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Built Heritage 2023年第1期7卷 44-58页

作者： kelly anderson Independent Consultant ManchesterEngland

Despite 30 years of discussion,adaptation work is not routinely being carried out at heritage sites to minimise future impacts of climate change,particularly increased flooding *** understand barriers to essential work being carried out,interviews were carried out with six heritage sites that have already experienced river flooding to understand levels of preparation both before and after the flooding *** results prove that despite funding,or lack of,being an important contributor,it is not the sole barrier to *** flooded sites still do not have a flood plan in place,outside agencies are preventing work being carried out,measures which have been put in place through listing status are prohibiting necessary work and delays in decision making about what is acceptable are all delaying adaptation while allowing more damage to be caused from weather *** responsibility for adaptation lies locally this situation will not improve;responsibility needs to lie more *** the principle of replacing like for like is a sound one with the best of intentions behind it,this is also contributing to losses in heritage and must be reconsidered when big decisions are finally made about what will be acceptable if impacts to heritage from future climate change are to be minimised.

关键词： climate change adaptation barriers heritage flooding site interviews

Linking the spatiotemporal variation of litterfall to standing vegetation biomass in Brazilian savannas

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Journal of Plant Ecology 2020年第5期13卷 517-524页

作者： Alan N.Costa Jeane R.Souza Karyne M.Alves anderson Penna-Oliveira Geisciele Paula-Silva Ingrid S.Becker kelly Marinho-Vieira Ana L.Bonfim Alessandra Bartimachi Ernane H.M.Vieira-Neto Instituto de Biologia Universidade Federal de UberlândiaUberlândia 38405-320MGBrazil Instituto de Biotecnologia Universidade Federal de GoiásCatalão 75704-000GOBrazil Department of Wildlife Ecology and Conservation University of FloridaGainesvilleFL 32611USA

Aims Litterfall at a global scale is affected by climate,edaphic features and vegetation structure,with litter production increasing from grasslands to forests following the rise in standing ***,at landscape scales,the same relationship between litter production and vegetation structure has rarely been studied and comparisons of litterfall patterns between adjacent,structurally distinct communities are ***,we use a standardized methodology to describe the structural differences among four savanna physiognomies and analyze their relationship with changes in litterfall across the *** We evaluated the woody vegetation structure and composition in 48 sites,equally distributed across four physiognomies and monitored the monthly litter production from April 2014 to March *** Findings Results showed that the density,basal area,cylindrical volume and aboveground biomass of woody vegetation differ among physiognomies,increasing consistently from cerrado ralo,cerrado típico,cerrado denso and cerradã***,we found a strong and positive relationship between aboveground biomass and annual litter production,with litter yield increasing from 0.9 to 8.4 Mg ha^(−1)across different physiognomies,following the increment in vegetation *** production was seasonal and similar among vegetation types,increasing during the dry *** comprised the dominant fraction(approx.85%)and litterfall seasonality primarily resulted from the concentration of leaf shedding during dry ***,the temporal pattern of litterfall throughout the year showed a gradual reduction in the seasonality from open to closed vegetation types,likely following the decrease of deciduous species abundance in the plant *** results showed that changes in vegetation structure may affect spatial and temporal litterfall patterns in different physiognomies,which co-occur across the Cerrado landscape,with potential implications for the overall f

关键词： Cerrado ecosystem functioning habitat heterogeneity Neotropical savannas nutrient cycling

Synthesis, Characterization, and Evaluation of Antitumor Potential in MCF-7 Cells of Ruthenium-Derived Compounds

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Advances in Biological Chemistry 2020年第3期10卷 86-98页

作者： Moraes Fabricio Tarso Galvão anderson Dourado Fortaleza Dário Batista Amorin kelly Aparecida da Encarnação Sousa Claudia Cristina Honorio-França Adenilda Cristina França Eduardo Luzia Costa Daniel Tizo Santos Wagner Batista Institute of Exact Sciences and Earth Federal University of Mato Grosso Barra do Garcas/MT Brazil Institute of Biological and Health Sciences Federal University of Mato Grosso Barra do Garcas/MT Brazil UniRv-University of Rio Verde Rio Verde/Go Brazil

To synthesize, characterize and evaluate the antitumor potential derived from ruthenium compounds was generated in this study, from the precursor K[RuCl4(bipy)] a route in a simple and reproducible synthesis for a novel compound of coordinating Ru+3 with bipy and L-trip. The spectroscopic characterization in the middle infrared region (FTIR) shows the interactions between Ru-(L-trip), evidenced by the displacement of the carboxylate ion band for higher energies, and also by the displacements of aliphatic amine bands, suggesting that bidentate coordination of the L-trip ligand occurred. Analysis of the results obtained with thermoanalytical techniques showed that the minimum formula of the compound, [RuCl2(bipy)(L-trip)]1/2H2O. Evaluation of the antitumor potential of precursor K[RuCl4(bipy)] showed the toxic effects on MCF-7 cell line, but did not show selectivity and not reached PBMC cells to the same extent. The evaluation of the antitumor potential of the newly synthesized compound, [RuCl2(bipy)(L-trip)], demonstrated that the insertion of an L-tryptophan molecule into the precursor coordination sphere made it selective when compared to PBMC cells, for MCF-7 type tumor cells.

关键词： Ruthenium Compounds Pyridine Ligands Antitumor Activity Tryptophan Amino Acid MCF-7 Cells Ligand N-Heterocyclic

美国能走动成年人群的用药近况—Slone普查

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美国医学会杂志（中文版） 2003年第3期22卷 131-137页

作者： DavidW.Kaufman,ScD JudithP.kelly,MS LynnRosenberg,ScD TheresaE.anderson,RN AllenA.Mitchell,MD Slone Epidemiology Unit Boston University School of Public Health Boston Mass

目的：提供最近美国人群所有的药物使用信息，包括处方药和非处方药、维生素和矿物质、草药制剂／天然补充剂。结果：在2590名≥18岁的参加者中，81％在前一周使用了至少一种药物；50％使用了至少一种处方药；7％使用了5种或以上。总用... 详细信息

目的：提供最近美国人群所有的药物使用信息，包括处方药和非处方药、维生素和矿物质、草药制剂／天然补充剂。结果：在2590名≥18岁的参加者中，81％在前一周使用了至少一种药物；50％使用了至少一种处方药；7％使用了5种或以上。总用药率最高者为年龄≥65岁的妇女，其中12％应用了至少10种药，23％应用了至少5种处方药。调查人群14％应用了草药/补充剂。处方药使用者中，16％也使用了一种草药/补充剂；同时用药率最高的是氟西汀使用者，为22％。用药原因各不相同，诉说最多的是高血压和头痛(各占9％)。维生素／矿物质的使用常是为“保健”(35％)之类非特殊原因；草药/补充剂最常见也是为“保健”而用(16％)。结论：在所调查的任何一周中，大多数美国成年人都使用了至少一种药，很多人服用了多种药。处方药和草药/补充剂大量同时使用，引起了对意外相互作用的担忧。用药情况的记录文件可为改善用药安全性提供依据。

关键词：用药情况药物不良反应处方药非处方药维生素矿物质草药制剂美国

Theoretical and Comparative Study of the Complex[RuCl_(3)(H_(2)O)_(2)(Gly)]by Density Functional Theory

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Open Journal of Inorganic Chemistry 2018年第1期8卷 43-53页

作者： Katia Meirelles D.de Sousa Marcio Adriano S.Chagas Jesyca Mayra F.D.dos Santos anderson D.Galvao Fabricio Tarso de Moraes Andressa Teixeira Barros Nunes Ribeiro Dario Batista Fortaleza kelly Aparecida da Encarnacao Amorim Wagner B.dos Santos Materials Research Lab Federal University of Mato Grosso—Campus ⅡBarra do GarcasBrazil Institute of Chemistry Brasilia UniversityUNBBrasíliaBrazil

In this work, the use of computational methods was essential to distinguish the three possible isomeric structures of the [RuCl3(H2O)2(Gly)] molecule. The characterization of these molecules was performed using IR, NMR and UV-VIS simulations. Some calculations related to the optimization of structures and properties such as chemical hardness and dipole moment were also conducted. The fac-cis isomer presented promising data when compared to the experimental data, indicating that this is the likely experimentally synthesized isomer. This study demonstrates the technical utility of the computational calculations by virtue of situations that prevent the realization of X-ray diffraction.

关键词： Computational Methods Isomeric Structures Simulations

MEDICATION USE AND THE RISK OF STEVENS-JOHNSON SYNDROME OR TOXIC EPIDERMAL NECROLYSIS

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MEDICATION USE AND THE RISK OF STEVENS-JOHNSON SYNDROME OR T...