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Clinical and hemodynamic profiles of elderly patients with pulmonary arterial hypertension： a single center, prospective study

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Journal of Geriatric Cardiology 2017年第1期14卷 20-27页

作者： Ebru Ozpelit Bahri Akdeniz Dilek Sezgin can Sevinc kemal can tertemiz Mehmet Emre Ozpelit Mustafa Baris Nezihi Baris Department of Cardiology School of Medicine Dokuz Eylul University Izmir Turkey Department of lnternal Medicine Faculty of Nursing Dokuz Eylul University Izmir Turkey Department of Chest Disease School of Medicine Dokuz Eylul University Izmir Turkey Department of Cardiology Medicalpark Hospital Izmir Turkey Department of Radiology School of Medicine Dokuz Eylul University Izmir Turkey

Backgrounds Pulmonary arterial hypertension （PAH） was previously considered an illness that affects mostly the young, but now it is also increasingly recognized in the elderly. The aim of this study was to compare the features of elderly versus younger patients diagnosed with PAH, and to define the prognostic factors which affect their long-term survival. Methods In this prospective, single center study, the clinical, echocardiographic, hemodynamic characteristics, and the outcomes of younger （18-65 years） and elderly （〉 65 years） patients with definitive diagnosis of precapillary PAIl were compared. Results A total of 119 patients were analyzed in this study; 43 were elderly （mean age： 71.5 ± 5.5 years）, while 76 were non-elderly （mean age 44.5 ±15.2 years）. During the mean follow-up duration of 26.8 ±25.0 months, 43 deaths occurred, 17 of which were among the elderly group, with 28 among non-elderly group. Comparison of baseline parameters showed that 6 min walking distance, hemoglobin levels, pulmonary artery pressures and pulmonary vascular resistance were significantly lower; and estimated glomerular filtration rate, body mass index, E/e＇ and pulmonary capillary wedge pressure were significantly higher in the elderly group than in the younger group. Survival analysis demonstrated that the independent predictors of death were tricuspid plane annular systolic excursion （TAPSE; HR： 1.272, 95% CI： 1.079-1.499, P = 0.004） and uric acid （HR： 1.291, 95% CI： 1.042-1.600, P = 0.019） in the elderly group. In contrast, in the non-elderly group, higher brain natriuretic peptide （HR： 1.002, 95% CI： 1.001-1.004, P 〈 0.001） and higher right atrial pressure （HR： 1.128, 95% CI： 1.026-1.241, P = 0.013） values were the only parameters associated with mortality. Conclusions Our data suggest that elderly PAH patients have a unique clinical and hemodynamic profile, with totally different prognostic markers compared to younger PAH patients.

关键词： Clinical characteristics Prognosis Pulmonary hypertension The elderly

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Persistent currents of ultrarelativistic plasma-encased endofullerene molecules entrapping a H atom

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Communications in Theoretical Physics 2024年第6期76卷 148-164页

作者： Mustafa kemal Bahar Department of Physics Faculty of ScienceSivas Cumhuriyet University58140SivasTurkey

In this work,for the first time in the relevant literature,the persistent currents(PC)and induced magnetic fields(IMF)of an endofullerene molecule entrapping a hydrogen atom,under spherical confinement,are *** endofullerene molecule is enclosed within a spherical region and embedded in a plasma *** plasma environment is depicted with the more general exponential cosine screened Coulomb potential,and its relevant effects are analyzed by considering plasma screening *** relevant model for endohedral confinement is the Woods-Saxon confinement potential,which is compatible with experimental *** effects of various forms of Cn are thoroughly elucidated via the analysis of the confinement depth,spherical shell thickness,the inner radius,and the smoothing *** find the bound states in the spherically confined endofullerene,the decoupling of the second-order Dirac equation for the large and small components of the radial atomic wave functions is *** Dirac equation with the interaction potential is solved numerically by using the Runge-Kutta-Fehlberg method via the decoupling *** influence of spin orientations on the PC and IMF is also *** effects of spherical confinement,plasma shielding,and the structural properties of the fullerene on the PC and IMF are thoroughly ***,under given physical conditions,the optimal ranges of these effects are determined.

关键词： quantum plasma endohedral fullerene persistent current ultrarelativistic interaction induced magnetic field

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Complementary comments on metastatic liver lesions with exceptional and rare cases

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World Journal of Gastroenterology 2024年第7期30卷 770-773页

作者： kemal Bugra Memis Sonay Aydin Department of Radiology Erzincan Binali Yıldırım UniversityFaculty of MedicineErzincan 24000Turkey

Liver metastases can appear in different forms in magnetic resonance *** to popular belief,while radiologists report hypovascular or hypervascular metastatic lesions,exceptional examples may be detected in various *** aim of this article is to improve this review by presenting rare and atypical examples of liver metastasis,as well as cases that might potentially be misdiagnosed as metastases during the process of differential diagnosis.

关键词： Hepatic lesions Magnetic resonance imaging Liver metastases Echinococcus alveolaris Prostate adenocarcinoma Appendix neuroendocrine tumor

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Deep neck infections mortal complications:Intrathoracic complications and necrotising fasciitis

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World Journal of Clinical Cases 2024年第30期12卷 6383-6390页

作者： kemal Koray Bal can Aslan Harun Gür Seda Turk Bal Recep Okan Ustun Murat Unal Department of Otorhinolaryngology Mersin UniversityMersin 33160Türkiye Department of Emergency Medicine Tarsus State HospitalMersin 33460Türkiye Department of Aestetic Division of Plastic and Reconstructive SurgeryUniversity of Health Sciences Mersin City HospitalMersin 33230Türkiye

BACKGROUND We planned this study considering that complications of deep neck infections can be seriously life *** To raise awareness that introthoracic complications and necrotizing fasciitis are causes of serious mortality and *** This study was carried out with the participation of 188 patients who were treated at Mersin University Department of Otorhinolaryngology and Head and Neck Surgery at January 1,*** the patient files were retrospectively examined,16 of 188 patients(8.5%)were included in the study because they were observed to have necrotizing fasciitis and/or intrathoracic *** There were a total of 16 patients in this study,9 males(56.25%)and 7 females(43.75%).All patients were adults(>18 years)and the mean age was 50.37 years±15.37 *** patients had a mean age of 40.42 years±13.38 years,whereas for male patients was 58.11 years±12.44 *** Patients with necrotizing fasciitis and/or intrathoracic complications require more complicated and serious surgeries,intensive care unit monitoring,and mechanical ventilator *** rates of morbidity and mortality should be expected in Bal KK et *** neck infections mortal complications WJCC https://*** 6384 October 26,2024 Volume 12 Issue 30 these patients who are hospitalized for longer periods of time.

关键词： Deep neck infection Necrotising fasciitis Mediastinitis Complications Mortality

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Knowledge, attitudes, and practices regarding Covid-19 and their relationship with Covid-19 booster vaccination status among women with infertility

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Asian pacific Journal of Reproduction 2024年第2期13卷 68-75页

作者： Gita Pratama Mila Maidarti Kanadi Sumapradja Achmad kemal Harzif Natasha Talya Kevin Ezekia Irfan Arieqal Hatta Ampri Reproductive Immunoendocrinology Division Department of Obstetrics and GynecologyFaculty of Medicine Universitas Indonesia-dr.Cipto Mangunkusumo General HospitalJakartaIndonesia Yasmin IVF Clinic dr.Cipto Mangunkusumo General Hospital JakartaIndonesia Human Reproduction Infertilityand Family Planning ClusterIndonesia Reproductive Medicine Research and Training CenterFaculty of MedicineUniversitas IndonesiaJakarta 10430Indonesia Department of Obstetrics and Gynecology Faculty of Medicine Universitas Indonesia-dr.Cipto Mangunkusumo General HospitalJakartaIndonesia

Objective:To elucidate the relationship among knowledge,attitudes,and practices regarding Covid-19 and their relationship with booster vaccination status among women with ***:This questionnaire-based cross-sectional study was performed online and offline among women with infertility who visited an infertility clinic in Jakarta,*** assessed the patient’s knowledge,attitudes,and practices regarding Covid-19 and their relationship with booster vaccination status and sociodemographic ***:A total of 178 subjects participated in this study,and most participants(92.6%)had received booster Covid-19 *** the questionnaire,74.2%had good knowledge,and 99.4%had good attitudes regarding Covid-19;however,only 57.9%of patients had good practices.A weak positive correlation existed between knowledge and attitudes(r=0.11,P=0.13)and a moderate negative correlation between attitudes and practices(r=-0.44,P=0.56).Participants’knowledge about vaccines and infertility was correlated with booster vaccination status(P=0.04).Academic background(P=0.01)and attitudes(P=0.01)were also correlated with booster vaccination *** significant determinants of hesitance of receiving Covid-19 booster vaccines were high school education or below(OR=0.08,95%CI 0.02-0.36)and poor practices(OR=0.21,95%CI 0.05-0.95).Conclusions:The majority of the participants had received the Covid-19 booster vaccine and had good knowledge and attitudes but poor practices regarding *** participants had poor knowledge about the relationship between infertility and the Covid-19 *** general population should be more informed and reminded about practices to prevent Covid-19 and the relationship between vaccination and fertility to increase the number of people who receive Covid-19 booster vaccines.

关键词： Covid-19 Booster vaccine Infertility Knowledge Attitude Practice Human reproduction Pandemic

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Imaging features and management of focal liver lesions

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World Journal of Radiology 2024年第6期16卷 139-167页

作者： Gökhan Kahraman kemal Murat Haberal Osman Nuri Dilek Department of Radiology Suluova State HospitalAmasya 05500Türkiye Department of Radiology Başkent University Faculty of MedicineAnkara 06490Türkiye Department of Surgery İzmir Katip Celebi UniversitySchool of Medicineİzmir 35150Türkiye

Notably,the number of incidentally detected focal liver lesions(FLLs)has increa-sed dramatically in recent years due to the increased use of radiological *** diagnosis of FLLs can be made through a well-documented medical history,physical examination,laboratory tests,and appropriate imaging *** benign FLLs are more common than malignant ones in adults,even in patients with primary malignancy,accurate diagnosis of incidental FLLs is of utmost clinical *** clinical practice,FLLs are frequently evaluated non-invasively using ultrasound(US),computed tomography(CT),and magnetic resonance imaging(MRI).Although US is a cost-effective and widely used imaging method,its diagnostic specificity and sensitivity for FLL characterization are *** are primarily characterized by obtaining enhancement patterns through dynamic contrast-enhanced CT and *** is a problem-solving method with high specificity and sensitivity,commonly used for the evaluation of FLLs that cannot be characterized by US or *** technical advancements in MRI,along with the use of hepatobiliary-specific MRI contrast agents,have significantly improved the success of FLL characterization and reduced unnece-ssary *** American College of Radiology(ACR)appropriateness criteria are evidence-based recommendations intended to assist clinicians in selecting the optimal imaging or treatment option for their *** Appropriateness Criteria Liver Lesion-Initial Characterization guideline provides recommend-ations for the imaging methods that should be used for the characterization of incidentally detected FLLs in various clinical *** American College of Gastroenterology(ACG)Clinical Guideline offers evidence-based recommend-ations for both the diagnosis and management of *** Association for the Study of Liver Diseases(AASLD)Practice Guidance provides an approach to the diagnosis and management of patients with hepatocellular *** th

关键词： Focal liver lesions Imaging Ultrasonography Computed tomography Magnetic resonance imaging Management

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Characteristics of the imaging diagnosis of alveolar echinococcosis

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World Journal of Gastrointestinal Surgery 2024年第9期16卷 2748-2754页

作者： Sonay Aydin Baris Irgul kemal Bugra Memis Volkan Kızılgoz Mecit Kantarci Department of Radiology Erzincan Binali Yıldırım UniversityFaculty of MedicineErzincan 24100Türkiye Department of Radiology Erzurum Ataturk UniversityErzurum 25000Türkiye

Alveolar echinococcosis(AE)primarily manifests in the liver and exhibits charac-teristics resembling those of slow-growing malignant *** Echino-coccus multilocularis infection can be *** infiltrating the vascular systems,biliary tracts,and the hilum of the liver,it might lead to various *** to its ability to infiltrate neighbouring tissues or metastasize to distant organs,AE can often be mistaken for *** present a concise overview of the epi-demiological and pathophysiological characteristics of AE,as well as the clinical manifestations of the *** article primarily examines the imaging charac-teristics of AE using various imaging techniques such as ultrasonography,com-puted tomography(CT),magnetic resonance imaging,diffusion-weighted ima-ging,and virtual non-enhanced dual-energy *** additionally examined the contribution of radiography in the diagnosis,treatment,and monitoring of the condition.

关键词： Alveolar echinococcosis Echinococcus multilocularis Virtual non-enhanced dual-energy computed tomography Percutaneous cyst drainage Cyst infection Interven-tional radiology

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Endoscopic and histopathological evaluation of acute gastric injury in high-dose acetaminophen and nonsteroidal anti-inflammatory drug ingestion with suicidal intent

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World Journal of Gastroenterology 2008年第43期14卷 6704-6710页

作者： Aliye Soylu can Dolapcioglu kemal Dolay Aydin Ciltas Nurgul Yasar Mustafa kalayci Halil Alis Nurten Sever Gastroenterology Bakirkoy Dr Sadi Konuk Research and Training HospitalIstanbul 34147Turkey Gastroenterology Dr.Lutfi Kirdar Kartal Research and Training HospitalIstanbul 34865Turkey General Surgery Bakirkoy Dr Sadi Konuk Research and Training HospitalIstanbul 34147Turkey Internal Medicine Bakirkoy Dr Sadi Konuk Research and Training HospitalIstanbul 34147Turkey Pathology Bakirkoy Dr Sadi Konuk Research and Training HospitalIstanbul 34147Turkey

AIM： To evaluate endoscopic and histopathologic aspects of acute gastric injury due to ingestion of high-dose acetaminophen and nonsteroidal antiinflammatory drugs （NSAIDs） with respect to some risk factors and patient characteristics. METHODS： The study group consists of 50 patients admitted to emergency department with high dose analgesic ingestion （group Ⅰ ） with suicidal intent. Thirty patients with or without mild complaints of dyspepsia （group Ⅱ） were selected as the control group. The study group was stratified according to the use of type and number of analgesics. Endoscopic findings were evaluated according to the Lanza score （LS）, expressing the severity of the gastroduodenal damage and biopsies according to a scoring system based on histopathologic findings of acute erosive gastritis. RESULTS： Gastroduodenal damage was significantly more severe in group Ⅰ compared to group Ⅱ （P 〈 0.01）. The LS was similar in both groups Ⅰ a and Ⅰb. However LS was significantly higher in patients who had ingested multiple NSAIDs （group Ⅰ c） compared to other patients （P 〈 0.01）. The LS was correlated to age （P 〈 0.01） and total amount of drug ingested （P 〈 0.05） in group Ⅰ ; but it was not correlated with Helicobacter pylori （H pylori） infection or duration of exposure （P 〉 0.05）. The biopsy score （BS） was higher in group Ⅰ than group Ⅱ （P 〈 0.01）, and higher in group Ⅰb than group Ⅰa （P 〈 0.05）. CONCLUSION： The histopathologic damage was more severe among NSAID ingesting patients compared to those ingesting only acetaminophen and there is no significant difference in the endoscopic findings between the groups. There is no significant difference in the LS between the groups. This lack of significance is remarkable in terms of the gastric effects of highdose acetaminophen.

关键词： Acute gastric injury Nonsteroidal anti-inflammatory drug Acetaminophen Endoscopic lesion Gastroscopy

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Growing and Pruning Based Deep Neural Networks Modeling for Effective Parkinson’s Disease Diagnosis

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Computer Modeling in Engineering & Sciences 2020年第2期122卷 619-632页

作者： kemal Akyol Kastamonu University Kuzeykent YerleşkesiKastamonu37100Turkey.

Parkinson’s disease is a serious disease that causes ***,a new dataset has been introduced on this *** aim of this study is to improve the predictive performance of the model designed for Parkinson’s disease *** and large,original DNN models were designed by using specific or random number of neurons and *** study analyzed the effects of parameters,i.e.,neuron number and activation function on the model performance based on growing and pruning *** other words,this study addressed the optimum hidden layer and neuron numbers and ideal activation and optimization functions in order to find out the best Deep Neural Networks *** this context of this study,several models were designed and *** overall results revealed that the Deep Neural Networks were significantly successful with 99.34%accuracy value on test ***,it presents the highest prediction performance reported so ***,this study presents a model promising with respect to more accurate Parkinson’s disease diagnosis.

关键词： Parkinson’s disease machine learning growing and pruning deep neural networks.

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Spontaneous rupture of a hepatic hydatid cyst into the peritoneum causing only mild abdominal pain:A case report

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World Journal of Gastroenterology 2007年第5期13卷 806-808页

作者： kemal Karakaya Department of General Surgery Zonguldak Karaelmas University Faculty of Medicine Kozlu Zonguldak 67600 Turkey

Hydatid disease is an endemic disease in certain areas of the world. It is located mostly in the liver. Spontaneous rupture of the hydatid cyst into the peritoneum is a rare condition, which is accompanied by serious morbidity and mortality generally. We present herein a case with a spontaneous rupture of a hepatic hidatid disease into the peritoneum without any serious symptoms. A 15-year- old boy was admitted to the emergency room with a mild abdominal pain lasting for a day. Physical examination revealed only mild abdominal tenderness. There was no history of trauma or complaints related to hydatid diseases. Ultrasonography showed a large amount of free fluid and a cystic lesion with irregular borders in the liver. He was operated on. Postoperative albendazol therapy was given for 2 mo. No recurrence or secondary hydatidosis was seen on CT investigation in the 3^th, 6^th and 12^th mo following surgery.

关键词： Hydatid disease Spontaneous rupture Liver

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