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Helicobacter pylori eradication lowers serum homocysteine level in patients without gastric atrophy

World Journal of Gastroenterology 2005年第18期11卷 2764-2767页

作者： Birol Ozer Ender Serin Yuksel Gumurdulu Fazilet Kayaselcuk Ruksan Anarat Gurden Gur kemal kul Mustafa Guclu Sedat Boyacioglu Departments of Gastroenterology Baskent University Faculty of Medicine Adana Teaching and Medical Research Center Adana Turkey Departments of Pathology Baskent University Faculty of Medicine Adana Teaching and Medical Research Center Adana Turkey Central Laboratory Baskent University Faculty of Medicine Adana Teaching and Medical Research Center Adana Turkey

AIM: To determine whether Helicobacter pylori (H pylori) infection caused hyperhomocysteinemia by altering serum vitamin B_(12), serum folate and erythrocyte folate levels and whether eradication of this organism decreased serum homocysteine level. METHODS: The study involved 73 dyspeptic H pylork positive patients, none of them had gastric mucosal atrophy based on rapid urease test and histology. Out of 73 patients, 41 (56.2%) showed a successful eradication of H pylori 4 wk after the end of treatment. In these 41 patients, fasting serum vitamin B_(12) folate and homocysteine levels, and erythrocyte folate levels before and 4 wk after H pylori eradication therapy were compared. RESULTS: The group with a successful eradication of H pylori had significantly higher serum vitamin B_(12) and erythrocyte folate levels in the post-treatment period compared to those in pre-treatment period (210±97 pg/mL vs 237±94 pg/mL,P＜0.001 and 442±212 ng/mL vs 539±304 ng/mL, P=0.024, respectively), but showed no significant change in serum folate levels (5.6±2.6 ng/mL vs 6.0+2.4 ng/mL, P=0.341). Also, the serum homocysteine levels in this group were significantly lower after therapy (13.1±5.2 μmol/L vs 11.9±6.2 μmol/L, P=0.002). Regression analysis showed that serum homocysteine level was positively correlated with age (P=0.01) and negatively with serum folate level before therapy (P=0.003). CONCLUSION: Eradication of H pylori decreases serum homocysteine even in patients who do not exhibit gastric mucosal atrophy. It appears that the level of homocysteine in serum is related to a complex interaction among serum vitamin B_(12), serum folate and erythrocyte folate levels.

关键词： H pylorr Gastritis Vitamin B_(12) Folate Erythrocyte folate Homocysteine

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The Detection of STAT1 Gene Influencing Milk Related Traits in Turkish Holstein and Jersey Cows

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Journal of Agricultural Science and Technology(A) 2016年第4期6卷 261-269页

作者： Ozden Cobanoglu Eser kemal Gurcan Soner Cankaya Ertugrul kul Hasan Samet Abaci Department of Genetics Faculty of Veterinary Medicine Uludag University Bursa 16059 Turkey Department of Animal Science Faculty of Agriculture Namik Kemal University Tekirdag 59030 Turkey Department of Biostatistics Faculty of Medicine Ordu University Ordu 52200 Turkey Department of Animal Science Faculty of Agriculture Ahi Evran University Kirsehir 40200 Turkey Department of Animal Science Faculty of Agriculture Ondokuz Mayis University Samsun 55100 Turkey

The main purpose of this study was to detect an association of cytoplasmic signal transducers and activators of transcription-1 （STAT1） with milk production traits in 472 Holstein and 283 Jersey cattle breeds of Turkey. This gene, located on chromosome 2, was chosen due to its role on development of mammary gland. A polymorphism of selected 314 bp allele fragment was detected by the restriction fragment length polymorphism analysis of polymerase chain reaction-amplified fragments （PCR-RFLP） method and also confirmed by DNA sequencing. The association tests were conducted between STAT1 genotypes and some economically important dairy traits. The genotypes for C/T as a single nucleotide polymorphism （SNP） were identified at interval 60 cM to 63 cM. The effects of STAT1 gene on milk production traits were not significant in Holstein cows, although animals with CT genotypes showed fairly close to significant value for the corrected 305 d milk yield. However, Jersey cows with/7＂ genotype were 2.07 kg higher for test-day milk yield （P 〈 0.05）, 0.13 kg for fat yield （P 〈 0.01） and 0.07 kg for protein yield （P 〈 0.05） compared with animals having CC and CT genotypes. Definitely, the further research should be conducted to search this gene intensively with larger samples to identify polymorphism and any association between the economically important traits and genotypic class in Holstein cows. Finally, based on the findings, it was concluded that STATI gene might be used as a potential candidate gene to improve milk yield and milk fat and protein contents in dairy cows breeding programs.

关键词： STAT1 gene dairy cattle PCR-RFLP milk production milk content.

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