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STOCHASTIC SYSTEM IDENTIFICATION VIA ADAPTIVE SPECTRAL FACTORIZATION

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Systems Science and Mathematical Sciences 1991年第3期4卷 275-288页

作者：郭雷 John b.moore Institute of Systems Science Academia SinicaBeijing 100080China Department of Systems Engineering Research School of Physical SciencesAustralian National UniversityG.P.O.Box 4CanberraA.C.T.2601Australia

We consider in this paper the problem of recursive identification for stochastic systemswhen the noise model does not satisfy the positive real condition associated with convergence ofstandard *** avoid the positive real condition,adaptive spectral factorization techniquesare exploited on the basis of a class of non-standard time-varying recursive Riccati *** properties of the Riccati equations are studied as a crucial step to the convergence resultsof the paper.

关键词： Adaptive parameter estimation spectral factorization

Effect of glaucoma on identification of bottle cap color in ophthalmic medications

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International Journal of Ophthalmology(English edition) 2019年第1期12卷 169-171页

作者： Jonathan Paul Jon David Hammer Roozbeh Akhtari brede Skillings Daniel b.moore Department of Ophthalmology University of Kentucky Northwell Health Department of Ophthalmology Krieger Eye Institute

A prospective, nonrandomized, observational trial of 60 glaucoma patients to correlate visual acuity and visual field with ability to distinguish bottle cap color of commonly used ophthalmic medications was conducted. A total of 103 eyes from 60 patients(30 women) were evaluated. The mean logMAR acuity was 0.34±0.54(approximately 20/45 Snellen acuity), average Humphrey Visual Field(HVF) mean deviation was-8.58±8.69 db, mean Ishihara plates(out of 14) were 11.78±4.15, and bottle cap color score(out of 10) was 8.56±2.51. Multiple linear regression analysis revealed an independent correlation of visual acuity(P=0.0137) and Ishihara score(Pbut no significant effect with visual field mean deviation(P>0.05). Glaucoma patients with poor visual acuity, but not necessarily advanced visual field loss, are likely to have difficultly identifying the color of their bottle caps. Physicians should be cognizant of this potential issue when reviewing medications with patients.

关键词： glaucoma color vision compliance medication patient communication

Crosstalk Complexities between Auxin, Cytokinin, and Ethylene in Arabidopsis Root Development： From Experiments to Systems Modeling, and back Again

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Molecular Plant 2017年第12期10卷 1480-1496页

作者： Junli Liu Simon moore Chunli Chen keith Lindsey Department of biosciences Durham University South Road Durham DH1 3LE UK College of Life Science and Technology Huazhong Agricultural University Wuhan 430070 China These authors contributed equally to this article.

Understanding how hormones and genes interact to coordinate plant growth in a changing environment is a major challenge in plant developmental biology. Auxin, cytokinin, and ethylene are three important hormones that regulate many aspects of plant development. This review critically evaluates the crosstalk between the three hormones in Arabidopsis root development. We integrate a variety of experimental data into a crosstalk network, which reveals multiple layers of complexity in auxin, cytokinin, and ethylene crosstalk. In particular, data integration reveals an additional, largely overlooked link between the ethylene and cytokinin pathways, which acts through a phosphorelay mechanism. This proposed link addresses outstanding questions on whether ethylene application promotes or inhibits receptor kinase activity of the ethylene receptors. Elucidating the complexity in auxin, cytokinin, and ethylene crosstalk requires a combined experimental and systems modeling approach. We evaluate important modeling efforts for establishing how crosstalk between auxin, cytokinin, and ethylene regulates patterning in root develop- ment. We discuss how a novel methodology that iteratively combines experiments with systems modeling analysis is essential for elucidating the complexity in crosstalk of auxin, cytokinin, and ethylene in root development. Finally, we discuss the future challenges from a combined experimental and modeling perspective.

关键词： Arabidopsis auxin cytokinin ethylene hormonal crosstalk spatiotemporal modeling

A predictive model for ethylene-mediated auxin and cytokinin patterning in the Arabidopsis root

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Plant Communications 2024年第7期5卷 120-137页

作者： Simon moore George Jervis Jennifer F.Topping Chunli Chen Junli Liu keith Lindsey Department of biosciences Durham UniversitySouth RoadDurham DH13LEUK Hubei Hongshan Laboratory College of Life Science and TechnologyHuazhong Agricultural UniversityWuhan 430070China National Key Laboratory for Germplasm Innovation and Utilization for Fruit and Vegetable Horticultural Crops Huazhong Agricultural UniversityWuhanHubei 430070China

The interaction between auxin and cytokinin is important in many aspects of plant *** measurements of both auxin and cytokinin concentration and reporter gene expression clearly show the coexistence of auxin and cytokinin concentration patterning in Arabidopsis root ***,in the context of crosstalk among auxin,cytokinin,and ethylene,little is known about how auxin and cytokinin concentration patterns simultaneously emerge and how they regulate each other in the Arabidopsis *** work utilizes a wide range of experimental observations to propose a mechanism for simultaneous patterning of auxin and cytokinin *** addition to revealing the regulatory relationships between auxin and cytokinin,this mechanism shows that ethylene signaling is an important factor in achieving simultaneous auxin and cytokinin patterning,while also predicting other experimental *** the mechanism with a realistic in silico root model reproduces experimental observations of both auxin and cytokinin *** made by the mechanism can be compared with a variety of experimental observations,including those obtained by our group and other independent experiments reported by other *** of these predictions include patterning of auxin biosynthesis rate,changes in PIN1 and PIN2 patterns in pin3,4,7 mutants,changes in cytokinin patterning in the pls mutant,PLS patterning,and various trends in different *** research reveals a plausible mechanism for simultaneous patterning of auxin and cytokinin concentrations in Arabidopsis root development and suggests a key role for ethylene pattern integration.

关键词： Arabidopsis root auxin patterning cytokinin patterning ethylene signaling in silico digital root spatiotemporal modeling

Does the scent of a potential mate prevent the resorption of oocytes by apoptosis in Nauphoeta cinerea？

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Insect Science 2009年第5期16卷 393-398页

作者： Emma L. b. barrett Allen J. moore Patricia J. moore Centre for Ecology and Conservation School of Biosciences University of Exeter Cornwall Campus Penryn Cornwall UK

We expect organisms to have evolved mechanisms to gather and use the information available within their environments, to steer resource investment decisions toward the traits that will give the greatest fitness returns. Pheromones are social signals, a common purpose of which is to act as indicators of mate presence. Consequently, pheromones have the potential to act as signals to increase or maintain reproductive investment over that of competing life-history traits. In the cockroach, Nauphoeta cinerea （Oliver）, females pay costs of maintaining investment in reproduction when there are no males, and males produce pheromones that are known to effect female reproductive outcomes. Whether the pheromones have an influence on resource physiology is unknown. We subjected newly eclosed females to either a synthetic blend of male pheromones or control. We dissected females at 7, 12, 17 or 22 days. We measured apoptosis levels and size of all oocytes within the vitellerium, and measured dry fat body mass. Synthetic male pheromone blend did not have an effect on any measure of female reproductive or somatic resource physiology. Although negative results are always problematic, the success of the synthetic pheromone method in the past suggests that females may be insensitive to male pheromones in the pre-oviposition period, and may rely on mating stimulus rather than pheromone as the cue for oocyte maintenance and growth. Previous studies reporting effects of male pheromones on female reproduction suggest that the period of pheromone sensitivity may be between mating and birth.

关键词： apoptosis environment oocyte ovary pheromone predictable trade-off

Factors controlling nutrient availability to the developing fetus in ruminants

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Journal of Animal Science and biotechnology 2015年第2期6卷 205-214页

作者： Kathrin A Dunlap Jacob D brown Ashley b keith M Carey Satterfield Department of Animal Science Texas A&M University2471 TAMU College Station

Inadequate delivery of nutrients results in intrauterine growth restriction （IUGR）, which is a leading cause of neonatal morbidity and mortality in livestock. In ruminants, inadequate nutrition during pregnancy is often prevalent due to frequent utilization of exensive forage based grazing systems, making them highly susceptible to changes in nutrient quality and availability. Delivery of nutrients to the fetus is dependent on a number of critical factors including placental growth and development, utero-placental blood flow, nutrient availability, and placenta metabolism and transport capacity. Previous findings from our laboratory and others, highlight essential roles for amino acids and their metabolites in supporting normal fetal growth and development, as well as the critical role for amino acid transporters in nutrient delivery to the fetus. The focus of this review will be on the role of materna nutrition on placental form and function as a regulator of fetal development in ruminants.

关键词： Intrauterine growth restriction Nutrient transport Placenta Ruminant

The signal-transduction pathways of the peripheral olfactory organ and their impairment in vertebrates

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Aquaculture and Fisheries 2024年第3期9卷 388-403页

作者： Arash Shahriari bouthaina Aoudi keith b.Tierney College of Natural and Applied Sciences Faculty of ScienceBiological SciencesEdmontonABT6G 2E9Canada Department of Civil and Environmental Engineering University of AlbertaEdmontonABT6G 1H9Canada College of Health Sciences School of Public HealthEdmontonABT6G 1C9Canada

Animals rely on olfaction to detect and process invaluable chemical information about their *** olfaction to function,chemicals must first be detected,which leads to the activation of signal-transduction pathways at the peripheral olfactory *** the olfactory system is in direct contact with the environment,the system is constantly vulnerable to damage by contaminants entering the atmosphere or *** may have a variety of effects,including disrupting olfactory signals generated during chemical detection,or altering numerous targets along the signal transduction *** any impairment of chemical detection,animals may be unable to rely on olfaction to make correct decisions about their environment and thus their *** other reviews have focussed on olfactory toxicology in general,here we specifically explore how contaminants may affect the signal-transduction pathways at various points and link those changes to olfactory functionality across vertebrates with a focus on fishes.

关键词： Olfaction Signal-transduction Vertebrate Fish

Is salmonid migration at risk from chemical information disruption?

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Aquaculture and Fisheries 2024年第3期9卷 378-387页

作者： keith b.Tierney Gregory G.Pyle biological Sciences College of Natural and Applied SciencesEdmontonABT6G 2E9Canada School of Public Health College of Health SciencesEdmontonABT6G 1C9Canada Department of biological Sciences University of LethbridgeLethbridgeABT1K 3M4Canada

Good information is the basis for good *** many invaluable salmon species,chemical information is necessary to guide and fine-tune their migrations to and from freshwater mating grounds.A problem is that salmon of the current world are running a gauntlet of toxic chemicals arising from diverse anthropogenic inputs and these chemicals are known to disrupt *** is sufficient evidence that effluents from cities,mines,agriculture and industry contain chemicals that can rapidly,and sometimes irreversibly,impair the olfactory sense that salmon use to gather *** toxic inputs may not only be strong enough to impair migration,but be strong enough to redirect salmon away from their *** is also evidence that some synthetic chemicals may serve as the basis for ‘new’ information and be useful in making correct migratory *** the plus side,there are examples of new regulations that limit the input of chemicals of known olfactory toxicity,but on the minus side,increased urbanization and global climate change will likely increase the number and/or severity of some neurotoxic *** we identify the specific avenues of chemical risks to information disruption and in so doing prioritize and rank the risks to migrating *** data collected here can be used to lay the foundation for modelling the effects of anthropogenic inputs on information disruption in diverse salmonid species from around the world and therefore help secure their longevity in a changing chemical environment.

关键词： Salmon migration Ocean ranching Chemical information disruption Homing disruption Olfactory toxicity

Liquid deposition photolithography for submicrometer resolution three-dimensional index structuring with large throughput

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Light(Science & Applications) 2013年第1期2卷 209-214页

作者： Adam C Urness Eric D moore keith K Kamysiak Michael C Cole Robert R McLeod Department of Electrical Engineering University of Colorado at BoulderBoulderCO 80309USA.

Photonic devices increasingly require three-dimensional control of refractive index,but existing fabrication methods such as femtosecond micromachining,multilayer lithography and bulk diffusion can only address a select scale range,are often limited in complexity or thickness and have low *** introduce a new fabrication method and polymeric material that can efficiently create mm^(3) optical devices with programmable,gradient index of refraction with arbitrary feature *** contrast of 0.1 is demonstrated,which is 100 times larger than femtosecond micromachining,and 20 times larger than commercial holographic *** is achieved by repetitive microfluidic layering of a self-developing photopolymer structured by projection *** process has the unusual property that total fabrication time for a fixed thickness decreases with the number of layers,enabling fabrication 10^(5) faster than femtosecond *** demonstrate the process by sequentially writing 100 layers to fabricate a mm thick waveguide array.

关键词： holographic photopolymers lithography photonic device fabrication single photon polymerization three-dimensional structuring