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Coffee protection against the development of hepatocellular carcinoma: review article

Hepatoma Research 2020年第2期6卷 33-38页

作者： kellyane s.d.carvalho Helma P.Cotrim Programa de Pós-Graduação em Medicina e saúde Faculdade de Medicina-Universidade Federal da BahiaBahia 40110-060Brazil

Coffee, a popular drink around the world, is composed of a complex mix of biologically active molecules, including caffeine, chlorogenic acid, and diterpenes. These compounds have antioxidant, anti-inflammatory, antifibrotic, and anticarcinogenic properties, which may explain observational data showing that coffee drinkers have lower rates of chronic liver disease, including cirrhosis and hepatocellular carcinoma (HCC). Recent studies have also shown that coffee consumption may also increase patient survival before and after liver transplantation. The mechanism by which coffee consumption protects against HCC is not clear;however, its relevant role has been demonstrated. This literature review article focuses on the role of coffee consumption in protecting against the development of HCC. Methodology: scientific articles indexed through PubMed, including Medline, scielo, and Lilacs, published in English were used as search methods. The terms used in English were: "hepatocellular carcinoma" or "Liver cancer" or "HCC" and "coffee". According to the study design or review article, cross-sectional, longitudinal, or descriptive investigations were included, showing site and year of publication until 2019.

关键词： Hepatocellular carcinoma coffee consumption protection liver cancer

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Hepatocellular carcinoma in patients without cirrhosis: relevance and clinical characteristics

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Hepatoma Research 2018年第5期4卷 22-27页

作者： kellyane santana dias carvalho Luciano E.Fonseca Helma P.Cotrim Medicine school Universidade Federal da BahiaSalvador 40110-060Brazil University Hospital Edgar santos Universidade Federal da BahiaSalvador 40110-060Brazil

Aim: The present study evaluated the frequency of hepatocellular carcinoma (HCC) in patients without cirrhosis. Methods: HCC patients were recruited from two reference centers for liver disease in Northeast Brazil from 2010 to 2016. The diagnosis of HCC and cirrhosis was based on international criteria. Results: A total of 169 patients were included, and 16% (27) of the patients did not have hepatocellular carcinoma in non-cirrhosis (HCC-NC). The mean age of HCC-NC was 64.4 ± 11.3 years, and 74.1% of the patients were male. The main risk factors were hepatitis C virus (HCV) in 29.6% (8), nonalcoholic steatohepatitis (NAsH) in 14.8% (4) and hepatitis B virus (HBV) in 11.1% (3). Histological HCC diagnosis was performed in 81.5% (22) of the patients, and in 18.5% (5) of these patients, the diagnosis was performed by ultrasonography, computed tomography or nuclear magnetic resonance imaging methods. single nodules were found in 56% of HCC-NC (14) when assessed by imaging methods. Conclusion: The frequency of HCC-NC was elevated and more common in males. HCV, NAsH and HBV were the most frequent risk factors. These data contribute to discussion on future protocols and criteria for the early diagnosis and treatment of HCC in patients with chronic liver disease without cirrhosis.

关键词： Hepatocellular carcinoma primary liver tumor liver cirrhosis

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