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Evidence of a conservative gait strategy in athletes with a history of concussions

Journal of Sport and Health Science 2016年第4期5卷 417-423页

作者： Thomas A.Buckley Srikant Vallabhajosula Jessie R.Oldham Barry A.munkasy kelsey m.evans David A.Krazeise Caroline J.Ketcham Eric E.Hall Department of Kinesiology and Applied Physiology University of Delaware Department of Physical Therapy Education Elon University Department of Health and Kinesiology Georgia Southern University Department of Intercollegiate Athletics Stetson University Department of Exercise Science Elon University

Background：A history of 3 or more concussions is frequently associated with numerous short-and long-term *** in postural control are a known acute consequence of concussion;however,limited evidence exists on the effects of multiple concussions on *** purpose of this study was to assess gait stepping characteristics in collegiate aged student-athletes based on concussion ***：There were 63 participants divided into 3 even groups based on concussion history：≥3 concussions,1–2 concussions,and 0 *** participants completed 10 trials of gait on a 4.9 m instrumented *** dependent variables of interest included both gait stepping characteristics（step velocity,length,and width,double support time,and the percentage of the gait cycle in stance） and coefficien of variability（CoV） measures（step length,time,and width）.The gait stepping characteristics were compared firs with a mANOVA with follow-up 1-way ANOVAs and Tukey post hoc tests as *** Co V measures were compared with 1-way ANOVAs and Tukey post hoc ***：There were main effects for group for step velocity,length,width,and double support ***,the 0 concussion group displayed typical healthy young gait parameters and performed significant y better than either concussion *** 0 concussion group had a significant y greater step length Co V,but there were no differences in the step time or width Co ***：This findin provides evidence of subtle impairments in postural control during gait among individuals with prior history of concussion which could be an early indicator of future neurological deficiencies The limited difference in the variability measures is consistent with prior static stance studies and could suggest the individuals constrain their motor systems to reduce *** together,these findi gs suggest a conservative gait strategy which is adopted by individuals with a history of concussions.

关键词： Balance Brain injury Gait performance Locomotion mild traumatic Postural control Postural stability Variability

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Fire blight QTL analysis in a multi-family apple population identifies a reduced-susceptibility allele in ‘Honeycrisp’

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Horticulture Research 2021年第1期8卷 355-367页

作者： Sarah A.Kostick Soon Li Teh John L.Norelli Stijn Vanderzande Cameron Peace Kate m.evans Tree Fruit Research and Extension Center Department of HorticultureWashington State UniversityWenatcheeWA 98801USA United States Department of Agriculture Agricultural Research ServiceAppalachian Fruit Research LaboratoryKearneysvilleWV 25430USA Department of Horticulture Washington State UniversityPullmanWA 99164USA

Breeding apple cultivars with resistance offers a potential solution to fire blight,a damaging bacterial disease caused by Erwinia *** resistance alleles at quantitative trait loci(QTLs)were previously characterized in diverse malus germplasm with poor fruit quality,which reduces breeding *** study utilized a pedigree-based QTL analysis approach to elucidate the genetic basis of resistance/susceptibility to fire blight from multiple genetic sources in germplasm relevant to *** breeding ***-seven important breeding parents(IBPs)were represented by 314 offspring from 32 full-sib families,with‘Honeycrisp’being the most highly represented *** resistance/susceptibility data from a two-year replicated field inoculation study and previously curated genome-wide single nucleotide polymorphism data,QTLs were consistently mapped on chromosomes(Chrs.)6,7,and *** QTLs together explained~28% of phenotypic *** Chr.6 and Chr.15 QTLs colocalized with previously reported QTLs,while the Chr.7 QTL is possibly novel.‘Honeycrisp’inherited a rare reduced-susceptibility allele at the Chr.6 QTL from its grandparent‘Frostbite’.The highly resistant IBP‘Enterprise’had at least one putative reduced-susceptibility allele at all three *** general,lower susceptibility was observed for individuals with higher numbers of reduced-susceptibility alleles across *** study highlighted QTL mapping and allele characterization of resistance/susceptibility to fire blight in complex pedigree-connected apple breeding *** gained will enable more informed parental selection and development of trait-predictive DNA tests for pyramiding favorable alleles and selection of superior apple cultivars with resistance to fire blight.

关键词： blight breeding cultivar

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Divergent Nanotube Synthesis through Reversible macrocycle Assembly

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Accounts of materials Research 2022年第9期3卷 935-947页

作者： michael J.Strauss Austin m.evans Emily K.Roesner Richard J.monsky madison I.Bardot William R.Dichtel Department of Chemistry Northwestern UniversityEvanstonIllinois 60208United States

CONSPECTUS:Nanotubes offer a unique combination of structural precision,tunable interior environments,and high aspect ratios that will be useful for many *** these desirable attributes,widespread explorations into the properties and applications of chemically designed nanotubes have been limited by challenges related to their *** realization has motivated developing a unified synthetic nanotube design,which would enable wide-reaching explorations into one-dimensional molecular architectures.

关键词： realization cycle interior

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Application of a long short-term memory for deconvoluting conductance contributions at charged ferroelectric domain walls

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npj Computational materials 2020年第1期6卷 319-325页

作者： Theodor S.Holstad Trygve m.Ræder Donald m.evans Didirk R.Småbråten Stephan Krohns Jakob Schaab Zewu Yan Edith Bourret Antonius T.Jvan Helvoort Tor Grande Sverre m.Selbach Joshua C.Agar Dennis meier Department of materials Science and Engineering Norwegian University of Science and Technology(NTNU)7491 TrondheimNorway Department of materials Science and Engineering Lehigh UniversityBethlehemPA 18015USA Experimental Physics V Center for Electronic Correlations and MagnetismUniversity of Augsburg86159 AugsburgGermany Department of materials ETH Zurich8093 ZürichSwitzerland materials Sciences Division Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA Department of Physics ETH Zurich8093 ZürichSwitzerland Department of Physics Norwegian University of Science and Technology(NTNU)7491 TrondheimNorway

Ferroelectric domain walls are promising quasi-2D structures that can be leveraged for miniaturization of electronics components and new mechanisms to control electronic signals at the *** the significant progress in experiment and theory,however,most investigations on ferroelectric domain walls are still on a fundamental level,and reliable characterization of emergent transport phenomena remains a challenging task.

关键词： walls ferroelectric conductance

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Evolving Frameworks for the Foundation and Practice of Electronic Fetal monitoring

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maternal-Fetal medicine 2022年第2期4卷 141-151页

作者： mark I.evans David W.Britt Shara m.evans Lawrence D.Devoe Fetal medicine Foundation of America New YorkNY 10065USA Comprehensive Genetics PLLCNew YorkNY 10065USA Department of Obstetrics&Gynecology Icahn School of Medicine at Mt.SinaiNew YorkNY10029USA Department of maternal Child Health Gillings School of Public Health University of North Carolina at Chapel HillChapel HillNY 27599USA Department of Obstetrics and Gynecology Medical College of GeorgiaAugusta UniversityAugustaGA 30907USA.

Since the 1970s,electronic fetal monitoring(EFm)also known as cardiotocography(CTG)has been used extensively in labor around the world,despite its known failure to help prevent many babies from developing neonatal encephalopathy and cerebral *** of EFm’s poor performance with respect to these outcomes arises from a fundamental misunderstanding of the differences between screening and diagnostic tests,subjective classifications of fetal heart rate(FHR)patterns that lead to large inter-observer variability in its interpretation,failure to appreciate early stages of fetal compromise,and poor statistical modeling for its use as a screening *** have developed a new approach to the practice and interpretation of EFm called the fetal reserve index(FRI)which does the following:(1)breaking FHR components down into 4 components,(heart rate,variability,accelerations,and decelerations);(2)contextualizing the metrics by adding increased uterine activity;(3)adding specific maternal,fetal,and obstetric risk *** result is an eight-point scoring metric that,when directly compared with current American College of Obstetricians and Gynecologists EFm categories,even in version 1.0 with equal weighting of variables,shows that the FRI has performed much better for identifying cases at risk before damage had occurred,reducing the need for emergency deliveries,and lowering overall Cesarean delivery *** increased data,we expect further refinements in the specifics of scoring that will allow even earlier detection of compromise in labor.

关键词： Fetal monitoring Cardiotocography Fetal reserve index

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On ultrahigh temperature crustal metamorphism:Phase equilibria,trace element thermometry,bulk composition,heat sources,timescales and tectonic settings

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Geoscience Frontiers 2015年第3期6卷 311-356页

作者： David E.kelsey martin Hand Department of Geology and Geophysics School of Physical SciencesThe University of Adelaide

Ultrahigh temperature （UHT） metamorphism is the most thermally extreme form of regional crustal metamorphism, with temperatures exceeding 900 ℃. UHT crustal metamorphism is recognised in more than 50 localities globally in the metamorphic rock record and is accepted as ＇normal＇ in the spectrum of regional crustal processes. UHT metamorphism is Wpically identified on the basis of diagnostic mineral assemblages such as sapphirine ＋ quartz, orthopyroxene ＋ sillimanite ＋ quartz and osumilite in mg-Al- rich rock compositions, now usually coupled with pseudosection-based thermobarometry using internally-consistent thermodynamic data sets and/or Al-in-Orthopyroxene and ternary feldspar thermobarometry. Significant progress in the understanding of regional UHT metamorphism in recent years includes：（1） development of a ferric iron activity-composition thermodynamic model for sapphirine, allowing phase diagram calculations for oxidised rock compositions; （2） quantification of UHT conditions via trace element thermometry, with Zr-in-rutile more commonly recording higher temperatures than Ti-in-zircon. Rutile is likely to be stable at peak UHT conditions whereas zircon may only grow as UHT rocks are cooling. In addition, the extent to which Zr diffuses out of rutile is controlled by chemical communication with zircon; （3） more fully recognising and utilising temperature-dependent thermal properties of the crust, and the possible range of heat sources causing metamorphism in geodynamic modelling studies; （4） recognising that crust partially melted either in a previous event or earlier in a long-duration event has greater capacity than fertile, unmelted crust to achieve UHT conditions due to the heat energy consumed by partial melting reactions; （5） more strongly linking U-Pb geochronological data from zircon and monazite to P-T points or path segments through using Y ＋ REE partitioning between accessory and major phases, as well as phase diagrams incorporating Zr and REE; and （

关键词： Sapphirine + quartz P-T pseudosections Zr-in-rutile Ti-in-zircon U-Pb geochronology Subduction

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Cost and accuracy of advanced breeding trial designs in apple

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Horticulture Research 2016年第1期3卷 267-276页

作者： Julia m Harshman Kate m.evans Craig m Hardner Department of Horticulture Washington State University Tree Fruit Research and Extension CenterWenatchee98801WAUSA Queensland Alliance for Agriculture and Food Innovation University of QueenslandSt Lucia4072QueenslandAustralia

Trialing advanced candidates in tree fruit crops is expensive due to the long-term nature of the planting and labor-intensive evaluations required to make selection *** closely the trait evaluations approximate the true trait value needs balancing with the cost of the *** of field trials of advanced apple candidates in which reduced number of locations,the number of years and the number of harvests per year were modeled to investigate the effect on the cost and accuracy in an operational breeding *** aim was to find designs that would allow evaluation of the most additional candidates while sacrificing the least *** percentage difference,response to selection,and correlated response were used to examine changes in accuracy of trait *** the quality traits evaluated,accuracy and response to selection were not substantially reduced for most trial *** management influences the decision to change trial design,and some designs had greater risk associated with *** cost and accuracy with risk yields valuable insight into advanced breeding trial *** methods outlined in this analysis would be well suited to other horticultural crop breeding programs.

关键词： breeding crops planting

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Unexpected cancellation on a catatonic patient’s electroconvulsive therapy due to the coronavirus pandemic

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General Psychiatry 2020年第6期33卷 442-444页

作者： kelsey Casano Erin Capone Department of Psychiatry LSU Health Sciences Center New OrleansNew OrleansLouisianaUSA Psychiatry LSU Health Sciences Center New OrleansNew OrleansLouisianaUSA

We report a case of a 39-year-old woman with a psychiatric history of schizoaffective disorder with catatonia,dependent personality disorder and substance use disorder whose symptoms have been very difficult to *** her most recent inpatient admission,she w as treated with electroconvulsive therapy(ECT)for *** treatment team was hopeful that ECT was making a difference for this ***,she w as only able to receive two sessions of treatment due to new hospital protocols related to the coronavirus *** the patient was not suspected to have the coronavirus,she could no longer undergo ventilation with a bag and mask during the ***-m ask ventilation is known to aerosolise the coronavirus and other diseases and potentially put healthcare workers at *** orotracheal intubation also aerosolises the coronavirus,this was the only means of airway management still allowed by anaesthesia providers at this *** psychiatry team estimated that the risks of intubation outweighed the benefits of treatment,and ECT was *** additional ECT treatments,the patient again decompensated for several weeks before being stabilised on clozapine,haloperidol and *** she eventually had a positive treatment outcome,her hospital course w as likely prolonged due to unforeseen events related to the novel *** feel that the current medical climate is unprecedented and is interfering with necessary psychiatric treatment In an unanticipated *** will need to be flexible while working with psychiatrists and identify safe ways to provide this necessary psychiatric treatment for patients.

关键词： patient treatment aerosol

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NCoR1 protects positive-selecting thymocytes from negative selection

NCoR1 protects positive-selecting thymocytes from negative s...

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第9届中国中西医结合学会妇产科专业委员会第二次学术会议

作者： Na Zhang Jianrong Wang Nanhai He Ronald m.evans Dajin Li Ling Wang Qibin Leng Laboratory for Reproductive Immunology Hospital & Institute of Obstetrics and Gynecology IBS Fudan University Shanghai Medical College The Academy of Integrative medicine of Fudan University Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases Key Laboratory of molecular Virology and Immunology Institut Pasteur of Shanghai Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Gene Expression Laboratory Salk Institute for Biological Studies

机体自身的免疫调控、炎症反应以及抵抗外来感染的过程中,T细胞发挥着不可或缺的作用。在胸腺发育中,T细胞受体信号介导阳性选择和阴性选择,在这个过程中需要精密的转录调控以开启和关闭细胞的增殖与凋亡通道。之前研究表明,转录辅抑制...

机体自身的免疫调控、炎症反应以及抵抗外来感染的过程中,T细胞发挥着不可或缺的作用。在胸腺发育中,T细胞受体信号介导阳性选择和阴性选择,在这个过程中需要精密的转录调控以开启和关闭细胞的增殖与凋亡通道。之前研究表明,转录辅抑制子NCoR1很可能在T细胞胸腺发育中发挥重要作用。我们建立了T细胞特异性缺失NCoR的小鼠品系,发现与全身性NCoR1缺失小鼠胚胎胸腺

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Gibberellic acid induced parthenocarpic‘Honeycrisp’apples(malus domestica)exhibit reduced ovary width and lower acidity

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Horticulture Research 2019年第1期6卷 1129-1141页

作者： kelsey D.Galimba Daniel G.Bullock Chris Dardick Zhongchi Liu Ann m.Callahan Appalachian Fruit Research Station Agricultural Research ServiceUnited States Department of Agriculture2217 Wiltshire RoadKearneysvilleWV 25430USA Department of Cell Biology and molecular Genetics College of Mathematics and Natural SciencesUniversity of MarylandCollege ParkMD 20742USA

Fruit set and development are dependent on auxin,gibberellin,and cytokinin,which cause parthenocarpic development in many species when applied *** sprays containing these hormones are used to improve apple fruit set,size,and shape,but have been implicated negatively in other aspects of fruit *** applied gibberellic acid(GA_(3)),synthetic auxin(NAA),and the auxin-transport inhibitor NPA to‘Honeycrisp’apple *** retention and size were quantified throughout development,and seed number and fruit quality parameters were measured at ***_(3)alone caused the development of seedless parthenocarpic *** maturity,GA_(3)-treated apples were narrower due to reduced ovary width,indicating that GA_(3)induced normal growth of the hypanthium,but not the ***_(3)-treated fruits were also less acidic than hand-pollinated controls,but had similar firmness,starch,and sugar *** further understand the regulation of parthenocarpy,we performed tissue-specific transcriptome analysis on GA_(3)-treated,NAA-treated,and control fruits,at 18 days after treatment and again at ***,transcriptome analysis showed GA_(3)-treated and hand-pollinated fruits were highly similar in RNA expression *** expression differences in putative cell division,cytokinin degradation,and cell wall modification genes in GA_(3)-treated ovaries correlated with the observed shape differences,while early expression differences in the acidity gene ma1 may be responsible for the changes in *** together,our results indicate that GA_(3)triggers the development of parthenocarpic apple fruit with morphological deviations that correlate with a number of candidate gene expression differences.

关键词： maturity width acidity

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