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Assessment of cerebral oxygenation response to hemodialysis using near-infrared spectroscopy (NIRS):Challenges and solutions

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Journal of Innovative Optical Health Sciences 2021年第6期4卷 55-70页

作者： Ardy Wong Lucy Robinson Seena Soroush Aditi Suresh Dia Yang kelechi madu Meera N.Harhay Kambiz Pourrezaei Drexel University School of Bioengineering Philadelphia Pennsylvania Department of Epidemiology&Biostatistics Drexel University Dornsife School of Public Health Philadelphia Pennsylvania Drexel University College of Arts and Sciences Philadelphia Pennsylvania Department of Medicine Drexel University College of Medicine Philadelphia Pennsylvania Tower Health Transplant Institute Tower Health System West Reading Pennsylvania

To date,the clinical use of functional near-infrared spectroscopy(NIRS)to detect cerebral ischemia has been largely limited to surgical settings,where motion artifacts are *** this study,we present novel techniques to address the challenges of using NIRS to monitor ambu-latory patients with kidney disease during approximately eight hours of hemodialysis(HD)*** with end-stage kidney disease who require HD are at higher risk for cognitive impairment and dementia than age-matched *** studies have suggested that HD-related declines in cerebral blood flow might explain some of the adverse outcomes of HD ***,there are currently no established paradigms for monitoring cerebral per-fusion in real-time during HD *** this study,we used NIRS to assess cerebral hemo-dynamic responses among 95 prevalent HD patients during two consecutive HD *** observed substantial signal attenuation in our predominantly Black patient cohort that required probe *** also observed consistent motion artifacts that we addressed by devel-oping a novel NIRS methodology,called the HD cerebral oxygen demand algorithm(HD-CODA),to identify episodes when cerebral oxygen demand might be outpacing supply during HD *** then examined the association between a summary measure of time spent in cerebral deoxygenation,derived using the HD-CODA,and hemodynamic and treatment-related *** found that this summary measure was associated with intradialytic mean arterial pressure,heart rate,and volume *** studies should use the HD-CODA to implement studies of real-time NIRS monitoring for incident dialysis patients,over longer time frames,and in other dialysis modalities.

关键词： Motion artifact removal cerebral oxygenation end-stage kidney disease near-infrared spectroscopy

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Simultaneous repair of bilateral pectoralis major tendons: A case report

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World Journal of Orthopedics 2021年第10期12卷 802-810页

作者： Muhammad J Abbas Patrick Buckley Sabin Shah kelechi R Okoroha Department of Orthopedic Surgery Henry Ford Health SystemDearbornMI 48124United States Department of Orthopaedic Surgery Mayo ClinicMinneapolisMN 55403United States

BACKGROUND Injuries to the pectoralis major are infrequent,with only a few hundred cases currently recorded in the *** SUMMARY We report a case of a patient who sustained bilateral pectoralis major tendon *** other cases of bilateral pectoralis major tears have been reported in the literature,the operative management in this report *** to delayed presentation of the patient right and left pectoralis major repairs were performed *** Patients with delayed presentation of bilateral pectoralis major tendon ruptures can undergo simultaneous repair of both tendon with a good postoperative outcome and high patient satisfaction.

关键词： Bilateral repair Pectoralis major Tendon rupture Simultaneous repair Case report

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Microalgae contribution in enhancing the circular economy drive of biochemical conversion systems-A review

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Carbon Resources Conversion 2024年第2期7卷 95-109页

作者： kelechi E.Anyaoha Felix Krujatz Isla Hodgkinson Roman Maletz Christina Dornack Technische Universität Dresden Chair of Waste Management and Circular EconomyPratzschwitzer Str.1501796 PirnaGermany Institute of Natural Materials Technology RadebergGermany Biotopa gGmbH Center for Applied Aquaculture and Bioeconomy RadebergGermany Department of Agricultural Engineering Imo State Polytechnic OmumaNigeria

The global impact of greenhouse gas emissions requires concerted efforts to reduce emissions and energy use,and to increase carbon capture and *** the circular economy in CO_(2)sequestration systems optimises resource use and reduces the emissions burden throughout the supply *** capture from anaerobic digestion,composting and fermentation(particularly ethanol)processes offers great opportunities for climate change *** waste/by-products generated from these processes can limit the need to source nutrients from outside the system and increase the potential for circular *** integration of microalgae cultivation with each of anaerobic digestion,composting and ethanol fermentation processes provides a new model for climate change mitigation of biogenic CO_(2)and circular *** this model is limited by high energy consumption and nutrient demand,seasonal variability,operational efficiency and end-user requirements,further research and policy support will go a long way in realising the associated benefits,including in CO_(2)fixation,nutrient recovery,waste remediation and as an alternative source of animal feed.

关键词： Circular economy Anaerobic digestion Composting Microalgae

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Evaluation of Peripheral Neuropathy in Diabetic Adults with and without Foot Ulcers in an African Population

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Journal of Biosciences and Medicines 2018年第12期6卷 71-78页

作者： Osita Ede Gabriel O. Eyichukwu Kenechi A. madu Iheuko S. Ogbonnaya Kelechukwu A. Okoro Chinonso Basil-Nwachuku kelechi A. Nwokocha Department of Orthopaedics Plastic and Reconstructive Surgery National Orthopaedic Hospital Enugu Nigeria

Background: Foot ulcers frequently precede lower extremity amputations (LEA) in diabetic subjects. Peripheral neuropathy (PN) is a strong risk factor for diabetic foot ulceration. Majority of diabetic patients with PN are asymptomatic;hence foot ulceration may be the first clinical presentation. Early detection of PN can forestall the development of foot ulcers through active preventive strategies. Few studies have been done to assess PN in diabetic individuals in Africa. The study aims to evaluate the incidence and risk factors for PN in diabetic adults with and without foot ulcers in an indigenous African population. Method: This cross-sectional study involved 90 diabetic adults, 45 with foot ulcers and 45 without foot ulcers. Assessment of PN was done with the Michigan Neuropathy Screening Instrument (MNSI), the 10 g Semmes-Weinstein monofilament (SWM) and the 128-Hz vibrating tuning fork (VTF). Demographic data were collected by questionnaire. Associations between PN and risk factors such as age, alcohol consumption, duration of diabetes, cigarette smoking, BMI, height and sex were also investigated. Results: There were 59 males (65.6%) and 31 females (34.4%) in the study. The mean age of the subjects with foot ulcers was 59.62 years (SD = 6.47), while those without ulcers was 57.47 years (SD = 6.94). Forty-two subjects (93.33%) with foot ulcers have PN using the MNSI, while 33 subjects without foot ulcers (73.33%) have PN. Both the SWM and the VTF showed a high positive correlation with themselves and with the MNSI. Advancing age, duration of diabetes, alcohol intake, hyperglycaemia and cigarette smoking showed a significant association with peripheral neuropathy, while BMI, height and sex did not. Conclusion: The incidence of PN is quite high in diabetic adults in Africa. This calls for early screening and aggressive control of risk factors to prevent the development of diabetic foot ulceration.

关键词： Peripheral Neuropathy African Diabetic Adults Foot Ulcers

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Pore pressure prediction in offshore Niger delta using data-driven approach: Implications on drilling and reservoir quality

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Energy Geoscience 2023年第3期4卷 252-265页

作者： Joshua Pwavodi Ibekwe N.kelechi Perekebina Angalabiri Sharon Chioma Emeremgini Vivian O.Oguadinma Univ.Grenoble Alpes Univ.Savoie Mont BlancCNRSIRDUGEISTerre38000GrenobleFrance TotalEnergies SA CSTJF Avenue Larribau64000PauFrance Centre of Excellence in Petroleum Geoscience and Engineering University of BeninBenin CityEdo StateNigeria Univ.Lille CNRSUniv.Littoral Cote d’OpaleUMR 8187LOGLaboratoire d’Oceanologie et de Geosciences59000LilleFrance

Despite exploration and production success in Niger Delta,several failed wells have been encountered due to ***,it is very essential to understand the spatial distribution of pore pressure and the generating mechanisms in order to mitigate the pitfalls that might arise during *** research provides estimates of pore pressure along three offshore wells using the Eaton's transit time method,multi-layer perceptron artificial neural network(MLP-ANN)and random forest regression(RFR)*** results show that there are three pressure magnitude regimes:normal pressure zone(hydrostatic pressure),transition pressure zone(slightly above hydrostatic pressure),and over pressured zone(significantly above hydrostatic pressure).The top of the geopressured zone(2873 mbRT or 9425.853 ft)averagely marks the onset of overpressurization with the excess pore pressure above hydrostatic pressure(P∗)varying averagely along the three wells between 1.06−24.75 *** results from the three methods are self-consistent with strong correlation between the Eaton's method and the two machine learning *** models have high accuracy of about>97%,low mean absolute percentage error(MAPE0.98).Our results have also shown that the principal generating mechanisms responsible for high pore pressure in the offshore Niger Delta are disequilibrium compaction,unloading(fluid expansion)and shale diagenesis.

关键词： Niger Delta Pore pressure Reservoir Fracturing pressure Artifidal neural network Machine leaming algorithm Random forest regression

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Design of a Low-Cost Air Quality Monitoring System Using Arduino and ThingSpeak

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Computers, Materials & Continua 2022年第1期70卷 151-169页

作者： Anabi Hilary kelechi Mohammed H.Alsharif Chidumebi Agbaetuo Osichinaka UbadikeAlex Aligbe Peerapong Uthansakul Raju Kannadasan Ayman A.Aly Department of Aerospace Engineering College of EngineeringAirForce Institute of TechnologyKadunaNigeria Department of Electrical Engineering College of Electronics and Information EngineeringSejong UniversitySeoul05006Korea Department of Electrical Engineering and Information Engineering College of EngineeringCovenant UniversityCanaanlandOtaP.M.B 1023OgunNigeria School of Telecommunication Engineering Suranaree University of TechnologyNakhon RatchasimaThailand Department of Electrical and Electronics Engineering Sri Venkateswara College of EngineeringChennai602117India Department of Mechanical Engineering College of EngineeringTaif UniversityTaif21944Saudi Arabia

The impact of daily emissions of gaseous and particulate pollutants of machines and industries on human health and the environment has attracted increasing *** impact has significantly led to a notable increase in mortality in the highly industrialized ***,monitoring air quality and creating public awareness are important for a safer future,which led the governments globally to investmulti-billion in policymaking and solution stratification to address the *** study aims to design a realtime Internet of Things low-cost air quality monitoring *** system utilizes air quality and carbon monoxide sensors for monitoring gaseous ***,the system utilizes an Arduino Nano development board equipped with a WiFi module to effectively send readings to a ThingSpeak online channel platformfor instantaneous and real-time display of air *** ThingSpeak uses HTTP protocols to send emails in raising awareness of poor air *** level of concentration is monitored graphically through channels with the help of ThingSpeak to aid remote *** value is ***,when pollutants have become unhealthy and harmful,the system trips off an alarm,and e-mail notifications are sent to the *** results have shown that the work was successfully implemented a design of a low-cost air quality monitoring system using Arduino and ThingSpeak,showing that an air quality system can be implemented using a low-cost technology,Arduino and ThingSpeak.

关键词： IoT air quality MQ 135 sensor MQ-7 sensor air pollution

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Epidemiology and Pathophysiology of Acquired Heart Failures Amenable to Surgical Interventions in the Sub-Saharan Africa

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World Journal of Cardiovascular Surgery 2014年第7期4卷 116-122页

作者： kelechi E. Okonta Division of Cardiothoracic Surgery Department of Surgery University of Port Harcourt Teaching Hospital Port Harcourt Nigeria

Heart failure (HF) is an important cause of morbidity and mortality in sub-Saharan Africa and indeed worldwide. The management of this condition has largely been thought to be within the domain of the Physician with the Surgeon having little or no role to play. The commonest cause of HF that may require surgical intervention is rheumatic valvular heart disease especially in the young age group while ischaemic heart disease still remains at the low rung of the ladder and interestingly, hypertrophic cardiomyopathy is becoming common. Most of the literatures reviewed failed to identify pericardial diseases, though it ranked topmost in the face of tuberculosis and HIV infections in the sub-region, and the other non-cardiac structures as important causes of HF which is amenable to surgical intervention. Equally, what have not been clearly identified are the surgical aspects;indeed its sub-classifications into heart and non-heart causes have hitherto not been documented. Even though these lists from this review are not exhaustive of the numerous unidentified causes of surgical HF, this would act as stimulus for further and extensive documentation of guideline for the recognition of these sub-classifications of HF amenable to surgery.

关键词： Epidemiology and Pathophysiology Heart Failure Surgical Intervention Sub-Saharan Africa

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Exploring awareness of obstetric fistula in Eastern and Northern Nigeria:perceived causes,symptoms,and availability of treatment services

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Global Health Research and Policy 2022年第1期7卷 222-231页

作者： Emmanuel kelechi Nwala Charles Nwaigwe Pooja Sripad Charlotte EWarren Salisu Ishaku Solomon Kongyamba Maternal Newborn and Child HealthPopulation CouncilNigeriaHouse 4No 16 Mafemi CrescentOff Solomon Lar WayUtakoAbujaNigeria Population Council WashingtonDCUSA

Background:Evidence suggests that there are approximately two female genital fistula cases per 1000 women of reproductive age in sub-Saharan *** is estimated that more than 200,000 women are affected by fistula in Nigeria,primarily due to obstetric *** has been indicated as a risk factor for the development of obstetric *** study explored the awareness of obstetric fistula such as causes,symptoms,and availability of and access to treatment services in southeastern and northwestern ***:An exploratory qualitative study design was used to conduct this research in Kano and Ebonyi states in northern and eastern Nigeria,respectively.A total of six(6)focus group discussions were conducted with three categories of participants:women who were successfully repaired and discharged(n=2),community-married men(n=2),and women(n=2).Forty-four(44)In-depth interviews were conducted three categories of participants:18 with women with fistula who were either awaiting repair or had been repaired;6 family member caregivers accompanying fistula patients,and 20 health service providers at fistula repair *** developed a data analysis plan based on the emerging *** transcripts and field notes were imported into QSR Nvivo version 11 and coded *** and thematic analysis was run by inductively drawing themes based on the elicited information from ***:There was lack of knowledge of obstetric fistula and its causes among married men and women in the community,caregivers,and some patients were unaware of what caused their fistula for *** this study,none of the community men and women nor caregivers correctly identified the causes and symptoms of a fistula or knew where to seek *** about fistula was more common among women who had undergone *** repaired women attributed the cause of fistula to the providers who attended to them during ***:Findings reveal a widespread

关键词： Women with obstetric fistula Fistula awareness Knowledge about fistula Treatment seeking behavior Fistula repair services

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Superior Sinus Venosus Atrial Septal Defect: Overview of Surgical Options

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Open Journal of Thoracic Surgery 2013年第4期3卷 114-122页

作者： kelechi Emmanuel Okonta Michael Sanusi Cardiothoracic Surgery Unit Department of Surgery Lagos State University Teaching Hospital Ikeja Lagos State Nigeria. Cardiothoracic Surgery Unit Department of Surgery University of Port Harcourt Rivers State Nigeria

Background: Superior sinus venosus atrial septal defect (SV-ASD) is an interatrial defect with partial anomalous pulmonary venous connection (PAPVC) draining into the right atrium. The principle for SV-ASD surgical repair involves redirecting the pulmonary venous blood back to the left atrium and closure of the atrial septal defect without compromising the adjoining structures. Methods: We reviewed English literature relating to this topic via a MEDLINE and Google scholar search using the following terms: surgery for sinus venosus atrial septal defect (SV-ASD), surgery for partial anomalous pulmonary venous connection (PAPVC) and complications of the surgery. Results: A total of 910 consecutive cohort patients with different surgical options between 1984 to 2012 were analyzed. The breakdown showed that 291(32.0%) had single-patch, 275(30.2%) had Warden’s procedure, 185(20.3%) had a double-patch and 159(17.5%) had use of autologous right atrial appendage for the anastomosis. The total follow-up was between 0.008-30 years. Sinus node dysfunction (SND) was the commonest complication occurring mostly in patients who had double-patch technique 16(8.6%) followed by 15(5.5%) patients with single-patch technique, 7(4.4%) patients in whom right atrial appendage was used and 5(1.8%) patients with Warden’s procedure. Venous obstruction occurred in 22(7.7%) patients with SP, 13(5.1%) patients with Warden’s Procedure and 5(2.7%) patients with double-patch. Conclusion: The two major complications, SND and venous obstruction, assumed a see-saw approach as surgical maneuvers avoiding venous obstruction encouraged SND and vice versa. However, adopting surgical options which avoided incision across the Cavoatrial junction attenuated all the complications.

关键词： Sinus Venosus-Atrial Septal Defect Warden’s Procedure Right Atrial Appendage Single-Patch Technique Double-Patch Technique

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Design and Implementation of a Low-Cost Portable Water Quality Monitoring System

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Computers, Materials & Continua 2021年第11期69卷 2405-2424页

作者： Anabi Hilary kelechi Mohammed H.Alsharif Anya Chukwudi-eke Anya Mathias *** Samson Aiyudubie Uyi Peerapong Uthansakul Jamel Nebhen Ayman A.Aly Department of Aerospace Engineering College of EngineeringAirForce Institute of TechnologyKadunaNigeria Department of Electrical Engineering College of Electronics and Information EngineeringSejong UniversityGwangjin-guSeoul05006Korea Department of Electrical Engineering and Information Engineering College of EngineeringCovenant UniversityCanaanlandOtaP.M.B 1023OgunNigeria School of Telecommunication Engineering Suranaree University of TechnologyNakhon RatchasimaThailand Prince Sattam bin Abdulaziz University College of Computer Engineering and SciencesAlkharj11942Saudi Arabia Department of Mechanical Engineering College of EngineeringTaif UniversityTaif21944Saudi Arabia

Water is one of the needs with remarkable significance to man and other living *** quality management is a concept based on the continuous monitoring of water *** monitoring scheme aims to accumulate data to make decisions on water resource descriptions,identify real and emergent issues involving water pollution,formulate priorities,and plan for water quality *** regularly considered parameters when conducting water quality monitoring are turbidity,pH,temperature,conductivity,dissolved oxygen,chemical oxygen demand,biochemical oxygen demand,ammonia,and metal *** usual method employed in capturing these water parameters is the manual collection and sending of samples to a laboratory for detection and ***,this method is impractical in the long run because it is laborious and consumes a considerable amount of human *** integrated into a mobile phone application interface can address this *** paper aims to design and implement an Internet of Things-based system comprising pH,temperature,and turbidity sensors,which are all integrated into a mobile phone application interface for a water monitoring *** project utilizes the Bluetooth Standard(IEEE 802.15.1)for communication/transfer of data,while the water quality monitoring system relies on the pH,turbidity,and temperature of the test water.

关键词： Temperature sensor pH sensor turbidity IoT water monitoring

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