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World Integrated Medicine Master chen keji

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World Journal of Integrated Traditional and Western Medicine 2018年第2期4卷 1-5页

作者： zou jianhua chen keji wjim 不详

Interview Time:15:00,April 2nd,2018 Location:Office of Academician chen keji Interviewer:Professor Zou Jianhua,Associate Editor-in-Chief of WJIM Interviewee:Academician chen keji Introduction of chen keji The senior academician of the Chinese Academy of Sciences,*** keji is the national master of traditional Chinese medicine,honorary and lifelong researcher of the China Academy of Chinese Medical Sciences,scientific innovation strategic consultant of National Health and Family Planning Commission,and expert consultant of State Administration of Traditional Chinese *** is the member of the Expert Advisory Committee of the Central Health Care Committee,Chairman of the Senior Expert Advisory Committee of World Federation of Chinese Medicine Societies,honorary President of China Association of Integrative Medicine and China Geriatrics Society Association,President of Chinese and Western Medicine Doctors Branches of Chinese Medical Doctor Association,senior expert of the expert committee of National Heart Center,of Clinical Center for National Neuroscience,and of Clinical Medical Research Center for National Geriatric Committee.

关键词： Chinese Academy honorary Planning Commission

硅基聚合物耐高温衍生陶瓷涂层制备与应用研究进展

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材料工程 2024年第4期52卷 12-23页

作者：陈科吉李鹏飞徐彩虹吴子剑张宗波哈尔滨理工大学材料科学与化学工程学院哈尔滨150000 中国科学院化学研究所北京100190

随着航空航天领域的不断发展,金属以及碳材料等高温结构部件的服役条件日益苛刻。通过恰当的工艺在高温结构部件表面制备硅基陶瓷涂层并赋予其特殊性能,可有效提高高温结构部件的使用寿命。近年来,聚合物前驱体转化陶瓷涂层逐渐成为一... 详细信息

随着航空航天领域的不断发展,金属以及碳材料等高温结构部件的服役条件日益苛刻。通过恰当的工艺在高温结构部件表面制备硅基陶瓷涂层并赋予其特殊性能,可有效提高高温结构部件的使用寿命。近年来,聚合物前驱体转化陶瓷涂层逐渐成为一种无机涂层制备的新方法。该方法具有制备工艺简便、涂层功能拓展性强等特点,得到了研究者越来越多的关注。本文主要综述了硅基聚合物前驱体转化陶瓷涂层的研究进展。首先从聚合物陶瓷涂层的制备展开,简要介绍了硅基聚合物前驱体、填料种类以及涂覆工艺和裂解方式对涂层结构以及性能的影响。随后,重点讨论了聚合物前驱体转化陶瓷涂层在耐高温防护领域,包括抗氧化、环境障、热障涂层的应用进展。最后,指出了聚合物陶瓷涂层在涂层性能提升及缺陷控制等方面的问题,并对其发展方向进行了展望,例如通过在硅基前驱体中引入Hf,Zr,Ta等超高温元素,提高陶瓷涂层的耐温等级,以及发展高效的陶瓷化新技术,从而提高陶瓷转化效率及涂层适用性范围等。

关键词：聚合物前驱体转化法陶瓷涂层高温防护抗氧化环境障热障

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π形山脉主山脊线风速加速效应研究

湖南大学学报（自然科学版） 2024年第1期51卷 170-179页

作者：鲍旭明楼文娟廖孙策林晨琦陈科技卞荣浙江大学结构工程研究所浙江杭州310058 国网浙江省电力有限公司经济技术研究院浙江杭州310008

为研究真实地形的加速效应,提取真实地形的几何特征建立理想简化地形,提出一种π形山脉模型.采用CFD数值模拟研究顺子山脉风向下子山脉间距、长度及坡度对主山脊线加速效应的影响,结合地形特征比较π形山脉与三维余弦山脉的主山脊线加... 详细信息

为研究真实地形的加速效应,提取真实地形的几何特征建立理想简化地形,提出一种π形山脉模型.采用CFD数值模拟研究顺子山脉风向下子山脉间距、长度及坡度对主山脊线加速效应的影响,结合地形特征比较π形山脉与三维余弦山脉的主山脊线加速比差异,在后者基础上获得π形山脉主山脊线特征点的风速加速比简化计算公式,并通过一处真实π形山脉加以验证.结果表明:π形山脉主山脊线中点的加速比受子山脉间距、长度影响较大,而山脊线交点的加速比受子山脉长度、坡度影响较大;与三维余弦山脉相比,π形山脉主山脊线加速比在山脊线端部相同,但整体偏小,尤其受子山脉遮挡的部分显著偏小,超过离地70 m高度后差异基本消失;通过与真实π形山脉的风场比较,发现简化地形和简化计算公式能较好反映真实地形主山脊线特征点的加速效应.

关键词：山脉简化地形加速比计算流体力学(CFD) 数值模拟

山区输电线路跳线风偏状态方程及临界风速研究

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哈尔滨工业大学学报 2024年第3期56卷 164-170页

作者：陈科技卞荣鲍旭明顾逸楼文娟徐海巍张琳琳国网浙江省电力有限公司经济技术研究院杭州310008 浙江大学结构工程研究所杭州310058

为研究山区微地形中的竖向风速对跳线风偏的影响,基于刚性直棒法对导线、跳线及绝缘子串增加竖向风荷载分析,确定跳线处最大风偏位移值作为风偏指标,建立风荷载作用前后跳线静力平衡平面的几何变换关系,提出了考虑竖向风速影响的跳线风... 详细信息

为研究山区微地形中的竖向风速对跳线风偏的影响,基于刚性直棒法对导线、跳线及绝缘子串增加竖向风荷载分析,确定跳线处最大风偏位移值作为风偏指标,建立风荷载作用前后跳线静力平衡平面的几何变换关系,提出了考虑竖向风速影响的跳线风偏状态方程。建立半径5 km的地形模型,包含跳线风偏事故地点与微气象站点,采用数值模拟方法将微气象站点风速推演到事故地点风速,获得了考虑微地形影响的跳线风偏闪络事故风速。将事故线路参数及竖向风速代入跳线风偏状态方程,得到跳线风偏临界水平风速,通过与事故风速进行比较验证了跳线风偏状态方程的可靠性。最后根据风偏状态方程分析竖向风速的变化对跳线风偏临界水平风速的影响。结果表明:随着竖向风速的增大,跳线风偏临界水平风速线性减小,当风攻角为20°时临界水平风速可降低16%。考虑竖向风速影响的跳线风偏临界水平风速取值较为安全,建议在山区输电线路跳线设计过程中加以考虑。

关键词：跳线风偏状态方程临界风速竖向风速数值模拟微地形

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输电线路跳线风偏共振响应特性及风振系数分析

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振动与冲击 2024年第16期43卷 1-8页

作者：楼文娟周为政卞荣陈科技黄增浩浙江大学结构工程研究所杭州310058 国网浙江省电力有限公司经济技术研究院杭州310008 南方电网科学研究院有限责任公司广州510663

该研究构建了跳线-导线-绝缘子串精细化有限元耦合模型,进行脉动风荷载作用下的动力响应分析,着重探究了跳线风偏与导线风偏动力特性的差异性。阐明了导、跳线在模态、气动阻尼比等动力特性上存在明显不同的特征,采用频域法结合多工况分... 详细信息

该研究构建了跳线-导线-绝缘子串精细化有限元耦合模型,进行脉动风荷载作用下的动力响应分析,着重探究了跳线风偏与导线风偏动力特性的差异性。阐明了导、跳线在模态、气动阻尼比等动力特性上存在明显不同的特征,采用频域法结合多工况分析,研究了平均风速、湍流度、跳线悬垂串质量及振型组合阶数对导、跳线脉动背景响应及共振响应的影响。研究结果表明,跳线基频约为导线的1.5倍~2.0倍,并且气动阻尼效应对跳线风偏的影响远小于导线。导线脉动风偏位移响应以背景响应为主,而共振响应并不明显,但跳线脉动风偏位移响应的共振分量不可忽略,产生的共振增量可使跳线脉动风偏位移增大30%以上。跳线共振响应特性由跳线自身动力特性决定,受来流平均风速、湍流度影响较小,1阶振型对跳线共振响应起决定作用。该研究基于准静态法及惯性力法推导了峰值脉动风力共振部分,引入共振因子,修正了DL/T 5551-2018《架空输电线路荷载规范》中跳线风振系数表达式。修正的跳线风振系数最终相较DL/T 5551-2018《架空输电线路荷载规范》增大约9%~12%。

关键词：输电线路跳线风偏气动阻尼共振频域法风振系数

Bile acid coordinates microbiota homeostasis and systemic immunometabolism in cardiometabolic diseases

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Acta Pharmaceutica Sinica B 2022年第5期12卷 2129-2149页

作者： Baoyi Guan Jinlin Tong Haiping Hao Zhixu Yang keji chen Hao Xu Anlu Wang Xiyuan Hospital China Academy of Chinese Medical SciencesBeijing 100091China National Clinical Research Center for Chinese Medicine Cardiology Beijing 100091China State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 210009China

Cardiometabolic disease(CMD), characterized with metabolic disorder triggered cardiovascular events, is a leading cause of death and disability. Metabolic disorders trigger chronic low-grade inflammation, and actually, a new concept of metaflammation has been proposed to define the state of metabolism connected with immunological adaptations. Amongst the continuously increased list of systemic metabolites in regulation of immune system, bile acids(BAs) represent a distinct class of metabolites implicated in the whole process of CMD development because of its multifaceted roles in shaping systemic immunometabolism. BAs can directly modulate the immune system by either boosting or inhibiting inflammatory responses via diverse mechanisms. Moreover, BAs are key determinants in maintaining the dynamic communication between the host and microbiota. Importantly, BAs via targeting Farnesoid X receptor(FXR) and diverse other nuclear receptors play key roles in regulating metabolic homeostasis of lipids, glucose, and amino acids. Moreover, BAs axis per se is susceptible to inflammatory and metabolic intervention, and thereby BAs axis may constitute a reciprocal regulatory loop in metaflammation. We thus propose that BAs axis represents a core coordinator in integrating systemic immunometabolism implicated in the process of CMD. We provide an updated summary and an intensive discussion about how BAs shape both the innate and adaptive immune system, and how BAs axis function as a core coordinator in integrating metabolic disorder to chronic inflammation in conditions of CMD.

关键词： Bile acid Nuclear receptors Cardiometabolic diseases Systemic immunometabolism Therapeutic opportunities

基于BP-Adaboost算法的输电塔-线结构整体可靠性分析

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广东电力 2024年第5期37卷 112-120页

作者：陈科技彭思思王秀龙王涛李茂华李正良国网浙江省电力有限公司经济技术研究院浙江杭州310008 重庆大学土木工程学院重庆400045 国家电网有限公司北京100031 中国电力科学研究院有限公司北京100055

针对传统结构可靠性分析方法的应用局限性和计算成本较大等不足,引入BP-Adaboost集成学习算法,提出一种准确高效、简单易行的输电塔线结构整体可靠性分析方法。首先,建立输电塔线结构有限元分析模型,分析结构的失效准则并推导相应的极... 详细信息

针对传统结构可靠性分析方法的应用局限性和计算成本较大等不足,引入BP-Adaboost集成学习算法,提出一种准确高效、简单易行的输电塔线结构整体可靠性分析方法。首先,建立输电塔线结构有限元分析模型,分析结构的失效准则并推导相应的极限状态功能函数;然后,将BP-Adaboost集成学习算法与蒙特卡洛模拟方法相结合,建立高精度预测模型来替代分析过程复杂的有限元模型,提出基于BP-Adaboost模型的输电塔线结构整体可靠性分析方法;最后,通过数值算例对所提方法进行应用与验证,证明所提方法具有更高的精度和效率,并进一步将其应用于实际输电塔线结构工程,分析多失效模式下输电塔线结构的整体可靠性。

关键词：输电塔线结构整体可靠性失效准则 BP-Adaboost 机器学习

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Diabetic vascular diseases:molecular mechanisms and therapeutic strategies

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Signal Transduction and Targeted Therapy 2023年第5期8卷 2151-2179页

作者： Yiwen Li Yanfei Liu Shiwei Liu Mengqi Gao Wenting Wang keji chen Luqi Huang Yue Liu National Clinical Research Center for Chinese Medicine Cardiology Xiyuan HospitalChinese Academy of Chinese Medical SciencesBeijing100091China The Second Department of Gerontology Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing100091China Department of Nephrology and Endocrinology Wangjing HospitalChina Academy of Chinese Medical SciencesBeijing100102China China Center for Evidence-based Medicine of TCM China Academy of Chinese Medical SciencesBeijing100010China

Vascular complications of diabetes pose a severe threat to human *** and treatment protocols based on a single vascular complication are no longer suitable for the long-term management of patients with *** panvascular disease(DPD)is a clinical syndrome in which vessels of various sizes,including macrovessels and microvessels in the cardiac,cerebral,renal,ophthalmic,and peripheral systems of patients with diabetes,develop atherosclerosis as a common *** manifestations of DPDs usually manifest macrovascular atherosclerosis,as well as microvascular endothelial function impairment,basement membrane thickening,and ***,cerebral,and peripheral microangiopathy coexist with microangiopathy,while renal and retinal are predominantly *** following associations exist between DPDs:numerous similar molecular mechanisms,and risk-predictive relationships between *** glycemic control combined with early comprehensive vascular intervention is the key to prevention and *** addition to the widely recommended metformin,glucagon-like peptide-1 agonist,and sodium-glucose cotransporter-2 inhibitors,for the latest molecular mechanisms,aldose reductase inhibitors,peroxisome proliferator-activated receptor-γagonizts,glucokinases agonizts,mitochondrial energy modulators,*** under active *** are proposed for patients to obtain more systematic clinical care requires a comprehensive diabetes care center focusing on panvascular *** would leverage the advantages of a cross-disciplinary approach to achieve better integration of the pathogenesis and therapeutic *** a strategy would confer more clinical benefits to patients and promote the comprehensive development of DPD as a discipline.

关键词： therapeutic Diabetic prevention

Harmonically trapped quasi-two-dimensional Fermi gases with synthetic spin-orbit coupling

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Science China(Physics,Mechanics & Astronomy) 2016年第9期59卷 69-76页

作者： JingKunWang JinGe chen keji chen Wei Yi Wei Zhang Department of Physics Renmin University of China Department of Physics The Chinese University of Hong Kong Key Laboratory of Quantum Information University of Science and Technology of China Chinese Academy of Sciences Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of China Beijing Key Laboratory of Opto-Electronic Functional Materials and Micro-nano Devices Renmin University of China

We study the properties of spin-orbit coupled and harmonically trapped quasi-two-dimensional Fermi gas with tunable s-wave interaction between the two spin species. We adapt an effective two-channel model which takes the excited states occupation in the strongly confined axial direction into consideration by introducing dressed molecules in the closed channel, and use a Bogoliubovde Gennes(BdG) formalism to go beyond local density approximation. We find that both the in-trap phase structure and density distribution can be significantly modified near a wide Feshbach resonance compared with the single-channel model without the dressed molecules. Our findings will be helpful for the experimental search for the topological superfluid phase in ultracold Fermi gases.

关键词：自旋轨道耦合费米气体二维囚禁 Feshbach共振合成通道模型局域密度近似