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Hereditary diffuse gastric cancer: One family's story

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World Journal of Clinical Cases 2018年第1期6卷 1-5页

作者： Haley M Zylberberg keith Sultan Steven Rubin Donald and Barbara Zucker School of Medicine at Hofstra/Northwell Division of Gastroenterology Donald and Barbara Zucker School of Medicine at Hofstra/Northwell

Hereditary diffuse gastric cancer(HDGC) is an inherited form of gastric cancer that carries a poor prognosis. Most HDGCs are caused by an autosomal dominant genetic mutation in the CDH1 gene, which carries a 70%-80% lifetime risk of gastric cancer. Given its submucosal origin, endoscopic surveillance is an unreliable means of early detection, and prophylactic gastrectomy is recommended for CDH1 positive individuals older than age 20 years. We describe the case of a male with recurrent gastric cancer who was diagnosed with HDGC secondary to the CDH1 mutation, and we also describe the patient's pedigree and outcomes of recommended genetic testing.

关键词： Hereditary diffuse gastric cancer Genetic testing Genetic diseases Gastric cancer Lobular breast cancer Inheritable diseases

Applying Spray Drying to Customized Powder Manufacture

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Chinese Journal of Chemical Engineering 2004年第6期12卷 744-749页

作者： keith Masters Spray Dry Consult Intl ApS Krathusparken 2 DK-2920 Charlottenlund Denmark

Spray drying is an important continuous industrial process for drying pumpable liquid formulations irrespective of their heat sensitivity, rheology, solids content and processing rate. Furthermore spray drying has the capability through drying chamber design, plant layout and mode of operation to produce dried products of specific particulate size and morphology. These are important aspects when spray drying technology is applied to the needs of customized powder manufacture. There are many examples in industry where spray dried powders have to meet stringent specifications set by such factors as end-product powder quality standards dictated by global competition,dry raw material characteristics required for optimum downstream processing, and dry materials handling to comply with environmental, health and safety issues. Spray drying is no longer regarded just as a convective industrial drying concept, but also as an integral part of modern manufacturing practices applying powder technology. This paper reviews the aspects of spray dryer design and operation for consideration when customized powder manufacture is involved.

关键词： industrial plant design and selection particle morphology powderproperties spray drying

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数据可视化,用设计“读懂”数据

艺术与设计 2024年第3期 16-35页

作者：谭智恒九月(译) 三度(图) 不详

我们生活在一个日益复杂的世界中。我们的日常生活涉及到与数以万计的信息的交互,主要通过视觉(如果视力正常的话)以及许多不同的物理和数字渠道。其中许多信息可能对我们而言并无意义或毫不相关,但却同样要求我们关注。信息图表成为我... 详细信息

我们生活在一个日益复杂的世界中。我们的日常生活涉及到与数以万计的信息的交互,主要通过视觉(如果视力正常的话)以及许多不同的物理和数字渠道。其中许多信息可能对我们而言并无意义或毫不相关,但却同样要求我们关注。信息图表成为我们更高效地理解世界的一种捷径。信息不再仅仅是单向传播以供我们消费。

关键词：单向传播数据可视化信息图表更高效读懂日常生活

OPTION PRIORITIZATION FOR UNKNOWN PREFERENCE

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Journal of Systems Science and Systems Engineering 2016年第1期25卷 39-61页

作者： Jing Yu keith W. Hipel D. Marc Kilgour Min Zhao Business School Hohai University Nanjing Jiangsu 211100 China Department of Systems Design Engineering University of Waterloo Waterloo N2L 3G1 Canada Department of Mathematics Wt'lfrid Laurier University Waterloo N2L 3C5 Canada Centre for International Governance Innovation Waterloo Ontario Canada Water Resources and Sustainable Development Research Centre of Jiangsu Province Nanjing 210098 China

An option prioritization technique is developed to efficiently elicit the preferences, both unknown and crisp, of decision makers （DMs） in strategic conflicts. In the Graph Model for Conflict Resolution, each DM has one or more options, each of which may be selected or not. A state, or possible scenario, is formed when all DMs make an option selection. The software GMCR II contains an option prioritization procedure that makes it easy for a modeUer to enter a DM＇s crisp preference ordering over the states using prioritized statements describing the DM＇s preferred option combinations. This procedure is extended by adding two new logical connectives that describe uncertainty of preference. For each DM, a range of possible scores for each feasible state can then be calculated, facilitating the determination of a preference ordering containing uncertainty by comparing and ranking scores. To demonstrate how this new methodology can be used to represent tmknown preferences in a real-world decision problem, it is applied to a Canadian dispute over proposed water exports.

关键词： Graph model for conflict resolution option prioritization unknown preference logical connectives

Revisiting the death of geography in the era of Big Data:the friction of distance in cyberspace and real space

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International Journal of Digital Earth 2018年第5期11卷 451-469页

作者： Su Yeon Han Ming-Hsiang Tsou keith C.Clarke Department of Geography San Diego State UniversitySan DiegoCAUSA Department of Geography University of CaliforniaSanta BarbaraCAUSA

Many scholars have argued that the importance of geographic proximity in human interactions has been diminished by the use of the Internet,while others disagree with this *** have noted the distance decay effect in both cyberspace and real space,showing that interactions occur with an inverse relationship between the number of interactions and the distance between the locations of the ***,these studies rarely provide strong evidence to show the influence of distance on interactions in cyberspace,nor do they quantify the differences in the amount of friction of distance between cyberspace and real *** fill this gap,this study used massive amounts of social media data(Twitter)to compare the influence of distance decay on human interactions between cyberspace and real space in a quantitative *** estimate the distance decay effect in both cyberspace and real space,the distance decay function of interactions in each space was *** the distance decay in cyberspace in this study can help predict the degree of information flow across space through social *** how far ideas can be diffused through social media is useful for users of location-based services,policy advocates,public health officials,and political campaigners.

关键词： First law of geography distance decay Big Data Twitter social media information diffusion

ROBUSTNESS OF EQUILIBRIA IN THE GRAPH MODEL FOR CONFLICT RESOLUTION

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Journal of Systems Science and Systems Engineering 2015年第4期24卷 450-465页

作者： Yasser T.Matbouli D.Marc Kilgour keith W.Hipel Department of Industrial Engineering King Abdulaziz University Department of Systems Design Engineering University of Waterloo Department of Mathematics Wilfrid Laurier University Centre for International Governance Innovation(CIGI)

A novel approach for assessing the robustness of an equilibrium in conflict resolution is presented. Roughly, an equilibrium is robust if it is resilient, or resistant to deviation. Robustness assessment is based on a new concept called Level of Freedom, which evaluates the relative freedom of a decision maker to escape an equilibrium. Resolutions of a conflict can be affected by changes in decision makers＇ preferences, which may destabilize an equilibrium, causing the conflict to evolve. Hence, a conflict may become long-term and thereby continue to evolve, even after reaching an equilibrium. The new robustness measure is used to rank equilibria based on robustness, to facilitate distinguishing equiiibria that are relatively sustainable. An absolutely robust equilibrium is a special case in which the level of freedom is at an absolute minimum for each individual stability definition.

关键词： Robustness equilibria level of freedom conflict evolution graph model

Bacterial degradation of coal discard and geologically weathered coal

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International Journal of Coal Science & Technology 2020年第2期7卷 405-416页

作者： Jacob Taiwo Olawale Oghenekume Gerald Edeki Ashton keith Cowan Institute for Environmental Biotechnology Rhodes University(EBRU)P.O.Box 94Makhanda6140South Africa

The biodegradation of coal discard is being intensively studied in South Africa in an effort to develop passive methods for the successful revegetation and rehabilitation of waste dumps, to mitigate pollution, and facilitate mine closure. Bacteria were isolated from slurries of coal tailings and diesel-contaminated soil, screened for coal biodegradation competence, characterized, and the colonization and degradation of coal discard and geologically weathered coal investigated using individual isolates and consortia. Ten novel coal-degrading bacterial strains were isolated and characterized, the gene sequences deposited with GenBank, and the (wild-type) strains deposited at Microbial Culture Collection, India. The results from the present work show that bituminous coal discard and geologically weathered coal is used by these isolates as carbon and energy source. Isolated strains and consortia colonized and degraded both coal substrates. Growth rate of the isolates is faster and stationery phase achieved sooner in minimal medium containing geologically weathered coal. This observation suggests that the oxygen-rich weathered coal is a more friable substrate and thus readily colonised and biodegraded. A reduction in mass of substrate is demonstrated for both individual isolates and consortia. The changes in pH and associated media colouration occurred concomitant with formation of humic acid-like (HS) and fulvic acid-like substances (FS) which is confirmed following analysis of these products by FT-IR spectroscopy. It is concluded that preferential metabolism of alkanes from the coal substrates provided the carbon and energy for bacterial growth and transformation of the substrates to HS and FS.

关键词： Bacteria Biodegradation Coal discard Humic acid Fulvic acid FT-IR Geologically weathered coal

Investigation of the unstable flow phenomenon in a pump turbine

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Science China(Physics,Mechanics & Astronomy) 2014年第6期57卷 1119-1127页

作者： YIN JunLian WANG DeZhong WALTERS D.keith WEI XianZhu School of Mechanical Engineering Shanghai Jiaotong University Department of Mechanical Engineering Mississippi State University State Key Laboratory of Hydropower Equipment

Instability of pump turbine with S-shaped curve is characterized by large fluctuations of rotational speed during the transient *** investigating this phenomenon,a numerical model based on the dynamic sliding mesh method(DSSM)is presented and used to numerically solve the 3D transient flow which is characterized by the variable rotation speed of *** method is validated by comparison with measured data for a load rejection process in a prototype pump *** results show that the calculated rotation speed agrees well with the experimental *** on the validated model,simulations were performed for the runaway process using an artificially assumed operating condition under which the unstable rotation speed is expected to *** results confirm that the instability of runner rotational speed can be effectively captured with the proposed *** results include the time history profiles of unit flow rate and unit rotating *** internal flow characteristics in a typical unstable period are discussed in detail and the mechanism of the unstable hydraulic phenomenon is ***,the results suggest that the method presented here can be a viable alternative to predict the dynamic characteristics of pump turbines during transient processes.

关键词： pump turbine transient process dynamic sliding mesh flow stability

Percutaneous embolization of varicocele： technique, indications, relative contraindications, and complications

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Asian Journal of Andrology 2016年第2期18卷 234-238,J0005页

作者： Joshua Halpern Sameer Mittal keith Pereira Shivank Bhatia Ranjith Ramasamy Department of Urology New York-Presbyterian Hospital Weill Cornell Medical College New York 10065 USA Department of Radiology University of Miami- Miller School of Medicine Miami 33136 USA Department of Urology University of Miami - Miller School of Medicine Miami 33136 USA.

There are several options for the treatment of varicocele, including surgical repair either by open or microsurgical approach, laparoscopy, or through percutaneous embolization of the internal spermatic vein. The ultimate goal of varicocele treatment relies on the occlusion of the dilated veins that drain the testis. Percutaneous embolization offers a rapid recovery and can be successfully accomplished in approximately 90% of attempts. However, the technique demands interventional radiologic expertise and has potential serious complications, including vascular perforation, coil migration, and thrombosis of pampiniform plexus. This review discusses the common indications, relative contraindications, technical details, and risks associated with percutaneous embolization of varicocele.

关键词： interventional radiology male infertility therapeutic embolization varicocele