检索结果-南通市图书馆

Back to the drawing board:Overview of the next generation of combination therapy for inflammatory bowel disease

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第25期30卷 3182-3184页

作者： Jeffrey A Lowell Michael J Farber keith Sultan Department of Medicine Zucker School of Medicine at HofstraNorth Shore University Hospital-Long Island Jewish Medical CenterManhassetNY 11030United States Preclinical Studies New York Institute of Technology College of Osteopathic MedicineGlen HeadNY 11545United States Division of Gastroenterology Northwell HealthNorth Shore University Hospital and Long Island Jewish Medical CenterGreat NeckNY 10021United States

Inflammatory bowel disease(IBD)is entering a potentially new era of combined *** et al provide an insightful review of the current state of combination therapy,with a focus on the use of a combined biologic and immunomodulator,as well as emerging data on the future potential of dual-biologic therapy(DBT).While current evidence for DBT is limited,encouraging safety profiles and ongoing trials suggest a brighter future for this *** importance of controlled trials should be stressed in establishing new treatment *** prospective randomized trials of DBT and perhaps future combinations of biologics and small molecule therapies will hopefully guide the next generation of IBD care.

关键词： Inflammatory bowel disease Biologics Immunomodulators Dual-therapy Combination therapy

Se及Cu_2Se纳米线的大面积合成及其纳米电子学器件性能

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

化工新型材料 2008年第9期36卷 26-28页

作者：赵云覃东欢陶洪兰林峰 keith chan 华南理工大学特种功能材料及其制备新技术教育部重点实验室广州510641 加州大学圣地亚哥分校材料科学工程及磁记录研究中心加州920930407

通过液相化学反应制备了高质量硒(Se)纳米线,同时以Se纳米线为模板,合成了Cu2Se纳米线。利用透射电镜(TEM)、高分辨透射电镜(HRTEM)以及X射线衍射仪(XRD)研究了纳米线的形貌结构特征。结果显示,Se纳米线为单晶结构,生长方向沿其[001]面... 详细信息

通过液相化学反应制备了高质量硒(Se)纳米线,同时以Se纳米线为模板,合成了Cu2Se纳米线。利用透射电镜(TEM)、高分辨透射电镜(HRTEM)以及X射线衍射仪(XRD)研究了纳米线的形貌结构特征。结果显示,Se纳米线为单晶结构,生长方向沿其[001]面。结合先进的光刻技术及磁控溅射,成功制备了Se和Cu2Se纳米电子学器件。初步测试表明,这种Se纳米线为p型半导体,而Cu2Se纳米线则表现出明显的相变行为。这些发现有利于开发纳米线场效应晶体管以及相变存储器件方面的应用。

关键词： Se Cu2Se 纳米线

Matt Cutts: Try something new for 30 days

在线全文

学校读者我要写书评

暂无评论

新世纪智能 2024年第40期 17-19页

作者： keith

当你开始感叹生活枯燥，每天的生活除上学放学、吃饭看书、洗漱睡觉之外再无乐趣可言时，不妨试着改变你的生活方式：培养一种新的爱好，每天做一件你喜欢做的事情，或者培养一种新的生活习惯。每天只需努力一点点，你的生活就会因此而...

当你开始感叹生活枯燥，每天的生活除上学放学、吃饭看书、洗漱睡觉之外再无乐趣可言时，不妨试着改变你的生活方式：培养一种新的爱好，每天做一件你喜欢做的事情，或者培养一种新的生活习惯。每天只需努力一点点，你的生活就会因此而大不相同。A few years ago, I felt like I was stuck in a rut,

关键词：

Embracing the Year of the Dragon

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

China Today 2024年第2期73卷 30-32页

作者： keith BENNETT Friends of Socialist China based in London

The Lunar New Year has increasingly become a common festival of people throughout the *** people,and people throughout the world,are looking forward to welcoming the Year of the Dragon,which falls on February 10,*** Dragon is considered the most auspicious of the 12 signs in the Chinese zodiac and this year is specifically the Year of the Wood Dragon,the first since *** to Lifestyle Asia,“Wood Dragons enjoy fulfilling ***’re likely to materialize all their ambitions into actions,coming up with truly revolutionary ideas.”

关键词： looking has likely

Five Principles as Relevant Today as 70 Years Ago

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China Today 2024年第8期73卷 18-19页

作者： keith BENNETT 不详

The Chinese initiative has become an international consensus with productive actions.A conference marking the 70th anniversary of the Five Principles of Peaceful Coexistence,a cornerstone of Chinese foreign policy,was held in Beijing on June 28,attracting attendees from around the world,including former political leaders from some 20 *** the conference,President Xi Jinping made an important speech in which he said that the Five Principles“marked a groundbreaking and epoch-making achievement in the history of international relations.”

关键词： corners attracting Peace

Symptom presentation and evolution in the first 48 hours after injury are associated with return to play after concussion in elite Rugby Union

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2024年第3期13卷 387-397页

作者： Ross Tucker Matt Cross keith Stokes Lindsay Starling Rosy Hyman Simon Kemp Stephen West Martin Raftery Eanna Falvey James Brown Institute of Sport and Exercise Medicine(ISEM) Department of ExerciseUniversity of StellenboschTygerberg 7505South Africa World Rugby Ltd. Dublin D02 AE93Ireland Premiership Rugby London SW1V 1PXUK Centre for Health and Injury and Illness Prevention in SportUniversity of BathClaverton Down BA27AYUK UK Collaborating Centre on Injury and Illness Prevention in Sport(UKCCIIS) University of BathClaverton Down BA27AYUK Rugby Football Union London TW27BAUK London School of Tropical Medicine London WC1E 7HTUK Sport Injury Prevention Research Centre Faculty of KinesiologyUniversity of CalgaryCalgary T2N 1N4Canada Department of Medicine School of Medicine and HealthUniversity College CorkCork T12 EC8PIreland Carnegie Applied Rugby Research(CARR)centre Carnegie School of SportLeeds Beckett UniversityLeeds LS63QSUK

Background:Return to play(RTP)in elite rugby is managed using a 6-stage graduated RTP protocol,which can result in clearance to play within 1 week of *** aimed to explore how symptom,cognitive,and balance presentation and evolution during concussion screens 2 h(head injury assessment(HIA2)and 48 h(HIA3)after injury were associated with time to RTP)to identify whether a more conservative graduated RTP may be ***:A retrospective cohort study was conducted in 380 concussed rugby players from elite men’s rugby over 3 consecutive *** were classified as shorter or longer returns,depending on whether RTP occurred within 7 days(allowing them to be considered to play the match 1 week after injury)or longer than 8 days,***,cognitive,and balance performance during screens was assessed relative to baseline(normal or abnormal)and to the preceding screen(improving or worsening).Associations between sub-test abnormalities and RTP time were explored using odds ratios(OR,longer ***).Median day absence was compared between players with abnormal or worsening results and those whose results were normal or ***:Abnormal symptom results during screens 2 h and 48 h after concussion were associated with longer return time(HIA2:OR=2.21,95%confidence interval(95%CI):1.39-3.50;HIA3:OR=3.30,95%CI:1.89-5.75).Worsening symptom number or severity from the time of injury to 2 h and 48 h post-injury was associated with longer return(HIA2:OR=2.49,95%CI:1.36-4.58;HIA3:OR=3.34,95%CI:1.10-10.15).Median days absence was greater in players with abnormal symptom results at both HIA2 and *** and balance performance were not associated with longer return and did not affect median days ***:Symptom presentation and evolution within 48 h of concussion were associated with longer RTP *** may guide a more conservative approach to RTP,while still adhering to individualized concussion management principles.

关键词： Brain injury Concussion management General return to play Medical management

在线全文

学校读者我要写书评

暂无评论

欧洲MRO正在积极应对欧盟对俄制裁

航空维修与工程 2024年第8期 21-22页

作者： keith Mwanalushi 文峻

俄乌冲突爆发后，欧盟出台的一系列对俄严格制裁措施，给欧洲MRO市场带来了较大影响，如钛等航空原材料的供应、供应链的管控流程、租赁市场的合规运营等。为此，欧洲MRO供应商正在采取多项策略，努力缓解成本增长、交货期延长和合规风...

俄乌冲突爆发后，欧盟出台的一系列对俄严格制裁措施，给欧洲MRO市场带来了较大影响，如钛等航空原材料的供应、供应链的管控流程、租赁市场的合规运营等。为此，欧洲MRO供应商正在采取多项策略，努力缓解成本增长、交货期延长和合规风险等方面的压力。自2022年2月俄乌冲突爆发以来，欧盟对俄罗斯采取了一系列前所未有的制裁措施。在俄罗斯经济遭受严重打击的情形下，航空维修领域中的MRO企业已明显感受到来自欧盟对俄罗斯制裁的负面影响。为了应对挑战，欧洲MRO通过重新评估发展战略，采用多样化选择供应商的策略来分散供应链风险，努力缓解成本增长、交货期延长和合规风险等方面的压力。

关键词：

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

一种基于协商的软件过程协同方法

计算机研究与发展 2006年第2期43卷 314-320页

作者：赵欣培李明树陈振冲王青中国科学院软件研究所互联网软件技术实验室北京100080 香港理工大学计算学系

大型软件系统的开发大多要求多人协同完成·软件过程协同的一个重要特点是协同的参与者都试图通过实施协同任务来取得最大化的获利,因而协同的决策和实施不是强制性的,而是由软件开发人员或软件组织经过协商来进行的·传统的软件过程建... 详细信息

大型软件系统的开发大多要求多人协同完成·软件过程协同的一个重要特点是协同的参与者都试图通过实施协同任务来取得最大化的获利,因而协同的决策和实施不是强制性的,而是由软件开发人员或软件组织经过协商来进行的·传统的软件过程建模方法中对软件过程协同的描述是刚性的,即在满足进入条件或者被显式调用时,协同就一定会被触发,并按照一个规定好的规则或方针来实施,这样的方法难以适应软件过程协同中所表现的协商特性·提出了一个基于协商的软件过程协同方法,将软件过程描述为一组相对独立的、自治的、理性的、协作的软件过程Agent,过程Agent之间的协同关系由过程Agent通过协商确定,相比传统的方法,具有能够更好地适应软件过程协同的特点·

关键词：软件过程协同软件过程建模协商 Agent 人工智能

EZH2 inhibitors promote β-like cell regeneration in young and adult type 1 diabetes donors

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第2期9卷 679-692页

作者： keith Al-Hasani Safiya Naina Marikar Harikrishnan Kaipananickal Scott Maxwell Jun Okabe Ishant Khurana Thomas Karagiannis Julia J.Liang Lina Mariana Thomas Loudovaris Thomas Kay Assam El-Osta Epigenetics in Human Health and Disease Program Baker Heart and Diabetes Institute75 Commercial RoadMelbourne 3004 VICAustralia Department of Diabetes Central Clinical SchoolMonash UniversityMelbourne 3004 VICAustralia Epigenetics in Human Health and Disease Laboratory Central Clinical SchoolMonash UniversityMelbourne 3004 VICAustralia School of Science STEM CollegeRMIT UniversityMelbourne 3001 VICAustralia Immunology and Diabetes Unit St Vincent’s Institute of Medical ResearchFitzroy 3065 VICAustralia Department of Medicine and Therapeutics The Chinese University of Hong KongSha TinHong Kong SAR Hong Kong Institute of Diabetes and Obesity Prince of Wales HospitalThe Chinese University of Hong Kong3/F Lui Che Woo Clinical Sciences Building30-32-Ngan Shing StreetSha TinHong Kong SAR Li Ka Shing Institute of Health Sciences The Chinese University of Hong KongSha TinHong Kong SAR Biomedical Laboratory Science Department of TechnologyFaculty of HealthUniversity College CopenhagenCopenhagenDenmark

β-cells are a type of endocrine cell found in pancreatic islets that synthesize,store and release *** type 1 diabetes(T1D),T-cells of the immune system selectively destroy the insulin-producingβ-*** of these cells leads to a lifelong dependence on exogenous insulin administration for ***,there is an urgent need to identify novel therapies that stimulateβ-cell growth and induceβ-cell *** and others have shown that pancreatic ductal progenitor cells are a promising source for regeneratingβ-cells for T1D owing to their inherent differentiation *** transcriptional suppression is refractory to exocrine reaction and tightly controls the regenerative potential by the EZH2 *** the present study,we show that transient stimulation of exocrine cells,derived from juvenile and adult T1D donors to the FDAapproved EZH2 inhibitors GSK126 and Tazemetostat(Taz)influence a phenotypic shift towards aβ-like cell *** transition from repressed to permissive chromatin states are dependent on bivalent H3K27me3 and H3K4me3 chromatin *** EZH2 is fundamental toβ-cell regenerative *** pancreatic ductal cells exhibit insulin production and secretion in response to a physiological glucose challenge ex *** pre-clinical studies underscore the potential of small molecule inhibitors as novel modulators of ductal progenitor differentiation and a promising new approach for the restoration ofβ-like cell function.

关键词： EZH2 struction inhibitors