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河南科学 2012年第8期30卷 1029-1032页

作者：薛宝玉李文锋陈羽飞樊燕鸽 keith b.dillon 河南省科学院化学研究所郑州450002 Chemistry Department University of Durham

GeCl4与ArLi和Ar′Li(Ar″Li与Ar′Li 1∶1的混合物)反应生成化合物GeAr2Cl2,GeArCl3和GeAr″2Cl2,测定了GeAr2Cl2和GeAr″2Cl2的晶体结构,并进行了19F NMR表征.

关键词：大的吸电子基 Ar=24,,6-(CF3)3C6H2 Ar′=2,6-(CF3)2C6H3 Ar″=24,-(CF3)2C6H3 GeAr2Cl2 GeAr2′Cl2 19F NMR

含有大的吸电子取代基的主族元素新化合物的合成(英文)

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河南科学 2011年第8期29卷 907-909页

作者：薛宝玉赵俊宏樊燕鸽李文锋 keith b.dillon 河南省科学院化学研究所郑州450002 Chemistry Department University of DurhamDurham DH1 3LEUK

通过四氯化物ECl(4E是Si,Ge,Sn或As)和三氯化砷AsCl3分别与ArLi,Ar’Li或Ar"Li反应首先合成了10种新的主族元素化合物R1-2ECl1-2,其中R是2,4,6-(CF3)3C6H(2Ar),2,6-(CF3)2C6H3(Ar’)或2,4-(CF3)3C6H(3Ar");Ar,Ar’和Ar"均是大的吸电子... 详细信息

关键词：主族元素化合物吸电子取代基元素分析

Neuroendocrine facets of behavior and toxicology

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Aquaculture and Fisheries 2024年第3期9卷 337-338页

作者： keith b.Tierney balasubramanian Senthilkumaran Department of biological Sciences and the School of Public HealthUniversity of AlbertaEdmontonABT6G 2E9Canada Department of Animal biology School of Life SciencesUniversity of HyderabadP O Central UniversityGachibowliHyderabad500046TelanganaIndia

Professor ***,who I came to know as Senthil,came over to visit the University of Alberta in the summer of 2022 in connection with his Global Ambassador Fellowship program at University of Saskatechewan,***,there was that reason to visit,but there was another one as well,one that tied us *** years before Senthil had been considered for a postdoctoral fellowship with the legend that was Dick ***,it didn’t materialize and then he moved to Japan to do his Post Doc Under *** *** had been Dean and a preeminent endocrinologist at the U of A.I came to know Dick near the end of my PhD;he had brought me out to bamfield Marine Sciences Centre to carryout research using their then-new,and very expensive,simulated *** left an incredible mark on all of us that knew him;he represented all that was wonderful and achievable in *** spent time with him was akin to shaking Sinatra’s hand,at least in the world of biology in that *** this common history,Senthil and I were fast friends.

关键词： Canada shaking carry

The signal-transduction pathways of the peripheral olfactory organ and their impairment in vertebrates

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Aquaculture and Fisheries 2024年第3期9卷 388-403页

作者： Arash Shahriari bouthaina Aoudi keith b.Tierney College of Natural and Applied Sciences Faculty of ScienceBiological SciencesEdmontonABT6G 2E9Canada Department of Civil and Environmental Engineering University of AlbertaEdmontonABT6G 1H9Canada College of Health Sciences School of Public HealthEdmontonABT6G 1C9Canada

Animals rely on olfaction to detect and process invaluable chemical information about their *** olfaction to function,chemicals must first be detected,which leads to the activation of signal-transduction pathways at the peripheral olfactory *** the olfactory system is in direct contact with the environment,the system is constantly vulnerable to damage by contaminants entering the atmosphere or *** may have a variety of effects,including disrupting olfactory signals generated during chemical detection,or altering numerous targets along the signal transduction *** any impairment of chemical detection,animals may be unable to rely on olfaction to make correct decisions about their environment and thus their *** other reviews have focussed on olfactory toxicology in general,here we specifically explore how contaminants may affect the signal-transduction pathways at various points and link those changes to olfactory functionality across vertebrates with a focus on fishes.

关键词： Olfaction Signal-transduction Vertebrate Fish

Is salmonid migration at risk from chemical information disruption?

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Aquaculture and Fisheries 2024年第3期9卷 378-387页

作者： keith b.Tierney Gregory G.Pyle biological Sciences College of Natural and Applied SciencesEdmontonABT6G 2E9Canada School of Public Health College of Health SciencesEdmontonABT6G 1C9Canada Department of biological Sciences University of LethbridgeLethbridgeABT1K 3M4Canada

Good information is the basis for good *** many invaluable salmon species,chemical information is necessary to guide and fine-tune their migrations to and from freshwater mating grounds.A problem is that salmon of the current world are running a gauntlet of toxic chemicals arising from diverse anthropogenic inputs and these chemicals are known to disrupt *** is sufficient evidence that effluents from cities,mines,agriculture and industry contain chemicals that can rapidly,and sometimes irreversibly,impair the olfactory sense that salmon use to gather *** toxic inputs may not only be strong enough to impair migration,but be strong enough to redirect salmon away from their *** is also evidence that some synthetic chemicals may serve as the basis for ‘new’ information and be useful in making correct migratory *** the plus side,there are examples of new regulations that limit the input of chemicals of known olfactory toxicity,but on the minus side,increased urbanization and global climate change will likely increase the number and/or severity of some neurotoxic *** we identify the specific avenues of chemical risks to information disruption and in so doing prioritize and rank the risks to migrating *** data collected here can be used to lay the foundation for modelling the effects of anthropogenic inputs on information disruption in diverse salmonid species from around the world and therefore help secure their longevity in a changing chemical environment.

关键词： Salmon migration Ocean ranching Chemical information disruption Homing disruption Olfactory toxicity

EZH2 inhibitors promote β-like cell regeneration in young and adult type 1 diabetes donors

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Signal Transduction and Targeted Therapy 2024年第2期9卷 679-692页

作者： keith Al-Hasani Safiya Naina Marikar Harikrishnan Kaipananickal Scott Maxwell Jun Okabe Ishant Khurana Thomas Karagiannis Julia J.Liang Lina Mariana Thomas Loudovaris Thomas Kay Assam El-Osta Epigenetics in Human Health and Disease Program Baker Heart and Diabetes Institute75 Commercial RoadMelbourne 3004 VICAustralia Department of Diabetes Central Clinical SchoolMonash UniversityMelbourne 3004 VICAustralia Epigenetics in Human Health and Disease Laboratory Central Clinical SchoolMonash UniversityMelbourne 3004 VICAustralia School of Science STEM CollegeRMIT UniversityMelbourne 3001 VICAustralia Immunology and Diabetes Unit St Vincent’s Institute of Medical ResearchFitzroy 3065 VICAustralia Department of Medicine and Therapeutics The Chinese University of Hong KongSha TinHong Kong SAR Hong Kong Institute of Diabetes and Obesity Prince of Wales HospitalThe Chinese University of Hong Kong3/F Lui Che Woo Clinical Sciences Building30-32-Ngan Shing StreetSha TinHong Kong SAR Li Ka Shing Institute of Health Sciences The Chinese University of Hong KongSha TinHong Kong SAR biomedical Laboratory Science Department of TechnologyFaculty of HealthUniversity College CopenhagenCopenhagenDenmark

β-cells are a type of endocrine cell found in pancreatic islets that synthesize,store and release *** type 1 diabetes(T1D),T-cells of the immune system selectively destroy the insulin-producingβ-*** of these cells leads to a lifelong dependence on exogenous insulin administration for ***,there is an urgent need to identify novel therapies that stimulateβ-cell growth and induceβ-cell *** and others have shown that pancreatic ductal progenitor cells are a promising source for regeneratingβ-cells for T1D owing to their inherent differentiation *** transcriptional suppression is refractory to exocrine reaction and tightly controls the regenerative potential by the EZH2 *** the present study,we show that transient stimulation of exocrine cells,derived from juvenile and adult T1D donors to the FDAapproved EZH2 inhibitors GSK126 and Tazemetostat(Taz)influence a phenotypic shift towards aβ-like cell *** transition from repressed to permissive chromatin states are dependent on bivalent H3K27me3 and H3K4me3 chromatin *** EZH2 is fundamental toβ-cell regenerative *** pancreatic ductal cells exhibit insulin production and secretion in response to a physiological glucose challenge ex *** pre-clinical studies underscore the potential of small molecule inhibitors as novel modulators of ductal progenitor differentiation and a promising new approach for the restoration ofβ-like cell function.

关键词： EZH2 struction inhibitors

CI-WGAN:融合临床指标和WGAN的孤独症个体化脑功能连接网络生成

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数据采集与处理 2024年第4期39卷 813-826页

作者：孙海林严加栋张嵘 KENDRICK keith 蒋希电子科技大学生命科学与技术学院成都611731 麦吉尔大学蒙特利尔神经研究所蒙特利尔H3A 2B4 北京大学基础医学院神经生物学系北京100191 北京大学神经科学研究所北京100191 神经科学教育部重点实验室北京100191 卫健委神经科学重点实验室北京100191 北京大学医学部孤独症研究中心北京100191

脑功能连接(Functional connectivity,FC)网络作为潜在的脑影像标志物对孤独症谱系障碍(Autism spectrum disorder,ASD)的辅助诊疗研究具有重要作用。然而现有的FC生成方法大多仅基于脑影像数据,未充分考虑个体的临床指标从而易丢失疾... 详细信息

脑功能连接(Functional connectivity,FC)网络作为潜在的脑影像标志物对孤独症谱系障碍(Autism spectrum disorder,ASD)的辅助诊疗研究具有重要作用。然而现有的FC生成方法大多仅基于脑影像数据,未充分考虑个体的临床指标从而易丢失疾病的特异性信息。而且,ASD作为一种谱系障碍,其临床指标存在显著的个体化差异。因此,仅基于脑影像数据的传统生成模型在生成准确的且能反映个体化临床指标的ASD个体FC的任务上存在挑战。针对上述挑战,提出了个体化临床指标引导的沃瑟斯坦生成对抗网络模型(Clinical-indicator-aware Wasserstein generative adversarial network,CI-WGAN),用于生成孤独症个体化FC网络。该模型引入个体化临床指标引导机制,实现了高精度ASD患者FC网络的生成。基于全世界最大孤独症脑影像公开数据集之一的AbIDE I数据集进行实验,CI-WGAN生成FC与真实FC的峰值信噪比(Peak signal-to-noise ratio,PSNR)、结构相似度(Structural similarity,SSIM)与平均绝对误差(Mean absolute error,MAE)分别达到19.037、0.236与0.178,相较于其他FC生成模型分别提升了3%、12%与2%。此外基于生成FC和独立临床验证指标的表征相似度分析(Representational similarity analysis,RSA),CI-WGAN生成的FC相较其他模型生成FC最少提高了0.1倍和3.7倍,证明了CI-WGAN生成的FC包含更多的ASD个体特异性信息。本文提出的CI-WGAN模型实现了高质量个体化FC的生成,为ASD的早期诊断和个性化治疗提供了有力的技术支持。

关键词：孤独症谱系障碍大脑功能连接生成对抗网络临床指标引导机制梯度惩罚机制

Management of distal cholangiocarcinoma with arterial involvement: Systematic review and case series on the role of neoadjuvant therapy

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2689-2701页

作者： Lewis A Hall Duncan Loader Santiago Gouveia Marta burak James Halle-Smith Peter Labib Moath Alarabiyat Ravi Marudanayagam bobby V Dasari keith J Roberts Syed S Raza Michail Papamichail David C bartlett Robert P Sutcliffe Nikolaos A Chatzizacharias Department of Hepatopancreatobiliary Surgery and Liver Transplantation University Hospitals Birmingham NHS Foundation TrustBirmingham B152GWUnited Kingdom Institute of Immunology and Immunotherapy University of BirminghamBirmingham B152TTUnited Kingdom College of Medical and Dental Sciences University of BirminghamBirmingham B152TTUnited Kingdom Institute of Clinical Sciences University of BirminghamBirmingham B152TTUnited Kingdom

bACKGROUND The use of neoadjuvant therapy(NAT)in distal cholangiocarcinoma(dCCA)with regional arterial or extensive venous involvement,is not widely accepted and evidence is *** To synthesise evidence on NAT for dCCA and present the experience of a highvolume tertiary-centre managing dCCA with arterial *** A systematic review was performed according to PRISMA guidance to identify all studies reporting outcomes of patients with dCCA who received *** patients from 2017 to 2022 who were referred for NAT for dCCA at our centre were retrospectively collected from a prospectively maintained *** characteristics,NAT type,progression to surgery and oncological outcomes were *** Twelve studies were *** definition of“unresectable”locally advanced dCCA was *** studies reported outcomes for 9 patients who received NAT for dCCA with extensive vascular involvement.R0 resection rate ranged between 0 and 100%but without survival benefit in most *** studies considered either NAT in resectable dCCA or inclusive with extrahepatic *** presented case series includes 9 patients(median age 67,IQR 56-74 years,male:female 5:4)referred for NAT for borderline resectable or locally advanced *** patients progressed to surgery and 2 were *** patient died at 14 months with evidence of recurrence at 6 months and the other died at 51 months following recurrence 6 months *** Evidence for benefit of NAT is *** on criteria for uniform definition of resectability for dCCA is *** propose using the established National-Comprehensive-Cancer-Network®criteria for pancreatic ductal adenocarcinoma.

关键词： Cholangiocarcinoma Neoadjuvant therapy Arterial involvement Locally advanced Systematic review

Connexins in neurons and glia: targets for intervention in disease and injury

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Neural Regeneration Research 2015年第7期10卷 1013-1017页

作者： keith b.Moore John O'brien Richard S.Ruiz M.D.Department of Ophthalmology & Visual Science The University of Texas Health Science Center at Houston The University of Texas Graduate School of biomedical Sciences

both neurons and glia throughout the central nervous system are organized into networks by gap junctions. Among glia, gap junctions facilitate metabolic homeostasis and intercellular communication. Among neurons, gap junctions form electrical synapses that function primarily for communication. However, in neurodegenerative states due to disease or injury gap junctions may be detrimental to survival. Electrical synapses may facilitate hyperactivity and bystander killing among neurons, while gap junction hemichannels in glia may facilitate inflammatory signaling and scar formation. Advances in understanding mechanisms of plasticity of electrical synapses and development of molecular therapeutics to target glial gap junctions and hemichannels offer new hope to pharmacologically limit neuronal degeneration and enhance recovery.

关键词： ischemia retinal degeneration amacrine cells astrocytes dopamine receptors adenosine receptors NMDA receptors connexin mimetic peptides

Factors controlling nutrient availability to the developing fetus in ruminants

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Journal of Animal Science and biotechnology 2015年第2期6卷 205-214页

作者： Kathrin A Dunlap Jacob D brown Ashley b keith M Carey Satterfield Department of Animal Science Texas A&M University2471 TAMU College Station

Inadequate delivery of nutrients results in intrauterine growth restriction （IUGR）, which is a leading cause of neonatal morbidity and mortality in livestock. In ruminants, inadequate nutrition during pregnancy is often prevalent due to frequent utilization of exensive forage based grazing systems, making them highly susceptible to changes in nutrient quality and availability. Delivery of nutrients to the fetus is dependent on a number of critical factors including placental growth and development, utero-placental blood flow, nutrient availability, and placenta metabolism and transport capacity. Previous findings from our laboratory and others, highlight essential roles for amino acids and their metabolites in supporting normal fetal growth and development, as well as the critical role for amino acid transporters in nutrient delivery to the fetus. The focus of this review will be on the role of materna nutrition on placental form and function as a regulator of fetal development in ruminants.

关键词： Intrauterine growth restriction Nutrient transport Placenta Ruminant