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Elucida.ing regula.ory processes of intense physica. a.tivity by multi-omics a.a.ysis

Milita.y Medica. Resea.ch 2024年第4期 479-499页

作者： Ernesto S.Na.a.a.u Ma.ina.a.Gritsenko Young-Mo Kim Jennifer E.Kyle Kelly G.Stra.ton Ca.rie D.Nicora.Na.ha.ie Munoz Ka.hleen M. Na.a.ro Da.iel Cla.orne Yuqia. Ga. Ka.l K.Weitz Va.essa.L. Pa.rus Kent J. Bloodsworth kelsey a. allen Lisa.M. Bra.er Ferna.do Montes Ka.hleen a. Cla.k Gra.t Tietje Justin Teegua.den Kristin E.Burnum-Johnson Biologica. Sciences Division Pacific Northwest National Laboratory Environmenta. a.d Molecula. Sciences Division Pacific Northwest National Laboratory Centers for Disea.e Control a.d Prevention National Institute for Occupational Safety and Health Western States Division Computa.iona. a.a.ytics Division Pacific Northwest National Laboratory Na.iona. Security Directora.e Pacific Northwest National Laboratory Los a.geles County Fire Depa.tment Centers for Disea.e Control a.d Prevention National Institute for Occupational Safety and Health Respiratory Health Division Environmenta. a.d Molecula. Toxicology Oregon State University

Ba.kground: Physiologica. a.d biochemica. processes a.ross tissues of the body a.e regula.ed in response to the high dema.ds of intense physica. a.tivity in severa. occupa.ions, such a. firefighting, la. enforcement, milita.y, a.d sports. a.better understa.ding of such processes ca. ultima.ely help improve huma. performa.ce a.d prevent illnesses in the work ***: To study regula.ory processes in intense physica. a.tivity simula.ing rea.-life conditions, we performed a.multi-omics a.a.ysis of 3 biofluids(blood pla.ma. urine, a.d sa.iva. collected from 11 wildla.d firefighters before a.d a.ter a.45 min, intense exercise regimen. Omics profiles post-vs. pre-exercise were compa.ed by Student's t-test followed by pa.hwa. a.a.ysis a.d compa.ison between the different omics ***: Our multi-omics a.a.ysis identified a.d qua.tified 3835 proteins, 730 lipids a.d 182 meta.olites combining the 3 different types of sa.ples. The blood pla.ma.a.a.ysis revea.ed signa.ures of tissue da.a.e a.d a.ute repa.r response a.compa.ied by enha.ced ca.bon meta.olism to meet energy dema.ds. The urine a.a.ysis showed a.strong, concomita.t regula.ion of 6 out of 8 identified proteins from the renin-a.giotensin system supporting increa.ed excretion of ca.a.olites, rea.sorption of nutrients a.d ma.ntena.ce of fluid ba.a.ce. In sa.iva. we observed a.decrea.e in 3 pro-infla.ma.ory cytokines a.d a. increa.e in 8 a.timicrobia. peptides. a.systema.ic litera.ure review identified 6 pa.ers tha. support a. a.tered susceptibility to respira.ory ***: This study shows simulta.eous regula.ory signa.ures in biofluids indica.ive of homeosta.ic ma.ntena.ce during intense physica. a.tivity with possible effects on increa.ed infection susceptibility, suggesting tha. ca.tion a.a.nst respira.ory disea.es could benefit workers on highly physica. dema.ding jobs.

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Recent clinica. tria.s a.d optica. control a. a.potentia. stra.egy to develop microtubule-ta.geting drugs in colorecta. ca.cer ma.a.ement

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World Journa. of Ga.troenterology 2024年第13期30卷 1780-1790页

作者： Ka.suhiro Kita.allen Burdowski Depa.tment of Biology St.Francis CollegeBrooklynNY 11201United States

Colorecta. ca.cer(CRC)ha. rema.ned the second a.d the third lea.ing ca.se of ca.cer-rela.ed dea.h worldwide a.d in the United Sta.es,*** significa.t improvement in overa.l surviva. ha. been a.hieved,dea.h in a.ult popula.ions under the a.e of 55 a.pea.s to ha.e increa.ed in the pa.t *** new cla.ses of thera.eutic stra.egies such a. immunothera.y ha.e emerged,their a.plica.ion is very limited in CRC so ***(MT)inhibitors such a. ta.a.es,a.e not genera.ly successful in *** ma. be some wa. to ma.e MT inhibitors work effectively in *** potentia. a.va.ta.e tha. we ca. ta.e to trea. CRC ma. be the combina.ion of optica. techniques coupled to a. endoscope or other fiber optics-ba.ed devices.a.combina.ion of optica. devices a.d photo-a.tiva.a.le drugs ma. a.low us to loca.ly ta.get a.va.ced CRC cells with highly potent MT-ta.geting *** this Editoria. review,we would like to discuss the potentia. of optogenetic a.proa.hes in CRC ma.a.ement.

关键词： Colorecta. ca.cer Chemothera.y Microtubule Combreta.ta.in Photopha.ma.ology

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Physiology of medicina. a.d a.oma.ic pla.ts under drought stress

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The Crop Journa. 2024年第2期12卷 330-339页

作者： Zohreh Ema.i Bistga.i allen V.Ba.ker Ma.oud Ha.hemi Isfa.a. a.ricultura. a.d Na.ura. Resources Resea.ch a.d Educa.ion Center Agricultural Research Education and Extension Organization(AREEO)Isfahan 81748-35117Iran Stockbridge School of a.riculture University of MassachusettsAmherstMA 01002USA

Drought poses a.significa.t challenge,restricting the productivity of medicina. a.d a.oma.ic *** stra.n induced by drought ca. impede vita. processes like respira.ion a.d photosynthesis,a.fecting va.ious a.pects of pla.ts’growth a.d *** response to this a.versity,medicina. pla.ts employ mecha.isms such a. morphologica. a.d structura. a.justments,modula.ion of drought-resista.t genes,a.d a.gmented synthesis of seconda.y meta.olites a.d osmotic regula.ory substa.ces to a.levia.e the *** wa.er sca.city ca. lea. to lea. wilting a.d ma. ultima.ely result in pla.t *** cultiva.ion a.d ma.a.ement of medicina. pla.ts under stress conditions often differ from those of other *** is beca.se the ma.n goa. with medicina. pla.ts is not only to increa.e the yield of the a.ove-ground pa.ts but a.so to enha.ce the production of a.tive ingredients such a. essentia. *** elucida.e these mecha.isms of drought resista.ce in medicina. a.d a.oma.ic pla.ts,the current review provides a.summa.y of recent litera.ure encompa.sing studies on the morphology,physiology,a.d biochemistry of medicina. a.d a.oma.ic pla.ts under drought conditions.

关键词： Drought stress Medicina. a.d a.oma.ic pla.ts Phytochemistry Physiology

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微塑料和纳米塑料威胁青藏高原环境

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Science Bulletin 2024年第5期69卷 589-592页

作者：张玉兰康世昌罗犀 Ta.uj Shukla.高坛光 Deonie allen Steve allen Mela.ie Bergma.n Sta.e Key La.ora.ory of Cryospheric Science Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China College of Ea.th a.d Environmenta. Sciences Lanzhou UniversityLanzhou 730000China School of Geogra.hy Earth and Environmental SciencesUniversity of BirminghamBirmingham 200003UK Ocea. Frontiers Institute Dalhousie UniversityHalifax B3H 4R2Canada a.fred-Wegener-Institut Helmholtz-Zentrum für Pola.-und Meeresforschung Bremerhaven D-27515Germany University of Chinese a.a.emy of Sciences Beijing 100049China

Pla.tic pollution is a.pla.eta.y level threa. which a.fects Ea.th’s environment a.d *** the poles to deep ocea. ba.ins,the growth of pla.tic wa.te ha. a.rea.y exceeded its *** projected increa.e of pla.tic production a.d wa.te genera.ion over the coming yea.s ma.es the situa.ion even more *** a.ter sta.na.ion in 2020 due to the COVID-19 pa.demic,the globa. pla.tic production ha. a.so increa.ed from 335 to 391 million metric tons(Mt)between 2016 a.d 2021(Fig.S1 online);yet currently post-consumer recycled a.d bio-ba.ed/a.tributed pla.tics only a.counts~9%of the world’s pla.tic production[1].Sta.istica.ly.

关键词：微塑料 a.tributed pla.tics

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Low pha.e noise K-ba.d signa. genera.ion using pola.iza.ion diverse single-soliton integra.ed microcombs

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Photonics Resea.ch 2024年第6期12卷 1175-1185页

作者： a.Wa.EED a.DHa.EERI HSIa.-HSUa. CHIN TRISTa. MELTON DONG IL LEE allen CHU WENTING Wa.G MINGBIN YU Pa.RICK GUO-QIa.G LO DIM-LEE KWONG CHEE WEI WONG Fa.g Lu Mesoscopic Optics a.d Qua.tum Electronics La.ora.ory University of CaliforniaLos AngelesCalifornia 90095USA Institute of Microelectronics A*STARSingapore 117865Singapore Sta.e Key La.ora.ory of Functiona. Ma.eria.s for Informa.ics Shanghai Institute of Microsystem and Information Technologyand Shanghai Industrial Technology Research InstituteShanghai 200050China

Frequency microcombs with microwa.e a.d millimeter-wa.e repetition ra.es provide a.compa.t solution for coherent communica.ion a.d informa.ion *** implementa.ion of these microcombs using a.CMOS-compa.ible pla.form further pa.es the wa. for la.ge-sca.e photonic integra.ion a.d ***,we demonstra.e free-running soliton microcombs with K-ba.d repetition ra.es with very low pha.e noise over a.4 GHz pump detuning ra.ge rea.hing−117(−123)dBc/Hz a. 10 kHz offset for a.19.7(10)GHz ca.rier without a.tive pump sta.iliza.ion,exceeding commercia. electronic microwa.e oscilla.ors a. frequency offsets a.ove 40 *** minimum la.er noise to soliton microwa.e signa. tra.sduction fa.tor observed is−*** noise performa.ce is a.hieved using a.hybridized dua.-mode for soliton genera.ion to a.hieve pa.sive therma. sta.iliza.ion a.d minima. soliton spectrum shift from prior Ra.a. sca.tering a.d dispersive wa.e *** further exa.ine the locking of the repetition ra.e to a. externa. ultra.ta.le photonic oscilla.or to illustra.e the fea.ibility of pha.e noise suppression below the thermorefra.tive noise limits of microresona.or frequency combs.

关键词： pump pola.iza.ion millimeter

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Exploring the Rea.ons for Selfie-Ta.ing a.d Selfie-Posting on Socia. Media.with Its Effect on Psychologica. a.d Socia. Lives:a.Study a.ong India. Youths

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Interna.iona. Journa. of Menta. Hea.th Promotion 2024年第5期26卷 389-398页

作者： Divya.P.Vija.a. Toka.i Ghuha.o Esla.a.h Ra.kuma. allen Joshua.George Roma.e John John a.ra.a. Depa.tment of Psychology Central University of KarnatakaKalaburagi585367India Depa.tment of Libera. a.ts Indian Institute of Technology BhilaiChhattisgarh491002India Libera. a.ts&Sciences Indian Institute of Management RanchiJharkhand834001India Depa.tment of Fa.ily Medicine/Geria.rics St.John’s National Academy of Health SciencesBangalore560034India

‘Selfie’ta.ing wa. introduced to the common people by sma.tphones a.d ha. become a.common pra.tice a.ross the globe in no *** technologica. a.va.cement a.d the popula.ity of sma.tphones,selfie-ta.ing ha. grown ra.idly within a.short *** light of the new trend set by the genera.ion,this study a.med to explore rea.ons for selfie-ta.ing a.d selfie-posting on socia. media.a.d their effects on the socia. a.d psychologica. lives of young a.ults.a.purposive sa.pling method wa. a.opted to select 20 India. citizens,between 18 a.d 24 *** da.a.were collected through semi-structured interviews a.d a.a.ysed using thema.ic ***-ta.ing a.d posting on socia. media.give positive feelings,a.d it a.ts a. a.mood modifier dependent mostly on the fa.oura.ility a.d feedba.k a.out the post which in turn a.fects emotions a.d self-sa.isfa.tion.

关键词： Selfie socia. media socia. networking sites obsessive selfie-ta.ing India. youth

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a.tificia. light a. night(a.a.) pollution a.ters ba. luna. chronobiology:insights from broa.-sca.e long-term a.oustic monitoring

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Ecologica. Processes 2024年第1期13卷 176-187页

作者： Ha. Li Pa.line allen Sa.ge Boris Sa.a.tha.La.ra.a.Ja.e Lyons Christina.Mills Pa.line Moussi Ca.ey Nichols Ca.ter Ta.osik Mc Kenzie Tsa.usis Nyza.a.Livingston Wilson John F.Grider Kevin a.Pa.ker Ma.ina.C.Ka.counis-Rueppell Depa.tment of Biology University of Nebraska Omaha Depa.tment of Biology University of North Carolina Greensboro Colora.o Pa.ks a.d Wild-life Pa.ker Ecology LLC Depa.tment of Biologica. Sciences University of Alberta

Ba.kground The timing of beha.ior a.d ha.ita. use of nocturna. a.ima.s ca. be influenced by the luna. cycle in na.ure. The preva.ence of a.tificia. light a. night(a.a.) ha. been recognized a. a.source of environmenta. pol-lution. The intera.tion between a.a. a.d the luna. cycle on ba. beha.ior is importa.t for understa.ding a.thro-pogenic effects on ba.s. We utilized a.deca.e(2012–2022) of a.oustic monitoring da.a.collected in North Ca.olina. United Sta.es, to investiga.e the rela.ionship between ba. a.tivity, luna. cycle, a.d light pollution. We exa.ined whether the a.ount of luna. illumina.ion a.fected species-specific nightly a.tivity a.d whether hourly ba. a.tivity pa.terns va.ied between nights with different moon pha.es. We further investiga.ed if the rela.ionship between ba. a.tivity a.d the luna. cycle might be a.tered by light *** We found tha. seven ba. species showed a.tivity va.ia.ion a.ross nights in rela.ion to the a.ount of moon illumina.ion when a.a. wa. a.sent. In genera., ba.s were less a.tive on full moon nights compa.ed to new moon nights. Light pollution intera.ted with the ba.–luna. rela.ionship in five of the seven species, ma.king the effect of the luna. cycle. We identified dela.ed ba. a.tivity pa.terns on nights with a.full or wa.ing moon in seven species, a.d light pollution a.tered tha. pa.tern in four species. Overa.l, a.a. wa. a.socia.ed with decrea.ed ba. a.tivity inde-pendent of luna. cycle *** Our study demonstra.ed tha. a. a.broa. spa.ia. sca.e, a.a. nega.ively a.fected ma.y North a.erica. tempera.e ba. species a.d a.tered their luna. chronobiology. a. light pollution is sprea.ing to historica.ly da.k a.ea. a.d ha.ita.s, a.a. might couple with other threa.s, such a. the white-nose syndrome or clima.e cha.ge, to ca.se ca.ca.ing da.a.e in the environment tha. depends on ecosystem services such a. pest control provided by ba.s. We a.gue tha. further resea.ch a.d conserva.ion a.tions a.e needed to mitiga.e

关键词： a.tificia. light a. night a.a. Ba.s Chiroptera Chronobiology Light pollution Luna. cycle Moonlight

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Ma.sive Dira. pa.ticles ba.ed on ga.ped gra.hene with Rosen-Morse potentia. in a.uniform ma.netic field

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Chinese Physics B 2024年第8期33卷 170-178页

作者： a.Ka.a.i a.ireza.a.a.i M.a.Ra.za.pour Depa.tment of Physics Ayatollah Amoli BranchIslamic Azad UniversityAmolIran

We explore the ga.ped gra.hene structure in the two-dimensiona. pla.e in the presence of the Rosen-Morse potentia. a.d a. externa. uniform ma.netic *** order to describe the corresponding structure,we consider the propa.a.ion of electrons in gra.hene a. rela.ivistic fermion qua.i-pa.ticles,a.d a.a.yze it by the wa.e functions of two-component spinors with pseudo-spin symmetry using the Dira. ***,to solve a.d a.a.yze the Dira. equa.ion,we obta.n the eigenva.ues a.d eigenvectors using the Legendre differentia. *** tha.,we obta.n the bounded sta.es of energy depending on the coefficients of Rosen-Morse a.d ma.netic potentia.s in terms of qua.tum numbers of principa. n a.d spin-orbit ***,the va.ues of the energy spectrum for the ground sta.e a.d the first excited sta.e a.e ca.cula.ed,a.d the wa.e functions a.d the corresponding proba.ilities a.e plotted in terms of coordina.es *** wha. follows,we explore the ba.d structure of ga.ped gra.hene by the modified dispersion rela.ion a.d write it in terms of the two-dimensiona. wa.e vectors K_(x) a.d K_(y).Fina.ly,the energy ba.ds a.e plotted in terms of the wa.e vectors K_(x) a.d K_(y) with a.d without the ma.netic term.

关键词： ma.sive Dira. equa.ion Rosen–Morse potentia. Legendre polynomia. ga.ped gra.hene pseudospin symmetry

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Kerogen Kinetic Distributions a.d Simula.ions Provide Insights into Petroleum Tra.sforma.ion Fra.tion (TF) Profiles of Orga.ic-Rich Sha.es

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Journa. of Ea.th Science 2024年第3期35卷 747-757页

作者： Da.id a.Wood DWa.Energy Limited Lincoln LN59JPUnited Kingdom

Two hundred a.d fifty single first-order a.rhenius rea.tions a.e simula.ed to genera.e S2 pyrogra.s a. three hea.ing ra.es 25,15,a.d 5°C·*** a.tiva.ion energy(E)a.d pre-exponentia. fa.tor(a.of the rea.tions simula.ed follow a.long-esta.lished trend of those va.ia.le va.ues displa.ed by sha.es a.d *** cha.a.teristics of the tra.sforma.ion fra.tion(TF)profiles(product genera.ion window tempera.ures)of the simula.ed single rea.tions a.e compa.ed to the TF profiles of recorded sha.e pyrogra.s genera.ed by multiple rea.tions with different E-a.va.ues lying nea. the defined E-a.*** simila.ities a.d differences a.e observed between the TF profile va.ues of the two *** simila.ities support the sprea. of E-a.va.ues involved in sha.e pyrogra. best *** differences a.e most likely expla.ned by the complexity of the multiple kerogen first-order a.d second-order rea.tions contributing to the recorded sha.e pyrogra.s versus the simplicity a.d crispness of the single first-order rea.tions *** results a.so justify the va.idity of using the previously described“va.ia.le E-a.pyrogra.-fitting method”of multi-hea.ing-ra.e sha.e pyrogra.s ena.ling optimizers to choose multiple rea.tions from a. unlimited ra.ge of E-a.*** contra.t,further doubt is ca.t on the va.idity of the consta.t-a.pyrogra.-fitting method used by the Ea.y%Ro technique,in tha. a.distribution of rea.tions with a.single a.va.ue is unlikely to represent the complex va.iety of kerogen ma.era.s observed in sha.e *** profiles genera.ed by the va.ia.le E-a.pyrogra.-fitting method lie close to the esta.lished E-a.trend a.d a.e likely to provide more rea.istic TF genera.ion window tempera.ures tha. TF profiles genera.ed by the consta.t-a.pyrogra.-fitting method.

关键词： tra.sforma.ion fra.tion profiles simula.ed S2 pyrogra.s multiple hea.ing ra.es kerogen/sha.e kinetics S2 pyrogra. fitting techniques kerogen petroleum resea.ch.

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库夫施泰因在童话世界和无垠山野共振

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环球人文地理 2024年第11期 144-152页

作者：十一 a.ocha. Erika.Ka.l allen Lugma.er Nikola. Sorokin Olivier pictureserver Roma. Ba.a.in Stepha. Sühling Thoma. Gross 摄图网

欧洲最适合隐居的地方在哪里？近日Lonely Pla.et公布的名单中，阿尔卑斯山脚下的库夫施泰因榜上有名。古典音乐环绕小镇，而走进大自然的方式有无数种：夏季徒步，冬季滑雪……库夫施泰因，奥地利西部的一个美丽小镇。得益于德、奥边...

欧洲最适合隐居的地方在哪里？近日Lonely Pla.et公布的名单中，阿尔卑斯山脚下的库夫施泰因榜上有名。古典音乐环绕小镇，而走进大自然的方式有无数种：夏季徒步，冬季滑雪……库夫施泰因，奥地利西部的一个美丽小镇。得益于德、奥边界的地理之势，无论从慕尼黑还是萨尔茨堡出发，都只需乘车约1小时就能到达。小镇夹在阿尔卑斯山的一个河谷，碧绿草坪、原始森林和清澈湖水环绕四周，八个村庄点缀其间，从高空俯瞰，犹如散落的珍珠。

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