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Effects of novel vaccines on weight loss in diet-induced-obese(DIO) mice

Journal of Animal Science and Biotechnology 2012年第3期3卷 136-142页

作者： keith N Haffer Braasch Biotech LLC 421 Rose AvenueGarrestonSD 570303-0430USA

The purpose of the study was to test the therapeutic effects of novel vaccines for reducing weight gain and increasing weight loss in diet induced obesity （DIO） model. Male C57BL/6 J mice, fed a 60% Kcal fat diet for 8 weeks prior to the start of the study, were vaccinated via the intraperitoneal route with two formulations （JH17 ＆ JH]8） of chimeric-somatostatin vaccines at 1 and 22 days of the study. Control mice were injected with PBS. All mice continued to be feed the 60% Kcal fat diet for the week and food intake was measured weekly. At week 6 6 week study. Body weights were measured two times a mice were euthanized and a terminal bleed was made and antibody levels to somatostatin and levels of insulin-like growth factor 1 （IGF-1） were determined. Vaccination with both vaccine formulations induced a statistically significant body weight change over the study period, as compared with PBS controls. Percentage of baseline body weight was also significantly affected by vaccination during the study period. Vaccinates finished the study at 104% and 107% of baseline weight, JHI7 ＆ JH18 respectively, while untreated controls reached 115% of baseline weight. Food intake per mouse was similar in all mouse groups during the entire study. Control mice did not demonstrate any antibody titers to somatostatin, while all vaccinated mice had measurable antibody responses （〉 1：500,000 titer）. IGF-1 levels were not statistically significant among the groups, but were elevated in the JH18 vaccinates （mean 440.4 ng/mL） when compared with PBS controls （mean 365.6 ng/mL）. Vaccination with either JH17 or JH18 chimeric -somatostatin vaccines produced a statistically significant weight loss as compared with PBS controls （P 〈 0.0001）, even though the DIO mice with continually fed a 60% Kcal fat diet. The weight loss/lower weight gain observations were even more significant, as all mice consumed similar amounts of food for the entire study. The presence of high levels of anti-somatostatin

关键词： Obesity Treatment Vaccines Weight loss Weight management

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MODEL, GUESS, CHECK: Wordle as a primer on active learning for materials research

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npj Computational Materials 2022年第1期8卷 937-939页

作者： keith A.Brown Department of Mechanical Engineering Physics Departmentand Division of Materials Science&EngineeringBoston UniversityBostonMAUSA

Research and games both require the participant to make a series of *** learning is a process borrowed from machine learning for algorithmically making choices that has become increasingly used to accelerate materials *** this process may seem opaque to researchers outside the field of machine learning,examining active learning in games provides an accessible way to showcase the process and its ***,we examine active learning through the lens of the game Wordle to both explain the active learning process and describe the types of research questions that arise when using active learning for materials research.

关键词： Wordle learning outside

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EMDS 3.0:A modeling framework for coping with complexity in environmental assessment and planning

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Science China(Technological Sciences) 2006年第Z1期49卷 63-75页

作者： keith M.Reynolds U.S.Dept.Agriculture Forest ServicePacific Northwest Research Station3200 SW Jefferson WayCorvallisOR 97331USA

The Ecosystem Management Decision Support (EMDS) system is an application framework for knowledge-based decision support of ecological assessments at any geographic scale. The system integrates state-of-the-art geographic information system (GIS) as well as knowledge-based reasoning and decision modeling technologies to provide decision support for a substantial portion of the adaptive management process of ecosystem management. EMDS 3.0 is implemented as an ArcMap extension and integrates the logic engine of NetWeaver to perform landscape evaluations, and the decision modeling engine of Criterium DecisionPlus for evaluating management priorities. Key features of the system's evaluation component include abilities to (1) reason about large, abstract, multi-faceted ecosystem management problems, (2) perform useful evaluations with incomplete information, (3) evaluate the influence of missing information, and (4) determine priorities for missing information. A key feature of the planning component is the ability to determine priorities for management activities, taking into account not only ecosystem condition, but also criteria that account for the feasibility and efficacy of potential management actions. Both components include powerful and intuitive diagnostic features that facilitate communicating the explanation of modeling results to a broad audience.

关键词： natural resources, modeling, assessment, analysis, planning, software, ecosystem management.

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Compaction analysis and optimisation of convex-faced pharmaceutical tablets using numerical techniques

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Particuology 2019年第6期17卷 10-21页

作者： Ahmad Baroutaji Sandra Lenihan keith Bryan School of Engineering Faculty of Science and EngineeringUniversity of WolverhamptonTelfordUK School of Mechanical Electrical and Process EngineeringCork Institute of TechnologyCorkIreland

Capping failure,edge chipping,and non-uniform mechanical properties of convex-faced pharmaceutical tablets are common problems in the pharma *** this paper,the finite element method(FEM)and design of experiment techniques are used to determine the optimal shape of convex-faced(CF)pharmaceutical tablet which has more uniform mechanical properties and less capping and chipping *** effects of different geometrical parameters and friction on the compaction responses of convex-faced pharmaceutical tablets were first identified and *** FEM model of the tabletting process was generated using the implicit code ABAQUS and validated against experimental *** surface methodology was used to establish the relationship between the design variables,represented by the geometrical parameters and friction coefficient,and compaction responses of interest including residual die pressure,relative density variation within a tablet,and relative shear stress at the edge of a tablet.A statistical-based optimisation approach was then used to optimise the shape of CF *** obtained results demonstrated how the geometrical parameters and friction coefficient of CF pharmaceutical tablets strongly affect their compaction behaviour and quality.

关键词： Capping failure Edge chipping Tabletting FEM Optimisation Residual radial pressure

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Using LaModel to analyze coal bumps

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International Journal of Mining Science and Technology 2018年第5期28卷 729-737页

作者： keith A.Heasley Ihsan Berk Tulu Department of Mining Engineering West Virginia University

Coal bumps have long been a safety hazard in coal mines, and even after decades of research, the exact mechanics that cause coal bumps are still not well understood. Therefore, coal bumps are still difficult to predict and control. The LaModel program has a long history of being used to effectively analyze displacements and stresses in coal mines, and with the recent addition of energy release and local mine stiffness calculations, the LaModel program now has greatly increased capabilities for evaluating coal bump potential. This paper presents three recent case histories where coal stress, pillar safety factor, energy release rate and local mine stiffness calculations in LaModel were used to evaluate the pillar plan and cut sequencing that were associated with a number of bumps. The first case history is a longwall mine where a simple stress analysis was used to help determine the limiting depth for safely mining in bump-prone ground. The second case history is a room-and-pillar retreat mine where the LaModel analysis is used to help optimize the pillar extraction sequencing in order to minimize the frequent pillar line bumps. The third case history is the Crandall Canyon mine where an initial bump and then a massive pillar collapse/bump which killed 6 miners is extensively back-analyzed. In these case histories, the calculation tools in LaModel are ultimately shown to be very effective for analyzing various aspects of the bump problem, and in the conclusions, a number of critical insights into the practical calculation of mine failure and stability developed as a result of this research are presented.

关键词： Coal bump Burst Energy release rate Local mine stiffness LaModel

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INTERRELATIONSHIPS AMONG NONCOOPERATIVE AND COALITION STABILITY CONCEPTS

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Journal of Systems Science and Systems Engineering 2008年第1期17卷 1-29页

作者： Takehiro INOHARA keith W.HIPEL Department of Value and Decision Science Tokyo Institute of TechnologyJapan Department of Systems Design Engineering University of WaterlooCanada

Insightful theorems are established on interrelationships among coalition and noncooperative stability concepts defined within the paradigm of the Graph Model for Conflict Resolution. More specifically, the newly defined coalition stability def＇mitions that are considered are coalition Nash stability （CNash）, coalition general metarationality （CGMR）, coalition symmetric metarationality （CSMR） and coalition sequential stability （CSEQ）, along with their earlier-defined noncooperative versions. A range of interesting new theorems are derived to establish connections among these coalition stability concepts as well as between noncooperative and coalition stability definitions. Applications with respect to the games of Prisoner＇s Dilemma and Chicken, as well as a groundwater contamination dispute, demonstrate how the various stability definitions can be applied in practice and confirm the validity of some of the theorems as well as point out, by example, certain types of relationships which cannot hold.

关键词： Chicken coalitions environmental conflict Graph Model for Conflict Resolution noncooperative behaviour Prisoner's Dilemma stability relationships

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Prognostic factors for a favorable outcome after varicocele repair in adolescents and adults

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Asian Journal of Andrology 2016年第2期18卷 217-221,J0004页

作者： Mary K Samplaski keith A Jarvi Institute of Urology University of Southern California Los Angeles CA USA Division of Urology Department of Surgery Mount Sinai Hospital University of TorontoToronto Ontario Canada.

The effect of varicocele repair on male fertility remains controversial. It would be helpful to determined which men would benefit most from varicocele repair, and target repair efforts at those individuals. A detailed review of the literature on prognostic factors for varicocele repair was performed using the PubMed NLM database. We found that the best predictor of postvaricocelectomy semen parameters is the preoperative semen parameters. The greatest improvements in semen parameters were found in men with larger varicoceles. While there is controversy, higher testosterone, younger age and larger testis size, in some studies predict for improvements in semen parameters postvaricocelectomy. A nomogram has been developed to predict the postvaricocelectomy semen parameters based on the preoperative semen parameters, varicocele grade and the age of the man （***. com）. Limited data consistently demonstrates the greatest improvements in DNA fragmentation rates in men with higher baseline DNA fragmentation rates. With respect to reproductive outcomes, higher baseline sperm density consistently predicts for natural pregnancy or assisted reproductive technology （ART） pregnancy rates. In addition, varicocele repair does seem to reduce the need for more invasive modalities of ART. In conclusion, we can now start to use specific parameters such as baseline semen quality, varicocele grade and patient age to predict post-repair semen oualitv and fertility potential following varicocelectomy.

关键词： prediction prognosis varicocelectomy varicoceles

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Clinical features and management of primary sclerosing cholangitis

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World Journal of Gastroenterology 2008年第21期14卷 3338-3349页

作者： Marina G Silveira keith D Lindor Division of Gastro-enterology and Hepatology Miles and Shirley Fiterman Center for Digestive DiseasesMayo Clinic and FoundationRochesterMinnesotaUnited States

Primary sclerosing cholangitis is a chronic cholestatic liver disease characterized by inflammation and fibrosis of the bile ducts,resulting in cirrhosis and need for liver transplantation and reduced life *** majority of cases occur in young and middle-aged men,often in association with inflammatory bowel *** etiology of primary sclerosing cholangitis includes immune-mediated components and elements of undefined *** effective medical therapy has been *** multiple complications of primary sclerosing cholangitis include metabolic bone disease,dominant strictures,bacterial cholangitis,and malignancy,particularly cholangiocarcinoma,which is the most lethal complication of primary sclerosing *** transplantation is currently the only life-extending therapeutic alternative for patients with end-stage disease,although recurrence in the allografted liver has been described.A PSC-like variant attracting attention is cholangitis marked by raised levels of the immunoglobulin G4 subclass,prominence of plasma cells within the lesions,and steroid responsiveness.

关键词： Sclerosing cholangitis Diagnosis Therapy Cholestasis Cholangiocarcinoma Liver transplantation

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IDeATe @ Hunt Library

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图书馆建设 2017年第2期 40-41页

作者： keith Webster 美国卡内基梅隆大学图书馆

Good evening!Thank you for your invitation!Today I will mainly talk about my perspectives on maker spaces especially on academic *** change is that the real thing is not simply about creating opportunities for students but for librarians to build academic *** the program language I'm talking about is IDeA Te.I will also talk about a few words

关键词：英语阅读理解图书馆

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Network Motif Detection: Algorithms, Parallel and Cloud Computing,and Related Tools

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Tsinghua Science and Technology 2013年第5期18卷 469-489页

作者： Wooyoung Kim Martin Diko keith Rawson the Department of Computing and Software Systems University of Washington Bothell

Network motif is defined as a frequent and unique subgraph pattern in a network, and the search involves counting all the possible instances or listing all patterns, testing isomorphism known as NP-hard and large amounts of repeated processes for statistical evaluation. Although many efficient algorithms have been introduced, exhaustive search methods are still infeasible and feasible approximation methods are yet ***, the fast and continual growth of biological networks makes the problem more challenging. As a consequence, parallel algorithms have been developed and distributed computing has been tested in the cloud computing environment as well. In this paper, we survey current algorithms for network motif detection and existing software tools. Then, we show that some methods have been utilized for parallel network motif search algorithms with static or dynamic load balancing techniques. With the advent of cloud computing services, network motif search has been implemented with MapReduce in Hadoop Distributed File System（HDFS）, and with Storm, but without statistical testing. In this paper, we survey network motif search algorithms in general, including existing parallel methods as well as cloud computing based search, and show the promising potentials for the cloud computing based motif search methods.

关键词： network motif parallel search MapReduce HDFS storm

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