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Black Sheep and the mysterious Uncle Bob

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新世纪智能 2018年第12期 40-41页

作者： keith Sands

I’m an English teacher working in Russia,and for some reason I really don’t like that classroom topic ‘Talk about your family’.Perhaps it’s because everyone studied English from the same book at *** all the stude...

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Identification of Phymatolithon lamii(***)*** 1991 following bleaching in the upper intertidal zone of the minas Basin,Nova Scotia,Canada

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Journal of Coastal Life medicine 2016年第3期4卷 181-186页

作者： Brady keith Quinn Department of Biology University of New BrunswickP.O.Box 5050100 Tucker Park RoadSaint JohnNew Brunswick E2L 4L5Canada

Objective:To identify an unusual encrusting calcareous organism found growing on upper intertidal rocks along the coast of the minas Basin,Nova Scotia,Canada,which was thought to potentially represent a new,perhaps invasive species to the ***:Observations were made of the organism growing in situ and of intact and dissected specimens under microscopes in the *** keys were used to determine probable identity of the organism as a tunicate,sponge,bryozoan,marine lichen,or coralline red *** keys were then further used to identify samples to ***:The organism was determined to be Phymatolithon lamii(***)*** 1991,an encrusting coralline red alga native to the study *** species normally occurs in the subtidal zone,so its occurrence in the high intertidal zone was unusual and resulted in the alga becoming bleached and taking on an unusual ***:The sample did not represent a new or invasive species to the study ***,occurrence of this species on the high intertidal zone was novel and may have resulted from unusual climatic and/or oceanographic conditions in the study area in 2015 that allowed this alga to settle and grow in the intertidal zone for a time before death and bleaching *** such as this resulting from climate change may negatively impact recruitment to populations of coastal marine species and should be investigated further.

关键词： Red algae Taxonomy Invasive species Climate change marine ecology Phymatolithon lamii minas Basin

沃特世QUATTROmICRoGC对水中多环芳烃(PAHs)的快速GC／mS／mS分析

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环境化学 2008年第2期27卷 278-279页

作者： keith Worrall 沃特世公司英国曼彻斯特

GC／mS分析多环芳烃（PAHs）被认为是分析这些持久性有机污染物最灵敏的方法之一，PAHs使用标准的GC色谱柱很容易分离且无需衍生化．使用一根长30m，内径0．25mm，膜厚0．25μm的5％苯基聚甲基硅烷固定相的色谱柱，可以在不到30min内分... 详细信息

GC／mS分析多环芳烃（PAHs）被认为是分析这些持久性有机污染物最灵敏的方法之一，PAHs使用标准的GC色谱柱很容易分离且无需衍生化．使用一根长30m，内径0．25mm，膜厚0．25μm的5％苯基聚甲基硅烷固定相的色谱柱，可以在不到30min内分离所有的PAHs,使用细内径、薄膜厚的色谱柱能够提高分离能力，并减少分析时间。

关键词： GC/mS/mS 多环芳烃持久性有机污染物 GC/mS分析分离能力 PAHs 聚甲基硅烷色谱柱

在Twitter的帮助下,我决定不做心肺复苏

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英国医学杂志中文版 2019年第10期22卷 614-615页

作者： keith Cass 任倩(译) 不详北京大学人民医院内分泌科

讨论自己的死亡,并非易事。如何看待心肺复苏并作出抉择,keith Cass认为社交媒体是很有用的。当我第一次在门诊见到我的缓和医疗顾问mark的时候,我们主要讨论的是关于我的疼痛,在那个时候,我的疼痛几乎难以控制。我患有前列腺癌晚期,已... 详细信息

讨论自己的死亡,并非易事。如何看待心肺复苏并作出抉择,keith Cass认为社交媒体是很有用的。当我第一次在门诊见到我的缓和医疗顾问mark的时候,我们主要讨论的是关于我的疼痛,在那个时候,我的疼痛几乎难以控制。我患有前列腺癌晚期,已经发展到全身骨转移。

关键词：心肺复苏前列腺癌社交媒体疼痛全身骨转移缓和医疗

Connexins in neurons and glia: targets for intervention in disease and injury

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Neural Regeneration Research 2015年第7期10卷 1013-1017页

作者： keith B.moore John O'Brien Richard S.Ruiz M.D.Department of Ophthalmology & Visual Science The University of Texas Health Science Center at Houston The University of Texas Graduate School of Biomedical Sciences

Both neurons and glia throughout the central nervous system are organized into networks by gap junctions. Among glia, gap junctions facilitate metabolic homeostasis and intercellular communication. Among neurons, gap junctions form electrical synapses that function primarily for communication. However, in neurodegenerative states due to disease or injury gap junctions may be detrimental to survival. Electrical synapses may facilitate hyperactivity and bystander killing among neurons, while gap junction hemichannels in glia may facilitate inflammatory signaling and scar formation. Advances in understanding mechanisms of plasticity of electrical synapses and development of molecular therapeutics to target glial gap junctions and hemichannels offer new hope to pharmacologically limit neuronal degeneration and enhance recovery.

关键词： ischemia retinal degeneration amacrine cells astrocytes dopamine receptors adenosine receptors NmDA receptors connexin mimetic peptides

Classification and management of the tandem ossification of the posterior longitudinal ligament and flaval ligament

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Chinese medical Journal 2009年第2期122卷 219-224页

作者： GUO Jiong-jiong YANG Hui-lin Kenneth m.C. Cheung TANG Tian-si keith D.K. Luk Department of Orthopaedics the First Affiliated Hospital of Soochow University Suzhou Jiangsu 215006 China Department of Orthopaedics and Traumatology the University of Hong Kong Hong Kong SAR China

Objective To provide appropriate guidelines for treatment of tandem ossification of the posterior longitudinal ligament （OPLL） and flaval ligament （OFL）. Data sources Published articles about OPLL and OFL were selected using medline and Embase electronic databases. Study selection An English literature search from January 1980 to December 2006 was conducted. Because many reported cases were incorporated in OFL studies, the key words for search were OFL or OFL and OPLL. The first step revealed 93 studies of which 13 reports of tandem OPLL and OFL （tandem ossification） were selected. Results All studies were case series or case report and advocated that the primary therapy for tandem ossification should be operative. The clinical outcomes of surgery were evaluated in most reports, predominantly using the JOA scores. Gender is the only factor which has prognostic value. A higher proportion of women was found in the failure group A two- stage classification of tandem ossification was developed to relate diagnosis to outcome. Conclusions All patients with suspected ossification of the spinal ligaments should undergo routine mRI screening of the whole spine. The correlation of the classification with surgical treatments needs further studies to validate its usefulness. Chin med J 2009; 122（2）：219-224

关键词： ossification posterior longitudinal ligament flaval ligament ligamentum flavum, tandem

Inhibition of pancreatic EZH2 restores progenitor insulin in T1D donor

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Signal Transduction and Targeted Therapy 2022年第8期7卷 3045-3053页

作者： keith Al-Hasani Ishant Khurana Lina mariana Thomas Loudovaris Scott maxwell K.N.Harikrishnan Jun Okabe mark ECooper Assam El-Osta Department of Diabetes Central Clinical SchoolMonash UniversityMelbourneVictoria 3004Australia Epigenetics in Human Health and Disease Laboratory Central Clinical SchoolMonash UniversityMelbourneVictoria 3004Australia Immunology and Diabetes Unit St Vincent’s Institute of Medical ResearchFitzroyVictoriaAustralia Department of Clinical Pathology The University of MelbourneParkvilleVictoriaAustralia Department of medicine and Therapeutics The Chinese University of Hong KongSha TinHong Kong SAR Hong Kong Institute of Diabetes and Obesity Prince of Wales HospitalThe Chinese University of Hong Kong3/F Lui Che Woo Clinical Sciences Building30-32 Ngan Shing StreetSha TinHong Kong SAR Li Ka Shing Institute of Health Sciences The Chinese University of Hong KongSha TinHong Kong SAR Faculty of Health Department of TechnologyBiomedical Laboratory ScienceUniversity College CopenhagenCopenhagenDenmark

Type 1 diabetes(T1D)is an autoimmune disease that selectively destroys insulin-producingβ-cells in the *** unmet need in diabetes management,current therapy is focussed on *** the reprogramming of progenitor cells into functional insulin-producingβ-cells has also been proposed this remains controversial and poorly *** challenge is determining why default transcriptional suppression is refractory to exocrine *** the death of a 13-year-old girl with established insulin-dependent T1D,pancreatic cells were harvested in an effort to restore and understand exocrine *** pancreas showed classic silencing ofβ-cell progenitor genes with barely detectable insulin(Ins)***126,a highly selective inhibitor of EZH2 methyltransferase activity influenced H3K27me3 chromatin content and transcriptional control resulting in the expression of coreβ-cell markers and ductal progenitor ***126 also reinstated Ins gene expression despite absoluteβ-cell *** studies show the refractory nature of chromatin characterises exocrine suppression influencingβ-cell *** regeneration studies are warranted to determine if the approach of this n-of-1 study generalises to a broader T1D population.

关键词： EZH2 progenitor donor

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脉冲星搜寻软件的安装和使用(英文)

天文研究与技术 2012年第3期9卷 219-228页

作者： m.J.keith CSIRO Astronomy & Space Science ATNFP.O.Box 76Epping 1710NSW Australia

搜寻射电脉冲星需要成熟的软件套路以保证有效地得到新发现。介绍了脉冲星搜寻过程,提供了安装脉冲星搜寻软件的工具,并给出了脉冲星搜寻的例子。

关键词：脉冲星搜寻软件

Pituitary carcinoma: Two case reports and review of literature

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World Journal of Clinical Oncology 2020年第2期11卷 91-102页

作者： Lai Xu Karam Khaddour Jie Chen keith m Rich Richard J Perrin Jian Li Campian Divisions of Hematology and Oncology Department of MedicineWashington University School of MedicineSt.LouisMO 63110United States Department of Pathology and Immunology Washington University School of MedicineSt.LouisMO 63110United States Department of Neurological Surgery Washington University School of MedicineSt.LouisMO 63110United States

BACKGROUND Pituitary carcinoma is a rare type of malignancy that can be very difficult to diagnose and *** cases were diagnosed at *** in diagnosis often adversely impact patients’*** with prompt diagnosis,treatment decisions remain challenging in the absence of randomized controlled *** SUmmARY We report two cases of pituitary carcinoma in men with a history of pituitary *** the first case,a 55-year-old man was initially diagnosed with pituitary *** underwent subtotal debulking of the tumor followed by adjuvant ***,he developed relapsed disease and multifocal intracranial metastases and a diagnosis of pituitary carcinoma was *** passed away despite several lines of systemic therapies including temozolomide,lomustine and *** 52-year-old man was diagnosed with atypical pituitary adenoma with presentation of sudden onset of vision loss in the right *** had recurrent pituitary carcinoma with spinal metastases,treated with surgery,radiation and *** Pituitary carcinoma is a rare neoplasm with poor prognosis that is difficult to diagnose and *** small number of cases restricts our ability to design randomized clinical *** is largely driven by retrospective studies and case *** molecular biomarkers and comprehensive genomic profiling could help in decisions about diagnosis and management of pituitary carcinoma.

关键词： Pituitary carcinoma Diagnosis Treatment Pituitary adenoma Temozolomide Case report