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Management of distal cholangiocarcinoma with arterial involvement: systematic review and case series on the role of neoadjuvant therapy

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World journal of Gastrointestinal surgery 2024年第8期16卷 2689-2701页

作者： Lewis A Hall Duncan Loader santiago Gouveia Marta Burak james Halle-smith Peter Labib Moath Alarabiyat Ravi Marudanayagam Bobby V Dasari keith j roberts.s.ed s.raza Michail Papamichail David C Bartlett Robert P sutcliffe Nikolaos A Chatzizacharias Department of Hepatopancreatobiliary surgery and Liver Transplantation University Hospitals Birmingham NHS Foundation TrustBirmingham B152GWUnited Kingdom Institute of Immunology and Immunotherapy University of BirminghamBirmingham B152TTUnited Kingdom College of Medical and Dental sciences University of BirminghamBirmingham B152TTUnited Kingdom Institute of Clinical sciences University of BirminghamBirmingham B152TTUnited Kingdom

BACKGROUND The use of neoadjuvant therapy(NAT)in distal cholangiocarcinoma(dCCA)with regional arterial or extensive venous involvement,is not widely accepted and evidence is *** To synthesise evidence on NAT for dCCA and present the experience of a highvolume tertiary-centre managing dCCA with arterial *** A systematic review was performed according to PRIsMA guidance to identify all studies reporting outcomes of patients with dCCA who received *** patients from 2017 to 2022 who were referred for NAT for dCCA at our centre were retrospectively collected from a prospectively maintained *** characteristics,NAT type,progression to surgery and oncological outcomes were *** Twelve studies were *** definition of“unresectable”locally advanced dCCA was *** studies reported outcomes for 9 patients who received NAT for dCCA with extensive vascular involvement.R0 resection rate ranged between 0 and 100%but without survival benefit in most *** studies considered either NAT in resectable dCCA or inclusive with extrahepatic *** presented case series includes 9 patients(median age 67,IQR 56-74 years,male:female 5:4)referred for NAT for borderline resectable or locally advanced *** patients progressed to surgery and 2 were *** patient died at 14 months with evidence of recurrence at 6 months and the other died at 51 months following recurrence 6 months *** Evidence for benefit of NAT is *** on criteria for uniform definition of resectability for dCCA is *** propose using the established National-Comprehensive-Cancer-Network®criteria for pancreatic ductal adenocarcinoma.

关键词： Cholangiocarcinoma Neoadjuvant therapy Arterial involvement Locally advanced systematic review

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Knowledge‐based deep learning system for classifying Alzheimer's disease for multi‐task learning

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CAAI Transactions on Intelligence Technology 2024年第4期9卷 805-820页

作者： Amol Dattatray Dhaygude Gaurav Kumar Ameta Ihtiram raza Khan Pavitar Parkash singh Renato R.Maaliw III Natrayan Lakshmaiya Mohammad shabaz Muhammad Attique Khan Hany s.Hussein Hammam Alshazly Department of Data science University of WashingtonSeattleWashingtonUSA Department of Computer science&Engineering Parul Institute of TechnologyParul UniversityVadodaraGujaratIndia Department of Computer science Jamia HamdardDelhiIndia Department of Management Lovely Professional UniversityPhagwaraIndia 5 College of Engineering Southern Luzon State UniversityLucbanQuezonPhilippines Department of Mechanical Engineering Saveetha School of EngineeringSIMATSChennaiTamil NaduIndia Model Institute of Engineering and Technology JammuJ&KIndia Department of Computer science HITEC UniversityTaxilaPakistan Department of Computer science and Mathematics Lebanese American UniversityBeirutLebanon Electrical Engineering Department College of EngineeringKing Khalid UniversityAbhaSaudi Arabia Electrical Engineering Department Aswan UniversityAswanEgypt Faculty of Computers and Information South Valley UniversityQenaEgypt

Deep learning has recently become a viable approach for classifying Alzheimer's disease(AD)in medical ***,existing models struggle to efficiently extract features from medical images and may squander additional information resources for illness *** address these issues,a deep three‐dimensional convolutional neural network incorporating multi‐task learning and attention mechanisms is *** upgraded primary C3D network is utilised to create rougher low‐level feature *** introduces a new convolution block that focuses on the structural aspects of the magnetORCID:ic resonance imaging image and another block that extracts attention weights unique to certain pixel positions in the feature map and multiplies them with the feature map ***,several fully connected layers are used to achieve multi‐task learning,generating three outputs,including the primary classification *** other two outputs employ backpropagation during training to improve the primary classification *** findings show that the authors’proposed method outperforms current approaches for classifying AD,achieving enhanced classification accuracy and other in-dicators on the Alzheimer's disease Neuroimaging Initiative *** authors demonstrate promise for future disease classification studies.

关键词： classification deep learning

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Multi-functional metasurface:ultra-wideband/multi-band absorption switching by adjusting guided-mode resonance and local surface plasmon resonance effects

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Communications in Theoretical Physics 2024年第6期76卷 174-184页

作者： Wenxin Li shubo Cheng Huafeng Zhang Zao Yi Bin Tang Can Ma Pinghui Wu Qingdong Zeng Rizwan raza school of Physics and Optoelectronic Engineering Yangtze UniversityJingzhouHubei 434023China joint Laboratory for Extreme Conditions Matter Properties Southwest University of Science and TechnologyMianyang 621010China school of Chemistry and Chemical Engineering Jishou UniversityJishou 416000China school of Microelectronics and Control Engineering Changzhou UniversityChangzhou 213164China Department of Oncology Sichuan Science City HospitalMianyangSichuan Province 621000China Office of science and Technology Quanzhou Normal UniversityQuanzhou 362000China school of Physics and Electronic-information Engineering Hubei Engineering UniversityXiaogan 432000China Department of Physics COMsATs Institute of Information Technology 54000 LahorePakistan

This study introduces an innovative dual-tunable absorption film with the capability to switch between ultra-wideband and narrowband *** manipulating the temperature,the film can achieve multi-band absorption within the 30-45 THz range or ultra-wideband absorption spanning 30-130 THz,with an absorption rate exceeding ***,the structural parameters of the absorption film are optimized using the particle swarm optimization(PsO)algorithm to ensure the optimal absorption *** absorption response of the film is primarily attributed to the coupling of guided-mode resonance and local surface plasmon resonance *** film's symmetric structure enables polarization incoherence and allows for tuning through various means such as doping/voltage,temperature and structural *** the case of a multi-band absorption response,the film exhibits good sensitivity to refractive index changes in multiple absorption ***,the absorption spectrum of the film remains effective even at large incidence angles,making it highly promising for applications in fields such as biosensing and infrared stealth.

关键词： PsO optimization ultra-wideband/narrowband absorption switching intelligent absorption film vanadium dioxide

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Prehospital transdermal glyceryl trinitrate for ultra- acute ischaemic stroke: data from the RIGHT- 2 randomised sham- controlled ambulance trial

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stroke & Vascular Neurology 2024年第1期9卷 38-49,I0035-I0046页

作者： jason Philip Appleton Lisa j Woodhouse Craig s Anderson sandeep Ankolekar Lesley Cala Mark Dixon Timothy j England Kailash Krishnan Grant Mair keith W Muir john Potter Christopher I Price Marc Randall Thompson G Robinson Christine Roffe Else C sandset jeffrey L saver Angela shone Aloysius Niroshan siriwardena joanna M Wardlaw Nikola sprigg Philip M Bath stroke University Hospitals Birmingham NHS Foundation TrustBirminghamUK Institute of Applied HealthResearch University of Birmingham College of Medical and Dental SciencesBirminghamUK stroke Trials Unit Mental Health and Clinical NeurosciencesUniversity of NottinghamNottinghamUK Faculty of Medicine The George Institute for Global HealthSydneyNew South WalesAustralia The George Institute China at Peking University Health science Center BeijingChina Neurology Royal Prince Alfred HospitalSydney Health PartnersSydneyNew South WalesAustralia Department of Neurology King's College Hospital NHS Foundation TrustLondonUK Faculty of Health and Medical sciences University of Western AustraliaCrawleyWestern AustraliaAustralia East Midlands Ambulance service NHs Trust NottinghamUK stroke Queen's Medical CentreNottingham University Hospitals NHS TrustNottinghamUK Centre for Clinical Brain sciences Dementia Research InstituteUniveristy of EdinburghEdinburghUK Institute of Neurology and Psychology University of GlasgowGlasgowUK Bob Champion Research and education Building University of East AngliaNorwichUK Institute of Neuroscience Newcastle UniversityNewcastle upon TyneUK Department of Neurology Leeds Teaching Hospitals NHS TrustLeedsUK Department of Cardiovascular sciences and NIHR Leicester Biomedical Research Centre University of LeicesterLeicesterUK stroke Research in stoke Institute for Science and Technology in MedicineKeele UniversityStoke-on TrentUK Department of Neurology Oslo University HospitalOsloNorway Research and Development Norwegian Air Ambulance FoundationOsloNorway Department of Neurology and Comprehensive stroke Center David Geffen School of MedicineUCLALos AngelesCaliforniaUSA Research and Graduate services University of NottinghamNottinghamUK Community and Health Research Unit University of LincolnLincolnUK

Background The effect of transdermal glyceryl trinitrate(GTN,a nitrovasodilator)on clinical outcome when administered before hospital admission in suspected stroke patients is ***,we assess the safety and efficacy of GTN in the prespecified subgroup of patients who had an ischaemic stroke within the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2(RIGHT-2).Methods RIGHT-2 was an ambulance-based multicentre sham-controlled blinded-endpoint study with patients randomised within 4hours of *** primary outcome was a shift in scores on the modified Rankin scale(mRs)at day *** outcomes included death;a global analysis(Wei-Lachin test)containing Barthel Index,EuroQol-5D,mRs,telephone interview for cognitive status-modified and Zung depression scale;and neuroimaging-determined‘brain frailty’*** were reported as n(%),mean(sD),median[IQR],adjusted common OR(acOR),mean difference or Mann-Whitney difference(MWD)with 95%*** 597 of 1149(52%)patients had a final diagnosis of ischaemic stroke;age 75(12)years,premorbid mRs>2107(18%),Glasgow Coma scale 14(2)and time from onset to randomisation 67[45,108]***‘brain frailty’was common:median score 2[2,3](range 0–3).At day 90,GTN did not influence the primary outcome(acOR for increased disability 1.15,95%CI 0.85 to 1.54),death or global analysis(MWD 0.00,95%CI-0.10 to 0.09).In subgroup analyses,there were non-significant interactions suggesting GTN may be associated with more death and dependency in participants randomised within 1hour of symptom onset and in those with more severe *** In patients who had an ischaemic stroke,ultra-acute administration of transdermal GTN in the ambulance did not improve clinical outcomes in a population with more clinical and radiological frailty than seen in previous in-hospital *** Is ALREADY KNOWN ON THIs TOPIC⇒Transdermal glyceryl trinitrate(GTN)was associat-ed with less death and dependency in those w

关键词： Glasgow nitrate random

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EZH2 inhibitors promote β-like cell regeneration in young and adult type 1 diabetes donors

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signal Transduction and Targeted Therapy 2024年第2期9卷 679-692页

作者： keith Al-Hasani safiya Naina Marikar Harikrishnan Kaipananickal scott Maxwell jun Okabe Ishant Khurana Thomas Karagiannis julia j.Liang Lina Mariana Thomas Loudovaris Thomas Kay Assam El-Osta Epigenetics in Human Health and Disease Program Baker Heart and Diabetes Institute75 Commercial RoadMelbourne 3004 VICAustralia Department of Diabetes Central Clinical SchoolMonash UniversityMelbourne 3004 VICAustralia Epigenetics in Human Health and Disease Laboratory Central Clinical SchoolMonash UniversityMelbourne 3004 VICAustralia school of science STEM CollegeRMIT UniversityMelbourne 3001 VICAustralia Immunology and Diabetes Unit St Vincent’s Institute of Medical ResearchFitzroy 3065 VICAustralia Department of Medicine and Therapeutics The Chinese University of Hong KongSha TinHong Kong SAR Hong Kong Institute of Diabetes and Obesity Prince of Wales HospitalThe Chinese University of Hong Kong3/F Lui Che Woo Clinical Sciences Building30-32-Ngan Shing StreetSha TinHong Kong SAR Li Ka shing Institute of Health sciences The Chinese University of Hong KongSha TinHong Kong SAR Biomedical Laboratory science Department of TechnologyFaculty of HealthUniversity College CopenhagenCopenhagenDenmark

β-cells are a type of endocrine cell found in pancreatic islets that synthesize,store and release *** type 1 diabetes(T1D),T-cells of the immune system selectively destroy the insulin-producingβ-*** of these cells leads to a lifelong dependence on exogenous insulin administration for ***,there is an urgent need to identify novel therapies that stimulateβ-cell growth and induceβ-cell *** and others have shown that pancreatic ductal progenitor cells are a promising source for regeneratingβ-cells for T1D owing to their inherent differentiation *** transcriptional suppression is refractory to exocrine reaction and tightly controls the regenerative potential by the EZH2 *** the present study,we show that transient stimulation of exocrine cells,derived from juvenile and adult T1D donors to the FDAapproved EZH2 inhibitors GsK126 and Tazemetostat(Taz)influence a phenotypic shift towards aβ-like cell *** transition from repressed to permissive chromatin states are dependent on bivalent H3K27me3 and H3K4me3 chromatin *** EZH2 is fundamental toβ-cell regenerative *** pancreatic ductal cells exhibit insulin production and secretion in response to a physiological glucose challenge ex *** pre-clinical studies underscore the potential of small molecule inhibitors as novel modulators of ductal progenitor differentiation and a promising new approach for the restoration ofβ-like cell function.

关键词： EZH2 struction inhibitors

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Epstein-Barr virus associated secondary hemophagocytic lymphohistiocytosis with an unusual presentation of abdominal compartment syndrome

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Hepatoma Research 2016年第1期2卷 287-292页

作者： Li Lei Camilla j.Cobb jeffrey Cao Anwar s.raza Department of Pathology and Human Anatomy Loma Linda University Medical CenterLoma LindaCA 92354USA

Hemophagocytic lymphohistiocytosis(HLH)is a cytokine storm syndrome caused by an overactive but ineffective immune *** prompt diagnosis and treatment,HLH is ***,presenting symptoms are often nonspecific,with fatigue and fever being the most common.A high index of suspicion is therefore critical for early diagnosis and timely management.A previously healthy,65-year-old female who initially presented with fever and abdominal pain developed abdominal compartment syndrome(ACs)requiring decompressive laparotomy on hospital day *** frozen sections of biopsied liver showed intense portal lymphohistiocytic ***-Barr virus DNA copy numbers escalated from 600 copies/mL after admission to 134,000 copies/mL before *** diagnostic criteria of HLH-2004 were *** expired on hospital day *** is important to raise awareness of ACs being an unusual presentation of *** changes in diagnostic criteria tailored to adult HLH cases are reviewed.

关键词： Hemophagocytic lymphohistiocytosis abdominal compartment syndrome liver biopsy Epstein-Barr virus

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Distinct risk factors for early and late blood transfusion following pancreaticoduodenectomy

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Hepatobiliary & Pancreatic Diseases International 2018年第4期17卷 349-357页

作者： sukhchain s.Bansal james Hodson Khalid Khalil Bobby Dasari Ravi Marudanayagam Robert P.sutcliffe john Isaac keith j.roberts Department of Hepatobiliary Pancreatic surgery Queen Elizabeth Hospital BirminghamUniversity Hospitals Birmingham Institute of Translational Medicine Queen Elizabeth Hospital BirminghamUniversity Hospitals Birmingham

Background: The International study Group of Pancreatic surgery(IsGPs) has defined two periods of postpancreatectomy hemorrhage, early(24 h). A previously published Blood Usage Risk score(BURs) aimed to predict early and late blood transfusion. The primary aim of this study was to define risk factors for early and late blood transfusion after pancreaticoduodenectomy. secondary aims were to assess the predictive accuracy of the ***: In this retrospective observational study, multivariable analyses were used to identify independent risk factors for both early and late blood transfusion. The predictive ability of the BURs was then assessed using a receiver operating characteristic(ROC) curve ***: Among 628 patients, 99(15.8%) and 144(22.9%) received early and late blood transfusion, respectively. Risk factors for blood transfusion differed between early and late periods. Preoperative anemia and venous resection were associated with early blood transfusion whilst Whipple’s resection(as opposed to pylorus preserving pancreaticoduodenectomy), lack of biliary stent and a narrow pancreatic duct were predictors of late blood transfusion. The BURs was significantly predictive of early blood transfusion,albeit with a modest degree of accuracy(AUROC: 0.700, P sfusion(AUROC: 0.525, P = 0.360). Late blood transfusion was independently associated with increasing severity of postoperative pancreatic fistula(POPF)(OR: 1.85, 3.18 and 9.97 for biochemical, types B and C POPF,respectively, relative to no POPF).Conclusions: Two largely different sets of variables are related to early and late blood transfusion following pancreaticoduodenectomy. The BURs was significantly associated with early, albeit with modest predictive accuracy, but not late blood transfusion. An understanding of POPF risk allows assessment of the need for late blood transfusion.

关键词： Pancreatic cancer Blood transfusion Pancreaticoduodenectomy

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Evidence for particle acceleration approaching PeV energies in the W51 complex

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science Bulletin 2024年第18期69卷 2833-2841页

作者： LHAAsO Collaboration Zhen Cao F.Aharonian Axikegu Y.X.Bai Y.W.Bao D.Bastieri X.j.Bi Y.j.Bi W.Bian A.V.Bukevich Q.Cao W.Y.Cao Zhe Cao j.Chang j.F.Chang A.M.Chen E.s.Chen H.X.Chen Liang Chen Lin Chen Long Chen M.j.Chen M.L.Chen Q.H.Chen s.Chen s.H.Chen s.Z.Chen T.L.Chen Y.Chen N.Cheng Y.D.Cheng M.Y.Cui s.W.Cui X.H.Cui Y.D.Cui B.Z.Dai H.L.Dai Z.G.Dai Danzengluobu X.Q.Dong K.K.Duan j.H.Fan Y.Z.Fan j.Fang j.H.Fang K.Fang C.F.Feng H.Feng L.Feng s.H.Feng X.T.Feng Y.Feng Y.L.Feng s.Gabici B.Gao C.D.Gao Q.Gao W.Gao W.K.Gao M.M.Ge L.s.Geng G.Giacinti G.H.Gong Q.B.Gou M.H.Gu F.L.Guo X.L.Guo Y.Q.Guo Y.Y.Guo Y.A.Han M.Hasan H.H.He H.N.He j.Y.He Y.He Y.K.Hor B.W.Hou C.Hou X.Hou H.B.Hu Q.Hu s.C.Hu D.H.Huang T.Q.Huang W.j.Huang X.T.Huang X.Y.Huang Y.Huang X.L.ji H.Y.jia K.jia K.jiang X.W.jiang Z.j.jiang M.jin M.M.Kang I.Karpikov D.Kuleshov K.Kurinov B.B.Li C.M.Li Cheng Li Cong Li D.Li F.Li H.B.Li H.C.Li jian Li jie Li K.Li s.D.Li W.L.Li W.L.Li X.R.Li Xin Li Y.Z.Li Zhe Li Zhuo Li E.W.Liang Y.F.Liang s.j.Lin B.Liu C.Liu D.Liu D.B.Liu H.Liu H.D.Liu j.Liu j.L.Liu M.Y.Liu R.Y.Liu s.M.Liu W.Liu Y.Liu Y.N.Liu Q.Luo Y.Luo H.K.Lv B.Q.Ma L.L.Ma X.H.Ma j.R.Mao Z.Min W.Mitthumsiri H.j.Mu Y.C.Nan A.Neronov L.j.Ou P.Pattarakijwanich Z.Y.Pei j.C.Qi M.Y.Qi B.Q.Qiao j.j.Qin A.raza D.Ruffolo A.sáiz M.saeed D.semikoz L.shao O.shchegolev X.D.sheng F.W.shu H.C.song Yu.V.stenkin V.stepanov Y.su D.X.sun Q.N.sun X.N.sun Z.B.sun j.Takata P.H.T.Tam Q.W.Tang R.Tang Z.B.Tang W.W.Tian C.Wang C.B.Wang G.W.Wang H.G.Wang H.H.Wang j.C.Wang Kai Wang Kai Wang L.P.Wang L.Y.Wang P.H.Wang R.Wang W.Wang X.G.Wang X.Y.Wang Y.Wang Y.D.Wang Y.j.Wang Z.H.Wang Z.X.Wang Zhen Wang Zheng Wang D.M.Wei j.j.Wei Y.j.Wei T.Wen C.Y.Wu H.R.Wu Q.W.Wu s.Wu X.F.Wu Y.s.Wu s.Q.Xi j.Xia G.M.Xiang D.X.Xiao G.Xiao Y.L.Xin Y.Xing D.R.Xiong Z.Xiong D.L.Xu R.F.Xu R.X.Xu W.L.Xu L.Xue D.H.Yan j.Z.Yan T.Yan C.W.Yang C.Y.Yang F.Yang F.F.Yang L.L.Yang M.j.Yang R.Z.Yang W.X.Yang Y.H.Yao Z.G.Yao L.Q.Yin N.Yin X.H.You Z.Y.You Y.H.Yu Q.Yuan H.Yue H.D.Zeng T.X.Zeng W.Zeng M.Zha B.B.Zhang F.Zhang H.Zhang 不详 Key Laboratory of Particle Astrophysics&Experimental Physics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of sciences Beijing 100049China TIANFU Cosmic Ray Research Center ChengduChina Dublin Institute for Advanced studies 31 Fitzwilliam Place2 DublinIreland Max-Planck-Institut for Nuclear Physics P.O.Box 103980Heidelberg 69029Germany school of Physical science and Technology&school of Information science and Technology Southwest Jiaotong UniversityChengdu 610031China school of Astronomy and space science Nanjing UniversityNanjing 210023China Center for Astrophysics Guangzhou UniversityGuangzhou 510006China Tsung-Dao Lee Institute&school of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China Institute for Nuclear Research of Russian Academy of sciences Moscow 117312Russia Hebei Normal University Shijiazhuang 050024China University of science and Technology of China Hefei 230026China state Key Laboratory of Particle Detection and Electronics China Key Laboratory of Dark Matter and space Astronomy&Key Laboratory of Radio Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China Research Center for Astronomical Computing Zhejiang LaboratoryHangzhou 311121China Key Laboratory for Research in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China school of Physics and Astronomy Yunnan UniversityKunming 650091China Key Laboratory of Cosmic Rays(Tibet University) Ministry of EducationLhasa 850000China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China school of Physics and Astronomy(Zhuhai)&school of Physics(Guangzhou)&sino-French Institute of Nuclear Engineering and Technology(Zhuhai) Sun Yat-sen UniversityZhuhai 519000&Guangzhou 510275GuangdongChina Institute of Frontier and Interdisciplinary science Shandong UniversityQingdao 266237China APC UniversitéParis Cité

Theγ-ray emission from the W51 complex is widely acknowledged to be attributed to the interaction between the cosmic rays(CRs)accelerated by the shock of supernova remnant(sNR)W51C and the dense molecular clouds in the adjacent star-forming region,***,the maximum acceleration capability of W51C for CRs remains *** on observations conducted with the Large High Altitude Air shower Observatory(LHAAsO),we report a significant detection ofγrays emanating from the W51 complex,with energies from 2 to 200 *** LHAAsO measurements,for the first time,extend theγ-ray emission from the W51 complex beyond 100 TeV and reveal a significant spectrum bending at tens of *** combining the"π^(0)-decay bump"featured data from Fermi-LAT,the broadbandγ-ray spectrum of the W51 region can be well-characterized by a simple pp-collision *** observed spectral bending feature suggests an exponential cutoff at~400 TeV or a power-law break at~200 TeV in the CR proton spectrum,most likely providing the first evidence of sNRs serving as CR accelerators approaching the PeV ***,two young star clusters within W51B could also be theoretically viable to produce the most energeticγrays observed by *** findings strongly support the presence of extreme CR accelerators within the W51 complex and provide new insights into the origin of Galactic CRs.

关键词： UHE c-ray Cosmic rays sNR W51C star clusters

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RNA m^(6)A reader YTHDF2 facilitates precursor miR-126 maturation to promote acute myeloid leukemia progression

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Genes & Diseases 2024年第1期11卷 382-396页

作者： Zheng Zhang Keren Zhou Li Han Andrew small jianhuang Xue Huilin Huang Hengyou Weng Rui su Brandon Tan Chao shen Wei Li Zhicong Zhao Ying Qing Xi Qin Kitty Wang keith Leung Mark Boldin Chun-Wei Chen David Ann Zhijian Qian Xiaolan Deng jianjun Chen Zhenhua Chen Department of systems Biology Beckman Research Institute of City of HopeMonroviaCA 91016USA Irell and Manella Graduate school of Biological sciences Beckman Research Institute of City of HopeDuarteCA 91010USA Gehr Family Center for Leukemia Research City of HopeDuarteCA 91010USA sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdong 510060China Guangzhou Laboratory GuangzhouGuangdong 510005China Bioland Laboratory GuangzhouGuangdong 51005China Department of Liver surgery Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Diabetes Complications and Metabolism Beckman Research Institute of City of HopeDuarteCA 91010USA Department of Biochemistry and Molecular Biology University of FloridaGainesvilleFL 32603USA Tongji Hospital Affiliated to Tongji University Frontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China school of Pharmacy China Medical UniversityShenyangLiaoning 110001China

As the most common internal modification of mRNA,Ne-methyladenosine(m^(6)A)and its regulators modulate gene expression and play critical roles in various biological and patholog-ical processes including *** was reported previously that m^(6)A methyltransferase(writer),methyltransferase-like 3(METTL3)adds m^(6)A in primary microRNAs(pri-miRNAs)and fa-cilitates its processing into precursor miRNAs(pre-miRNAs).However,it is unknown whether m^(6)A modification also plays a role in the maturation process of pre-miRNAs and(if so)whether such a function contributes to ***,we found that YTHDF2 is aberrantly overexpressed in acute myeloid leukemia(AML)patients,especially in relapsed patients,and plays an onco-genic role in ***,YTHDF2 promotes expression of miR-126-3p(also known as miR-126,as it is the main product of precursor miR-126(pre-miR-126)),a miRNA that was reported as an oncomiRNA in AML,through facilitating the processing of pre-miR-126 into mature ***,YTHDF2 recognizes m^(6)A modification in pre-miR-126 and recruits AGO2,a regulator of pre-miRNA processing,to promote the maturation of ***2 posi-tively and negatively correlates with miR-126 and miR-126's downstream target genes,respec-tively,in AML patients,and forced expression of miR-126 could largely rescue YTHDF2/Ythdf2 depletion-mediated suppression on AML cell growth/proliferation and leukemogenesis,indi-cating that miR-126 is a functionally important target of YTHDF2 in ***,our studies not only reveal a previously unappreciated YTHDF2/miR-126 axis in AML and highlight the ther-apeutic potential of targeting this axis for AML treatment,but also suggest that m^(6)A plays a role in pre-miRNA processing that contributes to tumorigenesis.

关键词： AML miR-126 N^(6)-methyladenosine Pre-miRNA maturation YTHDF2

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The integrated use of chemical insecticides and the entomopathogenic nematode, steinemema carpocapsae （Nematoda： steinernematidae）, for the control of sweetpotato whitefly, Bemisia tabaci （Hemiptera： Aleyrodidae）

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Insect science 2008年第5期15卷 447-453页

作者： Andrew G. s. Cuthbertson james j. Mathers Phil Northing Anthony j. Prickett keith F. A. Waiters Central science Laboratory Sand Hutton York YO41 1LZ UK

The integration of chemical insecticides and infective juveniles of the entomopathogenic nematode steinernema carpocapsae （Wesier）（Nematoda： steinernematidae）, to control second instars of the sweetpotato whitefly, Bemisia tabaci Gennadius （Hemiptera： Aleyrodidae） was investigated. Using a sand bioassay, the effects of direct exposure of s. carpocapsae for 24 h to field rate dilutions of four insecticides （spiromesifen, thiacloprid, imidacloprid and pymetrozine） on infectivity to Galleria mellonella larvae were tested. Although all chemicals tested, except spiromesifen, produced acceptable nematode infectivity rates, they were all significantly less than the water control. The effect of insecticide treatment （dry residues of spiromesifen, thiacloprid and pymetrozine and soil drench of imidacloprid） on the efficacy of the nematode against B. tabaci was also investigated. Nematodes in combination with thiacloprid and spiromesifen gave higher B. tabaci mortality （86.5% and 94.3% respectively） compared to using nematodes alone （75.2%） on tomato plants. There was no significant difference in B. tabaci mortality when using the chemicals imidacloprid, pymetrozine and spiromesifen in conjunction with nematodes compared to using the chemicals alone. However, using thiacloprid in combination with the nematodes produced significantly higher B. tabaci mortality than using the chemical alone. The integration of s. carpocapsae and these chemical agents into current integrated pest management programmes for the control of B. tabaci is discussed.

关键词： entomopathogenic nematode infectivity insecticide residue pest management

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