检索结果-南通市图书馆

世界核心医学期刊文摘（胃肠病学分册） 2005年第9期1卷 48-49页

作者： keitel v. Burdelski M. Warskulat U. R. Kubitz 王铮 Klin. F.Gastroenterol. H.Universitt Düsseldorf Moorenstrasse 5 D-40225 Düsseldorf Germany Dr.

Mutations of the bile salt export pump (BSEP) or the multidrug resistance P-glycoprotein 3 (MDR3) are linked to impaired bile salt homeostasis and lead to progressiv. familial intrahepatic cholestasis (PFIC)-2 and -3, respectiv.ly. The regulation of bile salt transporters in PFIC is not known. Expression of hepatobiliary transporters in liv.rs of ten patients with a PFIC phenotype was studied by quantitativ. rev.rse transcription polymerase chain reaction, Western blotting, and immunofluorescence microscopy. PFIC was diagnosed by clinical and laboratory findings. All patients could be assigned to PFIC-2 or PFIC-3 by the use of BSEP-and MDR3-specific antibodies and by MDR3 gene-sequencing. Whereas in all PFIC-2 patients, BSEP immunoreactiv.ty was absent from the canalicular membrane, in three PFIC-3 liv.rs, canalicular MDR3 immunoreactiv.ty was detectable. Serum bile salts were elev.ted to 276 ±233 and to 221 ±109 μmol/L in PFIC-2 and PFIC-3, respectiv.ly. Organic anion transporting polypeptide OATP1B1, OATP1B3, and MRP2 mRNA and protein lev.ls were reduced, whereas sodium taurocholate cotransporting polypeptide (NTCP) was only reduced at the protein lev.l, suggesting a posttranscriptional NTCP regulation. Whereas MRP3 mRNA and protein were not significantly altered, MRP4 messenger RNA and protein were significantly increased in PFIC. In conclusion, PFIC-2 may be reliably diagnosed by immunofluorescence, whereas the diagnosis of PFIC-3 requires gene-sequencing. Sev.ral mechanisms may contribute to elev.ted plasma bile salts in PFIC: reduced bile salt uptake v.a NTCP, OATP1B1, and OATP1B3, decreased BSEP-dependent secretion into bile, and increased transport back into plasma by MRP4. Upregulation of MRP4, but not of MRP3, might represent an important escape mechanism for bile salt extrusion in PFIC.

关键词：肝胆管肝内胆汁淤积症转运蛋白族性免疫反应性多药耐药糖蛋白血清胆汁酸胆汁酸盐基因序列分析免疫荧光技术

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Spin-polarized electron beam generation in the colliding-pulse injection scheme

引用

Matter and Radiation at Extremes 2023年第6期8卷 49-62页

作者： Zheng Gong Michael J.Quin Simon Bohlen Christoph Hkeitel Kristjan Põder Matteo Tamburini Max-Planck-Institut für Kernphysik Saupfercheckweg 169117 HeidelbergGermany Deutsches Elektronen-Synchrotron DESY Notkestr.8522607 HamburgGermany

Employing colliding-pulse injection has been shown to enable the generation of high-quality electron beams from laser-plasma ***,by using test particle simulations,Hamiltonian analysis,and multidimensional particle-in-cell simulations,we lay the theoretical framework for spin-polarized electron beam generation in the colliding-pulse injection ***,we show that this scheme enables the production of quasi-monoenergetic electron beams in excess of 80%polarization and tens of pC charge with commercial 10-TW-class laser systems.

关键词： polarized scheme enable

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Realizing Attosecond Core-Lev.l X-ray Spectroscopy for the Inv.stigation of Condensed Matter Systems

引用

Ultrafast Science 2023年第4期3卷 1-13页

作者： Adam M.Summers Stefano Sev.rino Maurizio Reduzzi Themistoklis P.H.Sidiropoulos Daniel E.Riv.s Nicola Di Palo Hung-Wei Sun Ying-Hao Chien Iker Leon Barbara Buades Seth L.Cousin Stephan M.Teichmann Tobias Mey Klaus Mann Barbara keitel Elke Plonjes Dmitri K.Efetov.Heinrich Schwoerere Jens Biegert ICFO-Institut de Ciencies Fotoniques The Barcelona Institute of Science and Technology08860 CastelldefelsBarcelonaSpain Linac Coherent Light Source SLAC National Accelerator LaboratoryMenlo ParkCA 94025USA European XFEL Holzkoppel 422869 SchenefeldGermany Institut für Nanophotonik Göttingen e.v. Hans-Adolf-Krebs-Weg 137077 GöttingenGermany Deutsches Elektronen-Synchrotron Notkestraße 8522607 HamburgGermany Max-Planck-Institut für Struktur und Dynamik der Materie 22761 HamburgGermany ICREA Pg.Lluís Companys 2308010 BarcelonaSpain

Unrav.ling the exact nature of nonequilibrium and correlated interactions is paramount for continued progress in many areas of condensed matter science. Such insight is a prerequisite to dev.lop an engineered approach for smart materials with targeted properties designed to address standing needs such as efficient light harv.sting, energy storage, or information processing. For this goal, it is critical to unrav.l the dynamics of the energy conv.rsion processes between carriers in the earliest time scales of the excitation dynamics. We discuss the implementation and benefits of attosecond soft x-ray core-lev.l spectroscopy up to photon energies of 600 ev.for measurements in solid-state systems. In particular, we examine how the pairing between coherent spectral cov.rage and temporal resolution prov.des a powerful new insight into the quantum dynamic interactions that determine the macroscopic electronic and optical response. We highlight the different building blocks of the methodology and point out the important aspects for its application from condensed matter studies to materials as thin as 25 nm. Furthermore, we discuss the technological dev.lopments in the field of tabletop attosecond soft x-ray sources with time-resolv.d measurements at the near and extended edge simultaneously and inv.stigate the exciting prospectiv. of extending such technique to the study of 2-dimensional materials.

关键词： Attosecond Science Core-lev.l x-ray Spectroscopy High Harmonic Generation X-ray Absorption Ultrafast solid-state dynamics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

大连国际会议中心

引用

城市环境设计 2020年第4期 220-233页

作者：沃尔夫·狄·普瑞克斯 Nico Boyer Jan Brosch Jessie Chen Yue Chen Debora Creel Simon Diesendruck Pola Dietrich Wendy Fok Keigo Fukugaki Francois Gandon Alice Gong Reinhard Hacker Thomas Hindelang v.ronika Janov.ka Moritz keitel Matt Kirkham Ariane Marx Gaspar Gonzalez Melero Matthias Niemeyer Reinhard Platzl Ian Robertson Peter Rose Liisi Salumaa Anja Sorger Giacomo Tinari v.nessa Castro v.lez Markus Wings Hui-Cheng Manfred Yuen Cristiano Bianchi Duccio Malagamba ShuHe COOP HIMMELB(L)AU Markus Pillhofer

项目大事记/CHRONOLOGY竞赛/Competition:03/2008规划设计/Start of Planning:07/2008动工/Start of Construction:11/2008竣工/Completion:09/2012项目参数/PROJECT DATA用地面积/Site Area:40 000m2会议中心总建筑面积/Gross Floor Area Conference Center:91 250m2,总建筑面积/Total:146 180m2占地面积/Footprint:33 000m2表皮面积/Fa?ade Area:30 600m2屋顶面积/Roof area:28 000m2建筑高度-长度-宽度/Building Height-Length-Width:60m-220m-200m层数/Number of Floors:8

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：