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Navigating the Nomenclatur. of a Pur.or.ed “Dietar. Supplement”: A Cautionar. Tale for.Consumer. and Pr.ctitioner. r.gar.ing Tianeptine or.“Gas Station Her.in”

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Health 2023年第12期15卷 1338-1351页

作者： keith r. martin Center.for.Nutr.ceutical and Dietar. Supplement r.sear.h College of Health Sciences University of Memphis Memphis TN USA

Dietar. supplement sales have sur.assed $30 billion per.year.with their.use becoming and r.maining extr.mely popular.amongst the gener.l public. Ther. ar. numer.us bioactive components, both nutr.tive and non-nutr.tive, in dietar. supplements with consider.ble efficacy in pr.moting health. However. ther. ar. many ways disallowed ingr.dients may enter.the supplement pipeline with potentially toxic effects. Dietar. supplements can be r.gulated (either.pr.- or.post-mar.et) as a dr.g, dietar. supplement, a nutr.ceutical, new dietar. ingr.dient (NDI), gener.lly r.cognized as safe (Gr.S) food ingr.dient, a food additive, or.a food. A phar.aceutical dr.g (medication) is used to tr.at, cur., pr.vent, or.diagnose a disease and is r.gulated by the FDA pr.-mar.et only and allowed by medical pr.scr.ption, wher.as the other.labeling designations ar. lar.ely r.gulated post-mar.et. One such molecule with a labeling pr.blem is tianeptine, which has global use as an efficacious, pr.scr.bed dr.g, while at the same time being consider.d a non-dr.g and potentially danger.us adulter.nt often r.fer.ed to as gas station her.in. In this paper. we cr.tically evaluate the use and labeling of this compound and attempt to clar.fy the conundr.m sur.ounding its legal or.illegal use. Tianeptine is effective and efficacious as an antidepr.ssant in those r.sponding poor.y to selective ser.tonin r.uptake inhibitor. (SSr.s) and exhibits many medicinal char.cter.stics of tr.cyclic antidepr.ssants with fewer.opioid-like side effects. As a r.sult, sixty-six countr.es per.it use of tianeptine as a pr.scr.ption dr.g. At higher.doses, tianeptine has r.cently been shown to exhibit significant potential for.abuse and dependency along with toxicity. As such, the US does not r.cognize tianeptine as an FDA-appr.ved dr.g or.as a dietar. supplement, nutr.ceutical, new dietar. ingr.dient (NDI), Gr.S ingr.dient, or.a food. Instead, tianeptine is a synthetic adulter.nt of a dietar. supplement and consider.d technica

关键词： Tianeptine SSr. Tr.cyclic Antidepr.ssant Dietar. Supplement Phar.aceutical Nutr.ceutical Gr.S NDI

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Compar.son of Sensor. Qualities of Geogr.phically Pair.d Or.anic and Conventional r.d Wines fr.m the Southwester. US with Differ.ng Total Polyphenol Concentr.tions: A r.ndomized Pilot Study

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Food and Nutr.tion Sciences 2011年第10期2卷 1150-1159页

作者： keith r. martin Kr.sten K. r.smussen 不详

Dietar. polyphenols, or.phenolic compounds, ar. numer.us, diver.e, and ubiquitous phytochemicals occur.ing thr.ughout the plant kingdom. They ar. impor.ant components of the human diet because of their.capacity to r.duce the r.sk of chr.nic diseases such as car.iovascular.disease and cancer. In plants, polyphenols contr.bute to r.sistance to pathogens due to their.potent astr.ngency and function as phytoalexins. As a r.sult, or.anic gr.pevines gr.wn with r.duced pesticides may be mor. str.ssed by pathogens than conventionally gr.wn gr.pevines and pr.sumably pr.duce mor. polyphenols. Since polyphenols also play an impor.ant r.le in the sensor. qualities of fr.its and wines par.icular.y involving astr.ngency and bitter.ess, ther. may be differ.nces that affect sensor. per.eptions of wine. This establishes a conundr.m wher. dietar. polyphenols ar. healthful but potentially *** r.cr.ited and r.ndomized 18 female par.icipants (21 - 50 y) to one of five gr.ups (3 - 4 per.gr.up). Each gr.up evaluated the sensor. qualities of a geogr.phically pair.d or.anic (OW) and conventional wine (CW) and an ar.ificially color.d white wine placebo (PW) with significantly differ.ng total polyphenol concentr.tions (TP). Par.icipants r.por.ed for.thr.e visits (one wine per.visit) wher. they consumed 5 ounces (150 mL) of wine over.15 minutes while completing the sensor. sur.ey. Sensor. evaluations based on a Liker.-type scale included visual, ar.ma, and taste per.eptions and over.ll impr.ssions (scale 0 - 10). In two wine pair., the OW contained significantly mor. TP (3.49 and 5.86 g/L) than the r.spective CW (2.63 and 4.63 g/L). In two other.wine pair. both pr.duced by sustainable viticultur., the CW (5.23 and 8.38 g/L) contained sig- nificantly mor. TP than OW (4.55 and 3.70 g/L) and in one set the amounts wer. equivalent (4.10 and 4.17 g/L). The five PW aver.ged 1.26 ± 0.20 g/L. Although ther. wer. significant differ.nces in TP content of test wines, the r.sults indicated that

关键词： Or.anic Wine Conventional Polyphenols Sensor. Qualities

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Beyond Nutr.tion r.commendations: What Healthcar. Pr.fessionals Should Know about Dietar. Supplements to Best Ser.e Their.Patients

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Health 2021年第4期13卷 334-346页

作者： Jacquelyn C. Pence keith r. martin r.char. J. Bloomer Center.for.Nutr.ceutical and Dietar. Supplement r.sear.h College of Health Sciences University of Memphis Memphis TN USA

Although whole food nutr.tion will likely influence physical health mor. than any other.lifestyle component besides exer.ise, the use of dietar. supplements among men and women continues to be high. Due to this fact, it is imper.tive that healthcar. pr.fessionals under.tand how supplements may impact over.ll health and wellness of their.patients. With the major.ty of adults taking some for. of dietar. supplements and many concomitantly taking pr.scr.ption medications, healthcar. pr.vider. should be conscientious of adver.e effects and inter.ctions that may occur.between dietar. supplements and pr.scr.ption dr.gs. As many consumer. ar. misled by false mar.eting, healthcar. pr.vider. should encour.ge them to be war. of exagger.ted claims and dir.ct them to pr.ducts that ar. scientifically suppor.ed and safe. Continuing education for.healthcar. pr.vider. on dietar. supplements is cr.cial, with new dietar. supplement pr.ducts constantly r.aching the mar.ets, in addition to new findings being made thr.ugh clinical r.sear.h and case studies. While some dietar. supplements pr.vide no meaningful benefit, many dietar. supplements have been identified that can be used to amelior.te nutr.tional deficiencies and r.duce the r.sk of some common health conditions. Other. can ser.e to impr.ve mental and physical per.or.ance, while tr.ly enhancing health. This ar.icle pr.sents r.levant infor.ation on dietar. supplements that will be useful to the healthcar. pr.fessional.

关键词： Dietar. Supplements Nutr.ceuticals Healthcar. Pr.fessionals Adver.e Events

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Symptom pr.sentation and evolution in the fir.t 48 hour. after.injur. ar. associated with r.tur. to play after.concussion in elite r.gby Union

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Jour.al of Spor. and Health Science 2024年第3期13卷 387-397页

作者： r.ss Tucker.Matt Cr.ss keith Stokes Lindsay Star.ing r.sy Hyman Simon Kemp Stephen West martin r.fter. Eanna Falvey James Br.wn Institute of Spor. and Exer.ise Medicine(ISEM) Department of ExerciseUniversity of StellenboschTygerberg 7505South Africa Wor.d r.gby Ltd. Dublin D02 AE93Ireland Pr.mier.hip r.gby London SW1V 1PXUK Centr. for.Health and Injury and Illness Prevention in SportUniversity of BathClaverton Down BA27AYUK UK Collabor.ting Centr. on Injur. and Illness Pr.vention in Spor.(UKCCIIS) University of BathClaverton Down BA27AYUK r.gby Football Union London TW27BAUK London School of Tr.pical Medicine London WC1E 7HTUK Spor. Injur. Pr.vention r.sear.h Centr. Faculty of KinesiologyUniversity of CalgaryCalgary T2N 1N4Canada Depar.ment of Medicine School of Medicine and HealthUniversity College CorkCork T12 EC8PIreland Car.egie Applied r.gby r.sear.h(CAr.)centr. Carnegie School of SportLeeds Beckett UniversityLeeds LS63QSUK

Backgr.und:r.tur. to play(r.P)in elite r.gby is managed using a 6-stage gr.duated r.P pr.tocol,which can r.sult in clear.nce to play within 1 week of *** aimed to explor. how symptom,cognitive,and balance pr.sentation and evolution dur.ng concussion scr.ens 2 h(head injur. assessment(HIA2)and 48 h(HIA3)after.injur. wer. associated with time to r.P)to identify whether.a mor. conser.ative gr.duated r.P may be ***:A r.tr.spective cohor. study was conducted in 380 concussed r.gby player. fr.m elite men’s r.gby over.3 consecutive *** wer. classified as shor.er.or.longer.r.tur.s,depending on whether.r.P occur.ed within 7 days(allowing them to be consider.d to play the match 1 week after.injur.)or.longer.than 8 days,***,cognitive,and balance per.or.ance dur.ng scr.ens was assessed r.lative to baseline(nor.al or.abnor.al)and to the pr.ceding scr.en(impr.ving or.wor.ening).Associations between sub-test abnor.alities and r.P time wer. explor.d using odds r.tios(Or.longer.***).Median day absence was compar.d between player. with abnor.al or.wor.ening r.sults and those whose r.sults wer. nor.al or.***:Abnor.al symptom r.sults dur.ng scr.ens 2 h and 48 h after.concussion wer. associated with longer.r.tur. time(HIA2:Or.2.21,95%confidence inter.al(95%CI):1.39-3.50;HIA3:Or.3.30,95%CI:1.89-5.75).Wor.ening symptom number.or.sever.ty fr.m the time of injur. to 2 h and 48 h post-injur. was associated with longer.r.tur.(HIA2:Or.2.49,95%CI:1.36-4.58;HIA3:Or.3.34,95%CI:1.10-10.15).Median days absence was gr.ater.in player. with abnor.al symptom r.sults at both HIA2 and *** and balance per.or.ance wer. not associated with longer.r.tur. and did not affect median days ***:Symptom pr.sentation and evolution within 48 h of concussion wer. associated with longer.r.P *** may guide a mor. conser.ative appr.ach to r.P,while still adher.ng to individualized concussion management pr.nciples.

关键词： Br.in injur. Concussion management Gener.l r.tur. to play Medical management

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Navigating the Nomenclatur. of a Pur.or.ed “Dietar. Supplement”: A Cautionar. Tale for.Consumer. and Pr.ctitioner. r.gar.ing Tianeptine or.“Gas Station Her.in”

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Health（健康） 2023年第12期

作者： keith r. martin

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Tr.e str.ctur. and diver.ity shape the biomass of pr.mar. temper.te mountain for.sts

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For.st Ecosystems 2024年第4期11卷 568-579页

作者： Dheer.j r.lhan r.ffy r.dr.go Heather.keith Annemiek Ir.ne Stegehuis Jakob Pavlin Yumei Jiang Milos r.dval Juliana Nogueir. Alexandr. Fr.leux Mar.k Svitok martin Mikolas Daniel Kozak martin Dusatko Pavel Janda Oleh Chaskovsky Catalin-Constantin r.ibu Mir.slav Svoboda Czech Univer.ity of Life Sciences Pr.gue Faculty of Forestry and Wood SciencesKamycka 129Suchdol16521 Praha 6Czech Republic Depar.ment of For.st Science Biliran Province State UniversityBiliran6549Philippines Gr.ffith Climate Action Beacon Griffith UniversityParklands DriveSouthportGold CoastQueensland4222Australia Labor.toir. de Geologie IPSLCNRSUMR 8538Ecole Normale SuperieurePSL UniversityParisFrance Univ.Lille Institut Mines-TelecomUniv.ArtoisJuniaULR 4515LGCgELaboratoire de Genie Civil et Geo-EnvironnementF-59000LilleFrance Depar.ment of Biology and Gener.l Ecology Faculty of Ecology and Environmental SciencesTechnical University in ZvolenMasaryka 2496001ZvolenSlovakia Institute of For.st Management Ukrainian National Forestry UniversityLvivUkraine For.st Biometr.cs Labor.tor.–Faculty of For.str. Stefan Cel Mare University of SuceavaUniversitații Street Number.13Suceava720229Romania

Pr.mar. for.sts ar. spatially diver.e ter.estr.al ecosystems with unique char.cter.stics,being natur.lly r.gener.tive and heter.geneous,which suppor.s the stability of their.car.on stor.ge thr.ugh the accumulation of live and dead ***,little is known about the inter.ctions between biomass stocks,tr.e genus diver.ity and str.ctur. acr.ss a temper.te montane pr.mar. ***,we investigated the r.lationship between tr.e str.ctur.(var.ability in basal ar.a and tr.e size),genus-level diver.ity(abundance,tr.e diver.ity)and biomass stocks in temper.te pr.mar. mountain for.sts acr.ss Centr.l and Easter. *** used inventor. data fr.m726 per.anent sample plots fr.m mixed beech and spr.ce acr.ss the Car.athian *** used nonlinear.r.gr.ssion to analyse the spatial var.ability in for.st biomass,str.ctur.,and genus-level diver.ity and how they inter.ct with plot-level tr.e age,distur.ances,temper.tur. and *** found that the combined effects of genus and str.ctur.l indices wer. impor.ant for.addr.ssing the var.ability in biomass acr.ss differ.nt spatial *** pr.cesses in distur.ance r.gimes and uneven tr.e age suppor. for.st hete r.geneity and the accumulation of live and dead biomass thr.ugh the natur.l r.gener.tion,gr.wth and decay of the for.st *** complexities in basal ar.a index,suppor.e d by genus-level abundance,positively influence total biomass stocks,which was modulated by tr.e age and *** for.sts showed higher.tr.e density and basal ar.a than mixed beech for.sts,though mixed beech still contr.butes significantly to biomass acr.ss *** heter.geneity was str.ngly influenced by complexities in for.st composition(tr.e genus diver.ity,str.ctur.).We addr.ssed the impor.ance of pr.mar. for.sts as stable car.on stor.s,achieved thr.ugh str.ctur. and *** such ecosystems is cr.tical for.ensur.ng the stability of the pr.mar. for.st,car.on stor. and biodiver.ity into the futur..

关键词： Biodiver.ity indicator. Biomass car.on stock Ecosystem functioning For.st composition Pr.mar. for.st str.ctur. Tr.e size distr.bution

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Networ. Motif Detection: Algor.thms, Par.llel and Cloud Computing,and r.lated Tools

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Tsinghua Science and Technology 2013年第5期18卷 469-489页

作者： Wooyoung Kim martin Diko keith r.wson the Depar.ment of Computing and Softwar. Systems University of Washington Bothell

Networ. motif is defined as a fr.quent and unique subgr.ph patter. in a networ., and the sear.h involves counting all the possible instances or.listing all patter.s, testing isomor.hism known as NP-har. and lar.e amounts of r.peated pr.cesses for.statistical evaluation. Although many efficient algor.thms have been intr.duced, exhaustive sear.h methods ar. still infeasible and feasible appr.ximation methods ar. yet ***, the fast and continual gr.wth of biological networ.s makes the pr.blem mor. challenging. As a consequence, par.llel algor.thms have been developed and distr.buted computing has been tested in the cloud computing envir.nment as well. In this paper. we sur.ey cur.ent algor.thms for.networ. motif detection and existing softwar. tools. Then, we show that some methods have been utilized for.par.llel networ. motif sear.h algor.thms with static or.dynamic load balancing techniques. With the advent of cloud computing ser.ices, networ. motif sear.h has been implemented with Mapr.duce in Hadoop Distr.buted File System（HDFS）, and with Stor., but without statistical testing. In this paper. we sur.ey networ. motif sear.h algor.thms in gener.l, including existing par.llel methods as well as cloud computing based sear.h, and show the pr.mising potentials for.the cloud computing based motif sear.h methods.

关键词： networ. motif par.llel sear.h Mapr.duce HDFS stor.

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Micr.-por.us PLGA/β-TCP/TPU scaffolds pr.par.d by solvent-based 3D pr.nting for.bone tissue engineer.ng pur.oses

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r.gener.tive Biomater.als 2023年第1期10卷 1538-1551页

作者： Luan P.Hatt Sylvie Wir.h Aapo r.staniemi Daniel J.Cir.c keith Thompson David Eglin martin J.Stoddar. Angela r.Ar.iento AO r.sear.h Institute Davos 7270 Davos PlatzSwitzerland Institute for.Biomechanics ETH Zurich8093 ZurichSwitzerland UCB Phar.a SL13WE SloughUK Mines Saint-Etienne Universitede LyonUniversite´Jean MonnetINSERMU105942023 SainbioseSaint-EtienneFrance Medical Center Faculty of MedicineAlbert-Ludwigs-University of Freiburg79106 FreiburgGermany

The 3D pr.nting pr.cess of fused deposition modelling is an attr.ctive fabr.cation appr.ach to cr.ate tissue-engineer.d bone substitutes to r.gener.te lar.e mandibular.bone defects,but often lacks desir.d sur.ace por.sity for.enhanced pr.tein adsor.tion and cell ***-based pr.nting leads to the spontaneous for.ation of micr.por.s on the scaffold’s sur.ace upon solvent r.moval,without the need for.fur.her.post *** aim is to cr.ate and char.cter.ze por.us scaffolds using a new for.ulation composed of mechanically stable poly(lactic-co-glycol acid)and osteoconductiveβ-tr.calcium phosphate with and without the addition of elastic ther.oplastic polyur.thane pr.par.d by solvent-based 3D-pr.nting ***-scale r.gener.tive scaffolds can be 3D-pr.nted with adequate fidelity and show por.sity at multiple levels analysed via micr.-computer.tomogr.phy,scanning electr.n micr.scopy and N2 *** mechanical pr.per.ies compar.d to a commer.ially available calcium phosphate ink ar. demonstr.ted in compr.ssion and scr.w pull out *** assessments including cell activity assay and live-dead staining pr.ve the scaffold’s *** pr.per.ies ar. demonstr.ted by per.or.ing an osteogenic differ.ntiation assay with pr.mar. human bone mar.ow mesenchymal str.mal *** pr.pose a ver.atile fabr.cation pr.cess to cr.ate por.us 3D-pr.nted scaffolds with adequate mechanical stability and osteoconductivity,both impor.ant char.cter.stics for.segmental mandibular.bone r.constr.ction.

关键词： solvent-based pr.nting por.sity r.gener.tive scaffold osteogenesis mesenchymal str.mal cells

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Lymphoepithelial cysts of the pancr.as:a management dilemma

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Hepatobiliar. & Pancr.atic Diseases Inter.ational 2014年第5期13卷 539-544页

作者： Julie martin keith J r.ber.s Mar.a Sher.dan Gavin A Falk Daniel Joyce r.Matthew Walsh Andr.w M Smith Gar.th Mor.is-Stiff Depar.ments of Pancr.atic Sur.er. St James's University Hospital Depar.ments of r.diology St James's University Hospital Depar.ment of Gener.l Sur.er. Section of Surgical Oncology/HPB Cleveland Clinic Foundation

Pancr.atic lymphoepithelial cysts（LECs） ar. r.r.,benign lesions that ar. typically unexpected post-oper.tive pathological findings. We aimed to r.view clinical, r.diological and pathological featur.s of LECs that may allow their.pr.oper.tive diagnosis. Histopathology databases of two lar.e pancr.atic units wer. sear.hed to identify LECs and notes r.viewed to deter.ine patient demogr.phic details, mode of pr.sentation, investigations, tr.atment and outcome. Five male and one female patients wer. identified. Their.median age was 60 year.. Lesions wer. identified on computed tomogr.phy per.or.ed for.abdominal pain in two patients, and wer. incidentally obser.ed in four.patients. Five LECs wer. located in the tail and one in the body of the pancr.as, with a median cyst size of 5 cm. Obtaining cyst fluid was difficult and a lar.ely acellular.aspir.te was yielded. The pr.-oper.tive diagnosis was mucinous cystic neoplasm in all patients. This ser.es of patients wer. tr.ated distal pancr.atectomy and splenectomy. A r.tr.spective r.view of r.diological examinations suggested that LECs have a r.latively low signal on T2 imaging and a high signal intensity on T1 weighted images. LECs appear.mor. common in elder.y males, and ar. typically incidental, lar.e, unilocular.cysts. Close attention to signal intensity on Mr. may allow pr.oper.tive diagnosis of these lesions.

关键词： lymphoepithelial cyst pancr.as

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Down-r.gulation of IL-8 expr.ssion in human air.ay epithelial cells thr.ugh helper.dependent adenovir.l-mediated r.A inter.er.nce

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Cell r.sear.h 2005年第2期15卷 111-119页

作者： Ber.ar. martin,David r.KOEHLEr.Pamela L.ZEITLIN,A.keith TANAWELL,Jim HU Pr.gr.mme in Lung Biology r.sear.h and the Canadian Institutes of Health r.sear.h Gr.up in Lung Development Hospitalfor.Sick Childr.n Tor.nto Canada M5G 1X8 Pr.gr.mme in Lung Biology r.sear.h and the Canadian Institutes of Health r.sear.h Gr.up in Lung Development Hospitalfor.Sick Childr.n Tor.nto Canada M5G 1X8 Labor.tor. Medicine and Pathobiology Univer.ity of Tor.nto Tor.nto Canada M5S 1A1 Depar.ments of Pediatr.cs The Johns Hopkins Univer.ity School of Medicine Baltimor. MD 21287 USA. Pr.gr.mme in Lung Biology r.sear.h and the Canadian Institutes of Health r.sear.h Gr.up in Lung Development Hospitalfor.Sick Childr.n Tor.nto Canada M5G 1X8Depar.ment of Paediatr.cs Univer.ity of Tor.nto Tor.nto Canada M5S 1A1 Depar.ment of Physiology Univer.ity of Tor.nto Tor.nto Canada M5S 1A1 Pr.gr.mme in Lung Biology r.sear.h and the Canadian Institutes of Health r.sear.h Gr.up in Lung Development Hospitalfor.Sick Childr.n Tor.nto Canada M5G 1X8Depar.ment of Paediatr.cs Univer.ity of Tor.nto Tor.nto Canada M5S 1A1 Labor.tor. Medicine and Pathobiology Univer.ity of Tor.nto Tor.nto Canada M5S 1A1

Inter.eukin (IL)-8 is a potent neutr.phil chemotactic factor.and a cr.cial mediator.in neutr.phil-dependent *** cell types pr.duce IL-8, either.in r.sponse to exter.al stimuli such as cytokines or.bacter.al infection, or.after.alignant tr.nsfor.ation. Anti-IL-8 str.tegies have been consider.d for.anti-inflammator. ther.py. In this paper.wedemonstr.te that the r.A inter.er.nce technique can be used to efficiently down-r.gulate IL-8 pr.tein expr.ssion inair.ay epithelial cells. We used a helper.dependent adenovir.l vector.to expr.ss a small hair.in (sh)r.A tar.etinghuman IL-8 in cultur.d air.ay epithelial cells (IB3-1, Cftr./-; C38, Cftr.cor.ected) stimulated with TNF-α, IL-1β or.eat-inactivated Bur.holder.a cenocepacia. Stimulated IL-8 expr.ssion in IB3-1 and C38 cells was significantly r.ducedby shr.A expr.ssion. The shr.A tar.eting IL-8 had no effect on the activation of NF-κB, or.on the pr.tein levels ofIκB or.IL-6, suggesting that this anti-IL-8 str.tegy was highly specific, and ther.for. may offer.potential for.thetr.atment of inflammator. diseases.

关键词： Inter.eukin-8 r.A inter.er.nce helper.dependent adenovir.l vector inflammation chemokine neutr.phil cystic fibr.sis.

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