检索结果-南通市图书馆

chemosensitizing Effect of Monk Fruit Extract on Human Bladder cancer cells

Journal of cancer Therapy 2024年第6期15卷 250-264页

作者： Sensuke Konno Jonathan Wong Andrew Penunuri kelvin zheng.muhammad c.oudhury Department of Urology New York Medical College Valhalla New York USA

The outcomes of chemotherapy have been unsatisfactory with the palpable side effects. We hypothesized that natural products might help improve chemotherapy with few side effects. Recently, we came across the bioactive extracts of monk fruit (Siraitia grosvenori) with anticancer activity. We then investigated if these extracts might have chemosensitizing effect to improve the efficacy of drugs clinically used today. Four different drugs, cisplatin (cPL), carboplatin (cBL), mitomycin c (MMc), and gemcitabine (GEM), were used in this study. Human bladder cancer T24 cells were treated with each drug itself or drug combined with either LLE or MOG (two types of monk fruit extracts). cell viability was determined to assess anticancer effect and also explored the anticancer mechanism of such combinations, focusing on the status of glycolysis, cell cycle, and chromatin structure. cell viability test showed that all drugs had anticancer activity, reducing cell viability, but only cPL showed the enhanced anticancer effect when combined with LLE (not with MOG). The rest of three drugs had no such effects with LLE or MOG. The cPL/LLE combination was found to disrupt glycolysis, by inhibiting hexokinase activity, resulted in the decreased ATP synthesis. This combination also blocked the cell cycle progression, due to a G1 cell cycle arrest. Moreover, the two epigenetic regulators, DNA methyltransferase and histone deacetylase, were inactivated with the combination, indicating chromatin modifications. Ultimately, these treated cells were found to undergo apoptosis. In conclusion, anticancer activity of cPL can be significantly enhanced with LLE. This chemosensitizing effect is attributed to the glycolysis inhibition, a G1 cell cycle arrest, and chromatin modifications, ultimately leading to apoptosis. Thus, certain natural products such as LLE could be used as an adjuvant agent in current chemotherapy, improving the drug efficacy but minimizing side effects.

关键词： Monk Fruit Anticancer Bladder cancer chemosensitization Lakanto

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Influence of Micro/Nano-Ti Particles on the corrosion Behavior of AZ31-Ti composites

引用

Acta Metallurgica Sinica(English Letters) 2024年第3期37卷 484-498页

作者： Jinchao Jiao Jin Zhang Yong Lian Shengli Han Kaihong zheng Fusheng Pan Institute for Advanced Materials and Technology University of Science and Technology BeijingBeijing 10083China Beijing Key Laboratory for corrosion Erosion and Surface Technology Beijing 100083China Institute of New Materials Guangdong Academy of SciencesGuangzhou 510650China National Engineering Research center for Magnesium Alloys Chongqing UniversityChongqing 404100China

Adding Ti particles to magnesium alloy simultaneously enhances its strength and ***,how these particles influence on Mg alloy’s corrosion performance is seldom *** corrosion behavior of AZ31-Ti composites containing titanium nanoparticles(1.5 and 5 wt%)and micron particles(10 wt%)prepared by powder metallurgical in 3.5 wt%Nacl solution was *** results indicate that Ti particles serve as the primary location for the cathodic hydrogen reduction reaction,resulting in intense galvanic corrosion between the Ti and Mg *** nanoparticles distributed at the interface of the original AZ31 powder were in a discontinuous mesh structure,thus failing to act as a barrier against *** corrosion products with the existence of numerous cracks gradually peel off during the corrosion process and cannot protect the *** average corrosion rate P_(w) of AZ31,AZ31-1.5%Ti,AZ31-5%Ti,and AZ31-10%Ti after 7 days of immersion is 27.55,105.65,283.67,and 99.35 mm/y,***,AZ31-Ti composites can be considered as potential candidates for degradable fracturing ***,it is recommended to improve their corrosion resistance through surface treatment.

关键词： AZ31-Ti composite Nano-Ti Micro-Ti corrosion behavior Scanning kelvin probe force microscopy(SKPFM)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A case study of continental shelf waves in the northwestern South china Sea induced by winter storms in 2021

引用

Acta Oceanologica Sinica 2024年第1期43卷 59-69页

作者： Junyi Li chen Zhou Min Li Quanan zheng Mingming Li Lingling Xie Laboratory of coastal Ocean Variation and Disaster Prediction College of Ocean and MeteorologyGuangdong Ocean UniversityZhanjiang 524088China Key Laboratory of climate Resources and Environments in Continent Shelf Sea and Deep OceanDepartment of Education of Guangdong ProvinceZhanjiang 524088China Key Laboratory of Space Ocean Remote Sensing and Application Ministry of Natural ResourcesBeijing 100081China Department of Atmospheric and Oceanic Science University of MarylandCollege ParkMaryland 20742USA

This study aims to investigate characteristics of continental shelf wave(cSW)on the northwestern continental shelf of the South china Sea(ScS)induced by winter storms in *** and cruise observations,tidal gauge data at stations Hong Kong,Zhapo and Qinglan and sea surface wind data from January 1 to February 28,2021 are used to examine the relationship between along-shelf wind and sea level *** events of cSWs driven by the along-shelf sea surface wind are detected from wavelet spectra of tidal gauge *** signals are triply peaked at periods of 56 h,94 h and 180 h,propagating along the coast with phase speed ranging from 6.9 m/s to18.9 m/*** dispersion relation shows their property of the kelvin mode of *** develop a simple method to estimate amplitude of sea surface fluctuation by along-shelf *** results are comparable with the observation data,suggesting it is *** mode 2 cSWs fits very well with the mooring current velocity *** results from rare current help to understand wave-current interaction in the northwestern ScS.

关键词： continental shelf waves Ekman transport kelvin mode wavelet analysis northwestern South china Sea

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

contributors to tidal duration asymmetry with varied coastline configurations on western shelf of Yellow Sea

引用

Water Science and Engineering 2024年第1期17卷 1-12页

作者： Xi Feng zheng Li Hui Feng Jia-yan Yang Shou-peng Xie Wei-bing Feng college of Harbor.coastal and Offshore Engineering Hohai UniversityNanjing 210098China china Harbour Engineering co. LtdBeijing 100027China Key Laboratory of Port Waterway and Sedimentation Engineering of the Ministry of CommunicationsNanjing 210029China china South-to-North Water Diversion corporation Limited Beijing 100036China

coastal management in china is confronted with an urgent choice between natural restoration and maintenance of existing seawalls and reclaimed land for economic development.A key criterion for making this decision is the resilience to coastal flooding,which depends on the ability to predict tidal *** duration asymmetry(TDA)is a key parameter in determination of the arrival and duration of flood *** study selected the western inner shelf of the Yellow Sea(WYS)as the study area and investigated the responses of TDA to different shoreline configurations and relative sea level *** responses of TDA to shoreline reconstruction yielded spatial variability locally and *** the nearshore area,the responses of TDA to the complex ocean environment mainly originated from the combined functions of reflection,bottom friction,and advection,which controlled the energy transfer from M2 or S2 constituents to their overtides or compound *** sensitivity of TDA to coastline typologies was not limited to coastal waters but could stretch over the entire inner *** vulnerability of tidal responses was due to the displacement of the M2 amphidrome of the kelvin wave on the WYS,which in turn changed tidal energy fluxes over the *** relative sea level rise could intensify the feedback of TDA to seawalls and land reclamation.

关键词： Tidal duration asymmetry Western inner shelf of Yellow Sea Natural restoration Relative sea level rise Tidal amphidrome

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Degradation and biocompatibility of one-step electrodeposited magnesium thioctic acid/magnesium hydroxide hybrid coatings on ZE21B alloys for cardiovascular stents

引用

Journal of Magnesium and Alloys 2024年第1期12卷 120-138页

作者： Zhao-Qi Zhang Bing-Zhi Li Pei-Duo Tong Shao-Kang Guan Li Wang zheng-Hui Qiu cun-Guo Lin Rong-chang Zeng School of Material Science and Engineering&Henan Key Laboratory of Advanced Magnesium Alloy&Key Laboratory of Materials Processing and Mold Technology(Ministry of Education) Zhengzhou University100 Science RoadZhengzhou 450001China State Key Laboratory for Marine corrosion and Protection Luoyang Ship Material Research InstituteQingdao 266101China corrosion Laboratory for Light Metals College of Material Science and EngineeringShandong University of Science and TechnologyQingdao 266590China

constructing a functional hybrid coating appears to be a promising strategy for addressing the poor corrosion resistance and insufficient endothelialization of Mg-based ***,the steps for preparing composite coatings are usually complicated and ***,a novel composite coating,composed of bioactive magnesium thioctic acid(MTA)layer formed by deposition and corrosion-resistant magnesium hydroxide(Mg(OH)_(2))layer grown in situ,is simply fabricated on ZE21B alloys via one-step *** electron microscopy(SEM)shows that the electrodeposited coating has a compact and uniform *** the high adhesion of the MTA/Mg(OH)_(2)hybrid coating is also confirmed by the micro-scratch *** test,scanning kelvin probe(SKP),and hydrogen evolution measurement indicate that the hybrid coating effectively reduces the degradation rate of Mg *** experiment and cell culture trial detect that the composite coating is of fine ***,the preparation mechanism of MTA/Mg(OH)_(2)hybrid coatings is discussed and *** coating shows a great potential application for cardiovascular stents.

关键词： Magnesium alloy corrosion resistance Hybrid coating Endothelialization Biocompatibility

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

chemosensitizing Effect of Monk Fruit Extract on Human Bladder cancer cells

引用

Journal of cancer Therapy（癌症治疗） 2024年第6期 250页

作者： Sensuke Konno Jonathan Wong Andrew Penunuri kelvin zheng.muhammad c.oudhury

来源：博看期刊评论

在线全文

博看期刊

学校读者我要写书评

暂无评论

construction of TiO2/silane nanofilm on AZ31 magnesium alloy for controlled degradability and enhanced biocompatibility

引用

Rare Metals 2019年第6期38卷 588-600页

作者： Lei Huang Kun Su Yu-Feng zheng kelvin Wai-Kwok Yeung Xiang-Mei Liu School of Materials Science and Engineering Hubei UniversityWuhan 430062China State Key Laboratory for Turbulence and complex System Department of Materials Science and EngineeringCollege of EngineeringPeking UniversityBeijing 100871China Department of Orthopaedics and Traumatology Li Ka Shing Faculty of MedicineThe University of Hong KongPokfulam 999077Hong KongChina

A TiO2 nanofilm was prepared on the surface of AZ31 magnesium alloy with controllable thickness through atomic layer deposition(ALD) technique, which can adjust the corrosion behaviors of AZ31 Mg *** with the untreated Mg alloys, corrosion current densities(icorr)can decline by 58% in the 200-cycles TiO2-covered Mg alloy and further decline by up to 74% with the thickness of nanofilm up to 63 nm(400 cycles).The subsequent modification with a cross-linked conversion layer of 3-aminopropyltriethoxysilane(APTES) by a dipping method can produce a compact silane coating on TiO2 nanofilm, which can seal pinholes of TiO2 nanofilm and serve as a barrier to further adjust the corrosion behavior of the *** icorrcan decline about two orders of magnitude in the TiO2/silane composite *** the adjustable corrosion rate come true, which can be attributed to the precise control on the thickness of metal oxide nanofilm and additional protection from the compact silane *** vitro study discloses that the TiO2/silane hybrid coating shows higher expression of alkaline phosphatase(ALP)and can promote cellular adhesion and proliferation with better cytocompatibility than untreated Mg alloy.

关键词： Magnesium alloy TiO2 Biodegradability Atomic layer deposition Hybrid coating Biocompatibility

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Single-atom modified graphene cocatalyst for enhanced photocatalytic cO_(2)reduction on halide perovskite

引用

chinese Journal of catalysis 2024年第9期64卷 143-151页

作者： Hui Fu Jin Tian Qianqian Zhang Zhaoke zheng Hefeng cheng Yuanyuan Liu Baibiao Huang Peng Wang State Key Laboratory of crystal Materials Shandong UniversityJinan 250100ShandongChina

Metal halide perovskite(MHP)has become one of the most promising materials for photocatalytic cO_(2)reduction owing to the wide light absorption range,negative conduction band position and high reduction ***,photoreduction of cO_(2)by MHP remains a challenge because of the slow charge separation and ***,a cobalt single-atom modified nitrogen-doped graphene(co-NG)cocatalyst is prepared for enhanced photocatalytic cO_(2)reduction of bismuth-based MHP cs_(3)Bi_(2)Br_(9).The optimal cs_(3)Bi_(2)Br_(9)/co-NG composite exhibits the cO production rate of 123.16μmol g-1 h-1,which is 17.3 times higher than that of cs_(3)Bi_(2)Br_(9).Moreover,the cs_(3)Bi_(2)Br_(9)/co-NG composite photocatalyst exhibits nearly 100%cO selectivity as well as impressive long-term *** carrier dynamic characterizations such as kelvin probe force microscopy(KPFM),single-particle PL microscope and transient absorption(TA)spectroscopy demonstrate the vital role of co-NG cocatalyst in accelerating the transfer and separation of photogenerated charges and improving photocatalytic *** reaction mechanism has been demonstrated by in situ diffuse reflectance infrared Fourier-transform spectroscopy *** addition,in situ X-ray photoelectron spectroscopy test and theoretical calculation reveal the reaction reactive sites and reaction energy barriers,demonstrating that the introduction of co-NG promotes the formation of~(*)cOOH intermediate,providing sufficient evidence for the highly selective generation of *** work provides an effective single-atom-based cocatalyst modification strategy for photocatalytic cO_(2)reduction and is expected to shed light on other photocatalytic applications.

关键词： Bismuth-based perovskite Photocatalysis cO_(2)reduction Single-atom cocatalyst charge separation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于对数应变的孔隙黏弹性有限变形理论

引用

计算物理 2024年第3期41卷 287-297页

作者：唐熊郑佩上海理工大学机械工程学院上海200093

在有限变形理论框架下,基于对数应变和kelvin流变模型提出一个孔隙黏弹性理论模型。该模型通过假设Kirchhoff应力和孔隙压力与对数应变和Lagrangian孔隙度的变化量存在线性关系,将线性孔隙黏弹性模型中的无穷小应变直接替换为对数应变... 详细信息

在有限变形理论框架下,基于对数应变和kelvin流变模型提出一个孔隙黏弹性理论模型。该模型通过假设Kirchhoff应力和孔隙压力与对数应变和Lagrangian孔隙度的变化量存在线性关系,将线性孔隙黏弹性模型中的无穷小应变直接替换为对数应变而得到。作为验证,将该理论模型用于研究经典的Terzaghi一维固结问题,通过与孔隙弹性有限变形模型的数值结果对比,结果显示:在固结早期,孔隙固体骨架的黏弹性响应和弹性响应曲线几乎是一致的,但随着时间的推移,孔隙固体骨架的黏性逐渐主导骨架的变形,并影响固结的最终结果;并且,骨架的黏性会延迟孔隙压力的扩散。此外,通过设置黏性贡献系数ζ=0.001,从数值角度实现了孔隙黏弹性响应“退化”为孔隙弹性响应,这在一定程度上验证了模型的正确性。

关键词：孔隙黏弹性对数应变有限变形有限元流变模型

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Z-scheme heterojunction of ZnO/cDots/c_(3)N^(4) for strengthened photoresponsive bacteria-killing and acceleration of wound healing

引用

Journal of Materials Science & Technology 2020年第22期54卷 1-11页

作者： Yiming Xiang Qilin Zhou Zhaoyang Li Zhenduo cui Xiangmei Liu Yanqin Liang Shengli Zhu Yufeng zheng kelvin Wai Kwok Yeung Shuilin Wu Hubei Key Laboratory of Polymer Materials Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional MaterialsSchool of Materials Science&EngineeringHubei UniversityWuhan 430062China The Key Laboratory of Advanced ceramics and Machining Technology by the Ministry of Education of china School of Materials Science&EngineeringTianjin UniversityTianjin 300072China Department of Orthopaedics&Traumatology Li KaShing Faculty of MedicineThe University of Hong KongPokfulamHong Kong999077China State Key Laboratory for Turbulence and complex System and Department of Materials Science and Engineering College of EngineeringPeking UniversityBeijing 100871China

The abuse of antibiotics is leading to the emergence of resistant *** this work,a drug-free composite of ZnO/cDots/g-c3N4 with Z-scheme heterojunction was developed,which was employed to kill bacteria effectively within a very short time under the irradiation of visible light due to the enhanced photocatalytic and photothermal *** this system,the cDots acted as a bridge between g-c3N4 and ZnO,effectively inhibiting the recombination of photo-generated electrons with holes and consequently enhancing the photocatalytic *** addition,cDots endowed the system with excellent photothermal *** a result,the antibacterial efficacy of ZnO/cDots/g-c3N4 composite against *** and *** reached up to 99.97%and 99.99%respectively,after 15 min of visible light irradiation,due to the synergistic action of photo-inspired radical oxygen species and *** Zn ions released from the composite promoted the growth of fibroblasts,which accelerated the wound healing process.

关键词： Heterostructure Z-scheme Antibacterial Wound healing g-c3N4

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：