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Assessing the academic achievement of United States orthopaedic departments

World Journal of Orthopedics 2022年第2期13卷 201-211页

作者： rishi Trikha Thomas E Olson Ameen Chaudry Chad r Ishmael Cristina Villalpando Clark J Chen kellyn r hori Nicholas M Bernthal Department of Orthopaedic Surgery University of CaliforniaLos AngelesCA 90404United States Department of Orthopaedic Surgery David Geffen School of Medicine at UCLALos AngelesCA 90095United States

BACKGrOUND Assessing academic productivity allows academic departments to identify the strengths of their scholarly contribution and provides an opportunity to evaluate areas for *** To provide objective benchmarks for departments seeking to enhance academic productivity and identify those with significant improvement in recent *** Our study retrospectively analyzed a cohort of orthopaedic faculty at United States-based academic orthopaedic programs.5502 full-time orthopaedic faculty representing 178 programs were included in *** included for analysis were National Institutes of Health funding(2014-2018),leadership positions in orthopaedic societies(2018),editorial board positions of top orthopaedic journals(2018),total number of publications and Hirsch-index.A weighted algorithm was used to calculate a cumulative score for each academic *** study was performed at a large,United States medical *** All 178 programs included in analysis were evaluated using the comprehensive weighted *** five institutions with the highest cumulative score,in decreasing order,were:Washington University in ***,the Hospital for Special Surgery,Sidney Kimmel Medical College(SKMC)at Thomas Jefferson University,the University of California,San Francisco(UCSF)and Massachusetts General Hospital(MGH)/Brigham and Women’s/*** five institutions with the highest score per capita,in decreasing order,were:Mayo Clinic(rochester),Washington University in ***,rush University,Virginia Commonwealth University(VCU)and MGH/Brigham and Women’s/*** five academic programs that had the largest improvement in cumulative score from 2013 to 2018,in decreasing order,were:VCU,SKMC at Thomas Jefferson University,UCSF,MGH/Brigham and Women’s/Harvard,and Brown *** This algorithm can provide orthopaedic departments a means to assess academic productivity,monitor progress,and identify areas for improvement as th

关键词： Bibliometrics Academic achievement Number of publications National Institutes of Health funding Hirsch-index

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Evading the host response:Staphylococcus“hiding”in cortical bone canalicular system causes increased bacterial burden

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Bone research 2020年第4期8卷 447-457页

作者： Stephen D.Zoller Vishal Hegde Zachary D.C.Burke Howard Y.Park Chad r.Ishmael Gideon W.Blumstein William Sheppard Christopher Hamad Amanda H.Loftin Daniel O.Johansen ryan A.Smith Marina M.Sprague kellyn r.hori Samuel J.Clarkson rachel Borthwell Scott I.Simon Jeff F.Miller Scott D.Nelson Nicholas M.Bernthal Department of Orthopedic Surgery University of CaliforniaLos Angeles125016th St Suite 2100Santa MonicaCA 90404USA David Geffen School of Medicine University of CaliforniaLos Angeles10833 Le Conte AveLos AngelesCA 90095USA Department of Internal Medicine University of CaliforniaLos Angeles757 Westwood PlazaSuite 7501Los AngelesCA 90095USA Department of Biomedical Engineering University of CaliforniaDavisDavisCA 95616USA California NanoSystems Institute University of CaliforniaLos Angeles570 Westwood PlazaLos AngelesCA 90095USA Department of Microbiology Immunologyand Molecular GeneticsDavid Geffen School of MedicineUniversity of CaliforniaLos Angeles 90095USA Department of Pathology University of CaliforniaLos Angeles125016th St Suite 3450Santa MonicaCA 90404USA

Extremity reconstruction surgery is increasingly performed rather than amputation for patients with large-segment pathologic bone *** persists as to the optimal void filler for this“limb salvage”surgery,whether metal or allograft *** focus on optimizing important functional gains for patients,and the risk of devastating implant infection has been thought to be similar regardless of implant *** insights into infection pathophysiology are challenging this equipoise,however,with both basic science data suggesting a novel mechanism of infection of Staphylococcus aureus(the most common infecting agent)into the host lacunar–canaliculi network,and also clinical data revealing a higher rate of infection of allograft over *** current translational study was therefore developed to bridge the gap between these insights in a longitudinal murine model of infection of allograft bone and ***-time Staphylococci infection characteristics were quantified in cortical bone vs metal,and both microarchitecture of host implant and presence of host immune response were *** orders-of-magnitude higher bacterial burden was established in cortical allograft bone over both metal and cancellous *** establishment of immune-evading microabscesses was confirmed in both cortical allograft haversian canal and the submicron canaliculi network in an additional model of mouse femur bone *** study results reveal a mechanism by which Staphylococci evasion of host immunity is possible,contributing to elevated risks of infection in cortical *** presence of this local infection reservoir imparts massive clinical implications that may alter the current paradigm of osteomyelitis and bulk allograft infection treatment.

关键词： immunity insight reservoir

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Many Kinds of reserved Judgement in No-Data Problem

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Applied Mathematics 2024年第1期15卷 1-8页

作者： Houju hori Jr. Nara Community Tsubakikishi Shrine Nara Japan

The reserved judgment can be broadly categorized into three types: re-Do, re-Set, and Natural Flowing Case (i.e. step by step in re-Try). hori et al. constructed the Bayes-Fuzzy Estimation and demonstrated that system theory can be applied to the possibility of Markov processes, and that decision-making approaches can be applied to sequential Bayes estimation. In this paper, we focus on the Natural Flowing Case within reserved judgment. Here, the possibility of oblique (or principal) factor rotation is considered as a part of the tandem fuzzy system that follows step by step for sequential Bayes estimation. Ultimately, we achieve a significant result whereby the expected utility can be calculated automatically without the need to construct a utility function for reserved judgment. There, this utility in re-Do can be calculated by the prior utility, and that utility in re-set does not exist by our research in this paper. Finally, we elucidate the relationship between fuzzy system theory and fuzzy decision theory through an applied example of Bayes-Fuzzy theory. Fuzzy estimation can be applied to only normal making decision, but it is impossible to apply abnormal decision problem. Our Vague, specially Type 2 Vague can be applied to abnormal case, too.

关键词： Bayes-Fuzzy Estimation re-Do re-Set Indifferent Zone reserved Judgement

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report for Type 2 Bayes-Fuzzy Estimation in No-Data Problem

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Applied Mathematics 2024年第1期15卷 46-50页

作者： Houju hori Jr. Kazuhisa Takemura Yukio Matsumoto Nara Cmmunity Tsubakikishi Shrine Nara Japan Department of Psychology Waseda University Tokyo Japan The Institute of Mathematical Statistics Tachikawa Japan

It is well known that the system (1 + 1) can be unequal to 2, because this system has both observation error and system error. Furthermore, we must provide our mustered service within our cool head and warm heart, where two states of nature are existing upon us. Any system is regarded as the two-dimensional variable error model. On the other hand, we consider that the fuzziness is existing in this system. Though we can usually obtain the fuzzy number from the possibility theory, it is not fuzzy but possibility, because the possibility function is as same as the likelihood function, and we can obtain the possibility measure by the maximal likelihood method (i.e. max product method proposed by Dr. Hideo Tanaka). Therefore, Fuzzy is regarded as the only one case according to Vague, which has both some state of nature in this world and another state of nature in the other world. Here, we can consider that Type 1 Vague Event in other world can be obtained by mapping and translating from Type 1 fuzzy Event in this world. We named this estimation as Type 1 Bayes-Fuzzy Estimation. When the Vague Events were abnormal (ex. under War), we need to consider that another world could exist around other world. In this case, we call it Type 2 Bayes-Fuzzy Estimation. Where hori et al. constructed the stochastic different equation upon Type 1 Vague Events, along with the general following probabilistic introduction method from the single regression model, multi-regression model, Ar model, Markov (decision) process, to the stochastic different equation. Furthermore, we showed that the system theory approach is Possibility Markov Process, and that the making decision approach is Sequential Bayes Estimation, too. After all, Type 1 Bays-Fuzzy estimation is the special case in Bayes estimation, because the pareto solutions can exist in two stochastic different equations upon Type 2 Vague Events, after we ignore one equation each other (note that this is Type 1 case), we can obtain both its

关键词： Bayes-Fuzzy Estimation Possibility Markov Process Possibility reserved Judgement

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Inverse relationship between platelet Akt activity and hippocampal atrophy:A pilot case-control study in patients with diabetes mellitus

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World Journal of Clinical Cases 2024年第2期12卷 302-313页

作者： Haruhiko Tokuda Takamitsu hori Daisuke Mizutani Tomoyuki Hioki Kumi Kojima Takashi Onuma Yukiko Enomoto Tomoaki Doi rie Matsushima-Nishiwaki Shinji Ogura Hiroki Iida Toru Iwama Takashi Sakurai Osamu Kozawa Department of Metabolic research Research InstituteNational Center for Geriatrics and GerontologyObu 474-8511Japan Department of Clinical Laboratory National Center for Geriatrics and GerontologyObu 474-8511Japan Department of Pharmacology Gifu University Graduate School of MedicineGifu 501-1194Japan Department of Neurosurgery Gifu University Graduate School of MedicineGifu 501-1194Japan Department of Dermatology Central Japan International Medical CenterMinokamo 505-8510Japan Department of Anesthesiology and Pain Medicine Gifu University Graduate School of MedicineGifu 501-1194Japan Department of Emergency Medicine Faculty of MedicineUniversity of ToyamaToyama 930-0194Japan Department of Emergency and Disaster Medicine Gifu University Graduate School of MedicineGifu 501-1194Japan research Institute National Center for Geriatrics and GerontologyObu 474-8511Japan

BACKGrOUND Akt plays diverse roles in *** is involved in the pathogenesis of type 2 diabetes mellitus(T2DM),which is caused by insulin *** also plays a vital role in human platelet ***,the hippocampus is closely associated with memory and learning,and a decrease in hippocampal volume is reportedly associated with an insulin-resistant phenotype in T2DM patients without *** To investigate the relationship between Akt phosphorylation in unstimulated platelets and the hippocampal volume in T2DM *** Platelet-rich plasma(PrP)was prepared from the venous blood of patients with T2DM or age-matched *** pellet lysate of the centrifuged PrP was subjected to western blotting to analyse the phosphorylation of Akt,p38 mitogen-activated protein(MAP)kinase and glyceraldehyde 3-phosphate dehydrogenase(GAPDH).Phosphorylation levels were quantified by densitometric *** volume was analysed using a voxel-based specific regional analysis system for Alzheimer’s disease on magnetic resonance imaging,which proposes the Z-score as a parameter that reflects hippocampal *** The levels of phosphorylated Akt corrected with phosphorylated p38 MAP kinase were inversely correlated with the Z-scores in the T2DM subjects,whereas the levels of phosphorylated Akt corrected with GAPDH were ***,this relationship was not observed in the control *** These results suggest that an inverse relationship may exist between platelet Akt activation and hippocampal atrophy in T2DM *** findings provide insight into the molecular mechanisms underlying T2DM hippocampal atrophy.

关键词： Akt Platelet Hippocampal atrophy Magnetic resonance imaging Diabetes mellitus

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执迷于《欢愉》的人:戈达尔与马克斯·奥菲尔斯

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电影艺术 2024年第3期 36-40页

作者： [日]堀润之龚金浪(译) 应雄(校译) 不详江西师范大学新闻与传播学院北海道大学文学院

马克斯·奥菲尔斯的《欢愉》在戈达尔的电影生涯中有着特别的意义。该片上映时,巴赞批评影片过于“奢华”,其“巴洛克风格”与莫泊桑原著故事格格不入。而彼时的新生代影评人特吕弗、戈达尔等人则以全新的评判标准对此观点提出质疑。戈... 详细信息

马克斯·奥菲尔斯的《欢愉》在戈达尔的电影生涯中有着特别的意义。该片上映时,巴赞批评影片过于“奢华”,其“巴洛克风格”与莫泊桑原著故事格格不入。而彼时的新生代影评人特吕弗、戈达尔等人则以全新的评判标准对此观点提出质疑。戈达尔认为,奥菲尔斯精湛的摄影机运动,绝非“多余的奢华”,而是如同“素描”一般在曲线结束时自然显现内容的形式,其本身就是“另一种内容”,他以《影像之书》结尾处对《欢愉》的引用,完成了对巴赞的反驳。

关键词：马克斯·奥菲尔斯巴赞戈达尔奢华素描

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Technical aspects in pancreaticoduodenectomy and therapeutic strategies for pancreatic cancer:History,current status,and future perspectives

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Hepatobiliary & Pancreatic Diseases International 2022年第6期21卷 600-602页

作者： Tomohide hori Daiki Yasukawa Department of Surgery Shiga General HospitalMoriyama 524-8524Japan Department of Surgery Shiga University of Medical ScienceOtsu 520-2192Japan

The incidence of pancreatic cancer(PC)has increased,and in-vasive ductal adenocarcinoma is the most common among PC pa-tients[1].Even in patients who receive radical treatments,namely chemotherapy and surgery,the five-year survival is only 2%-9%[1].Currently,many physicians recognize that further developments in multidisciplinary therapy are crucial to overcome PC[1].

关键词： cancer chemotherapy surgery

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Associations of body mass index and hospital-acquired disability with post-discharge mortality in older patients with acute heart failure

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Journal of Geriatric Cardiology 2022年第3期19卷 209-217页

作者： Akihiro Sakuyama Masakazu Saitoh Kentaro hori Yuichi Adachi Keigo Iwai Masatoshi Nagayama Department of Physical Therapy Faculty of Health ScienceJuntendo UniversityTokyoJapan Department of rehabilitation Sakakibara Heart InstituteTokyoJapan Department of Cardiology Sakakibara Heart InstituteTokyoJapan

OBJECTIVES To investigate the effect of hospital-acquired disability(HAD)on all-cause mortality after discharge according to the body mass index(BMI)in older patients with acute decompensated heart *** We included 408 patients aged≥65 years who were hospitalized for acute decompensated heart failure and had undergone an acute phase of cardiac rehabilitation at the Sakakibara Heart Institute between April 2013 and September 2015(me-dian age:82 years,interquartile range(IQr):76-86;52%male).Patients were divided into three groups based on BMI at hospital admission:underweight(rmal weight(18.5 to 25 kg/m^(2)),and overweight(≥25 kg/m^(2)).HAD was defined as a decrease of at least five points at discharge compared to before hospitalization according to the Barthel *** The median follow-up period was 475(IQr:292-730)days,and all-cause mortality during the follow-up period was 84 deaths(21%).According to multivariate Cox regression analysis,being underweight(Hr:1.941,95%CI:1.134−3.321,P=0.016)or overweight(Hr:0.371,95%CI:0.171−0.803,P=0.012),with normal BMI as the reference,and HAD(Hr:1.857,95%CI:1.062−3.250,P=0.030)were independently associated with all-cause *** with HAD exhibited a significantly lower cumulative survival rate in the underweight group(P=0.001)and tended to have a lower cumulative survival rate in the normal weight group(P=0.072).HAD was not significantly associated with cumulative survival in the overweight group(P=0.392).CONCLUSIONS BMI and HAD independently predicted all-cause mortality after discharge in older patients with acute de-compensated heart ***,HAD was significantly associated with higher all-cause mortality after discharge,espe-cially in the underweight group.

关键词： patients acute index

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Mucosal patterns change after Helicobacter pylori eradication:Evaluation using blue laser imaging in patients with atrophic gastritis

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World Journal of Gastroenterology 2023年第17期29卷 2657-2665页

作者： Yoshiyuki Nishikawa Yoshio Ikeda Hidehiro Murakami Shin-Ichiro hori Megumi Yoshimatsu Naoki Nishikawa Department of Gastroenterology Nishikawa Gastrointestinal ClinicMatsuyama 790-0878EhimeJapan Endoscopy Center Ehime University HospitalToon 791-0295EhimeJapan Department of Internal Medicine Saiseikai Matsuyama HospitalMatsuyama 791-8026EhimeJapan Department of Gastroenterology Himeji Red Cross HospitalHimeji 670-8540HyogoJapan Department of Gastroenterology National Hospital Organization Shikoku Cancer CenterMatsuyama 791-0280EhimeJapan Department of Gastroenterology Matsuyama Shimin HospitalMatsuyama 790-0067EhimeJapan

BACKGrOUND Mucosal patterns(MPs)observed on blue laser imaging in patients with atrophic gastritis can be classified as spotty,cracked,and ***,we hypothesized that the spotty pattern may change to the cracked pattern after Helicobacter pylori(***)*** To further substantiate and comprehensively investigate MP changes after *** eradication in a larger number of *** We included 768 patients who were diagnosed with atrophic gastritis with evaluable MP using upper gastrointestinal endoscopy at the Nishikawa Gastrointestinal Clinic,*** them,325 patients were ***-positive,and of them,101 patients who underwent upper gastrointestinal endoscopy before and after *** eradication were evaluated for post-eradication MP *** patients’MPs were interpreted by three experienced endoscopists who were blinded to their clinical *** Among 76 patients with the spotty pattern before or after *** eradication,the pattern disappeared or decreased in 67 patients[88.2%,95%confidence interval(CI):79.0%-93.6%),appeared or increased in 8 patients(10.5%,95%CI:5.4%-19.4%),and showed no change in 1 patient(1.3%,95%CI:0.2%-7.1%).In 90 patients with the cracked pattern before or after *** eradication,the pattern disappeared or decreased in 7 patients(7.8%,95%CI:3.8%-15.2%),appeared or increased in 79 patients(87.8%,95%CI:79.4%-93.0%),and showed no change in 4 patients(4.4%,95%CI:1.7%-10.9%).In 70 patients with the mottled pattern before or after *** eradication,the pattern disappeared or decreased in 28 patients(40.0%,95%CI:29.3%-51.7%),appeared or increased in 35 patients(50.0%,95%CI:38.6%-61.4%),and showed no change in 7 patients(10.0%,95%CI:4.9%-19.2%).CONCLUSION After *** eradication,MPs changed from spotty to cracked in most patients,which may help endoscopists easily and precisely evaluate ***-related gastritis status.

关键词： Atrophic gastritis Helicobacter pylori Gastrointestinal endoscopy Image enhancement Classification

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Type 2 Possibility Factor rotation in No-Data Problem

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Applied Mathematics 2023年第10期14卷 673-683页

作者： Houju hori Nara Community Tsubakikishi Shrine Nara Japan

Uemura [1] discovered a mapping formula that transforms and maps the state of nature into fuzzy events with a membership function that expresses the degree of attribution. In decision theory in no-data problems, sequential Bayesian inference is an example of this mapping formula, and hori et al. [2] made the mapping formula multidimensional, introduced the concept of time, to Markov (decision) processes in fuzzy events under ergodic conditions, and derived stochastic differential equations in fuzzy events, although in reverse. In this paper, we focus on type 2 fuzzy. First, assuming that Type 2 Fuzzy Events are transformed and mapped onto the state of nature by a quadratic mapping formula that simultaneously considers longitudinal and transverse ambiguity, the joint stochastic differential equation representing these two ambiguities can be applied to possibility principal factor analysis if the weights of the equations are orthogonal. This indicates that the type 2 fuzzy is a two-dimensional possibility multivariate error model with longitudinal and transverse directions. Also, when the weights are oblique, it is a general possibility oblique factor analysis. Therefore, an example of type 2 fuzzy system theory is the possibility factor analysis. Furthermore, we show the initial and stopping condition on possibility factor rotation, on the base of possibility theory.

关键词： Type 2 Fuzzy Events Quadratic Mapping Formula Stochastic Differential Equation in Fuzzy Event Possibility Principal Factor Analysis Possibility Oblique Factor Analysis Initial and Stopping Condition

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