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河南化工 2024年第8期41卷 38-39,52页

作者：卢磊邹柯柯河南神马尼龙化工有限责任公司河南平顶山467000

针对苯部分加氢法生产环己醇工艺中萃取精馏塔萃取剂纯度降低现象,通过分析脱水过程、萃取精馏过程以及开停车过程等,确定了一些影响萃取精馏塔萃取剂纯度降低的原因。提出了相应的优化措施,有效地稳定了环己醇装置的生产。

关键词：环己醇二甲基乙酰胺减压精馏醋酸

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浅谈仪器分析实验教学改革与实践

科教导刊 2013年第11期 80-81页

作者：刘辉邹可可赵东旺郑州师范学院化学系河南郑州450044 郑州大学化学与分子工程学院河南郑州450052

文章分析了仪器分析实验教学中存在的普遍问题,阐述了本院在仪器分析实验教学改革方面所进行的积极探索,以期对改进和完善仪器分析实验教学提供参考和借鉴。

关键词：仪器分析实验教学教学改革

基于LSTM-GRU的污水水质预测模型研究

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能源与环保 2021年第12期43卷 59-63页

作者：邹可可李中原穆小玲李铁生于福荣河南省平顶山水文水资源勘测局河南平顶山467000 河南省水文水资源局河南郑州450003 河南省郑州水文水资源勘测局河南郑州450006 郑州大学化学与分子工程学院河南郑州450052 华北水利水电大学河南郑州450046

水质预测对水资源管理及水体保护至关重要,为提高污水水质预测模型准确率,考虑到水质参数是一个动态的时间序列,在研究RNN神经网络模型基础上,引入一种改进的长—短记忆网络结构(LSTM-GRU)来增加RNN的隐层,GRU和LSTM采用门结构代替标准... 详细信息

水质预测对水资源管理及水体保护至关重要,为提高污水水质预测模型准确率,考虑到水质参数是一个动态的时间序列,在研究RNN神经网络模型基础上,引入一种改进的长—短记忆网络结构(LSTM-GRU)来增加RNN的隐层,GRU和LSTM采用门结构代替标准RNN结构中的隐藏单元,可以选择性地记忆重要信息而忘记不重要信息,从而高效学习历史水质参数信息,使得预测结果更加精确。通过仿真分析,本文采用的LSTM-GRU模型与传统的污水水质参数预测模型相比,LSTM-GRU模型的泛化能力更强,预测精度更高,有效性及实用性更强。

关键词：水质预测神经网络长—短记忆模型门控循环单元

A NONLOCAL KRONECKER-BASIS-REPRESENTATION METHOD FOR LOW-DOSE CT SINOGRAM RECOVERY

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Journal of Computational Mathematics 2024年第4期42卷 1080-1108页

作者： Jian Lu Huaxuan Hu Yuru zou Zhaosong Lu Xiaoxia Liu keke Zu Lin Li Shenzhen Key Laboratory of Advanced Machine Learning and Applications College of Mathematics and StatisticsShenzhen UniversityShenzhen 518060China National Center for Applied Mathematics Shenzhen(NCAMS) Shenzhen 518055China Department of Industrial and Systems Engineering University of Minnesota Twin CitiesMinneapolisMN55455USA Department of Applied Mathematics The Hong Kong Polytechnic UniversityHong Kong SARChina School of Electronic Engineering Xidian UniversityXi'an 710071China

Low-dose computed tomography(LDCT)contains the mixed noise of Poisson and Gaus-sian,which makes the image reconstruction a challenging *** order to describe the statistical characteristics of the mixed noise,we adopt the sinogram preprocessing as a stan-dard maximum a posteriori(MAP).Based on the fact that the sinogram of LDCT has non-local self-similarity property,it exhibits low-rank *** conventional way of solving the low-rank problem is implemented in matrix forms,and ignores the correlations among similar patch *** avoid this issue,we make use of a nonlocal Kronecker-Basis-Representation(KBR)method to depict the low-rank problem.A new denoising model,which consists of the sinogram preprocessing for data fidelity and the nonlocal KBR term,is developed in this *** proposed denoising model can better illustrate the generative mechanism of the mixed noise and the prior knowledge of the ***-merical results show that the proposed denoising model outperforms the state-of-the-art algorithms in terms of peak-signal-to-noise ratio(PSNR),feature similarity(FSIM),and normalized mean square error(NMSE).

关键词： Low-dose computed tomography Kronecker-basis-representation Low-rank imation.Noise-generating-mechanism

Immunoregulatory effects of human amniotic mesenchymal stem cells and their exosomes on human peripheral blood mononuclear cells

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BIOCELL 2023年第5期47卷 1085-1093页

作者： XIN TIAN XIANGLING HE SHUQIN QIAN RUNYING zou keke CHEN CHENGGUANG ZHU ZEXI YIN Department of Hematology and Oncology Children’s Medical CenterThe First Affiliated Hospital of Hunan Normal UniversityChangsha410005China

Background:The immunomodulatory effects of mesenchymal stem cells(MSCs)and their exosomes have been receiving increasing *** study investigated the immunoregulatory effects of human amniotic mesenchymal stem cells(hAMSCs)and their exosomes on phytohemagglutinin(PHA)-induced peripheral blood mononuclear cells(PBMCs).Methods:The hAMSCs used in the experiment were identified by light microscopy and flow cytometry,and the differentiation ability of the cells was determined by Oil Red O and Alizarin Red *** expressions of transforming growth factor(TGF)-β,indoleamine 2,3-dioxygenase(IDO),cyclooxygenase-2(COX-2),hepatocyte growth factor(HGF),and interleukin(IL)-6 were detected by quantitative real-time polymerase chain reaction and western ***,hAMSCs,and their exosomes were collected for in vitro group *** the immunoregulatory ability of hAMSCs and their exosomes were analyzed by flow cytometry and Enzymelinked immunosorbent ***:The hAMSCs and exosomes were successfully extracted from the human amniotic ***-β,IDO,COX-2,HGF,and IL-6 were significantly expressed in *** vitro co-culture showed that hAMSCs promoted the proliferation of Th2 cells in PHA-induced PBMCs,while hAMSCs and exosomes inhibited the secretion of TNF-αin PHA-induced PBMCs,and promoted the secretion of IL-4 and IL-10,and hAMSCs had more significant effects than ***:hAMSCs or exosomes could exert immunoregulatory effects on PHA-induced PBMCs by affecting Th2 cell proliferation and cytokine secretion.

关键词： hAMSCs Exosomes Immunomodulatory effects

Switching Optimally Balanced Fe-N Interaction Enables Extremely Stable Energy Storage

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Energy & Environmental Materials 2023年第2期6卷 275-283页

作者： Zhenzhen Zhao Wei Zhang Miao Liu Dong Wang Xiyang Wang Lirong Zheng Xu zou Zizhun Wang Dabing Li keke Huang Weitao Zheng Key Laboratory of Mobile Materials MOE and School of Materials Science&Engineeringand Electron Microscopy Centerand International Center of Future ScienceJilin UniversityChangchun 130012China State Key Laboratory of Chem/Bio-Sensing and Chemometrics Provincial Hunan Key Laboratory for Graphene Materials and DevicesCollege of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China Department of Mechanical and Mechatronics Engineering University of WaterlooWaterloo Canada Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China State Key Laboratory of Luminescence and Applications Changchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of ChemistryJilin UniversityChangchun 130012China

The interaction between electrode materials and charge carriers is one of the central issues dominating underlying energy storage *** address the notoriously significant volume changes accompanying intercalation or formation of alloy/compounds,we aim to introduce and utilize a weak,reversible Fe-N interaction during the(de)intercalation of ammonium ions(NH_(4)^(+))within iron(Ⅲ)hexacyanoferrate(FeHCF),inspired by manipulating the electrostatic adsorption between N and Fe in the early stages of ammonia synthesis(Bosch-Harber Process,Chemical Engineering)and steel nitriding processes(Metal Industry).Such strategy of switching well-balanced Fe-N interaction is confirmed in between the nitrogen of ammonium ions and highspin Fe in FeHCF,as observed by using X-ray absorption *** resulting material provided an extremely stable energy storage(58 mAh g^(-1) after 10000 cycles at current density of 1 A g^(-1))as well as high-rate performance(23.6 mAh g^(-1) at current density of 10 A g^(-1)).

关键词： ammonium ion battery Iron(Ⅲ)hexacyanoferrate reversible Fe-N interaction stability

Milk fat globule epithelial growth factorⅧ(MFG-E8)sustains survival of cancer cells by prompting tumor angiogenesis and suppressing host immunities

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Oncology and Translational Medicine 2017年第1期3卷 31-37页

作者： keke Nie Shichao Liu Ling Zhang Zhongfa Zhang Xiao zou Youxin Ji Oncology Department Qingdao Cancer HospitalQingdao 266042China Oncology Department Qingdao Central HospitalThe 2nd Affiliated Hospital of Qingdao UniversityQingdao 266042China

Milk fat globule epithelial growth factor VIII(MFG-E8) is a novel adhesion protein mainly produced by macrophages and dendritic cells; it is expressed in most of the human tissues and functions to prompt cancer progression and survival. MFG-E8 contains a signal sequence for secretion, two epidermal growth factor(EGF)-like domains at the NH2 terminus and two discoidin domains with blood-clotting factor V/factor Ⅷ(C1 and C2) at the COOH terminus. The second EGF domain contains an arginine-glycine-aspartic(RGD) integrin-binding motif that engages α_vβ_5 integrins to facilitate cell adhesion and induce integrinmediated signal transduction. Integrin α_vβ_3 associates with VEGF receptor 2, engagement of integrins can promote angiogenesis, which plays key roles in growth, proliferation, and survival of cancer cells. VEGF stimulates the expression of α_vβ_3 and α_vβ_5 integrins on angiogenic vasculature, thereby potentiating effects of VEGF receptor engagement. Mice expressing a mutant form of α_vβ_3 integrin are unable to undergo tyrosine phosphorylation, confirming the important role that this integrin plays in pathological angiogenesis and providing important mechanistic insights. The C-terminus discoidin-like domains promote binding to membrane phospholipids, functioning close to VEGF like angiogenesis. MFG-E8 is an opsonin for apoptotic cells, and it acts as a bridging protein between apoptotic cells and phagocytes. It also influences cell immunities by altering CD4^+ and/or CD8^+ cells. Antibody or small peptide works with MFG-E8 at different functional sites or interacts with EGF-like domains and/or discoidin-like domains may play an important role in anti-angiogenesis or immune restoration. Altering the structures and/or functions of MFG-E8 and/or its domains is promising for development of novel anti-cancer strategies.

关键词： milk fat globule epithelial growth factor Ⅷ(MFG-E8) carcinoma target therapy angiogenesis apoptosis

基于含治愈患者生存数据的Cox-TEL方法性能的模拟研究

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南方医科大学学报 2024年第6期44卷 1182-1187页

作者：邹碧清徐利珊李柯柯安胜利南方医科大学公共卫生学院生物统计学系广东广州510515

目的探究针对长期生存数据的Cox比例风险模型的Taylor拓展调整(Cox-TEL)方法在含治愈患者的生存数据下的适用条件与适用范围。方法基于Weibull分布模拟生存数据方法,模拟生成不同治愈率、删失率和治愈率差值的生存数据。然后基于Cox-... 详细信息

目的探究针对长期生存数据的Cox比例风险模型的Taylor拓展调整(Cox-TEL)方法在含治愈患者的生存数据下的适用条件与适用范围。方法基于Weibull分布模拟生存数据方法,模拟生成不同治愈率、删失率和治愈率差值的生存数据。然后基于Cox-TEL方法进行分析,获得Ⅰ类错误和检验效能对其表现性能进行评价。结果针对模型的未治愈部分,Cox-TEL方法的Ⅰ类错误略高于0.05,其检验效能在样本量较大、治愈率差值较大时较为理想。针对治愈部分,Cox-TEL方法的Ⅰ类错误能够较好的控制在0.05左右,且在大多数情况下都能保持较高的检验效能。结论 Cox-TEL方法在多数情况下,比如样本量较大、删失率较低、组间治愈率差值较大时,能有效分析未治愈患者数据,得到较可靠的风险比HR值;在不同的样本量、删失率和治愈率下,该方法都能较准确地估计出治愈患者两组治愈率差值。

关键词： Cox-TEL 治愈模型生存分析检验效能

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基于特征融合的双模态低辨识度目标识别

中国机械工程 2021年第10期32卷 1205-1212,1221页

作者：吴愿薛培林殷国栋黄文涵耿可可邹伟东南大学机械工程学院南京211189

针对单一彩色相机对低辨识度目标识别准确率低的问题,提出了一种利用彩色相机和红外热成像仪同时检测自动驾驶目标的方案。为了同时提取彩色图像的颜色特征与红外图像的温度特征,在单模态YOLOv3网络基础上改进网络结构得到双模态YOLOv3... 详细信息

针对单一彩色相机对低辨识度目标识别准确率低的问题,提出了一种利用彩色相机和红外热成像仪同时检测自动驾驶目标的方案。为了同时提取彩色图像的颜色特征与红外图像的温度特征,在单模态YOLOv3网络基础上改进网络结构得到双模态YOLOv3神经网络,并设计四种特征融合对比实验以确定最佳融合方案;建立双模态数据集同步采集系统,采集彩色图像与红外图像对并用于双模态网络的训练与测试;使用未经网络训练的验证集得到4种双模态特征融合模型的平均精度值与损失值。实验结果表明,在训练30次后,该双模态网络模型的平均精度值最高可达59.42%。

关键词：低辨识度目标识别双模态YOLOv3神经网络双模态数据集特征融合

既往血吸虫感染者体检数据分析及其与脂肪肝、冠心病的关系

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中国热带医学 2019年第1期19卷 85-88页

作者：邹卓群孙可可关国跃华东疗养院老年病科江苏无锡214065

目的了解既往血吸虫感染者的健康状况,并研究其与脂肪肝、冠心病的关系。方法在华东疗养院2016年6万余例体检人群中,筛选出既往血吸虫感染者272人为研究对象;采用计算机产生的随机数字以1∶100的比例,从同期体检人群中抽取277人为对照... 详细信息

目的了解既往血吸虫感染者的健康状况,并研究其与脂肪肝、冠心病的关系。方法在华东疗养院2016年6万余例体检人群中,筛选出既往血吸虫感染者272人为研究对象;采用计算机产生的随机数字以1∶100的比例,从同期体检人群中抽取277人为对照组。收集研究对象的详细病史、彩色多普勒超声和实验室检查结果。利用Logistic回归分析既往血吸虫感染与脂肪肝、冠心病等疾病的关系。结果既往血吸虫感染组中脂肪肝和冠心病患病人数分别为26例和5例,对照组相应为119例和14例,两组比较差异均有统计学意义(P<0.05);既往血吸虫感染组的TG、AIP、空腹血糖以及血小板分别为(1.28±0.67)mmol/L、(-0.08±0.27)、(5.82±1.19)mmol/L和(182.01±49.20)×109/L,均比对照组的(1.79±1.26)mmol/L、(0.11±0.30)、(6.09±1.63)mmol/L和(199.22±47.03)×109/L低,两组比较差异均有统计学意义(P<0.05);既往血吸虫感染组的HDL-C为(1.42±0.35)mmol/L1、总胆红素为(14.59±5.08)μmol/L,分别与对照组的(1.22±0.34)mmol/L和(13.26±4.38)μmol/L比较差异均有统计学意义(P<0.05)。结论既往血吸虫感染者高血压、糖尿病患病率与同年龄段人群相仿,但既往血吸虫感染可能与轻度脂肪肝、冠心病呈负相关。

关键词：既往血吸虫感染脂肪肝冠心病