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Environmentally sensitive fluorescent probes with improved properties for detecting and imaging PDEδ in live cells and tumor slices

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Chinese Chemical Letters 2023年第11期34卷 214-219页

作者： keliang li Shanchao Wu Gaopan Dong Yu li Wei Wang Guoqiang Dong Zhanying Hong Minyong li Chunquan Sheng School of Pharmacy Second Military Medical UniversityShanghai 200433China Department of Medicinal Chemistry Key Laboratory of Chemical Biology(MOE)School of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJi’nan 250012China

Kirsten rat sarcoma viral oncogene homolog(KRAS)-phosphodiesterase-delta(PDEδ)is a promising target for antitumor drug ***,highly efficient and environmentally sensitive fluorescent probes of PDEδ(DS-Probes)were rationally *** compared with the reported PDEδprobes,DS-Probes showed higher binding affinity and selectivity,which were able to conveniently and efficiently label PDEδin live cells as well as tumor ***,these fluorescent probes are expected to facilitate PDEδ-based mechanism elucidation,drug discovery and pathologic diagnosis.

关键词： Antitumor PDEδ Fluorescent probes Environmentally sensitive Binding affinity

Quick repositioning maneuver for horizontal semicircular canal benign paroxysmal positional vertigo

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Journal of Otology 2015年第3期10卷 115-117页

作者： Jinrang li Pengfei Guo Shiyu Tian keliang li Hao Zhang Department of Otorhinolaryngology Head Neck Surgery Navy General Hospital

Objective:To investigate the efficacy of quick repositioning maneuver for horizontal semicircular canal benign paroxysmal positional vertigo (H-BPPV). Methods:Clinical data of 67 patients with H-BPPV who underwent quick repositioning maneuver in our hospital from July 2009 to November 2014 were retrospectively analyzed. The maneuver involved rotating the patient in the axial plane for 180? from the involved side towards contralateral side as quickly as possible. Results:Complete symptom resolution was achieved in 61 patients (91.0%) at one week and in 64 patients (95.5%) at 3 months post-treatment. During the repositioning maneuver process, there were no obvious untoward responses except transient nausea with or without vomiting in a few patients. Conclusion:The results indicate that the quick repositioning maneuver is an easy and effective alternative treatment in the management of H-BPPV. Copyright ? 2015 The Authors. Production & hosting by Elsevier (Singapore) Pte Ltd On behalf of PLA General Hospital Department of Otolaryngology Head and Neck Surgery. This is an open access article under the CC BY-NC-ND license (http://***/licenses/by-nc-nd/4.0/).

关键词： Vertigo Vestibular diseases Horizontal semicircular canal Repositioning maneuver

Distinct BSRs and their implications for natural gas hydrate formation and distribution at the submarine Makran accretionary zone

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Journal of Oceanology and limnology 2021年第5期39卷 1871-1886页

作者： Bin liU Waseem Haider SYED Jiangxin CHEN Xiguang DENG li YANG Leonardo AZEVEDO Minliang DUAN Tingting WU Jinfeng MA keliang li Key Laboratory of Marine Mineral Resources Ministry of Natural ResourcesGuangzhou Marine Geological SurveyGuangzhou 510760China National Institute of Oceanography Karachi 75600Pakistan Key Laboratory of Gas Hydrate Ministry of Natural ResourcesQingdao Institute of Marine GeologyQingdao 266071China Laboratory for Marine Mineral Resources Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China CERENA/Instituto Superior Técnico Lisbon UniversityLisbon 1049-001Portugal Key Lab of Submarine Geosciences and Prospecting Techniques MOE andCollege of Marine GeosciencesOcean University of ChinaQingdao 266100China

To investigate the nature of gas hydrates in the Makran area,new high-resolution geophysical data were acquired between *** data collected comprise multibeam and two-dimensional multi-channel seismic reflection *** multibeam bathymetry data show East-North-East(ENE)ridges,piggy-back basins,canyon and channel systems,and the morphology of the abyssal *** and discontinuous bottom simulating reflectors(BSRs)occur in the piggy-back basins on most of the seismic profiles *** BSRs cut the dipping layers with strong amplitude and reversed *** BSRs indicate a transition along a dipping high-permeable sand layers from gas-rich segment to the gas hydrate-bearing segment and sugge st alternating sediments of fine and relatively coarse grain *** BSRs are highly dynamic and attributed to slumps occurring in the study *** BSRs induced by slumps are located both at deep and shallow depths,responding to the temperature or pressure *** the first time,BSRs are observed in the abyssal plain of the Makran area,being associated with anticline structures,which do not show large spatial continuity and are strongly conditioned by structural conditions such as anticlines and fluid migration pathways,including deep fault,gas chimney,and high-permeable sedimentary *** results may help to assess the gas hydrate potential within the piggy-back basins and to determine the most promising target ***,results about the abyssal plain BSR may help to locate hydrocarbon reservoirs in the deep ocean.

关键词： gas hydrate-bearing sand-prone sediments double bottom simulating reflector(BSR) multiple BSR canyon channel system abyssal plain

Discovery of Multiple Tectonic Reformations of the Eastern Yingen-Ejinaqi Basin:Evidence from Detrital Chronology

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Acta Geologica Sinica(English Edition) 2021年第2期95卷 693-695页

作者： PENG Heng liU Chiyang WANG Jianqiang ZHANG Shaohua ZHAO Xiaochen MA Ming li keliang FENG Xiaolin GUAN Yuzhao State Key Laboratory of Continental Dynamics Department of GeologyNorthwest UniversityXi'an 710069China School of Earth Sciences and Engineering Xi'an Shiyou UniversityXi'an 710065China College of Geology and Environment Xi'an University of Science and TechnologyXi'an 710054China Department of Geological Engineering Qinghai UniversityXining 810016China

Objective The widely-distributed reformed basins in China are currently major areas for oil and gas *** tectonic movement of modified basins often plays an important role in controlling petroleum accumulation,migration and distribution(liu and Yang,2000).The petroliferous Carboniferous-Permian Yingen-Ejinaqi Basin is located in the junction area between the North China Craton and the Central Asian Orogenic Belt(Fig.1 a).

关键词： formations Eastern Basin

Design and test of centrifugal disc type sowing device for unmanned helicopter

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International Journal of Agricultural and Biological Engineering 2018年第2期11卷 55-61页

作者： Cancan Song Zhiyan Zhou Xiwen Luo Yubin Lan Xingang He Rui Ming keliang li Shahbaz Gul Hassan College of Engineering South China Agricultural University/Guangdong Engineering Research Center for Agricultural Aviation Application(ERCAAA)Guangzhou 510642China National Joint Research Center for Precision Agricultural Aviation Application Technology Guangzhou 510642China Key Laboratory of Key Technology on Agricultural Machine and Equipment(South China Agricultural University) Ministry of EducationGuangzhou 510642China

In China,it is difficult for manned aircraft to sow seeds in small and scattered plots,especially in areas including hills,swamps,telegraph poles,windbreaks,and residential areas;in such terrain,the sowing machinery cannot function ***,unmanned helicopters(UHs)are flexible enough to control and adapt to the complex environments that are not easily accessible by terrain sowing machinery and large agricultural aircraft,which have been widely used in *** this study,a centrifugal disc-type sowing device for an unmanned helicopter(CDTSDUH)was *** factors influencing the seed velocity when the seeds move away from the disc were explored by analyzing the forces of the seed acting on the sowing disc and the wind field of the *** influential factors include the distance from the falling mouth to the center of the disc,the offset angle of the falling mouth,and the rotation speed of the *** orthogonal test was designed with the sowing width and the curvature of the sowing area as the *** test results showed that the three factors mentioned above had a greater impact on the sowing width than the curvature of the seeding ***,the superior parameters of the disc were *** was also suggested that the above factor levels had little effect on the offset width of *** results of the test conducted for studying the sowing uniformity of the CDTSDUH indicated that the maximum and minimum difference values among the number of particles of the sampling points in the forward direction was 11 and 8,and the coefficient of variation of the number of particles in each row was more than 20%,indicating less uniformity was achieved when sowing in the lateral(perpendicular to the forward direction)direction,as compared to that in the forward *** study determined the ideal values for the radius of particles position,the offsetting angle,and the disc speed of the sowing machinery ***,considering that

关键词： sowing unmanned helicopter aircraft sowing centrifugal disc uniformity sowing disc

基于正交试验的拜耳法赤泥活化机理及性能分析

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材料导报 2022年第16期36卷 168-174页

作者：李克亮宋子明华北水利水电大学土木与交通学院郑州450045 河南省废物利用技术与装备工程研究中心郑州450045

拜耳法赤泥产生量大,污染严重,且活性较低,在胶结材料中直接利用难度较大。使用激光粒度分析仪(LPA)、扫描电镜(SEM)分析不同比表面积的拜耳法赤泥的粒度分布和颗粒形貌,使用X射线衍射仪(XRD)、热重分析(TGA)研究不同温度热活化后拜耳... 详细信息

拜耳法赤泥产生量大,污染严重,且活性较低,在胶结材料中直接利用难度较大。使用激光粒度分析仪(LPA)、扫描电镜(SEM)分析不同比表面积的拜耳法赤泥的粒度分布和颗粒形貌,使用X射线衍射仪(XRD)、热重分析(TGA)研究不同温度热活化后拜耳法赤泥的矿物组成及其矿物转化,并探究其活化机理。采用正交试验优化拜耳法赤泥的活化条件,分析比表面积、煅烧温度对水泥-拜耳法赤泥复合胶凝材料体系的胶砂抗压强度和水化产物的影响。结果表明,机械粉磨可显著增加拜耳法赤泥的比表面积和需水量,引起微细颗粒的团聚;低温煅烧过程中三水铝石、水钙铝榴石、钙霞石等矿物转化形成亚稳定状态的铝硅酸盐,有效提高了赤泥的反应活性。600℃下煅烧0.5 h后,拜耳法赤泥的活性指数高达95.93%,比室温(R.T.)下处理的高32.5%;使用600℃下煅烧的拜耳法赤泥时,复合胶凝材料的水化放热速率峰值最大,出现的时间最早。复合胶凝材料的水化产物主要有C-S-H凝胶和氢氧化钙晶体,活性高的热活化拜耳法赤泥发生水化反应时消耗的氢氧化钙更多。

关键词：拜耳法赤泥正交试验活化机理性能活性指数煅烧水化产物

Dynamic swallowing study for globus patients

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2016年第4期2卷 -页

作者： Jinrang li Jie Zhang Pengfei Guo Shiyu Tian keliang li Department of 0torhinolaryngology Head and Neck Surgery Navy General Hospital Beijing 100048 China

Objective:To examine whether pharyngeal swallowing function is impaired in glo-bus patients with swallowing difficulty by dynamic swallowing study. Methods:Dynamic swallowing studies were performed on 80 normal adult volunteers and 33 globus patients with swallowing difficulty. Objective parameters such as maximum displace-ment of the hyoid bone, pharyngeal transit time, pharyngeal constriction ratio, and maximum opening of the esophageal entrance were measured, which were closely associated with the pharyngeal swallowing function in the swallowing process. Results:There were no significant differences between globus patients and normal adults in hyoid bone displacement, pharyngeal transit time, pharyngeal constriction ratio, or maximum opening of the esophageal entrance (p>0.05). Conclusion:The results of the dynamic swallowing study indicated that the pharyngeal swal-lowing function of globus patients was not impaired.

关键词： Dynamic swallowing study Globus Pharynx Swallowing function

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铜对地聚合物化学结构的影响

建筑材料学报 2014年第4期17卷 711-714页

作者：李克亮仝玉萍华北水利水电大学土木与交通学院河南郑州450011 南京水利科学研究院瑞迪高新技术公司江苏南京210029

借助X射线衍射(XRD)、扫描电镜-能谱(SEM-EDS)、红外光谱(FTIR)、核磁共振(NMR)等技术,研究了铜对地聚合物化学结构的影响.地聚合物由硅粉、偏高岭土、氢氧化钾和水制得,铜以硝酸盐的形式加入.结果表明:加入的铜影响到地聚合物化学结构... 详细信息

借助X射线衍射(XRD)、扫描电镜-能谱(SEM-EDS)、红外光谱(FTIR)、核磁共振(NMR)等技术,研究了铜对地聚合物化学结构的影响.地聚合物由硅粉、偏高岭土、氢氧化钾和水制得,铜以硝酸盐的形式加入.结果表明:加入的铜影响到地聚合物化学结构中Al—O—Si键和Si—O—Si键的周围气氛,使其振动频率发生微小变化,也影响到Al和Si原子核周围的电子密度,使27 Al NMR和29Si NMR特征峰发生微小偏移,但加入的铜没有改变地聚合物中化学键振动模式,也没有引起硅氧四面体、铝氧四面体结构单元和两者之间键接方式的变化.

关键词：地聚合物铜化学结构

甲状腺术中喉返神经实时监测对预防喉返神经损伤的Meta分析

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临床耳鼻咽喉头颈外科杂志 2014年第24期28卷 1941-1944,1948页

作者：李可亮李进让海军总医院全军耳鼻咽喉头颈外科中心北京100048 安徽医科大学海军总医院临床学院北京100048

目的：通过Meta分析的方法,比较甲状腺手术中喉返神经实时监测与常规暴露两种方式在预防喉返神经损伤与喉返神经识别率方面的优缺点。方法：依照既定的纳入和排除标准,通过计算机对中国生物医学文献数据库（CBM）、Pubmed数据库、万方... 详细信息

目的：通过Meta分析的方法,比较甲状腺手术中喉返神经实时监测与常规暴露两种方式在预防喉返神经损伤与喉返神经识别率方面的优缺点。方法：依照既定的纳入和排除标准,通过计算机对中国生物医学文献数据库（CBM）、Pubmed数据库、万方数据库、中国知网（CNKI）等中英文数据库的相关文献进行检索,并结合文献追溯、网上查询的方法,收集所有相关的随机对照研究或病例对照研究。以客观有效率合并OR值为效应指标,对各资料进行异质性检验,以确定采用固定或随机效应模型进行合并分析。结果：共纳入文献6篇,涉及12 646例喉返神经,Meta分析结果显示：喉返神经实时监测组的喉返神经暂时性损伤发生率低于常规暴露组（OR=0.60,95%CI=0.49-0.73,P〈0.01）;实时监测组与常规暴露组的喉返神经永久性损伤发生率差异无统计学意义（OR=0.90,95%CI=0.57-1.40,P〉0.05）;实时监测组与常规暴露组的喉返神经识别率差异无统计学意义（OR=9.79,95%CI=0.17-548.64,P〉0.05）。结论：甲状腺术中喉返神经实时监测在降低喉返神经暂时性损伤发生率方面优于常规暴露组,但两组间喉返神经永久性损伤发生率和喉返神经识别率没有明显差异。甲状腺术中喉返神经监测对预防喉返神经损伤有一定作用。

关键词：喉返神经实时监测甲状腺手术 Meta分析