electric vehicles,future research plans positioned as“Alpha HEV”are envisioned,integrating Autopilot and energy-saving control.

关键词： New energy vehicle Hybrid power system Reinforcement learning Energy management strategy

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Protein post-translational modifications in auxin signaling

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Journal of Genetics and Genomics 2024年第3期51卷 279-291页

作者： Xiankui Cui Junxia Wang Ke li Bingsheng Lv Bingkai Hou Zhaojun Ding The Key Laboratory of Plant Development and Environmental Adaptation Biology Ministry of EducationSchool of Life SciencesShandong UniversityQingdaoShandong 266237China Shandong Academy of Grape JinanShandong 250100China College of Horticulture Qingdao Agricultural UniversityQingdaoShandong 266109China

Protein post-translational modifications(PTMs),such as ubiquitination,phosphorylation,and small ubiquitin-like modifier(SUMO)ylation,are crucial for regulating protein stability,activity,subcellular localization,and binding with *** modifications remarkably increase the variety and complexity of proteomes,which are essential for regulating numerous cellular and physiological *** regulation of auxin signaling is finely tuned in time and space to guide various plant growth and *** evidence indicates that PTMs play critical roles in auxin signaling ***,a thorough and systematic review of the functions of PTMs in auxin signal transduction will improve our profound comprehension of the regulation mechanism of auxin signaling and auxin-mediated various *** review discusses the progress of protein ubiquitination,phosphorylation,histone acetylation and methylation,SUMOylation,and S-nitrosylation in the regulation of auxin signaling.

关键词： Arabidopsis thaliana Auxin Auxin signaling Post-translational modifications Protein regulation

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Bi_(2)S_(3) nanofiber bunch for highly efficient CO_(2) electroreduction to formate at low overpotential

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Rare Metals 2024年第7期43卷 3391-3399页

作者： li Wang Wen-Ke Gui Shan Jiang liang Wang Jian-Ping Yang State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai 201620China Centre for Catalysis and Clean Energy Griffith UniversityGold Coast CampusGold CoastQLD 4222Australia

Electrochemical conversion of CO_(2) into valuable chemicals represents a promising strategy to alleviate the environmental issues caused by excessive CO_(2) levels in the *** this work,Bi_(2)S_(3) with different morphologies have been fabricated via facile hydrothermal method to investigate the CO_(2) electrochemical reduction process.

关键词： process. facile Electrochemical

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First Record of Cyclocarya from the Early Oligocene Qaidam Basin,North Tibet:Implications for the Paleogeography and Paleoecology

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Journal of Earth Science 2024年第1期35卷 201-211页

作者： Yafei Hou Bowen Song Xiangchuan li Fang Han Xu Zhang Kexin Zhang Institute of Geological Survey China University of GeosciencesWuhan 430074China Faculty of Materials Science and Chemistry China University of GeosciencesWuhan 430074China State Key Laboratory of Biogeology and Environmental Geology China University of GeosciencesWuhan 430074China College of Earth Sciences and Resources&Key Laboratory of Western Mineral Resources and Geological Engineering of the Ministry of Education Chang'an UniversityXi'an 710054China State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of SciencesNanjing 210008China School of Earth Sciences East China University of TechnologyNanchang 330013China

As the largest intermontane basin in the northeastern Tibetan Plateau(TP),the Qaidam Basin provides unique insight into paleoclimatic change and its relationship with global change and uplift on the *** this study,based on morphological comparison,fossil fruit of Cyclocarya from the Early Oligocene Shangganchaigou Formation in the Qaidam Basin is assigned as Cyclocarya *** discovery of Cyclocarya *** demonstrates the occurrence of Cyclocarya in the Oligocene sediment in Qaidam *** is the first record of Cyclocarya fossil of Early Oligocene Age in China and indicates that Cyclocarya has existed on the northeastern TP since at least the Early *** living analogues of the current fossil now lives in sub-tropical China,where the East Asian Monsoon is *** the new fossils and previously reported fossil remains of plants and fishes,it can be inferred that the Early Oligocene Qaidam Basin was primarily influenced by westerly circulation and had a relatively warm and humid climate,which was in sharp contrast to the present-day climate in Qaidam Basin.

关键词： biostratigraphy climate change winged-fruit fossil Qaidam Basin Early Oligocene paleoclimate paleogeography

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