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diabetic peripheral neuropathy and neuromodulation techniques:a systematic review of progress and prospects

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Neural Regeneration Research 2025年第8期20卷 2218-2230页

作者： Rahul Mittal Keelin McKenna Grant keith Evan McKenna Joana R.N.Lemos Jeenu Mittal Khemraj Hirani diabetes Research Institute University of Miami Miller School of MedicineMiamiFLUSA department of Otolaryngology University of Miami Miller School of MedicineMiamiFLUSA Herbert Wertheim College of Medicine Florida International UniversityMiamiFLUSA School of Medicine and Public Health University of WisconsinMadisonWIUSA

Neuromodulation for diabetic peripheral neuropathy represents a significant area of interest in the management of chronic pain associated with this *** peripheral neuropathy,a common complication of diabetes,is characterized by nerve damage due to high blood sugar levels that lead to symptoms,such as pain,tingling,and numbness,primarily in the hands and *** aim of this systematic review was to evaluate the efficacy of neuromodulatory techniques as potential therapeutic interventions for patients with diabetic peripheral neuropathy,while also examining recent developments in this *** investigation encompassed an array of neuromodulation methods,including frequency rhythmic electrical modulated systems,dorsal root ganglion stimulation,and spinal cord *** systematic review suggests that neuromodulatory techniques may be useful in the treatment of diabetic peripheral *** the advantages of these treatments will enable physicians and other healthcare providers to offer additional options for patients with symptoms refractory to standard pharmacologic *** these efforts,we may improve quality of life and increase functional capacity in patients suffering from complications related to diabetic neuropathy.

关键词： diabetes mellitus diabetic peripheral neuropathy neuromodulation neurostimulation therapy non-pharmacological treatment pain management

Attribution of Fano resonant features to plasmonic particle size, lattice constant, and dielectric wavenumber in square nanoparticle lattices

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Photonics Research 2014年第1期2卷 15-23页

作者： drew deJarnette Justin Norman d.keith Roper Microelectronics and Photonics Graduate Program University of ArkansasFayettevilleArkansas 72701USA department of Chemical Engineering University of ArkansasFayettevilleArkansas 72701USA

Fano resonances between plasmons and diffracted light offer tunable energies and locales,but attribution of Fano resonance features to geometry and physicochemistry of metal nanostructures and adjacent dielectrics has been confounded by complexity and computational *** work shows predictable modal shifts of Fano resonance in square lattices of plasmonic nanostructures can be attributed directly to changes in medium wavenumber,particle size,and lattice constant that alter plasmon polarizability and diffractive *** 45 to 80 nm radius particles,a window of lattice constants that support Fano resonances is identified in a range from 500 to 900 *** constants that support high intensity resonances are determined by individual particle polarizability and medium *** resonance wavelengths redshift from diffracted photon energies as local refractive index(RI)changes due to coupling with particle polarizability in the *** sensitivities for quadrupole,dipole,and Fano resonances are 150,348,and 541 nm,respectively,per RI *** resonance intensity may be enhanced more than tenfold by selecting nanoparticle sizes and lattice *** quantitative effects of such parametric changes are rapidly and intuitively distinguished using a semi-analytic approach,consisting of an exact expression for particle polarizability,a trigonometric description of diffraction,and a semianalytical coupled dipole approximation.

关键词： lattice particle wave

ANALYZING MARKET COMPETITION BETWEEN AIRBUS ANd BOEING USING A dUO HIERARCHICAL GRAPH MOdEL FOR CONFLICT RESOLUTION

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Journal of Systems Science and Systems Engineering 2017年第6期26卷 683-710页

作者： Shawei He keith W. Hipel d. Marc Kilgour 1.College of Economics & Management Nanjing University of Aeronautics and Astronautics Nanjing 211106 China 2.Department of Systems Design Engineering University of Waterloo Waterloo Ontario Canada N2L 3G1 3.Centre for International Governance Innovation Waterloo Ontario Canada N2L 6C2 4.Balsillie School of International Affairs Waterloo Ontario Canada N2L 6C2 5.Department of Mathematics Wilfrid Laurier University Waterloo Ontario Canada N2L 3C5

A duo hierarchical graph model for conflict resolution is developed to investigate market competition between Airbus and Boeing over aircraft sales in the Asia Pacific region. The duo hierarchical graph model, a significant extension of the graph model for conflict resolution methodology, contains two common decision makers, who take part in two related subconflicts, as well as local decision makers, who participate in only one subconflict. New stability definitions are proposed to describe forms of sanction unique to the hierarchical model. The interrelationships between stabilities in the overall graph model and in the two local models are investigated. Then the duo hierarchical graph model is applied to the competition between Airbus and Boeing in both the wide and narrow body markets in the Asia-Pacific region. The two types of Asian airlines have different operating strategies, so that the two markets constitute sub-competitions that can be modelled naturally using the duo hierarchical graph model. The stability results indicate a resolution for all decision makers that implies marketing strategies for the aircraft manufacturers and guidelines for aircraft purchase by the airlines. Thus, this model provides decision makers with a comprehensive understanding of the dynamics of the comoetition and guidance in identifving beneficial actions.

关键词： Hierarchical Graph Model Airbus and Boeing stability results strategic resolutions

Complementary Physical and Mechanical Techniques to Characterise Tooth: A Bone-like Tissue

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Journal of Bionic Engineering 2006年第1期3卷 19-31页

作者： Peter Zioupos keith d. Rogers Centre for Photo-manipulation and Photo-analysis of Materials Cranfield University Shrivenham SN 6 8LA UK Centre for Materials Science and Engineering Cranfield University Postgraduate Medical School Shrivenham SN 6 8LA UK

Bone like tissues are biocomposites comprising an organic matrix （mostly collagen） and a reinforcement phase in the form of mineral crystals （poorly stoichiometric apatite）. The composite properties are a result of the material characteristics of the two phases, their interaction, the relative composition, the orientation and the micro-architecture of the structure. The inherent spatial heterogeneity of these tissues （a result of evolutionary and functional requirements） and their exposure to various environmental and mechanical influences result in highly variable properties on the microscale, which can only be characterised by modern microanalytical methods. We present here results obtained by the complementary use of the modem nanoindentation and micro-X-ray diffraction techniques, which were used to probe the properties and structure of human dentine and enamel of primary molar teeth. The results show that both the addition and the higher organization of mineral within the organic matrix produce stiffer and harder tissue and that the examination of properties within small tissue volumes can be reliably achieved by use of these two methods in parallel. This opens new avenues in the study of biomaterial in general, and for the local characterisation of regions of teeth that suffered bacterial attack, mechanical wear, fluoridisation, chemical bleaching, or dental treatment such as laser ablation or drilling.

关键词： biogenic composites teeth nanoindentation hardness X-ray diffraction

Investigation of the unstable flow phenomenon in a pump turbine

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Science China(Physics,Mechanics & Astronomy) 2014年第6期57卷 1119-1127页

作者： YIN JunLian WANG deZhong WALTERS d.keith WEI XianZhu School of Mechanical Engineering Shanghai Jiaotong University department of Mechanical Engineering Mississippi State University State Key Laboratory of Hydropower Equipment

Instability of pump turbine with S-shaped curve is characterized by large fluctuations of rotational speed during the transient *** investigating this phenomenon,a numerical model based on the dynamic sliding mesh method(dSSM)is presented and used to numerically solve the 3d transient flow which is characterized by the variable rotation speed of *** method is validated by comparison with measured data for a load rejection process in a prototype pump *** results show that the calculated rotation speed agrees well with the experimental *** on the validated model,simulations were performed for the runaway process using an artificially assumed operating condition under which the unstable rotation speed is expected to *** results confirm that the instability of runner rotational speed can be effectively captured with the proposed *** results include the time history profiles of unit flow rate and unit rotating *** internal flow characteristics in a typical unstable period are discussed in detail and the mechanism of the unstable hydraulic phenomenon is ***,the results suggest that the method presented here can be a viable alternative to predict the dynamic characteristics of pump turbines during transient processes.

关键词： pump turbine transient process dynamic sliding mesh flow stability

OPTION PRIORITIZATION FOR UNKNOWN PREFERENCE

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Journal of Systems Science and Systems Engineering 2016年第1期25卷 39-61页

作者： Jing Yu keith W. Hipel d. Marc Kilgour Min Zhao Business School Hohai University Nanjing Jiangsu 211100 China department of Systems design Engineering University of Waterloo Waterloo N2L 3G1 Canada department of Mathematics Wt'lfrid Laurier University Waterloo N2L 3C5 Canada Centre for International Governance Innovation Waterloo Ontario Canada Water Resources and Sustainable development Research Centre of Jiangsu Province Nanjing 210098 China

An option prioritization technique is developed to efficiently elicit the preferences, both unknown and crisp, of decision makers （dMs） in strategic conflicts. In the Graph Model for Conflict Resolution, each dM has one or more options, each of which may be selected or not. A state, or possible scenario, is formed when all dMs make an option selection. The software GMCR II contains an option prioritization procedure that makes it easy for a modeUer to enter a dM＇s crisp preference ordering over the states using prioritized statements describing the dM＇s preferred option combinations. This procedure is extended by adding two new logical connectives that describe uncertainty of preference. For each dM, a range of possible scores for each feasible state can then be calculated, facilitating the determination of a preference ordering containing uncertainty by comparing and ranking scores. To demonstrate how this new methodology can be used to represent tmknown preferences in a real-world decision problem, it is applied to a Canadian dispute over proposed water exports.

关键词： Graph model for conflict resolution option prioritization unknown preference logical connectives

ROBUSTNESS OF EQUILIBRIA IN THE GRAPH MOdEL FOR CONFLICT RESOLUTION

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Journal of Systems Science and Systems Engineering 2015年第4期24卷 450-465页

作者： Yasser T.Matbouli d.Marc Kilgour keith W.Hipel department of Industrial Engineering King Abdulaziz University department of Systems design Engineering University of Waterloo department of Mathematics Wilfrid Laurier University Centre for International Governance Innovation(CIGI)

A novel approach for assessing the robustness of an equilibrium in conflict resolution is presented. Roughly, an equilibrium is robust if it is resilient, or resistant to deviation. Robustness assessment is based on a new concept called Level of Freedom, which evaluates the relative freedom of a decision maker to escape an equilibrium. Resolutions of a conflict can be affected by changes in decision makers＇ preferences, which may destabilize an equilibrium, causing the conflict to evolve. Hence, a conflict may become long-term and thereby continue to evolve, even after reaching an equilibrium. The new robustness measure is used to rank equilibria based on robustness, to facilitate distinguishing equiiibria that are relatively sustainable. An absolutely robust equilibrium is a special case in which the level of freedom is at an absolute minimum for each individual stability definition.

关键词： Robustness equilibria level of freedom conflict evolution graph model

Loss of oral mucosal stem cell markers in oral submucous fibrosis and their reactivation in malignant transformation

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International Journal of Oral Science 2020年第3期12卷 199-208页

作者： Mohit Sharma Felipe Paiva Fonseca keith d.Hunter Raghu Radhakrishnan department of Oral Pathology Sudha Rustagi College of Dental Sciences and ResearchFaridabadHaryanaIndia department of Oral Surgery and Pathology School of DentistryFederal University of Minas GeraisBelo HorizonteMGBrazil Academic Unit of Oral and Maxillofacial Medicine and Pathology School of Clinical DentistryUniversity of SheffieldClaremont CrescentSheffieldUK department of Oral Pathology Manipal College of Dental SciencesManipal Academy of Higher EducationManipalKarnatakaIndia

The integrity of the basal stem cell layer is critical for epithelial *** this paper,we review the expression of oral mucosal stem cell markers(OM-SCMs)in oral submucous fibrosis(OSF),oral potentially malignant disorders(OPMds)and oral squamous cell carcinoma(OSCC)to understand the role of basal cells in potentiating cancer stem cell behaviour in *** the loss of basal cell clonogenicity triggers epithelial atrophy in OSF,the transition of the epithelium from atrophic to hyperplastic and eventually neoplastic involves the reactivation of basal *** vacillating expression patterns of OM-SCMs confirm the role of keratins 5,14,19,Cd44,β1-integrin,p63,sex-determining region Y box(SOX2),octamer-binding transcription factor 4(Oct-4),c-MYC,B-cell-specific Moloney murine leukaemia virus integration site 1(Bmi-1)and aldehyde dehydrogenase 1(ALdH1)in OSF,OPMds and *** downregulation of OM-SCMs in the atrophic epithelium of OSF and their upregulation during malignant transformation are illustrated with relevant literature in this review.

关键词： epithelium malignant mucosal

Cancer risk in primary sclerosing cholangitis: Epidemiology,prevention, and surveillance strategies

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World Journal of Gastroenterology 2019年第6期25卷 659-671页

作者： Brian M Fung keith d Lindor James H Tabibian UCLA-Olive View Internal Medicine Residency Program Olive View-UCLA Medical Center Office of the University Provost Arizona State University division of Gastroenterology Department of MedicineOlive View-UCLA Medical Center

Primary sclerosing cholangitis(PSC) is a rare cholestatic liver disease characterized by progressive fibroinflammatory destruction of the intra-and/or extrahepatic biliary ducts. While its features and disease course can be variable,most patients with PSC have concurrent inflammatory bowel disease and will eventually develop liver cirrhosis and end-stage liver disease, with liver transplantation representing the only potentially curative option. Importantly,PSC is associated with a significantly increased risk of malignancy compared to the general population, mainly cholangiocarcinoma, gallbladder carcinoma,hepatocellular carcinoma, and colorectal cancer, with nearly 50% of deaths in patients with PSC being due to cancer. Therefore, robust surveillance strategies are needed, though uncertainty remains regarding how to best do so. In this review, we discuss the epidemiology, prevention, and surveillance of cancers in patients with PSC. Where evidence is limited, we present pragmatic approaches based on currently available data and expert opinion.

关键词： Bile duct diseases Cholangiocarcinoma Gallbladder carcinoma Hepatocellular carcinoma Colorectal cancer Chemoprotection Inflammatory bowel disease