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SENEX-mediated CDK4/6 inhibition promotes senescence and confers apoptosis resistance in B-cell non-Hodgkin lymphoma

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BIOCELL 2024年第3期48卷 453-462页

作者： JIYU WANG LIUYING YI keke huang YANGYANG WANG HUIPING WANG ZHIMIN ZHAI Department of Hematology The Second Affiliated Hospital of Anhui Medical UniversityHefei230601China Department of Hematology The Fourth Affiliated HospitalZhejiang University School of MedicineYiwu322000China

Background:The primary cause of treatment failure in patients with refractory or relapsed B-cell non-Hodgkin lymphoma(r/r B-NHL)is resistance to current therapies,and therapy-induced senescence(TIS)stands out as a crucial mechanism contributing to tumor drug resistance.Here,we analyzed SENEX/Rho GTPase Activating Protein 18(ARHGAP18)expression and prognostic signiﬁcance in doxorubicin-induced B-NHL-TIS model and r/r B-NHL patients,investigating its target in B-NHL cell senescence and the effect of combining speciﬁc inhibitors on apoptosis resistance in B-NHL-TIS cells.Methods:Raji cells were transfected with the human SENEX shRNA recombinant lentiviral vector(Sh-SENEX)and the empty vector negative(NC)to construct a stable transfection cell line with knockdown of SENEX.Effect of SENEX-silencing on B-NHL-TIS formation,cell function and cell cycle-related pathways was analyzed.Using doxorubicin(DOX)-inducible senescent B-NHL cells combined with the speciﬁc cyclin dependent kinase 4/6(CDK4/6)inhibitor Palbociclib to observe that blocking CDK4/6 effects on TIS formation.SENEX expression of 21 B-NHL patients and 8 healthy controls were analyzed by qRT-PCR,and the correlation between its expression and clinical indicators were evaluated.Results:The downregulation of SENEX expression promotes G1-S phase transition and apoptosis while inhibiting cell proliferation,collectively suppressing the formation of TIS in B-NHL.Blockade of CDK4/6 promotes the DOX-induced G1 phase arrest to enhance TIS formation in B-NHL cells which can reverse the regulatory effect of silencing SENEX on B-NHL cell cycle regulation and senescence.The expression levels of SENEX were notably elevated in B-NHL patients compared to healthy controls,and Elevated expression levels of SENEX were associated with poor prognosis of B-NHL patients.Conclusions:SENEX enhances apoptosis resistance in B-NHL by inhibiting CDK4/6,thereby preventing G1-S phase transition and promoting TIS formation.

关键词： SENEX B-cell non-Hodgkin lymphoma CDK4/6 G1-S phase transition Therapy-induced senescence Apoptosis resistance

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Multi-Objective Adaptive Optimization Model Predictive Control:Decreasing Carbon Emissions from a Zinc Oxide Rotary Kiln

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Engineering 2023年第8期27卷 96-105页

作者： Ke Wei keke huang Chunhua Yang Weihua Gui School of Automation Central South UniversityChangsha 410083China

The zinc oxide rotary kiln,as an essential piece of equipment in the zinc smelting industrial process,is presenting new challenges in process control.China’s strategy of achieving a carbon peak and carbon neutrality is putting new demands on the industry,including green production and the use of fewer resources;thus,traditional stability control is no longer suitable for multi-objective control tasks.Although researchers have revealed the principle of the rotary kiln and set up computational fluid dynamics(CFD)simulation models to study its dynamics,these models cannot be directly applied to process control due to their high computational complexity.To address these issues,this paper proposes a multi-objective adaptive optimization model predictive control(MAO-MPC)method based on sparse identification.More specifically,with a large amount of data collected from a CFD model,a sparse regression problem is first formulated and solved to obtain a reduction model.Then,a two-layered control framework including real-time optimization(RTO)and model predictive control(MPC)is designed.In the RTO layer,an optimization problem with the goal of achieving optimal operation performance and the lowest possible resource consumption is set up.By solving the optimization problem in real time,a suitable setting value is sent to the MPC layer to ensure that the zinc oxide rotary kiln always functions in an optimal state.Our experiments show the strength and reliability of the proposed method,which reduces the usage of coal while maintaining high profits.

关键词： Zinc oxide rotary kiln Model reduction Sparse identification Real-time optimization Model predictive control Process control

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Label propagation dictionary learning based process monitoring method for industrial process with between-mode similarity

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Science China(Information Sciences) 2022年第1期65卷 39-55页

作者： keke huang Shijun TAO Yishun LIU Chunhua YANG Weihua GUI School of Automation Central South University

With the development of the industrial cyber-physical systems, a small amount of labeled data and a large amount of unlabeled data are collected from the industrial process. Due to the variation of internal operation conditions and external environment, there is a between-mode similarity between data samples. The scarcity of labeled data and the existence of similarity make it challenging to extract data characteristics. In addition, it creates new challenges to process monitoring. To solve these problems, this study proposes a label propagation dictionary learning method. We first establish the connection between atoms and corresponding profiles and realize the propagation of their labels through graph Laplacian regularization. Then, considering the similarity of samples in the same class, the low-rank constraint is added to sparse coding to strengthen the mutual propagation of labels. Finally, an optimization method is designed to obtain the dictionary and classifier simultaneously. When new data samples arrive, we conduct process monitoring and condition prediction based on the learned dictionary and classifier. Experiments show that the proposed method can achieve satisfactory monitoring performance when compared to several state-of-the-art methods, indicating the superiority of the proposed method.

关键词： process monitoring label propagation dictionary learning between-mode similarity graph Laplacian regularization

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Smart manufacturing of nonferrous metallurgical processes:Review and perspectives

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International Journal of Minerals,Metallurgy and Materials 2022年第4期29卷 611-625页

作者： Bei Sun Juntao Dai keke huang Chunhua Yang Weihua Gui School of Automation Central South UniversityChangsha 410083China Peng Cheng Laboratory Shenzhen 518000China

The nonferrous metallurgical(NFM)industry is a cornerstone industry for a nation’s economy.With the development of artificial technologies and high requirements on environment protection,product quality,and production efficiency,the importance of applying smart manufacturing technologies to comprehensively percept production states and intelligently optimize process operations is becoming widely recognized by the industry.As a brief summary of the smart and optimal manufacturing of the NFM industry,this paper first reviews the research progress on some key facets of the operational optimization of NFM processes,including production and management,blending optimization,modeling,process monitoring,optimization,and control.Then,it illustrates the perspectives of smart and optimal manufacturing of the NFM industry.Finally,it discusses the major research directions and challenges of smart and optimal manufacturing for the NFM industry.This paper will lay a foundation for the realization of smart and optimal manufacturing in nonferrous metallurgy in the future.

关键词： nonferrous metallurgical industry smart and optimal manufacturing online perception intelligent control operational optimiza-tion automation of knowledge-based work

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Dynamic investigation of oxygen defects on transition metal-based electrocatalysts:formation,characterization,and mechanism during alkaline oxygen evolution reaction

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Science China Chemistry 2023年第8期66卷 2221-2237页

作者： Rongrong Zhang Qilong Wu Peter Sherrell Daohao Li keke huang Jun Chen Xiangdong Yao State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of ChemistryJilin UniversityChangchun130012China Intelligent Polymer Research Institute and ARC Centre of Excellence for Electromaterials Science Australian Institute for Innovative MaterialsUniversity of WollongongWollongongNSW2500Australia School of Science STEM CollegeRMIT UniversityMelbourneVIC3001Australia State Key Laboratory of Bio-fibers and Eco-textiles College of Materials Science and EngineeringQingdao UniversityQingdao266071China College of Advanced Energy Shenzhen CampusSun Yat-Sen University(SYSU)Shenzhen518100China

Oxygen defects play a critical role in the electrocatalytic oxygen evolution reaction(OER).Therefore,in-depth understanding the structure-activity-mechanism relationship of these defects is the key to design efficient OER electrocatalysts.This relationship needs to be understood dynamically due to the potential for irreversible phase transitions during OER.Consequently,significant efforts have been devoted to study the dynamic evolution of oxygen defects to shed light on the OER mechanism.This review critically examines and analyzes the dynamic processes occurring at oxygen defect sites during OER,including defect formation and defect evolution mechanisms,along with the advanced characterization techniques needed to understand these processes.This review aims to provide a comprehensive understanding of high-efficiency electrocatalysts,with a particular emphasis on the importance of in situ monitoring the dynamic evolution of oxygen defects,providing a new perspective towards efficient OER electrocatalyst design.

关键词： oxygen evolution reaction oxygen defects dynamic evolution in situ characterization electrocatalysis

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Palladium-catalyzed cyclization of 1-alkynyl-8-iodonaphthalene and double isocyanides for the synthesis of acenaphtho[1,2-b]pyrroles

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Chinese Chemical Letters 2022年第11期33卷 4870-4873页

作者： Shangfeng Ren keke huang Jin-Biao Liu Lianpeng Zhang Min Hou Guanyinsheng Qiu School of Metallurgical and Chemical Engineering Jiangxi University of Science and TechnologyGanzhou 341000China College of Biological Chemical Sciences and EngineeringJiaxing UniversityJiaxing 314001China International Joint Research Center for Biomass Materials Southwest Forestry UniversityKunming 650224China

A palladium-catalyzed formal[2+2+1]cyclization of 1-alkynyl-8-iodonaphthalene with double isocyanides is developed herein.The transformation worked well to produce a series of 7 H-acenaphtho[1,2-b]pyrrole with a broad reaction scope.Isocyanides play a dual role in the reaction.One is a C1 building block,and another is used as C1 N1 component.In the process,the[2+2+1]cyclization involves imidoylation,regioselective addition of imidoylpalladium species into alkyne,double imidoylation,and another addition of the resulting imidoylpalladium species into imine bonds.

关键词： [2+2+1]Cyclization Isocyanides Palladium catalysis Alkyne Pyrrole

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An emerging platform for electrocatalysis: perovskite exsolution

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Science Bulletin 2016年第23期61卷 1783-1784页

作者： keke huang State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of Chemistry Jilin University

The design of cost-effective,highly active,stable electrocatalysts for oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)is a critical element in the development of a new generation of energy technologies(e.g.,fuel cells,metal-air batteries)because the ORR and OER are inherently sluggish and require large over-potentials to drive a complex four-electron process[1].So far,precious metals platinum(Pt)and its alloys are the

关键词：电催化剂钙钛矿平台金属空气电池氧还原反应燃料电池能源技术析氧反应

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Switching Optimally Balanced Fe-N Interaction Enables Extremely Stable Energy Storage

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Energy & Environmental Materials 2023年第2期6卷 275-283页

作者： Zhenzhen Zhao Wei Zhang Miao Liu Dong Wang Xiyang Wang Lirong Zheng Xu Zou Zizhun Wang Dabing Li keke huang Weitao Zheng Key Laboratory of Mobile Materials MOE and School of Materials Science&Engineeringand Electron Microscopy Centerand International Center of Future ScienceJilin UniversityChangchun 130012China State Key Laboratory of Chem/Bio-Sensing and Chemometrics Provincial Hunan Key Laboratory for Graphene Materials and DevicesCollege of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China Department of Mechanical and Mechatronics Engineering University of WaterlooWaterloo Canada Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China State Key Laboratory of Luminescence and Applications Changchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of ChemistryJilin UniversityChangchun 130012China

The interaction between electrode materials and charge carriers is one of the central issues dominating underlying energy storage mechanisms.To address the notoriously significant volume changes accompanying intercalation or formation of alloy/compounds,we aim to introduce and utilize a weak,reversible Fe-N interaction during the(de)intercalation of ammonium ions(NH_(4)^(+))within iron(Ⅲ)hexacyanoferrate(FeHCF),inspired by manipulating the electrostatic adsorption between N and Fe in the early stages of ammonia synthesis(Bosch-Harber Process,Chemical Engineering)and steel nitriding processes(Metal Industry).Such strategy of switching well-balanced Fe-N interaction is confirmed in between the nitrogen of ammonium ions and highspin Fe in FeHCF,as observed by using X-ray absorption spectroscopy.The resulting material provided an extremely stable energy storage(58 mAh g^(-1) after 10000 cycles at current density of 1 A g^(-1))as well as high-rate performance(23.6 mAh g^(-1) at current density of 10 A g^(-1)).

关键词： ammonium ion battery Iron(Ⅲ)hexacyanoferrate reversible Fe-N interaction stability

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Electron transfer in Cu/Cu_(2)O generated by disproportionation promoting efficient CO_(2)photoreduction

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Nano Research 2022年第8期15卷 7099-7106页

作者： Qian Zhu Kainan Zhu Minmin Cai Yaowen Zhang Zhiyu Shao Mengpei Jiang Xiyang Wang Zhibin Geng Xiaofeng Wu Manrong Li keke huang Shouhua Feng State Key Laboratory of Inorganic Synthesis and Preparative Chemistry Jilin Provincial International Cooperation Key Laboratory of Advanced Inorganic Solid Functional Materials College of ChemistryJilin UniversityChangchun 130012China Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education School of ChemistrySun Yat-Sen UniversityGuangzhou 510275China

Constructing a high-efficiency composite material for CO_(2)photoreduction is a key step to the achievement of carbon neutralization,but a comprehensive understanding of the factors that dictate CO_(2)reduction activity remains elusive.Here,we constructed a series of Cu in situ combined on Cu_(2)O(Cu/Cu_(2)O-1,-2,-3)via an acid disproportionation method with various processing time.The optimal photocatalyst(Cu/Cu_(2)O-2)affords CO at a rate of 10.43μmol·g^(−1)·h^(−1),which is more than fourfold to that of pristine Cu_(2)O.Electron transfer in the samples was detected by X-ray absorption spectroscopy(XAS)as well as X-ray photoelectron spectroscopy(XPS).Interestingly,the best photoreduction performance was not achieved by the sample possessing the most electron transfer(Cu/Cu_(2)O-1)but by the one with moderate electron transfer(Cu/Cu_(2)O-2).By virtue of density functional theory(DFT)calculations,a linear relationship between Bader charge variation(Δq)of the active sites and adsorption energy of CO_(2)reduction intermediates was discovered,wherein the moderate charge transfer corresponds to appropriate adsorption energy,which benefits CO_(2)photoreduction activity substantially.This work provides guidance for the construction of composite catalysts for efficient CO_(2)photoreduction in a perspective of the quantity of electron transfer.

关键词： CO_(2)photocatalytic conversion charge transfer composite density functional theory(DFT)

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New perspective on the synthesis of highly efficient composites:regulating influence distance of interfacial charge transfer

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Science Bulletin 2018年第4期63卷 203-205页

作者： keke huang Zhibin Geng Yu Sun Shouhua Feng State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of Chemistry Jilin University

Interface effect is one of the central topics for decades[1–3].For inorganic composites,interface effect is mainly induced by interface stress[4]and interface charge transfer[4–6],in which interface charge transfer ... 详细信息

关键词：费用距离界面调整合成电子状态化学性质接口

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