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促甲状腺激素抗甲状腺过氧化物酶抗体抗甲状腺球蛋白抗体联合检测对自身免疫性甲状腺疾病的诊断价值

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实用医技杂志 2024年第5期31卷 351-354页

作者：李琰慕珂珂董炎红冯浩然郭佳佳杨景瑞肖凌云郑州四六○医院医学检验科郑州450007

目的探讨促甲状腺激素(TSH)、抗甲状腺过氧化物酶抗体(TPOAb)、抗甲状腺球蛋白抗体(TGAb)联合检测对自身免疫性甲状腺疾病(AITD)的诊断价值。方法选取2022年8月至2023年7月郑州四六○医院收治的96例AITD患者作为AITD组,另选取同期接... 详细信息

目的探讨促甲状腺激素(TSH)、抗甲状腺过氧化物酶抗体(TPOAb)、抗甲状腺球蛋白抗体(TGAb)联合检测对自身免疫性甲状腺疾病(AITD)的诊断价值。方法选取2022年8月至2023年7月郑州四六○医院收治的96例AITD患者作为AITD组,另选取同期接受体检的45名健康者作为对照组,均接受TSH、TPOAb、TGAb检测。比较2组、不同类型AITD患者上述指标水平,进行单因素与多因素logistic回归分析,采用受试者工作特征(ROC)曲线评估诊断价值。结果 AITD组TSH、TPOAb、TGAb水平较对照组更高(P0.05);多因素logistic分析结果显示,TSH[OR(95%CI)=2.369(1.295,3.417)]、TPOAb[OR(95%CI)=3.175(1.603,4.922)]、TGAb[OR(95%CI)=3.218(1.337,5.006)]是影响AITD发生的独立危险因素(P<0.05);绘制ROC曲线显示,TSH、TPOAb、TGAb、TSH+TPOAb、TSH+TGAb、TPOAb+TGAb、联合检测诊断AITD的曲线下面积(AUC)分别为0.819、0.832、0.862、0.908、0.909、0.886、0.950。结论 TSH、TPOAb、TGAb与AITD之间存在密切关系,且不同类型AITD患者有所差异,上述指标可作为诊断AITD的重要依据,联合检测时具有更高的诊断价值。

关键词：促甲状腺激素抗甲状腺过氧化物酶抗体抗甲状腺球蛋白抗体联合检测自身免疫性甲状腺疾病

基于光谱诊断的氩氮TIG焊电弧物理特性分析

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焊接学报 2019年第12期40卷 59-62,I0003页

作者：肖笑张柯柯李芳华学明河南科技大学洛阳471023 上海市激光制造与材料改性重点试验室上海200240

混合气体保护焊能够提高焊接质量及生产效率,由于混合气体保护焊电弧成分复杂多变,对其物理性能等的研究具有一定的难度.文中以氩氮混合气体钨极惰性气体保护焊(TIG焊)电弧为研究对象,采用双电荷耦合元件(CCD)电弧光谱图像采集试验系统... 详细信息

混合气体保护焊能够提高焊接质量及生产效率,由于混合气体保护焊电弧成分复杂多变,对其物理性能等的研究具有一定的难度.文中以氩氮混合气体钨极惰性气体保护焊(TIG焊)电弧为研究对象,采用双电荷耦合元件(CCD)电弧光谱图像采集试验系统,获取氩氮混合气体TIG焊电弧Ar I及N I的特征谱图像的动态分布;结合双元素双组分标准温度法对不同浓度(50%Ar+50%N2,80%Ar+20%N2及100%Ar)的氩氮电弧进行光谱诊断.结果表明,电弧半径最高收缩50%左右,温度最高升高12%.通过对氩氮电弧物理性能的定量分析为研究混合气体保护焊焊缝成形的本质奠定了理论基础.

关键词：氩氮混合气体钨极惰性气体保护焊光谱测量标准温度法

Milk fat globule epithelial growth factorⅧ(MFG-E8)sustains survival of cancer cells by prompting tumor angiogenesis and suppressing host immunities

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Oncology and Translational Medicine 2017年第1期3卷 31-37页

作者： keke Nie Shichao Liu Ling Zhang Zhongfa Zhang xiao Zou Youxin Ji Oncology Department Qingdao Cancer HospitalQingdao 266042China Oncology Department Qingdao Central HospitalThe 2nd Affiliated Hospital of Qingdao UniversityQingdao 266042China

Milk fat globule epithelial growth factor VIII(MFG-E8) is a novel adhesion protein mainly produced by macrophages and dendritic cells; it is expressed in most of the human tissues and functions to prompt cancer progression and survival. MFG-E8 contains a signal sequence for secretion, two epidermal growth factor(EGF)-like domains at the NH2 terminus and two discoidin domains with blood-clotting factor V/factor Ⅷ(C1 and C2) at the COOH terminus. The second EGF domain contains an arginine-glycine-aspartic(RGD) integrin-binding motif that engages α_vβ_5 integrins to facilitate cell adhesion and induce integrinmediated signal transduction. Integrin α_vβ_3 associates with VEGF receptor 2, engagement of integrins can promote angiogenesis, which plays key roles in growth, proliferation, and survival of cancer cells. VEGF stimulates the expression of α_vβ_3 and α_vβ_5 integrins on angiogenic vasculature, thereby potentiating effects of VEGF receptor engagement. Mice expressing a mutant form of α_vβ_3 integrin are unable to undergo tyrosine phosphorylation, confirming the important role that this integrin plays in pathological angiogenesis and providing important mechanistic insights. The C-terminus discoidin-like domains promote binding to membrane phospholipids, functioning close to VEGF like angiogenesis. MFG-E8 is an opsonin for apoptotic cells, and it acts as a bridging protein between apoptotic cells and phagocytes. It also influences cell immunities by altering CD4^+ and/or CD8^+ cells. Antibody or small peptide works with MFG-E8 at different functional sites or interacts with EGF-like domains and/or discoidin-like domains may play an important role in anti-angiogenesis or immune restoration. Altering the structures and/or functions of MFG-E8 and/or its domains is promising for development of novel anti-cancer strategies.

关键词： milk fat globule epithelial growth factor Ⅷ(MFG-E8) carcinoma target therapy angiogenesis apoptosis

Chemo-drugs in cell microparticles reset antitumor activity of macrophages by activating lysosomal P450 and nuclear hnRNPA2B1

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Signal Transduction and Targeted Therapy 2023年第2期8卷 757-770页

作者： keke Wei Huafeng Zhang Shuaishuai Yang Yuxiao Cui Bingxia Zhang Jincheng Liu Liang Tang Yaoyao Tan Simin Liu Shiqi Chen Wu Yuan xiao Luo Chen Chen Fei Li Junwei Liu Jie Chen Pingwei Xu Jiadi Lv Ke Tang Yi Zhang Jingwei Ma Bo Huang Department of Immunology Tongji Medical CollegeHuazhong University of Science&TechnologyWuhan 430030China Department of Pathology School of Basic MedicineTongji Medical CollegeHuazhong University of Science&TechnologyWuhan 430030China Department of Biochemistry&Molecular Biology Tongji Medical CollegeHuazhong University of Science&TechnologyWuhan 430030China Cardiovascular Surgery Union HospitalHuazhong University of Science&TechnologyWuhan 430071China Department of Immunology&National Key Laboratory of Medical Molecular Biology Institute of Basic Medical SciencesChinese Academy of Medical Sciences(CAMS)&Peking Union Medical CollegeBeijing 100005China Translational Medicine Laboratory First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang 325035China Biotherapy Center and Cancer Center The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China

Macrophages in tumors(tumor-associated macrophages,TAMs),a major population within most tumors,play key homeostatic functions by stimulating angiogenesis,enhancing tumor cell growth,and suppressing antitumor *** TAMs by simple,efficacious and safe approach(s)is highly desirable to enhance antitumor immunity and attenuate tumor cell ***,we used tumor cell-derived microparticles to package chemotherapeutic drugs(drug-MPs),which resulted in a significant treatment outcome in human malignant pleural effusions via neutrophil recruitments,implicating that drug-MPs might reset TAMs,considering the inhibitory effects of M2 macrophages on neutrophil recruitment and ***,we show that drug-MPs can function as an antitumor immunomodulator by resetting TAMs with M1 phenotype and IFN-β***,drug molecules in tumor MPs activate macrophage lysosomal P450 monooxygenases,resulting in superoxide anion formation,which further amplifies lysosomal ROS production and pH value by activating lysosomal ***,lysosomal Ca^(2+)signaling is activated,thus polarizing macrophages towards ***,the drug molecules are delivered from lysosomes into the nucleus where they activate DNA sensor hnRNPA2B1 for IFN-β*** lysosomal-nuclear machinery fully arouses the antitumor activity of macrophages by targeting both lysosomal pH and the nuclear innate *** findings highlight that drug-MPs can act as a new immunotherapeutic approach by revitalizing antitumor activity of *** mechanistic elucidation can be translated to treat malignant ascites by drug-MPs combined with PD-1 blockade.

关键词： drugs lysosomal immunity

Essential roles of exosome and circRNA_101093 on ferroptosis desensitization in lung adenocarcinoma

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Cancer Communications 2022年第4期42卷 287-313页

作者： xiao Zhang Yunhua Xu Lifang Ma keke Yu Yongjie Niu Xin Xu Yi Shi Susu Guo Xiangfei Xue Yikun Wang Shiyu Qiu Jiangtao Cui Hong Wang xiaoting Tian Yayou Miao Fanyu Meng Yongxia Qiao Yongchun Yu Jiayi Wang Department of Laboratory Medicine Shanghai Chest HospitalShanghai Jiao Tong University School of MedicineShanghai 200030P.R.China Department of Thoracic Surgery Shanghai Chest HospitalShanghai Jiao Tong University School of MedicineShanghai 200030P.R.China Shanghai Institute of Thoracic Oncology Shanghai Chest HospitalShanghai Jiao Tong University School of MedicineShanghai 200030P.R.China Shanghai Lung Cancer Center Shanghai Chest HospitalShanghai Jiao Tong University School of MedicineShanghai 200030P.R.China Department of Bio-bank Shanghai Chest HospitalShanghai Jiao Tong University School of MedicineShanghai 200030P.R.China Shanghai Municipal Hospital of Traditional Chinese Medicine Shanghai University of Traditional Chinese MedicineShanghai 200071P.R.China Bio-X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric disorderShanghai Jiao Tong UniversityShanghai 200030P.R.China Department of Clinical Laboratory Medicine Shanghai Tenth People’s Hospital of Tongji UniversityShanghai 200072P.R.China School of Public Health Shanghai Jiao Tong University School of MedicineShanghai 200025P.R.China

Background:Resistance to ferroptosis,a regulated cell death caused by irondependent excessive accumulation of lipid peroxides,has recently been linked to lung adenocarcinoma(LUAD).Intracellular antioxidant systems are required for protection against *** purpose of the present studywas to investigate whether and how extracellular system desensitizes LUAD cells to ***:Established human lung fibroblasts MRC-5,WI38,and human LUAD H1650,PC9,H1975,H358,A549,and H1299 cell lines,tumor and matched normal adjacent tissues of LUAD,and plasma from healthy individuals and LUAD patients were used in this *** and immunoblotting were used to analyze protein expression,and quantitative reverse transcription-PCR was used to analyze mRNA *** viability,cell death,and the lipid reactive oxygen species generationwere measured to evaluate the responses to *** were observed using transmission electron *** localization of arachidonic acid(AA)was detected using click chemistry labeling followed by confocal *** between RNAs and proteins were detected using RNA pull-down,RNA immunoprecipitation and photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation *** analysis was used to investigate RNA-regulated proteins,and metabolomic analysis was performed to analyze *** xenograft,patient-derived xenograft,cell-implanted intrapulmonary LUAD mouse models and plasma/tissue specimens from LUAD patients were used to validate the molecular ***:Plasma exosome from LUAD patients specifically reduced lipid peroxidation and desensitized LUAD cells to ferroptosis.A potential explanation is that exosomal circRNA_101093(cir93)maintained an elevation in intracellular cir93 in LUAD to modulate AA,a poly-unsaturated fatty acid critical for ferroptosisassociated increased peroxidation in the plasma ***,cir93 interac

关键词： exosome circRNA_101093 ferroptosis desensitization lung adenocarcinoma lipid peroxidation poly-unsaturated fatty acid taurine N-arachidonoyl taurine RNA-protein interaction

南方多雨地区村镇垃圾理化特性分析及对比研究

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环境卫生工程 2021年第6期29卷 59-66页

作者：吴莉鑫薛映虞文波于泽聪金攀关文义武艳王松林肖可可刘冰川袁书珊杨家宽华中科技大学环境科学与工程学院湖北武汉430074 固废处理处置与资源化技术湖北省工程实验室湖北武汉430074 武汉市危险废物处置与资源化工程技术研究中心湖北武汉430074 安徽国祯环卫科技有限公司安徽合肥230000

村镇垃圾管理是美丽乡村建设重要内容,通过垃圾特性分析以选择合适的垃圾处置方式是解决农村环境污染的重要途径。选择南方多雨地区典型村镇湖北省埠河镇的生活垃圾为主要研究对象,对当地生活垃圾物理组成、理化特性及重金属含量进行了... 详细信息

村镇垃圾管理是美丽乡村建设重要内容,通过垃圾特性分析以选择合适的垃圾处置方式是解决农村环境污染的重要途径。选择南方多雨地区典型村镇湖北省埠河镇的生活垃圾为主要研究对象,对当地生活垃圾物理组成、理化特性及重金属含量进行了系统的分析。并与当地垃圾填埋场陈腐垃圾以及安徽省小岗村垃圾特性进行对比研究,揭示了生活垃圾在填埋过程中的演化规律及存在的区域差异。研究结果表明:埠河镇生活垃圾以厨余类(62.0%)为主,含水率为63.6%,有机质含量为83.7%,湿基低位热值为(4269±1271)kJ/kg。填埋过程中陈腐垃圾含水率和有机质含量显著下降,物理组分由以厨余类为主逐渐转变成以橡塑类为主。小岗村生活垃圾中厨余类垃圾含量(73.3%)更高,生活垃圾含水率(76.4%)与有机质含量(85.1%)较高,湿基低位热值为(2829±414)kJ/kg。根据垃圾特性建议埠河镇垃圾处置采取有害垃圾分类收集,其他混合垃圾外运焚烧为主、微好氧填埋为辅的模式;小岗村垃圾处置采取有害垃圾分类收集,易腐垃圾就地堆肥处理,其他垃圾外运焚烧的模式。

关键词：南方多雨地区村镇垃圾陈腐垃圾理化特性垃圾处理处置模式

A Theoretical Study of Single-Atom Catalysis of CO Oxidation Using Au Embedded 2D h-BN Monolayer:A CO-Promoted O2 Activation

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A Theoretical Study of Single-Atom Catalysis of CO Oxidation...

The rice Yellow-Green Leaf 18 locus is essential for chlorophyll synthesis, plant growth and retrograde plastid-nuclear signaling

中国化学会第29届学术年会

作者： keke Mao Lei Li Wenhua Zhang Yong Pei xiao Cheng Zeng xiaojun Wu Jinlong Yang Key Lab of Materials for Energy Conversion Department of Materials Science and EngineeringUniversity of Science and Technology of China Hefei National Lab for Physical Sciences at Microscale University of Science and Technology of China Department of Chemistry and Department Mechanics and Materials Engineering University of Nebraska-Lincoln Synergetic Innovation Center of Quantum Information & Quantum Physics University of Science and Technology of China Department of Chemistry Xiangtan University

The CO oxidation behaviors on single Au atom embedded in two-dimensional h-BN monolayer are investigated on the basis of first-principles calculations,quantum Born-Oppenheim molecular dynamic simulations（BOMD）and micro-kinetic *** show that CO oxidation on h-BN monolayer support single gold atom prefers an unreported tri-molecular Eley-Rideal（E-R）reaction,where O2 molecule is activated by two pre-adsorbed CO *** formed OCOAuOCO intermediate dissociates into two CO2 molecules synchronously,which is the rate-limiting step with an energy barrier of 0.47 *** using the micro-kinetic analysis,the CO oxidation following the tri-molecular E-R reaction pathway entails much higher reaction rate（1.43×105 s-1）than that of bimolecular Langmuir-Hinshelwood（L-H）pathway（4.29 s-1）.Further,the quantum BOMD simulation at the temperature of 300 K demonstrates the whole reaction process in real time.

关键词： first-principles calculations h-BN monolayer CO oxidation gold O2 activation

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The rice Yellow-Green Leaf 18 locus is essential for chlorop...

2016年全国植物生物学大会

作者： Zhaohai Wang xiao Hong keke Hu Shiyun Du Yang Li Dandan Hu Kexin Cheng Yangsheng Li State Key Laboratory of Hybrid Rice College of Life SciencesWuhan University Rice research institute Anhui Academy of Agricultural Sciences State Key Laboratory of Hybrid Rice Key Laboratory for Research and Utilization of Heterosis in Indica RiceMinistry of AgricultureCollege of Life SciencesWuhan University

Chlorophyll synthesis from glutamyl-t RNA to chlorophyll b needs 15 steps of enzymatic reaction,and all 27 genes encoding these 15 enzymes have been identified in higher plants represented by Arabidopsis(Arabidopsis thaliana). However,only nine genes encoding six enzymes in chlorophyll synthesis pathway have been identified in rice(Oryza sativa). In this study,a spontaneous mutant,yellow-green leaf 18(ygl18),was isolated in rice(Oryza sativa). This mutant showed yellow-green leaf,decreased chlorophyll level,and clime-dependent growth difference. Map-based cloning of this mutant identified the YGL18 gene,and this gene has not yet been studied in rice. YGL18 is expressed in green tissues,especially in leaf,and it functions in chloroplast. Bioinformatic analysis showed that YGL18 encodes one of the key enzymes of the chlorophyll synthesis pathway. Multiple sequence alignment revealed that the amino-acid substitution of leucine(Leu) to phenylalanine(Phe) in ygl18 is originally conserved in different photosynthesis organisms. In-vitro enzymatic assays identified the YGL18 enzymatic activity,but ygl18 almost lost the enzymatic function. YGL18 plays important roles in light-dependent and photoperiod-regulated chlorophyll synthesis. Plastid-related nuclear genes were regulated in ygl18 leaves,and the majority of genes in the tetrapyrrole synthesis pathway were up-regulated,implying that there is a new model on retrograde plastid-nuclear signaling. Based on these findings,it is suggested that YGL18 plays essential roles in chlorophyll synthesis,plant growth and regulating plastid-nuclear signaling.

关键词： chlorophyll synthesis yellow-green leaf 18 plant growth plastid-nuclear signaling

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一种面向室内AGV路径规划的改进蚁群算法

仪器仪表学报 2022年第3期43卷 277-285页

作者：肖金壮余雪乐周刚孙可可周振河北大学电子信息工程学院保定071000

针对传统蚁群算法在大规模和复杂环境中,全局搜索效率差,收敛速度慢,路径转弯次数过多且不够平滑等问题,本文提出一种改进蚁群算法。该方法通过动态更新不同等级蚂蚁路径上的信息素,加快算法的收敛速度;通过引入距离函数和方向函数作为... 详细信息

针对传统蚁群算法在大规模和复杂环境中,全局搜索效率差,收敛速度慢,路径转弯次数过多且不够平滑等问题,本文提出一种改进蚁群算法。该方法通过动态更新不同等级蚂蚁路径上的信息素,加快算法的收敛速度;通过引入距离函数和方向函数作为启发因子,改善路径搜索质量;采用一种改进自适应伪随机转移策略,减小陷入局部最优解的概率;在最优路径的基础上引入三次均匀B样条曲线进行优化,提高路径的平滑性。通过在2种不同规模环境下的路径规划实验表明,本文算法相比传统算法在分别减少55.6%和59.4%转弯次数的基础上,提升87.5%和100%的收敛速度,验证了本文算法的优越性。最后,以QBot2e为平台,将本算法应用到室内自动导引车(AGV)路径规划中,进一步验证了算法的实用性。

关键词：路径规划蚁群算法 AGV B样条平滑