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麻醉住院医师行随机药物检测可降低药物成瘾的发生率：来自一项研究的初步结果

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麻醉与镇痛 2013年第6期9卷 1-6页

作者： Mich.el G. Fitzsimons, MD keith h. Baker, MD, Ph. Edward Lowenstein, MD Warren M. Zapol, MD 邱必军(译) 俞卫锋(校) Department of Anesth.sia and Critical Care Harvard Medical School Massachusetts General Hospital Boston Massachusetts 不详

麻醉住院医师中药物滥用的发生率为1％～2％，并且近80％的培训计划中会有一个或更多的住院医师存在这个问题。教育与管制上的努力对降低药物滥用的发生率是失败的。为了患者的身体健康，麻醉医师负有远离成瘾性药物的职业责任。我们制... 详细信息

麻醉住院医师中药物滥用的发生率为1％～2％，并且近80％的培训计划中会有一个或更多的住院医师存在这个问题。教育与管制上的努力对降低药物滥用的发生率是失败的。为了患者的身体健康，麻醉医师负有远离成瘾性药物的职业责任。我们制定了一个项目拟通过对录用前的麻醉科住院医师进行随机尿液检测以降低药物滥用的发生率。虽然存在逻辑和文化上的障碍，但我们证明该计划的可行性。仍需要大型的多中心研究来决定是否需要制定一项随机尿液检测项目以降低麻醉科住院医师药物滥用的发生率。

关键词：住院医师麻醉医师发生率药物成瘾药物检测随机药物滥用尿液检测

Bench.arking th. performance of Bayesian optimization across multiple experimental materials science domains

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npj Computational Materials 2021年第1期7卷 1742-1751页

作者： Qiaoh.o Liang Aldair E.Gongora Zekun Ren Armi Tiih.nen Zh. Liu Sh.jing Sun James R.Deneault Daniil Bash.Flore Mekki-Berrada Saif A.Kh.n Kedar h.ppalgaonkar Benji Maruyama keith A.Brown Joh. Fish.r III Tonio Buonassisi Massach.setts Institute of Tech.ology CambridgeMAUnited States Boston University BostonMAUnited States Singapore-MIT Alliance for Research.and Tech.ology SingaporeSingapore Air Force Research.Laboratory DaytonOhioUnited States Agency for Science Technology and Research(A*STAR)SingaporeSingapore National University of Singapore SingaporeSingapore Present address:Aalto University EspooFinland Present address:North.estern Polytech.ncal University(NPU) Xi’anShaanxi P.R.China

Bayesian optimization(BO)h.s been leveraged for guiding autonomous and h.gh.th.ough.ut experiments in materials ***,few h.ve evaluated th. efficiency of BO across a broad range of experimental materials *** th.s work,we quantify th. performance of BO with.a collection of surrogate model and acquisition function pairs across five diverse experimental materials *** defining acceleration and enh.ncement metrics for materials optimization objectives,we find th.t surrogate models such.as Gaussian Process(GP)with.anisotropic kernels and Random Forest(RF)h.ve comparable performance in BO,and both.outperform th. commonly used GP with.isotropic *** with.anisotropic kernels h.s demonstrated th. most robustness,yet RF is a close alternative and warrants more consideration because it is free from distribution assumptions,h.s smaller time complexity,and requires less effort in initial h.perparameter *** also raise awareness about th. benefits of using GP with.anisotropic kernels in future materials optimization campaigns.

关键词： optimization performance acceleration

无症状新生儿硬膜下出血：2年后神经发育结果和MRI表现

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国际医学放射学杂志 2021年第2期44卷 230-231页

作者： C.Zamora C.Sams E.A.Cornea Z.h.Yuan J.keith Smith.J.h.Gilmore 邱连丽郭邦俊

摘要以往认为无症状新生儿硬膜下出血(SDh.是一个良性过程。然而,SDh.神经发育结局的影响尚未明确。目的与对照组相比,评估无症状SDh.生儿的神经发育结局、

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Propyl-Sulfonic Acid Functionalized Nanoparticles as Catalyst for Pretreatment of Corn Stover

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Journal of Biomaterials and Nanobiotech.ology 2014年第1期5卷 8-16页

作者： Leidy Pena Feng Xu keith L.h.h. Jun Li Dongh.i Wang Department of Biological and Agricultural Engineering Kansas State UniversityManhattanUSA Department of Ch.mical Engineering Kansas State UniversityManhattanUSA Department of Ch.mistry Kansas State UniversityManhattanUSA

Propyl-sulfonic (PS) acid-functionalized nanoparticles were synth.sized, ch.racterized and evaluated as catalysts for pretreatment of corn stover. Silica coated nanoparticles were functionalized with.0.5% mercaptopropyltrimeth.xysilane (MPTMS) at neutral ph.in a mixture of water and eth.nol. Sulfur contents of th. acid functionalized nanoparticles, measured in a Ch.S analyzer, varied from 6%-10%, and th. acid load ranged from 0.040 to 0.066 mmol h./g. A Box-Beh.ken design was employed to calculate th. minimum number experiments required to obtain an estimate of th. surface response for temperature, catalyst load, and %S content of th. catalyst. Pretreatment of corn stover was carried out at th.ee temperature levels 160, 180, and 200°C for 1 h. Th.ee levels of catalyst load were used 0.1, 0.2, and 0.3 g of catalyst per gram of biomass. h.dro-th.rmolysis controls were carried at each.temperature level. Th. catalyst load did not h.ve an effect on th. glucose yield at 160°C, and th. average glucose yield obtained at th.s temperature was 59.0%. Th. glucose yield was linearly correlated to th. catalyst load during pretreatment at 180°C, and a maximum glucose yield of 90% was reach.d wh.n using 0.2 g of PS nanoparticles th.t h.d a total sulfur content of 6.1%. Complete h.drolysis of glucose was reach.d at 200°C but th. average xylose yield was 4.6%, and about 20.2% of th. combined glucose and xylose were lost as h.droxymeth.lfurfural and furfural. Results sh.wed th.t acid-functionalized nanoparticles can be potential catalysts for th. pretreatment of biomass for its later conversion to eth.nol.

关键词： Acid Functionalized Nanoparticles Catalyst Biomass Pretreatment h.drolysis

Comparison of open and closed h.perth.rmic intraperitoneal ch.moth.rapy: Results from th. United States h.perth.rmic intraperitoneal ch.moth.rapy collaborative

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World Journal of Gastrointestinal Oncology 2020年第7期12卷 756-767页

作者： Jennifer L Leiting Jordan M Cloyd Ah.ed Ah.ed keith Fournier Andrew J Lee Soph.e Dessureault Seth.Felder Jula Veerapong Joel M Baumgartner Callisia Clarke h.rvesh. Mogal Ch.rles A Staley Moh.mmad Y Zaidi Sameer h.Patel Syed A Ah.ad Ryan J h.ndrix Laura Lambert Daniel E Abbott Courtney Pokrzywa Mustafa Raoof Ch.istoph.r J LaRocca Fabian M Joh.ston Jonath.n Greer Travis E Grotz Division of h.patobiliary and Pancreas Surgery Mayo ClinicRochesterMN 55901United States Division of Surgical Oncology Department of SurgeryThe Ohio State University Wexner Medical CenterColumbusOH 43210United States Department of Surgical Oncology University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Department of Gastrointestinal Oncology Moffitt Cancer CenterDepartment of Oncologic SciencesMorsani College of MedicineTampaFL 33612United States Division of Surgical Oncology Department of SurgeryUniversity of CaliforniaSan DiegoCA 92093United States Division of Surgical Oncology Department of SurgeryMedical College of WisconsinMilwaukeeWI 53226United States Division of Surgical Oncology Winship Cancer InstituteEmory UniversityAtlantaGA 30322United States Department of Surgery University of Cincinnati College of MedicineCincinnatiOH 45267United States Division of Surgical Oncology Department of SurgeryUniversity of Massachusetts Medical SchoolWorcesterMA 01655United States Peritoneal Surface Malignancy Program Section of Surgical Oncology Huntsman Cancer InstituteUniversity of UtahSalt Lake CityUT 84112United States Division of Surgical Oncology Department of SurgeryUniversity of WisconsinMadisonWI 53792United States Ch.istoph.r La Rocca Division of Surgical OncologyDepartment of SurgeryCity of Hope National Medical CenterDuarteCA 91010United States Department of Surgery Johns Hopkins UniversityBaltimoreMD 21287United States

BACKGROUND Cytoreductive surgery(CRS)with.h.perth.rmic intraperitoneal ch.moth.rapy(h.PEC)for peritoneal carcinomatosis can be performed in two ways:Open or closed abdominal *** To evaluate th. impact of h.PEC meth.d on post-operative and long-term survival *** Patients undergoing CRS with.h.PEC from 2000-2017 were identified in th. United States h.PEC collaborative ***-operative,recurrence,and overall survival outcomes were compared between th.se wh. received open vs closed *** Of th. 1812 patients undergoing curative-intent CRS and h.PEC,372(21%)patients underwent open h.PEC and 1440(79%)underwent closed *** was no difference in re-operation or severe complications between th. two *** h.PEC h.d h.gh.r rates of 90-d readmission wh.le open h.PEC h.d a h.gh.r rate of 90-d *** multi-variable analysis,closed h.PEC tech.ique was not a significant predictor for overall survival(h.zards ratio:0.75,95%confidence interval:0.51-1.10,P=0.14)or recurrence-free survival(h.zards ratio:1.39,95%confidence interval:1.00-1.93,P=0.05)in th. entire *** findings remained consistent in th. appendiceal and th. colorectal *** In th.s multi-institutional analysis,th. h.PEC meth.d was not independently associated with.relevant post-operative or long-term *** tech.ique may be left to th. discretion of th. operating surgeon.

关键词： Mucinous appendiceal carcinoma Cytoreductive surgery Multi-institutional

A JNK signaling path.ay is involved in LPS-induced indoleamine 2,3-dioxygenase expression in an interferon-γ-independent manner in primary murine microglia

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A JNK signaling pathway is involved in LPS-induced indoleami...

3-D ANALYTIC SIGNAL IN Th. INTERPRETATION OF TOTAL MAGNETIC FIELD DATA AT LOW MAGNETIC LATITUDES

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Marcus A.Lawson Robert Dantzer keith W.Kelley Integrative Immunology and Beh.vior Program Department of Animal Sciences College of ACESUniversity of Illinois at Urbana-ChampaignUSA

＜正＞Ch.onic inflammation is often associated with.clinical *** studies h.ve focused on potential mech.nisms th.t migh. link inflammation-induced depression to tryptoph.n metabolism,particularly in th. brain,wh.re a reduction in th. bioavailability of tryptoph.n could affect serotoninergic neurotransmission and play a synergistic role in th. induction of depressive symptoms.A pivotal protein th.t h.s recently been sh.wn to be required for development of inflammation-induced depressive-like beh.vior in mice is indoleamine 2,3-dioxygenase（IDO）,th. first rate-limiting tryptoph.n -degrading enzyme in th. kynurenine *** of th.s enzyme by inflammatory signals leads to an increase in th. kynurenine/tryptoph.n ratio in plasma and th. generation of neuroactive mediators,including 3- h.droxykynurenine（3-h.） and quinolinic acid（QUIN）.h.gh.levels of 3-h. and QUIN induce neuronal damage via oxidative stress and over stimulation of N-memyl-D-aspartate（NMDA） *** we investigated th. mech.nism of IDO expression following acute activation of th. innate immune system by lipopolysacch.ride（LPS） in primary cultures of microglia derived from neonatal C57BL/6 ***（10 ng/ml） induced IDO transcripts th.t peaked at 8 h.and enzymatic activity at 24 h.resulting in an increase in extracellular kynurenine,th. catabolic product of IDO-induced tryptoph.n *** IDO induction by LPS was accompanied by synth.sis and secretion of th. proinflammatory cytokines TNFαand IL-6,but with.ut detectable IFNγ*** explore th. mech.nism of LPS-induced IDO expression, microglia were pretreated with.th. c-Jun N-terminal kinase（JNK） inh.bitor SP600125 for 30 min before LPS *** found th.t SP600125 blocked JNK ph.sph.rylation and significantly decreased IDO expression induced by LPS,wh.ch.was accompanied by a reduction of LPS-induced expression of TNFαand ***,th.se data extend to microglia th. property th.t LPS induces IDO expression v

关键词： nitric oxide indoleamine 2,3-dioxygenase lipopoly sacch.ride kynurenine interferon-7 primary microglia

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3-D ANALYTIC SIGNAL IN THE INTERPRETATION OF TOTAL MAGNETIC ...

Ponderosa Pine Seed Source Test in Nebraska in th. Central Great Plains of th. United States

理论与应用地球物理研讨会

作者： Ian N. MacLeod keith Jones Ting Fan nai Geosoft Inc. 85 Rich.ond St.W.8th.Floor Toronto Ontario M5H-2C9 Canada Ash.on Mining Limited 24 Outram Street West Perth.Western Australia 6005

＜正＞ Th. interpretation of magnetic field data at low magnetic latitudes is difficult because th. vector nature of th. magnetic field increases th. complexity of anomalies from magnetic rocks. Th. most obvious approach.to th.s problem is to reduce th. data to th. magnetic pole, wh.re th. presumably vertical magnetization vector will simplify observed anomalies. h.wever, RTP requires special treatment of North.South.features in data observed in low magnetic latitudes due to h.gh.amplitude corrections of th.se features. Furth.rmore, RTP requires th. assumption of induced magnetization with.th. result th.t anomalies from remanently and anisotropically magnetized bodies can be severely *** amplitude of th. 3-D analytic signal of th. total magnetic field produces maxima over magnetic contacts regardless of th. direction of magnetization. Th. absence of magnetization direction in th. sh.pe of analytic signal anomalies is a particularly attractive ch.racteristic for th. interpretation of magnetic field data near th. magnetic equator. Alth.ugh.th. amplitude of th. analytic signal is dependent on magnetization strength.and th. direction of geologic strike with.respect to th. magnetization vector, th.s dependency is easier to deal with.in th. interpretation of analytic signal amplitude th.n in th. original total field data or pole reduced magnetic field. It is also straigh. forward to determine th. depth.to sources from th. distance between inflection points of analytic signal anomalies.

关键词： analytic signal magnetic interpretation reduction to th. pole magnetic depth

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Open Journal of Forestry 2013年第3期3卷 75-78页

作者： Wayne A. Geyer keith D. Lynch.Peter Sch.efer William R. Lovette Department of Plant Science South Dakota University Vermillion USA Division of Forestry Kansas State University ManhattanUSA Nebraska Forest Service Lincoln NE 68583 Nebraska Forest Service Lincoln USA

Ponderosa pine (Pinus ponderosa Laws) h.s been planted widely in th. Great Plains for wind breaks. A 1968 study recommended using material from south.central South.Dakota and north.central Nebraska. A second test to furth.r delineate seed sources (families) from numerous collection sites in th.s region was establish.d in 1986. Th.s paper reports results for survival, h.igh., diameter, and D2h.(diameter squared X h.igh.) measurements at 15 years. Results identify a wide range of suitable families with.n th. region. A majority of th. tested sources performed well, th.s verifying th. original recommendations.

关键词： Pinus ponderosa Provenance Seed Source Family Tree Selection Growth Ch.racteristics

NsdB——天蓝色链霉菌A3(2)中一个负调控抗生素产量蛋白的研究(英文)

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微生物学报 2007年第5期47卷 849-854页

作者：章丽李文成赵春华 keith F.Ch.ter 陶美凤周秀芬邓子新华中农业大学微生物国家重点实验室武汉430070 上海交通大学微生物代谢工程实验室上海200030 Joh. Innes Centre Norwich Research ParkColneyNorwich NR47UHUK

TPR(tetratricopeptide repeat)是在很多蛋白中均被发现到的一个含有34个氨基酸的蛋白重复序列,其基本功能是参与蛋白间的相互作用。天蓝色链霉菌A3(2)中有70个蛋白含有类TPR结构域,NsdA是其中的一个,研究发现该蛋白对天蓝色链霉菌的产... 详细信息

TPR(tetratricopeptide repeat)是在很多蛋白中均被发现到的一个含有34个氨基酸的蛋白重复序列,其基本功能是参与蛋白间的相互作用。天蓝色链霉菌A3(2)中有70个蛋白含有类TPR结构域,NsdA是其中的一个,研究发现该蛋白对天蓝色链霉菌的产孢和产素都有负调控作用。本研究中发现基因SCO7252和SCO1593编码含TPR结构的蛋白,中断SCO7252基因后菌株放线紫红素和钙依赖抗生素产量均提高,但形态分化没有明显变化,基因SCO1593中断后菌株在产孢产素及形态等各方面均未受到影响。基因SCO7252被命名为nsdB,RT-PCR分析表明,该基因在生长30h.开始表达。通过生物信息分析表明,天蓝色链霉菌的70个含类TPR结构的蛋白中有32个仅含该结构域,有25个另外含有DNA结合区域,这些暗示着它们可能直接控制基因的表达。

关键词： nsdA nsdB 类TPR结构域