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Importance of abdominal X-ray to confirm the position of levonorgestrel-releasing intrauterine system:A case report

World Journal of Clinical Cases 2022年第15期10卷 4904-4910页

作者： Aki Maebayashi Kanoko Kato Nobuki hayashi Masaji Nagaishi Kei Kawana Obstetrics and Gynecology Nihon University HospitalTokyo 1018309Japan Obstetrics and Gynecology Nihon University School of MedicineTokyo 1738610Japan

BACKGROUND Levonorgestrel-releasing intrauterine systems(LNG-IUSs)gradually release levonorgestrel into the uterus and is effective against hypermenorrhoea and *** associated with the insertion include expulsion,displacement,and uterine *** identification of copper intrauterine devices(IUDs)is possible due to echogenicity from the copper ***,the barium sulfate coatings of LNG-IUSs do not always provide hyperechoic *** barium sulfate and copper are radiopaque and clearly identifiable on ***,X-ray imaging is required to locate *** SUMMARY A 46-year-old woman with hypermenorrhoea due to submucosal myomas was treated with LNG-IUS at another *** LNG-IUS insertions had apparently been followed by spontaneous expulsion,although objective confirmation using imaging was not *** patient was referred to our institution for *** the first visit,there appeared to be no device in the uterus,and none was observed on transvaginal ***,two LNGIUSs were observed in the pelvis on abdominal plain X-rays prior to *** myomectomy was performed,and the two LNG-IUSs were found to have perforated the *** devices were safely removed during surgery,and the submucosal myomas were also *** perforated section of the myometrium was minimal+ADs-therefore,a repair operation was not *** Plain abdominal X-rays facilitate the determination of whether an LNG-IUS is in the uterine ***,it is important to confirm a device’s location,regardless of whether spontaneous expulsion is suspected,prior to inserting another device.

关键词： Hysteroscope Intrauterine devices Levonorgestrel-releasing intrauterine system Submucosal myoma Uterine perforation Case report

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Assessing mixing uniformity in microreactors via in-line spectroscopy

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Chinese Journal of Chemical Engineering 2024年第2期66卷 119-124页

作者： Shusaku Asano Shinji Kudo Taisuke Maki Yosuke Muranaka Kazuhiro Mae Jun-ichiro hayashi Institute for Materials Chemistry and Engineering Kyushu UniversityKasuga 816-8580Japan Department of Chemical Engineering Graduate School of EngineeringKyoto UniversityJapan

Mixing behavior is critical for enhancing the selectivity of fast chemical reactions in microreactors.A high Reynolds number(Re)improves the mixing rate and selectivity of the reactions,but some exceptions of increasing side product yield with the higher Re have been *** study investigated the mixing uniformity in microreactors with in-line UV-vis spectroscopy to clarify the relationship between reaction selectivity and chaotic mixing with the higher Re.A colorization experiment of thymolphthalein in an acidic solution was conducted with an excess acid amount to the base to indicate a non-uniformly mixed ***-uniformity significantly increased with *** the same time,the degree of mixing,which was measured by a usual decolorization experiment,showed that the mixing rate increased with *** in-line analysis of the Villermaux-Dushman reaction during the mixing clarified that side product yield significantly increased with Re at around 300 and then decreased at around *** results suggest the compensation effect between the mixing uniformity and mixing rate on the selectivity of the mixing-sensitive *** mixing,characterized by a larger Re,can disturb mixing uniformity and,in some cases,decrease reaction selectivity.

关键词： Microreactor Villermaux-Dushman reaction In-line analysis Mixing Mass transfer Uniformity

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Pyrochemical treatment of spent nitride fuels for MA transmutation

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Science China Chemistry 2014年第11期57卷 1427-1431页

作者： hayashi Hirokazu SATO Takumi SHIBATA Hiroki KURATA Masaki IWAI Takashi ARAI Yasuo Nuclear Science and Engineering Center Sector of Nuclear Science Research Japan Atomic Energy Agency2-4 Shirakata-shiraneTokai-muraNaka-gun Ibaraki-ken 319-1195 Japan

Nitride fuels have several advantages including high thermal conductivity and high metal density(like metallic fuels) and high melting point and isotropic crystal structure(like oxide fuels). Since the late 1990 s, the partitioning and transmutation of minor actinides(MA) has been studied to decrease the long-term radio-toxicity of high-level waste and to mitigate the burden of final disposal. Japan Atomic Energy Agency(JAEA) has proposed a dedicated transmutation cycle using an accelerator-driven system(ADS) with nitride fuels containing MA. The nitride fuel cycle we have developed includes a pyrochemical process. Our focus is on the electrolysis of nitride fuels and their refabrication from the recovered actinides; other processes are similar to the technology for metal fuel treatment and have been studied elsewhere. Here, we summarize our activity on the development of the pyrochemical treatment of spent nitride fuels.

关键词： nitride fuels minor actinides pyrochemical process

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Specific acupuncture stimulation of Shenshu(BL23)affects sympathetic nervous activity-associated plasma renin concentration changes

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Journal of Traditional Chinese Medicine 2022年第2期42卷 250-255页

作者： Kanae Umemoto Tomoya hayashi Kaori Fukushige Shuichi Hirai Hayato Terayama Kou Sakabe Munekazu Naito Graduate School of Acupuncture and Moxibustion Meiji University of Integrative MedicineNantanKyoto 629-0392Japan Department of Anatomy Division of Basic Medical Sc+ienceTokai University School of MedicineIseharaKanagawa 259-1193Japan Department of Anatomy Aichi Medical University School of MedicineNagakuteAichi 480-1195Japan Graduate School of Acupuncture and Moxibustion Meiji University of Integrative MedicineNantanKyoto629-0392Japan Department of Physiology Meiji University of Integrative MedicineNantanKyoto 629-0392Japan Division of Anatomical Science Department of Functional MorphologyNihon University School of MedicineItabashi-kuTokyo 173-0032Japan Department of Anatomy Division of Basic Medical ScienceTokai University School of MedicineIseharaKanagawa 259-1193Japan

OBJECTIVE:To examine whether specific stimulation of Shenshu(BL23)affects sympathetic nervous activity(SNA)-associated plasma renin concentration(PRC).METHODS:Eight healthy volunteers participated in three pattern conditions in random order:control(Cont),stimulation of Shenshu(BL23),and stimulation of sham point(Sham).All participants were initially in the supine position for>60 min,and then remained in the standing position during the experimental procedure to increase *** electrocardiogram was used to calculate low frequency/high frequency(LF/HF)ratio;blood was collected to analyze ***:The LF/HF ratio was significantly increased in the standing position when compared with the supine position(P<0.01).There was no difference in LF/HF ratio during or after stimulation of Shenshu(BL23)in the standing position when compared with before the stimulation in the supine position;however,the LF/HF ratio was significantly increased in Cont and Sham conditions(P<0.01).There was no difference in PRC after stimulation of Shenshu(BL23)in the standing position when compared with before the stimulation in the supine position;however,there was a significant increase in PRC in the Cont and Sham conditions(Cont P<0.05,Sham P<0.01).CONCLUSION:Our results demonstrated that specific acupuncture stimulation of Shenshu(BL23)in the standing position decreased SNA-associated PRC,which was not observed during acupuncture stimulation of the sham point.

关键词： Acupuncture Point BL23(Shenshu) Sympathetic nervous activity Plasma renin concentration

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Broad-Spectrum Blast Resistance： Harnessing a Natural Allele of a Transcription Factor in Rice

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Molecular Plant 2017年第9期10卷 1144-1146页

作者： Hiroshi Takatsuji Institute of Agrobiological Sciences (NIAS) National Agriculture and Food Research Organization (NARO) 2-1-2 Kannondai Tsukuba Ibaraki 305-0051 Japan [∗]Corresponding author

Rice blast, which is caused by the fungus Magnaporthe oryzae, is a widespread and destructive plant disease that greatly reduces yield and grain quality worldwide. The use of host resistance is the most effective and economic way to control plant diseases. Many studies on blast resistance genes have focused on the nucleotide-binding site leucine-rich repeat （NB-LRR） resistance （called typical R） genes that mediate effector-triggered immunity. However, incorporating these R genes into rice varieties has not achieved durable blast resistance, because R-gene-mediated resistance is race-specific and often breaks down owing to the appearance of fungal variants that escape host recognition. Thus, the deployment of genes conferring non-race-specific du- rable resistance is highly desired by breeders. In plants, several genes conferring non-race-specific durable resistance genes have been isolated, but only a few of the molecular mechanisms responsible for resistance have been determined.

关键词： Broad-Spectrum Blast Resistance Harnessing a Natural Allele Transcription Factor in Rice

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Near-infrared imaging survey of faint companions around young dwarfs in the Pleiades cluster

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Research in Astronomy and Astrophysics 2011年第3期11卷 335-344页

作者： Yoichi Itoh Yumiko Oasa Hitoshi Funayama Masahiko hayashi Misato Fukagawa Toshio Hashiguchi Thayne Currie Graduate School of Science Kobe University1-1 RokkodaiNada-kuKobe 657-8501Japan Faculty of Education Saitama University255 Shimo-OkuboSakura-kuSaitamaSaitama 338-8570Japan Subaru Telescope 650 North A'ohoku PlaceHiloHawaii 96720USA School of Mathematical and Physical Science Graduate University for Advanced Studies(Sokendai)2-21-1 OsawaMitakaTokyo 181-8588Japan Graduate School of Science Osaka UniversityMachikaneyamaToyonakaOsaka 560-0043Japan NASA-Goddard Space Flight Center

We conducted a near-infrared imaging survey of 11 young dwarfs in the Pleiades cluster using the Subaru Telescope and the near-infrared coronagraph imager. We found ten faint point sources,with magnitudes as faint as 20 mag in the K-band,with around seven *** with the Spitzer archive images revealed that a pair of the faint sources around V 1171 Tau is very red in infrared wavelengths,which indicates very low-mass young stellar ***,the results of our follow-up proper motion measurements implied that the central star and the faint sources do not share common proper motions,suggesting that they are not physically associated.

关键词： planetary systems:formation—techniques:high angular resolution

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Characteristics of gas evolution profiles during coal pyrolysis and its relation with the variation of functional groups

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International Journal of Coal Science & Technology 2018年第4期5卷 452-463页

作者： Lu Zhang Shichao Qi Norihiro Takeda Shinji Kudo Junichiro hayashi Koyo Norinaga Department of Applied Science for Electronics and Materials Kyushu University6-1Kasuga KoenKasugaFukuoka 816-8580Japan Institute for Materials Chemistry and Engineering Kyushu University6-1Kasuga KoenKasugaFukuoka 816-8580Japan

Strict relation between the substituents or functional groups attached to the coal macromolecules and the generation of the volatile products, e.g., CH4 H2O, CO, CO2, etc., during the coal pyrolysis is an important but confusing subject. In this paper, quadrupole mass spectronletry, gas chromatography, and ^l3C nuclear magnetic resonance are applied to real-time monitoring the formations of volatile products, off-line quantitative determination of the total products from the pyrolysis of a sub-bituminous coal (SC), and the changes of diverse substitents in the SC along with coke foamation, respectively. These measurements are also performed for the pyrolysis of a caking coal to contrast SC. The qualitative and quantitative data reveal that, during coal pyrolysis, the functional groups related with the formation of CO, i.e., ether, carbonyl, and anhydride, can directly gen erate CO via bond breaking, or take a detour of the formation of other intermediates via condensation and recombination firstly. Moreover, the formations of CO2 and CH4 are related to the direct removal of -COO- and -CH3,respectively.

关键词： Light gas evolution Carbonization QMS GC ^13C NMR

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Effects of gamma-ray irradiation on electronic and non-electronic equipment of Large Helical Device

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Plasma Science and Technology 2017年第2期19卷 95-100页

作者： K OGAWA T NISHITANI M ISOBE M SATO M YOKOTA H hayashi T KOBUCHI T NISHIMURA National Institute for Fusion Science National Institutes of Natural Sciences322-6 0roshi-choToki 509-5292Japan SOKENDAI(The Graduate University for Advanced Studies) School of Physical Sciences322-6 Oroshi-choTold 509-5292Japan

In a deuterium operation on the Large Helical Device, the measurement and control equipment placed in the toms hall must survive under an environment of radiation, To study the effects of gamma-ray irradiation on the equipment, an irradiation experiment is performed at the Cobalt-60 irradiation facility of Nagoya University. Transient and permanent effects on a personal computer, media converters, programmable logic controllers, isolation amplifiers, a web camera, optical flow meters, and water sealing gaskets are experimentally surveyed. Transient noise appears on the web camera. Offset of the signal increases with an increase of the integrated dose on the programmable logic controller. The DeviceNet module on the programmable logic controller is broken at the integrated dose of 72 Gy, which is the expected range of the integrated dose of the toms hall. The other equipment can survive under the gamma-ray field in the toms hall.

关键词： large helical device gamma-ray irradiation radiation effect

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A Combined Computational and Experimental Study on the Structure-Regulation Relationships of Putative Mammalian DNA Replication Initiator GINS

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Genomics, Proteomics & Bioinformatics 2006年第3期4卷 156-164页

作者： Reiko hayashi Takako Arauchi Moe Tategu Yuya Goto Kenichi Yoshida Department of Life Sciences Meiji University School of Agriculture Kawasaki Kanagawa 214-8571 Japan.

GINS, a heterotetramer of SLD5, PSF1, PSF2, and PSF3 proteins, is an emerging chromatin factor recognized to be involved in the initiation and elongation step of DNA replication. Although the yeast and Xenopus GINS genes are well documented, their orthologous genes in higher eukaryotes are not fully characterized. In this study, we report the genomic structure and transcriptional regulation of mammalian GINS genes. Serum stimulation increased the GINS mRNA levels in human cells. Reporter gene assay using putative GINS promoter sequences revealed that the expression of mammalian GINS is regulated by 17β-Estradiolstimulated estrogen receptor a, and human PSF3 acts as a gene responsive to transcription factor E2F1. The goal of this study is to present the current data so as to encourage further work in the field of GINS gene regulation and functions in mammalian cells.

关键词： DNA replication initiation bioinformatics gene structure gene regulation 17β-Estradiol transcription factor E2F1

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A Revised Classification of Primary Iron Overload Syndromes

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Journal of Clinical and Translational Hepatology 2024年第4期12卷 346-356页

作者： Yasuaki Tatsumi Motoyoshi Yano Shinya Wakusawa Hiroaki Miyajima Tetsuya Ishikawa Shinsaku Imashuku Atsuko Takano Wataru Nihei Ayako Kato Koichi Kato Hisao hayashi Kentaro Yoshioka Kazuhiko hayashi Department of Medical Biochemistry Faculty of Pharmaceutical SciencesToho UniversityFunabashiJapan Department of Gastroenterology Yokkaichi Municipal HospitalYokkaichiJapan Department of Medical Technology Shubun UniversityIchinomiyaJapan Department of Medicine and Neurology Tenryu Kohseikai ClinicHamamatsuJapan Department of Gastroenterology and Hepatology Nagoya University Graduate School of MedicineNagoyaJapan Department of Laboratory Medicine Uji-Tokushukai Medical CenterUjiJapan Department of Medicine Saiseikai Takaoka HospitalTakaokaJapan Department of Medicine Aichi-Gakuin University School of PharmacyNagoyaJapan Department of Gastroenterology FNPS Meijo HospitalNagoyaJapan

Background and Aims:The clinical introduction of hepcidin25(Hep25)has led to a more detailed understanding of its relationship with ferroportin(FP)and divalent metal transporter1 in primary iron overload syndromes(PIOSs).In 2012,we proposed a classification of PIOSs based on the Hep25/FP system,which consists of prehepatic aceruloplasminemia,hepatic hemochromatosis(HC),and posthepatic FP disease(FP-D).However,in consideration of accumulated evidence on PIOSs,we aimed to renew the ***:We reviewed the 2012 classification and retrospectively renewed it according to new information on ***:Iron-loading anemia was included in PIOSs as a prehepatic form because of the newly discovered erythroferrone-induced suppression of Hep25,and the state of traditional FP-D was remodeled as the BIOIRON *** key molecules responsible for prehepatic PIOSs are low transferrin saturation in aceruloplasminemia and increased erythroferrone production by erythroblasts in iron-loading *** PIOSs comprise four genotypes of HC,in each of which the synthesis of Hep25 is inappropriately reduced in the *** Hep25 synthesis is adequate in posthepatic PIOSs;however,two mutant FP molecules may resist Hep25 differently,resulting in SLC40A1-HC and FP-D,*** phenotypes are diagnosed using laboratory tests,including circulating Hep25,followed by suitable *** sequencing of the candidate genes may be outsourced to gene centers when *** kits for the prevalent mutations,such as C282Y,may be the first choice for a genetic analysis of HC in ***:The revised classification may be useful worldwide.

关键词： Ethnicity Ferroportin Hemochromatosis Hepcidin25 Iron overload syndrome

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