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Daikenchuto (Da-Jian-Zhong-Tang) ameliorates intestinal fibrosis by activating myofibroblast transient receptor potential ankyrin 1 channel

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World Journal of Gastroenterology 2018年第35期24卷 4036-4053页

作者： keizo hiraishi Lin-Hai Kurahara Miho Sumiyoshi Yao-Peng Hu Kaori Koga Miki Onitsuka Daibo Kojima Lixia Yue Hidetoshi Takedatsu Yu-Wen Jian Ryuji Inoue Department of Physiology Graduate School of Medical Sciences Fukuoka University Department of Pathology Faculty of Medicine Fukuoka University Department of Gastroenterological Surgery Faculty of Medicine Fukuoka University Department of Cell Biology University of Connecticut Health Center Department of Gastroenterology and Medicine Faculty of Medicine Fukuoka University College of Letters and Science University of CaliforniaDavis

AIM To investigate the anti-fibrotic effects of the traditional oriental herbal medicine Daikenchuto(DKT) associated with transient receptor potential ankyrin 1(TRPA1) channels in intestinal myofibroblasts. METHODS Inflammatory and fibrotic changes were detected in a2,4,6-trinitrobenzenesulfonic acid(TNBS) chronic colitis model of wild-type and TRPA1-knockout(TRPA1-KO) mice via pathological staining and immunoblotting ***^(2+) imaging experiments examined the effects of DKT and its components/ingredients on intestinal myofibroblast(In Myo Fib) cell TRPA1 channel *** factors and transforming growth factor (TGF) -β1-associated signaling were tested in an In Myo Fib cell line by q PCR and immunoblotting *** from non-stenotic and stenotic regions of the intestines of patients with Crohn’s disease (CD) were used for pathological analysis. RESULTS Chronic treatment with TNBS caused more severe inflammation and fibrotic changes in TRPA1-KO than in wild-type mice.A one-week enema administration of DKT reduced fibrotic lesions in wild-type but not in TRPA1-KO *** active ingredients of DKT,i.e.,hydroxyα-sanshool and 6-shogaol,induced Ca^(2+) influxes in In Myo Fib,and this was antagonized by co-treatment with a selective TRPA1 channel blocker,*** counteracted TGF-β1-induced expression of TypeⅠcollagen andα-smooth muscle actin (α-SMA) ,which were accompanied by a reduction in the phosphorylation of Smad-2 and p38-mitogen-activated protein kinase (p38-MAPK) and the expression of ***,24-h incubation with a DKT active component Japanese Pepper increased the m RNA and protein expression levels of TRPA1 in In Myo Fibs,which in turn negatively regulated collagen *** the stenotic regions of the intestines of CD patients,TRPA1 expression was significantly *** The effects of DKT on the expression and activation of the TRPA1 channel could be advantageous for suppressing intestinal fibrosis

关键词： Intestinal fibrosis Myofibroblast Transient receptor potential ankyrin 1 Crohn’s disease Collagen α-smooth muscle actin

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Energy conversion due to non-ideal electric field in separatrix region of magnetotail reconnection

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Earth and Planetary Physics 2024年第5期8卷 787-796页

作者： YiNan Liu keizo Fujimoto JianQiang Wang XiaoChuan Duan School of Space and Environment Beihang University Key Laboratory of Space Environment Monitoring and Information Processing Ministry of Industry and Information Technology School of Automation Science and Electrical Engineering Beihang University

A recent satellite observation has revealed the presence of energy conversion in the separatrix region(SR) of magnetotail reconnection, driven by perpendicular components. We investigated this phenomenon by means of particle-in-cell simulations in twodimensional(2D) and three-dimensional(3D) systems. Our result indicates that in the 2D simulation, energy conversion in the SR is dominated by parallel components, with the main influencing factor being the parallel electric field, which is not consistent with the observation. However, a case that is similar to the observation is found in the 3D simulation, suggesting that the observation result may be attributed to the 3D characteristics. Our findings provide a potential explanation for the satellite observation.

关键词： magnetic reconnection energy conversion PIC simulation separatrix region

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Bio-mimetic walking with distributed controlled wave gait

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Science China(Technological Sciences) 2010年第11期53卷 2925-2931页

作者： MIYAHARA keizo College of Systems Engineering Shibaura Institute of Technology

This paper describes a multi-agent mobile system that walks. In particular, the gate of the system can be considered as an expansion of the ordinary wave gate, since the class of system configuration is not restricted in a line shape. The system consists of a number of identical units with distributed controllers. The homogeneous units are mechanically connected to construct a mobile platform. Every unit has its local controller that communicates only with its adjacent units. This basic configuration of supervisor-less structure affirmatively confines the dependence of each unit to a local area, and therefore any unit can be removed from/add into any part of a system regardless of the timing without disturbing the performance of the whole system. This flexibility of configuration significantly contributes to easy maintenance of units, such as battery charging or hot-replacing for faulty units. Utilizing the flexibility as well, the system is capable of adapting to a variety of tasks including transportation application and to target objects having various kinds of shape and/or a wide range of mass. A proposed example unit contains a Gough-Stewart Platform, a symmetrical type of parallel link manipulator, as its leg. The whole mobile system is aimed at transportation platform, with high system flexibility, i.e., the system is able to adapt to wide range of target objects. The "digital actuation (D-actuation)" concept is applied to the local unit controller. D-actuation is a concept to drive a mechatronic system with numbers of "digital actuator (D-actuator)" that has only discrete stable states, such as pneumatic cylinders or solenoids. D-actuation yields great benefits: high repeatability, system simplicity, and low cost. Because of the simplicity of the communication data, the control strategy, and the concept of D-actuation, the controlling framework can be implemented as distributed and localized one on every unit. The Schlafli symbol is applied to denote the sys

关键词： wave gait dstributed control multi-agent system digital actuation

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Application of FEM Analysis to Braced Excavation

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Tsinghua Science and Technology 2008年第S1期13卷 40-45页

作者：李明飞 Atsushi Nakamura 蔡飞 keizo Ugai FORUM8 Co. Ltd. Department of Civil and Environmental Engineering Gunma University

It is becoming possible to do detailed numerical analyses for the various mechanical behavior of braced excavation by researching and developing the numerical analysis technique such as the finite element method (FEM). However, the mechanical behavior of braced excavation has not been clarified fully both in theory and in experience. Therefore, improving the prediction accuracy during the prior design is very important for making the observational method of braced excavation more effective. In this paper, FEM analyses were performed for a model of braced excavation by using Geotechnical Finite Element Elasto-plastic Analysis Software, GeoFEAS (2D). As the constitutive law of ground, MC-DP model, and Duncan-Chang model were applied. The results were compared and discussed with that of a site measurement, and the effects of the constitutive law of ground on the analyzed result were verified. For the difference between the results, the reason was investigated by the analyses adjusting the elastic modulus of ground, and the appropriate application of the constitutive law was researched.

关键词： numerical analysis retaining wall finite element method (FEM) constitutive law

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Optical near-field excitation using liquid crystals on nanostruc- tured photoreactive molecular thin films

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Science China(Physics,Mechanics & Astronomy) 2012年第8期55卷 1351-1355页

作者： OHDAIRA Yasuo SHINBO Kazunari BABA Akira KATO keizo KANEKO Futao Graduate School of Science and Technology Niigata University 2-8050 Ikarashi Nishi-ku Niigata City Niigata 950-2181 Japan Center for Transdisciplinary Research Niigata University 2-8050 Ikarashi Nishi-ku Niigata City Niigata 950-2181 Japan

Optical near-field excitations were investigated on the basis of molecular alignment control of liquid crystals (LCs) on an optically rewritable nanostructure of photoreactive molecular thin films. Twisted nematic (TN) cells of LC molecules were constructed utilizing ITO substrates with 260 nm gratings of an azobenzene molecular thin film, fabricated using standing evanescent waves. The polarization changes of light transmitted through the TN cells, which were due to the alignment changes of LC molecules locally rubbed by the azobenzene nanogratings, were observed. Furthermore, we demonstrated local plasmon excitation of Au nanowires deposited on the azobenzene nanogratings using oblique vacuum evaporation, a phenomenon that produced strong anti-optical absorption spectra. The modulation of the local plasmon resonance in metallic nanowires decorated with LC molecules was confirmed.

关键词： optical near-field azobenzene molecular thin film liquid crystal optical polarization local plasmon excitation

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A Simple Lumped Mass Model to Describe Velocity of Granular Flows in a Large Flume

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Journal of Mountain Science 2012年第2期9卷 221-231页

作者： YANG Qingqing CAI Fei UGAI keizo SU Zhiman HUANG Runqiu XU Qiang Department of Civil and Environmental Engineering Gunma University Kiryu 3768515 Japan Institute of Mountain Hazards and Environment Chinese Academy of Sciences Chengdu 610041 China State Key Laboratory of Geo-Hazard Prevention and Geo-Environment Protection Chengdu University of Technology Chengdu 610059 China

This paper presents a lumped mass model to describe the run-out and velocity of a series of large flume tests,which was carried out to investigate some propagation mechanisms involved in rapid,dry,dense granular flows and energy transformation when the flows encountered obstacles and reoriented their movement *** between predicted and measured results show that the trend of predicted velocities was basically matched with that of measured *** scrutiny of test videos reveals that subsequent particles with a higher velocity collided with slowed fronts to make them accelerate. However,this simple model cannot reflect collisions between particles because it treated released materials as a rigid ***,the predicted velocity was somewhat lower than the measured velocity in most *** the flow changed its direction due to the variation in slope inclination,the model predicted a decrease in *** predicted decrease in velocity was less than the measured one within a reasonable range of 10% or *** some cases in which a convexity was introduced,the model also predicted the same trend of velocities as measured in the *** velocity increased greatly after the materials took a ballistic trajectory from the vertex of the convexity,and reduced dramatically when they finally made contact with the base of the lower *** difference between prediced and measured decrease in velocity was estimated to be about 5% due to the ***,the simple lumped mass model based on the energy approach could roughly predict the run-out and velocity of granular flows,although it neglected internal deformation,intergranular collision and friction.

关键词： Granular flow Large-scale flume test Mass-front velocity Deposit characteristic

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Factors Affecting Minimum Foot Clearance in the Elderly Walking: A Multiple Regression Analysis

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Open Journal of Therapy and Rehabilitation 2015年第4期3卷 109-115页

作者： keizo Sato Division of Biomedical Engineering for Health & Welfare Tohoku University Sendai Japan

Because falls among the elderly can cause serious injury leading to a bedridden state, methods to maintain motor function in the elderly and prevent falls are important. Among falls by the elderly are tripping falls, in which the forefoot gets caught on the floor to cause the fall. Minimum foot clearance (MFC), the smallest distance between the floor and the foot during the swing phase of gait, has been given attention as a cause of tripping falls, as elderly people at risk of falling have been reported to have low MFC. No research has been done, however, to examine what geriatric factors determine MFC. In this study, various measurements were taken on muscle strength, joint angles, and other characteristics as factors possibly influencing the height of MFC, a multiple regression analysis was performed with MFC as the dependent variable, and those factors with high degrees of influence were extracted. The results revealed that the height of MFC is highly influenced by strength of the hip flexors and angle of ankle dorsiflexion. The results of this study should be taken into consideration when having elderly people do fall prevention training.

关键词： Eldery Fall Prevention Minimum Foot Clearance Multiple Regression Analysis

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Generation of electromotive force in igneous rocks subjected to non-uniform loading

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Earthquake Science 2011年第6期24卷 593-600页

作者： Akihiro Takeuchi mer Aydan keizo Sayanagi Toshiyasu Nagao Earthquake Prediction Research Center Institute of Oceanic Research and DevelopmentTokai UniversityShizuoka 424-8610Japan Department of Marine Civil Engineering Faculty of Marine Science and TechnologyTokai UniversityShizuoka 424-8610Japan

When one end of an air-dry igneous rock block was uniaxially loaded in laboratory, there appeared an electromotive force that made electric currents flow from the stressed volume to the unstressed volume. Quartz-free rocks such as gabbro also generated this force, stronger than quartz-bearing rocks such as granite. This indicates that the piezoelectric effect of quartz and the electrokinetic effect of pore water do not make a large contribution toward generating the electromotive force. We focus on peroxy bond that is one of the abundant lattice defects in igneous rock-forming minerals. When mechanical loading deforms the lattice structure around this defect and breaks its bond, its energy levels change and act like an accepter. As an electron is trapped at this defect from a neighbor 02- site, a positive hole is activated there. They attempt to diffuse toward the unstressed volume through the valence band and are simultaneously affected by the attractive electric force with the electrons trapped in peroxy bonds. This leads to a polarization in the stressed volume and the generation of electromotive force between the stressed and unstressed volumes. Similar electromotive force may be generated in the Earth＇s crust where inhomogeneous stress/strain is changing.

关键词： electromotive force igneous rock non-uniform loading positive hole

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CRISPR/Cas9-mediated genome editing reveals 12 testis-enriched genes dispensable for male fertility in mice

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Asian Journal of Andrology 2022年第3期24卷 266-272页

作者： Yuki Oyama Haruhiko Miyata Keisuke Shimada Yoshitaka Fujihara keizo Tokuhiro Thomas X Garcia Martin M Matzuk Masahito Ikawa Graduate School of Pharmaceutical Sciences Osaka UniversitySuitaOsaka 565-0871Japan Department of Experimental Genome Research Research Institute for Microbial DiseasesOsaka UniversitySuitaOsaka 565-0871Japan Department of Bioscience and Genetics National Cerebral and Cardiovascular CenterSuitaOsaka 564-8565Japan Department of Genome Editing Institute of Biomedical ScienceKansai Medical UniversityHirakataOsaka 573-1191Japan Center for Drug Discovery Baylor College of MedicineHoustonTX 77030USA Department of Pathology and Immunology Baylor College of MedicineHoustonTX 77030USA Department of Biology and Biotechnology University of Houston-Clear LakeHoustonTX 77058USA The Institute of Medical Science The University of TokyoMinato-kuTokyo 108-8639Japan

Gene expression analyses suggest that more than 1000–2000 genes are expressed predominantly in mouse and human *** functional analyses of hundreds of these genes have been performed,there are still many testis-enriched genes whose functions remain *** gene function using knockout(KO)mice is a powerful tool to discern if the gene of interest is essential for sperm formation,function,and male fertility in *** this study,we generated KO mice for 12 testis-enriched genes,1700057G04Rik,4921539E11Rik,4930558C23Rik,Cby2,Ldhal6b,Rasef,Slc25a2,Slc25a41,Smim8,Smim9,Tmem210,and Tomm20l,using the clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9(CRISPR/Cas9)*** designed two gRNAs for each gene to excise almost all the protein-coding regions to ensure that the deletions in these genes result in a null *** tests of KO mice reveal that these 12 genes are not essential for male fertility,at least when individually ablated,and not together with other potentially compensatory paralogous *** results could prevent other laboratories from expending duplicative effort generating KO mice,for which no apparent phenotype exists.

关键词： CRISPR/Cas9 knockout mice male infertility spermatozoa testis

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TiAl ALLOYS FOR INDUSTRIAL USE

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Acta Metallurgica Sinica(English Letters) 1995年第Z1期8卷 509-518页

作者： keizo HASHIMOTO(Advanced Technologies Research Laboratories Nippon Steel Corp.1618 Ida Nakahara-ku Kawasaki 211 JAPAN) Nippon Steel Corp Kawasaki Japan

Gamma titanium aluminide (γ-TiAl)intermetallic compounds are spotlighted as lightweight heat-resistant materials, and have been investigated extensively to aiming commercial *** approaches in which phase diagrams of Ti -Al -Cr and TiAl -Nb have been studied based on the experimental data and calculations , have been performed in the national project For industrial approach, ingot process and direct casting process have been developed to provide sheet form of TiAl. By these approaches, γ-TiAl base ,intermetallic compounds show a great possibility to apply in the variety of fields .However, a more detailed understanding of phase equilibrium in Ti-Al -X and the relationship between the mechanical properties and microstructure will be necessary

关键词： TITANIUM ALUMINIDE PHASE DIAGRAM TENSILE PROPERTY MELTING PROCESS TWIN ROLL CASTING

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