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Elucidating regulatory processes of intense physical activity by multi-omics analysis

Military Medical Research 2024年第4期11卷 479-499页

作者： Ernesto S.Nakayasu Marina A.gritsenko Young-Mo Kim Jennifer E.Kyle kelly g.stratton Carrie D.Nicora Nathalie Munoz Kathleen M.Navarro Daniel Claborne Yuqian gao Karl K.Weitz Vanessa L.Paurus Kent J.Bloodsworth Kelsey A.Allen Lisa M.Bramer Fernando Montes Kathleen A.Clark grant Tietje Justin Teeguarden Kristin E.Burnum-Johnson Biological Sciences Division Pacific Northwest National LaboratoryRichlandWA 99352USA Environmental and Molecular Sciences Division Pacific Northwest National LaboratoryRichlandWA 99352USA Centers for Disease Control and Prevention National Institute for Occupational Safety and HealthWestern States DivisionDenverCO 80204USA Computational Analytics Division Pacific Northwest National LaboratoryRichlandWA 99352USA National Security Directorate Pacific Northwest National LaboratoryRichlandWA 99352USA Los Angeles County Fire Department Los AngelesCA 90063USA Centers for Disease Control and Prevention National Institute for Occupational Safety and HealthRespiratory Health DivisionMorgantownWV 26505USA Environmental and Molecular Toxicology Oregon State UniversityCorvallisOR 97331USA

Background:Physiological and biochemical processes across tissues of the body are regulated in response to the high demands of intense physical activity in several occupations,such as firefighting,law enforcement,military,and sports.A better understanding of such processes can ultimately help improve human performance and prevent illnesses in the work ***:To study regulatory processes in intense physical activity simulating real-life conditions,we performed a multi-omics analysis of 3 biofluids(blood plasma,urine,and saliva)collected from 11 wildland firefighters before and after a 45 min,intense exercise *** profiles ***-exercise were compared by Student’s t-test followed by pathway analysis and comparison between the different omics ***:Our multi-omics analysis identified and quantified 3835 proteins,730 lipids and 182 metabolites combining the 3 different types of *** blood plasma analysis revealed signatures of tissue damage and acute repair response accompanied by enhanced carbon metabolism to meet energy *** urine analysis showed a strong,concomitant regulation of 6 out of 8 identified proteins from the renin-angiotensin system supporting increased excretion of catabolites,reabsorption of nutrients and maintenance of fluid *** saliva,we observed a decrease in 3 pro-inflammatory cytokines and an increase in 8 antimicrobial peptides.A systematic literature review identified 6 papers that support an altered susceptibility to respiratory ***:This study shows simultaneous regulatory signatures in biofluids indicative of homeostatic maintenance during intense physical activity with possible effects on increased infection susceptibility,suggesting that caution against respiratory diseases could benefit workers on highly physical demanding jobs.

关键词： Multi-omics analysis Intense exercise Human performance Biofluids Metabolism Immunity

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Back to school after lockdown: The effect of COVID-19 restrictions on children’s device-based physical activity metrics

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Journal of Sport and Health Science 2022年第4期11卷 530-536页

作者： Liezel Hurter Melitta McNarry gareth stratton kelly Mackintosh Applied Sports TechnologyExercise and Medicine Research Centre(A-STEM)Swansea UniversitySwansea SA18ENUK

Background:The coronavirus disease-2019(COVID-19) pandemic and national lockdowns took away opportunities for children to be physically *** study aimed to determine the effect of the COVID-19 lockdown on accelerometer-assessed physical activity(PA) in children in ***:Eight hundred participants(8-18 years old),stratified by sex,age,and socio-economic status,wore Axivity AX3 accelerometers for7 days in February 2021,during the lockdown,and in May 2021,while in *** accelerometer data were processed in R-package ggIR,and cut-point data,average acceleration(AvAcc),intensity gradient,and the acceleration above which the most active X minutes are accumulated(MX) metrics were *** mixed models were used to assess the influence of time-point,sex,age,and socioeconomic status(SES) on ***:During lockdown,moderate-to-vigorous PA was 38.4±24.3 min/day;sedentary time was 849.4±196.6 min/day;mean± *** levels increased significantly upon return to school(all variables p g lockdown(p=0.233),girls engaged in significantly less moderate-to-vigorous PA than boys once back in school(p girls(intensity gradient:p gardless of *** levels decreased with age at both time-points;upper secondary school girls were the least active group,with an average M30 of 195.2 mg(while in school).Conclusion:The lockdown affected boys more than girls,as reflected by the disappearance of the typical sex difference in PA levels during lockdown,although these were re-established on return to *** secondary school(especially girls) might need specific COVID-recovery intervention.

关键词： Accelerometer Intensity gradient MX metrics

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Effect of high-intensity interval training in adolescents with asthma:The eXercise for Asthma with Commando Joe’s^(■)(X4ACJ)trial

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Journal of Sport and Health Science 2021年第4期10卷 488-498页

作者： Charles O.N.Winn kelly A.Mackintosh William T.B.Eddolls gareth stratton Andrew M.Wilson Melitta A.McNarry gwyneth A.Davies Swansea University Medical School Singleton CampusSwansea UniversitySwansea SA28PPUK Applied Sports Technology Exercise and Medicine(A-STEM)Research CentreCollege of EngineeringBay CampusSwansea UniversitySwansea SA18ENUK Norwich Medical School University of East AngliaNorwichEngland NR47TJUK

Background:Higher levels of cardiorespiratory fitness are associated with reduced asthma severity and increased quality of life in those with ***,the purpose of this study was to evaluate the effectiveness of a 6-month high-intensity interval training(HIIT)intervention in adolescents with and without ***:A total of 616 adolescents(334 boys;13.0±1.1 years,1.57±0.10 m,52.6±12.9 kg,mean±SD),including 155 with asthma(78 boys),were recruited as part of a randomized controlled trial from 5 schools(4 control and 1 intervention).The 221 intervention participants(116 boys;47 asthma)completed 6 months of school-based HIIT(30 min,3 times per week,10-30 s bouts at>90%age-predicted maximum heart rate with equal rest).At baseline,mid-intervention,post-intervention,and 3-month follow-up,measurements for 20-m shuttle run,body mass index(BMI),lung function,Pediatric Quality of Life Inventory,Paediatric Asthma Quality of Life Questionnaire,and Asthma Control Questionnaire were ***,69 adolescents(39 boys(of the 36 with asthma there were 21 boys))also completed an incremental ramp *** analysis,each group’s data(intervention and control)were divided into those with and without ***:Participants with asthma did not differ from their peers in any parameter of aerobic fitness,at any time-point,but were characterized by a greater *** intervention elicited a significant improvement in maximal aerobic fitness but no change in sub-maximal parameters of aerobic fitness,lung function,or quality of life irrespective of asthma *** in the intervention group maintained their BMI,whereas BMI significantly increased in the control group throughout the 6-month ***:HIIT represents an effective tool for improving aerobic fitness and maintaining BMI in adolescents,irrespective of asthma *** was well-tolerated by those with asthma,who evidenced a similar aerobic fitness to their healthy peers and responded equally

关键词： Body mass index Cardiorespiratory fitness Intermittent exercise Intervention Quality of life

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