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Intra-operative computed tomography guided navigation for pediatric pelvic instrumentation: A technique guide

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World Journal of Orthopedics 2018年第10期9卷 185-189页

作者： Jason B Anari Patrick J Cahill John m Flynn David A Spiegel keith D Baldwin Department of Orthopaedic Surgery Children's Hospital of Philadelphia

Pelvic instrumentation for neuromuscular scoliosis has been part of neuromuscular scoliosis surgery since the era of the Luque Galveston construct. Unit Rod(medtronic Sofamor-Danek, Nashville, TN) instrumentation brought with it the concept of cantilever correction by placing the implants in the pelvis and then gradually bringing the rod to the spine by sequentially tightening the sublaminar wires, with the goal of creating a level pelvis over a straight spine. more recently surgeons have utilized pedicle screw constructs in which the corrective strategies have varied. Challenges with pelvic fixation using iliac screws linked to the spinal rod have led to the development of the S2-alariliac technique(S2 AI) in which the spinal rod connects to the pelvic screw. The screw is placed in the S2 ala, crosses the sacro-iliac joint and into the ilium through a large column of supra-acetabular bone. This column is the same area used for anterior inferior iliac spine external fixation frames used in trauma surgery. S2 AI screw placement can be technically difficult and can require experienced radiology technologists to provide the appropriate views. Additionally, although the technique was originally described being placed via freehand technique with intra-operative flouroscopy, the freehand technique suffers from the anatomic anomalies present in the pelvis in neuromuscular scoliosis. As such, we prefer to place them using intra-operative navigation for all pediatric spinal deformity cases. Below in detail we report our intra-operative technique and an illustrative case example.

关键词： Posterior instrumentation Pediatric Spinal deformity Image guidance Technique

Rock1 Inhibitor Abrogates Chronic Rejection in Rat Cardiac model System

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Open Journal of Organ Transplant Surgery 2012年第4期2卷 46-51页

作者： Li Zhang malgorzata Kloc Neelam Tejpal Junping You Andrea m. Cordero-Reyes keith A. Youker Rafik m. Ghobrial Department of Surgery The Methodist Hospital The methodist DeBakey Heart & Vascular Center Houston TX USA

Background: We have shown previously that the abrogation of acute and chronic rejection of rat cardiac allografts occurs through the down-regulation of RhoA pathway and involves the changes in RhoA kinase (ROCK)-dependent actin cytoskeleton and T cell motility. Here we studied the ability of the Y-27632, a highly selective inhibitor of Rho-associated protein kinase p160ROCK (ROCK1), to abrogate chronic rejection of the allograft and influence T cell infiltration. methods: Heterotopic cardiac transplants were performed between donor Wistar Furth (WF) and ACI recipient rats. Controls received sub-therapeutic dose of cyclosporine (CsA, 10 mg/kg) for 3 days or 7 days therapeutic dose of cyclosporine. The experimental groups of ACI recipient received one preoperative dose of the Y-27632 inhibitor (2 mg/kg, gavage feed) in conjunction with the sub-therapeutic dose of CsA for 3 days or inhibitor alone for 7 days. The cardiac grafts were harvested at 100 days of post-transplantation for histological and immunohistochemical assessment of chronic rejection, vascular sclerosis, and infiltration by different T cell subtypes. Results: Cardiac allografts from recipients exposed to Y-27632 inhibitor in conjunction with sub-therapeutic dose of CsA showed drastically reduced vascular sclerosis, minimal myocardial total cellular infiltration, and were selectively infiltrated with Foxp3+ T regulatory (Treg) cells. Conclusions: Our novel finding that a single dose of the ROCK1 inhibitor Y-27632 attenuates chronic rejection in rat cardiac model system by promoting development of Treg cells warrants its potential as a novel therapeutic agent specific for the inhibition of chronic rejection.

关键词： Chronic Rejection Transplantation ROCK1 RhoA T Cell

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解决方案式营销才能卖高价!

经理人 2013年第6期 52-53页

作者： keith m.Eades SPI公司

大多数企业的销售方法已经过时,它们要做的是卖价值而不仅仅是卖东西,是帮客户解决问题,而不仅仅是提供某种产品。今天的市场环境要求销售人员能够准确把握买方所处的销售阶段,了解他们的需求点。

关键词：才能营销销售方法销售阶段销售人员市场环境企业买方

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寻找一个自洽的常数

物理 2020年第8期49卷 548-549页

作者：范祖辉(编译) keith Cooper 云南大学中国西南天文研究所不详

在宇宙学发展的历程中,最伟大的发现是天文学家哈勃意识到了宇宙在膨胀。这一突破为我们了解宇宙年龄.微波背景辐射和宇宙大爆炸奠定了基础。哈勃是一位拥有天时地利人和机缘的天文学家。1923年,利用美国加州威尔森天文台2.5 m胡克望远... 详细信息

在宇宙学发展的历程中,最伟大的发现是天文学家哈勃意识到了宇宙在膨胀。这一突破为我们了解宇宙年龄.微波背景辐射和宇宙大爆炸奠定了基础。哈勃是一位拥有天时地利人和机缘的天文学家。1923年,利用美国加州威尔森天文台2.5 m胡克望远镜,他在“旋涡星云”中观测到了造父变星,这类变星具有很好的周期-光度关系,可以用来测量距离。

关键词：微波背景辐射宇宙大爆炸造父变星宇宙年龄宇宙学哈勃测量距离美国加州

How completely are randomized controlled trials of non-pharmacological interventions following concussion reported? A systematic review

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Journal of Sport and Health Science 2024年第4期13卷 537-547页

作者： Jacqueline Josee van Ierssel Olivia Galea Kirsten Holte Caroline Luszawski Elizabeth Jenkins Jennifer O’Neil Carolyn A Emery Rebekah mannix Kathryn Schneider keith Owen Yeates Roger Zemek Children’s Hospital of Eastern Ontario Research Institute OttawaON K1H 8L1Canada The Centre for Health Activity and Rehabilitation ResearchUniversity of OtagoDunedin 9016New Zealand Sport Injury Prevention Research Centre Faculty of KinesiologyUniversity of CalgaryCalgaryAB T2N 1N4Canada Alberta Children’s Hospital Research Institute University of Calgary CalgaryAB T2N 1N4Canada Hotchkiss Brain Institute University of CalgaryCalgaryAB T2N 4N1Canada Department of Psychology University of CalgaryCalgaryAB T2N 1N4Canada g Faculty of MedicineUniversity of OttawaOttawaON K1H 8M5Canada School of Rehabilitation Sciences University of OttawaOttawaON K1H 8M5Canada Bruyere Research Institute OttawaON K1N 5C8Canada Departments of Pediatrics and Emergency medicine Harvard Medical SchoolBostonMA 02115USA Departments of Pediatrics and Emergency medicine University of OttawaOttawaON K1H 8M5Canada

Purpose:The study aimed to examine the reporting completeness of randomized controlled trials(RCTs)of non-pharmacological interventions following ***:We searched mEDLINE,Embase,PsycInfo,CINAHL,and Web of Science up to may *** reviewers independently screened studies and assessed reporting completeness using the Template for Intervention Description and Replication(TIDieR),Consensus on Exercise Reporting Template(CERT),and international Consensus on Therapeutic Exercise aNd Training(i-CONTENT)*** information was sought my study authors where reporting was *** of bias(ROB)was assessed with the Cochrane ROB-2 *** examining non-pharmacological interventions following ***:We included 89 RCTs(n=53 high ROB)examining 11 different interventions for concussion:sub-symptom threshold aerobic exercise,cervicovestibular therapy,physical/cognitive rest,vision therapy,education,psychotherapy,hyperbaric oxygen therapy,transcranial magnetic stimulation,blue light therapy,osteopathic manipulation,and head/neck *** scores were:TIDieR 9/12(75%;interquartile range(IQR)=5;range:5-12),CERT 17/19(89%;IQR=2;range:10-19),and i-CONTENT 6/7(86%;IQR=1;range:5-7).Percentage of studies completely reporting all items was TIDieR 35%(31/89),CERT 24%(5/21),and i-CONTENT 10%(2/21).Studies were more completely reported after publication of TIDieR(t_(87)=2.08;p=0.04)and CERT(t_(19)=2.72;p=0.01).Reporting completeness was not strongly associated with journal impact factor(TIDieR:rs=0.27;p=0.01;CERT:r_(s)=-0.44;p=0.06;i-CONTENT:r_(s)=-0.17;p=0.48)or ROB(TIDieR:rs=0.11;p=0.31;CERT:rs=0.04;p=0.86;i-CONTENT:rs=0.12;p=0.60).Conclusion:RCTs of non-pharmacological interventions following concussion demonstrate moderate to good reporting completeness,but are often missing key components,particularly modifications,motivational strategies,and qualified *** completeness improved after TIDieR and CERT publication,but p

关键词： Concussion Intervention Randomized controlled trial Systematic review

Formulation development and characterization of cellulose acetate nitrate based propellants for improved insensitive munitions properties

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Defence Technology（防务技术） 2014年第2期10卷 92-100页

作者： Thelma mANNING Jeffrey WYCKOFF Carlton ADAm Eugene ROZUmOV Kenneth KLINGAmAN Viral PANCHAL Joseph LAQUIDARA mike FAIR John BOLOGNINI keith LUHmANN Steve VELARDE Christine KNOTT Stephanie m.PIRAINO Kevin BOYD US Army RDECOM ARDECPicatinny Arsenal Alliiant Tech ATK RAFPRD AAP Naval Surface Warhead Center Indian Head Army Research Laboratory Aberdeen Proving Ground

Cellulose acetate nitrate(CAN) was used as an insensitive energetic binder to improve the insensitive munitions(Im) properties of gun propellants to replace the m1 propellant used in 105 mm artillery *** contains the energetic nitro groups found in nitrocellulose(NC),but also acetyl functionalities,which lowered the polymer's sensitivity to heat and shock,and therefore improved its Im properties relative to *** formulation,development and small-scale characterization testing of several CAN-based propellants were *** formulations,using insensitive energetic solid fillers and high-nitrogen modifiers in place of nitramine were *** small scale characterization testing,such as closed bomb testing,small scale sensitivity,thermal stability,and chemical compatibility were *** mechanical response of the propellants under high-rate uni-axial compression at,hot,cold,and ambient temperatures were also *** diameter testing,hot fragment conductive ignition(HFCI) tests were done to evaluate the propellants' responses to thermal and shock *** the propellant chemical composition,theoretical predictions of erosivity were *** the small scale test results were utilized to down-select the promising CAN based formulations for large scale demonstration testing such as the ballistic performance and fragment impact testing in the105 mm m67 artillery charge *** test results completed in the small and large scale testing are discussed.

关键词：硝酸纤维素弹道性能钝感弹药推进剂醋酸纤维素开发配方特性测试

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对流层中高层的锋生过程

气象科技 1992年第4期20卷 48-50页

作者： keith m.Hines Carlos R.mechoso 周文吉祁立新加利福尼亚大学洛杉矶分校

1.引言在本文中,我们仔细研究了高空锋生的基本问题:i)模式中几何因素(例如β-平面和球面)对模拟锋生有多大程度影响,ii)高空锋生是否基本上是一个二维过程,iii)在高空锋区的发展中,是否有正反馈机制起作用.我们的研究方案采用三维原始... 详细信息

1.引言在本文中,我们仔细研究了高空锋生的基本问题:i)模式中几何因素(例如β-平面和球面)对模拟锋生有多大程度影响,ii)高空锋生是否基本上是一个二维过程,iii)在高空锋区的发展中,是否有正反馈机制起作用.我们的研究方案采用三维原始方程模式,对不稳定斜压波生命史进行模拟,然后详细分析其结果.

关键词：对流层高层锋生过程

Participatory methods in the Georgian Caucasus: Understanding Vulnerability and Response to Debrisflow Hazards

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International Journal of Geosciences 2015年第7期6卷 666-674页

作者： Valentina Spanu George Gaprindashvili michael keith mcCall CRS4 Loc. Piscina Manna Pula Italy ministry of Environment and Natural Resources Protection of Georgia LEPL National Environmental Agency Department of Geology Tbilisi Georgia Ivane Javakhishvili Tbilisi State University Tbilisi Georgia CIGA-UNAm Universidad Nacional Autónoma de México Antigua Carretera a Pátzcuaro No. 8701 Col. Ex-Hacienda de San José de la Huerta Morelia México

Assessment and emergency planning to cope with disaster risks are usually founded primarily on expert evaluations, in part because local governments and public bodies mainly finance the recovery activities. Local communities affected by disasters are scarcely really involved in the processes of information collection, problem analysis, or design of emergency ***, the development of good practices for incorporating local people’s knowledge into disaster risk management, known as Community-Based Disaster Risk management (CBDRm), is becoming more common. Scientific communities increasingly realize the importance of local knowledge, though in Georgia this is still uncommon. Georgia faces frequent natural disasters and threats to its fragile ecosystems caused by unsustainable natural resource management and agricultural practices, improper infrastructure and urban development, as well as by innate geological and climatic factors. In this context, the lack of communication between local communities and public administrations is absolutely deleterious. The article analyzes the effectiveness of participatory methods and tools for better comprehension of people’s vulnerability and responses. Fieldwork in mountain areas of Caucasus involved local communities to investigate the direct participation of local people in Disaster Risk management and assess their availability and interest to engage in hazard mapping and risk responses.

关键词： Participatory methods PGS Debrisflow Vulnerability Local Knowledge Cyber Tracker

RADIATIVE CHARACTERISTICS OF AEROSOLS AT GOLmUD ON THE TIBETAN PLATEAU

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Acta meteorologica Sinica 1993年第2期7卷 199-211页

作者：孙治安 keith P.Shine Department of meteorology Reading University

The characteristics of atmospheric aerosols in the Golmud desert over the Tibetan (Qinghai-Xizang) Plateau are investigated using the measurements made during the *** spectroscopic observations at the surface and satellite data,the aerosol optical depth is calculated,from which the aerosol size distribution is worked out by means of an inversion *** effects of vertical distribution of aerosols on irradiance and heating rate profiles are investi- gated using radiation models in conjunction with the assumption of three idealized aerosol *** effect of aerosols on solar irradiance at the surface is also investigated and the results are compared with the *** is shown that the solar irradiance can be reduced by up to 100 W m^(-2) in the presence of aerosols,and the heating rate can be increased by 1 Kd^(-1).

关键词： dust aerosol absorption and scattering radiative transfer solar irradiance