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Decrease of Alpha-fetoprotein in Patients with Cirrhosis Treated with Direct-acting Antivirals

Journal of Clinical and Translational Hepatology 2017年第1期5卷 43-49页

作者： kelvin nguyen Melissa Jimenez Nima Moghadam Crystal Wu Alex Farid Jonathan Grotts David Elashoff Gina Choi Francisco A.Durazo Mohamed M.El-Kabany Steven-Huy B.Han Sammy Saab Departments of Medicine the University of California at Los AngelesLos AngelesCAUSA Departments of Surgery the University of California at Los AngelesLos AngelesCAUSA Departments of Biostatistics the University of California at Los AngelesLos AngelesCAUSA

Background and Aims:The lack of specificity has limited the role of serum alpha-fetoprotein(AFP)for hepatocellular carcinoma(HCC)screening among patients with cirrhosis related to hepatitis C virus(HCV)*** sought to examine whether AFP may decrease after achieving a sustained virological response(SVR)in patients with HCV-related ***:We performed a retrospective study of patients with HCV-related cirrhosis who were cured with direct-acting antiviral(DAA)therapy at the University of California,Los *** values,including serum AFP,were measured before and after completing the DAA ***:Fifty-six patients met the inclusion criteria,with median(interquartile range[IQR])age of 67(58-69)years and with 51.8%being *** patients received DAA therapy without *** decreased from median(IQR)7.2(4.2-13.4)ng/mL before DAAs to 4.2(2.7-6.3)ng/mL at the end of treatment and 4.2(2.9-6.8)ng/mL at 12 weeks after treatment(P<0.001).Model for end-stage liver disease(MELD),fibrosis-4(FIB4),and aspartate transaminase(AST)to platelet ratio index(APRI)scores at baseline were not significantly associated with AFP *** multivariate analysis,platelet count,AST and total bilirubin at baseline were significantly correlated to AFP reduction(P=0.04,0.009 and 0.04,respectively).The higher the baseline AFP,the greater the reduction in *** was no statistically significant correlation between baseline AFP and MELD,FIB4 or APRI ***:There was a significant decrease in AFP in patients with cirrhosis who achieved a SVR with *** a reduction in AFP after DAA treatment,AFP should be further studied as a screening modality for HCC in patients with cirrhosis.

关键词： Hepatitis C Hepatocellular carcinoma Screening Direct-acting antivirals

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