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Partial epithelial-mesenchymal transition in keloid scars: regulation of keloid keratinocyte gene expression by transforming growth factor-β1

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Burns & Trauma 2016年第3期4卷 199-215页

作者： Jennifer M.Hahn Kevin L.McFarland kelly a.combs Dorothy M.Supp Research Department Shriners Hospitals for Children-CincinnatiCincinnatiOHUSA Research Department Shriners Hospitals for Children-CincinnatiCincinnatiOHUSA Department of Surgery University of Cincinnati College of MedicineCincinnatiOHUSA

Background:Keloids are an extreme form of abnormal scarring that result from a pathological fibroproliferative wound healing *** molecular mechanisms driving keloid pathology remain incompletely understood,hindering development of targeted,effective *** studies in our laboratory demonstrated that keloid keratinocytes exhibit adhesion abnormalities and display a transcriptional signature reminiscent of cells undergoing epithelial-mesenchymal transition(EMT),suggesting a role for EMT in keloid *** the current study,we further define the EMT-like phenotype of keloid scars and investigate regulation of EMT-related genes in ***:Primary keratinocytes from keloid scar and normal skin were cultured in the presence or absence of transforming growth factor beta 1(TGF-β1)+/-inhibitors of TGF-β1 and downstream signaling *** expression was measured using quantitative polymerase chain *** was analyzed using an in vitro wound healing *** in keloid scar and normal skin sections were localized by *** analyses utilized SigmaPlot(SyStat Software,San Jose,CA)or SAS?(SAS Institute,Cary,NC).Results:In keloid and normal keratinocytes,TGF-β1 regulated expression of EMT-related genes,including hyaluronan synthase 2,vimentin,cadherin-11,wingless-type MMTV integration site family,member 5A,frizzled 7,ADAM metallopeptidase domain 19,and *** of canonical TGF-β1 signaling in keloid keratinocytes significantly inhibited expression of these genes,and TGF-β1 stimulation of normal keratinocytes increased their *** inhibition of the extracellular signal-regulated kinase 1/2(ERK1/2)signaling pathway or the p38 mitogen-activated protein kinase pathway attenuated TGF-β1-induced expression of subsets of these *** of keloid keratinocytes,previously shown to be increased compared with normal keratinocytes,was significantly reduced by inhibition of TGF-β1 or E

关键词： Keloid Keratinocyte Epithelial-mesenchymal transition Wound healing Scar Fibrosis

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偶联功能化炭黑的新方法

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现代橡胶技术 2019年第2期45卷 19-26页

作者：朱永康(编译) Zachary a.combs Chares Hard John Curtis 不详

以前已有研究表明,将功能化炭黑混入功能化丁苯橡胶(SBR)胶料中,可显著提高填料-弹性体相互作用,降低滚动阻力,其滚动阻力与白炭黑填充胶相近,但并没有增加加工和制造成本。不过,尽管使用功能化弹性体能够改善胶料性能,但由于这种材料... 详细信息

以前已有研究表明,将功能化炭黑混入功能化丁苯橡胶(SBR)胶料中,可显著提高填料-弹性体相互作用,降低滚动阻力,其滚动阻力与白炭黑填充胶相近,但并没有增加加工和制造成本。不过,尽管使用功能化弹性体能够改善胶料性能,但由于这种材料缺乏混炼灵活性及其成本较高,致使人们不得不选择其它有吸引力的材料。因此,改善表面改性炭黑(SM-CB)在非功能化弹性体中的填料-弹性体相互作用是有益的。这一目标通过加入一种偶联分子得以实现,该偶联分子在功能化炭黑表面与非功能化弹性体之间可起到化学键的作用。这些胶料的tanδ比非偶联SM-CB填充胶降低近30%,相比对应的ASTM炭黑填充胶更是降低50%以上,而各种静态力学性能则得以保持。总之,SM-CB在标准弹性体中的偶联可以不要求采用功能化橡胶胶料,从而可以提供混炼灵活性,同时可保持明显的性能优势。

关键词：偶联功能化炭黑丁苯橡胶聚丁二烯橡胶并用胶性能

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Bitter receptor TAS2R138 facilitates lipid droplet degradation in neutrophils during Pseudomonas aeruginosa infection

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Signal Transduction and Targeted Therapy 2021年第7期6卷 2154-2163页

作者： Qinqin Pu Kai Guo Ping Lin Zhihan Wang Shugang Qin Pan Gao Colin combs Nadeem Khan Zhenwei Xia Min Wu Department of Biomedical Sciences School of Medicine and Health SciencesUniversity of North DakotaGrand ForksNDUSA Department of Neurology University of MichiganAnn ArborMlUSA Wound Trauma Medical Center State Key Laboratory of TraumaBurns and Combined InjuryDaping HospitalArmy Medical UniversityChongqingChina Biological Science Research Center Southwest UniversityChongqing 400716China West China School of Basic Medical Sciences&Forensic Medicine Sichuan UniversityChengduSichuanChina State Key Laboratory of Biotherapy and Cancer Center West China HospitalSichuan Universityand Collaborative Innovation Center for BiotherapyChengduSichuanChina Department of Pediatrics Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiPeople's Republic of China

Bitter receptors function primarily in sensing taste,but may also have other functions,such as detecting pathogenic organisms due to their agile response to foreign *** mouse taste receptor type-2 member 138(TAS2R138)is a member of the G-protein-coupled bitter receptor family,which is not only found in the tongue and nasal cavity,but also widely distributed in other organs,such as the respiratory tract,gut,and *** its diverse functions,the role of TAS2R138 in host defense against bacterial infection is largely ***,we show that TAS2R138 facilitates the degradation of lipid droplets(LDs)in neutrophils during Pseudomonas aeruginosa infection through competitive binding with PPARG(peroxisome proliferator-activated receptor gamma)antagonist:A/-(3-oxododecanoyl)-L-homoserine lactone(AHL-12),which coincidently is a virulence-bound signal produced by this bacterium(***).The released PPARG then migrates from nuclei to the cytoplasm to accelerate the degradation of LDs by binding PLIN2(perilipin-2).Subsequently,the TAS2R138-AHL-12 complex targets LDs to augment their degradation,and thereby facilitating the clearance of AHL-12 in neutrophils to maintain homeostasis in the local *** findings reveal a crucial role for TAS2R138 in neutrophil-mediated host immunity against *** infection.

关键词： thereby maintain migrate

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音乐中流淌的英文 4

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2004年

作者： Kendall combs

书中的每一位歌手的背景知识完全是国外的第一手资料，让您更时尚，更前卫。本书中所囊括了十五首歌曲以及十五个歌手(或乐队)，首首传世，个个经典。本书附光盘。

ISBN: (纸本)7888351050

关键词：音乐英语

来源：畅想之星图书光盘版（南... 评论

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GV Technology for Exploration and Delineation of Lode Gold Claims

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Journal of Geological Resource and Engineering 2014年第1期2卷 1-12页

作者： Jim combs Jeffrey Drizin Geo Vision Inc. 12945 Vanderbilt Drive #207 Naples 34110 FL USA Geo Vision Inc. 1910 Browning Court Highland Park 60035 IL USA

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Regulation of Wnt/β-catenin signaling by herpesviruses

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World Journal of Virology 2016年第4期5卷 144-154页

作者： Kevin J Zwezdaryk Joseph a.combs Cindy A Morris Deborah E Sullivan Department of Microbiology and Immu-nology Tulane University School of Medicine

The Wnt/β-catenin signaling pathway is instrumental in successful differentiation and proliferation of mammalian cells. It is therefore not surprising that the herpesvirus family has developed mechanisms to interact with and manipulate this pathway. Successful coexistence with the host requires that herpesviruses establish a lifelong infection that includes periods of latency and reactivation or persistence. Many herpesviruses establish latency in progenitor cells and viral reactivation is linked to host-cell proliferation and differentiation status. Importantly, Wnt/β-catenin is tightly connected to stem/progenitor cell maintenance and differentiation. Numerous studies have linked Wnt/β-catenin signaling to a variety of cancers, emphasizing the importance of Wnt/β-catenin pathways in development, tissue homeostasis and disease. This review details how the alpha-, beta-, and gammaherpesviruses interact and manipulate the Wnt/β-catenin pathway to promote a virus-centric agenda.

关键词： Herpesvirus Herpes simplex virus-1 Varicella zoster virus Cytomegalovirus Epstein-Barr virus Kaposi’s sarcoma-associated herpesvirus Wnt/β-catenin Glycogen synthase kinase-3 Axin

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Neoadjuvant stereotactic radiosurgery for intracerebral metastases of solid tumors(NepoMUC):a phase I dose escalation trial

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Cancer Communications 2019年第1期39卷 623-631页

作者： Christian D.Diehl Ehab Shiban Christoph Straube Jens Gempt Jan J.Wilkens Markus Oechsner Carmen Kessel Claus Zimmer Benedict Wiestler Bernhard Meyer Stephanie E.combs Department of Radiation Oncology Klinikum rechts der Isar HospitalTechnical University of MunichIsmaninger Straße 2281675 MunichGermany Department of Radiation Sciences Institute of Innovative Radiotherapy85764 NeuherbergGermany Department of Neurosurgery Klinikum rechts der Isar HospitalTechnical University of Munich81675 MunichGermany Department of Diagnostic and Interventional Neuroradiology Klinikum rechts der Isar HospitalTechnical University of Munich81675 MunichGermany

Background:More than 25%of patients with solid cancers develop intracerebral *** of surgery,radia-tion therapy(RT)is a mainstay in the treatment of intracerebral *** fractionated stereotactic RT(FSRT)to the resection cavity of intracerebral metastases is a treatment of choice to reduce the risk of local ***,FSRT has to be delayed until a sufficient wound healing is attained;hence systemic therapy might be *** stereotactic radiosurgery(SRS)might offer advantages over adjuvant FSRT in terms of better target delineation and an earlier start of systemic ***,we conducted a study to find the maximum tolerated dose(MTD)of neoadjuvant SRS for intracerebral ***:This is a single-center,phase I dose escalation study on neoadjuvant SRS for intracerebral metastases that will be conducted at the Klinikum rechts der Isar Hospital,Technical University of *** rule-based traditional 3+3 design for this trial with 3 dose levels and 4 different cohorts depending on lesion size will be *** primary endpoint is the MTD for which no dose-limiting toxicities(DLT)*** adverse events of each participant will be evaluated according to the Common Terminology Criteria for Adverse Events(CTCAE)version 5.0 continuously during the study until the first follow-up visit(4-6 weeks after surgery).Secondary endpoints include local control rate,survival,immunological tumor characteristics,quality of life(QoL),CTCAE grade of late clinical,neurological,and neurocognitive *** addition to the intracerebral metastasis which is treated with neoadjuvant SRS and resection up to four additional intracerebral metastases can be treated with definitive *** on the occurrence of DLT up to 72 patients will be *** recruitment phase will last for 24 ***:Neoadjuvant SRS for intracerebral metastases offers potential advantages over postoperative SRS to the resection

关键词： Cancer Intracerebral metastasis Stereotactic radiosurgery Fractionated stereotactic radiation therapy Microsurgical resection Neoadjuvant radiation therapy Maximum tolerated dose Protocol

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用全染色体探针鉴定猪痢疾密螺旋体

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国外兽医学（畜禽传染病） 1993年第3期13卷 40-41页

作者： combs,BG 朱世强

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用全染色体探针鉴定猪痢疾密螺旋体

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国外兽医学（畜禽传染病） 1991年第4期11卷 39-41页

作者： B.G.combs

用光生命素标记的全染色体DNA探针做斑点印迹杂交试验鉴定猪痢疾密螺旋体（Th)分离物中DNA，用分离白猪的13株Th和13株非Th分离物的DNA评价该探针，首次试验敏感性和特异性均为92．3％，重复试验特异笥降到34．6％，本试验有助于鉴别Th... 详细信息

用光生命素标记的全染色体DNA探针做斑点印迹杂交试验鉴定猪痢疾密螺旋体（Th)分离物中DNA，用分离白猪的13株Th和13株非Th分离物的DNA评价该探针，首次试验敏感性和特异性均为92．3％，重复试验特异笥降到34．6％，本试验有助于鉴别Th和其他在形态上与猪Th相似的属于猪大肠中正常菌丛的密螺旋体，本探针能检测仅10ng和Th纯化DNA或在硝基纤维素膜上的2×10^6细菌的DNA。

关键词：猪痢疾密螺旋体全染色体探针鉴定

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奶牛饲料的蛋白质来源

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国外畜牧学（草食家畜） 1992年第4期 47-48页

作者： D.combs 朱钦龙

奶牛饲料中的粗蛋白质被瘤胃微生物分解成肽、氨基酸以及游离氨。氨和来自饲料及添加的非蛋白氮(NPN)能转化为微生物蛋白质,条件是必须提供充足而又能发酵的碳水化合物。由于瘤胃微生物蛋白不足以满足高产奶牛的最大产乳量之需要,因此... 详细信息

奶牛饲料中的粗蛋白质被瘤胃微生物分解成肽、氨基酸以及游离氨。氨和来自饲料及添加的非蛋白氮(NPN)能转化为微生物蛋白质,条件是必须提供充足而又能发酵的碳水化合物。由于瘤胃微生物蛋白不足以满足高产奶牛的最大产乳量之需要,因此,为达到高水平的产乳量,奶牛还须依赖于饲料中非降解蛋白质(UIP)或称过瘤胃蛋白质。美国NRC饲养标准(1988年版)中规定了奶牛降解蛋白质(DIP)的推荐量和UIP的需要量。但是,在目前完全按照DIP/UIP方法看来还有些困难,原因是在原料的测试上还不够完善。

关键词：牛奶牛饲料蛋白

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