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World Journal of Stem Cells 2017年第10期9卷 179-186页

作者： Harumichi Itoh Shimpei nishikawa Tomoya Haraguchi Yu Arikawa Shotaro Eto Masato Hiyama Toshie Iseri Yoshiki Itoh Munekazu Nakaichi Yusuke Sakai Kenji Tani Yasuho Taura Kazuhito Itamoto Department of Small Animal Clinical Science Joint Faculty of Veterinary Medicine Yamaguchi University Department of Veterinary Surgery Joint Faculty of Veterinary Medicine Yamaguchi University Department of Veterinary Radiology Joint Faculty of Veterinary Medicine Yamaguchi University Department of Veterinary Pathology Joint Faculty of Veterinary Medicine Yamaguchi University

AIMTo identify and characterize functionally distinct subpopulation of adipose-derived stem cells (ADSCs). METHODSADSCs cultured from mouse subcutaneous adipose tissue were sorted fluorescence-activated cell sorter based on aldehyde dehydrogenase (ALDH) activity, a widely used stem cell marker. Differentiation potentials were analyzed by utilizing immunocytofluorescece and its quantitative analysis. RESULTSApproximately 15% of bulk ADSCs showed high ALDH activity in flow cytometric analysis. Although significant difference was not seen in proliferation capacity, the adipogenic and osteogenic differentiation capacity was higher in ALDHHi subpopulations than in ALDHLo. Gene set enrichment analysis revealed that ribosome-related gene sets were enriched in the ALDHHi subpopulation. CONCLUSIONHigh ALDH activity is a useful marker for identifying functionally different subpopulations in murine ADSCs. Additionally, we suggested the importance of ribosome for differentiation of ADSCs by gene set enrichment analysis.

关键词： Adipose-derived stem/stromal cell Aldehyde dehydrogenase activity Flow cytometry Subpopulation Ribosome

Breakthrough therapy for peritoneal carcinomatosis of gastric cancer:Intraperitoneal chemotherapy with taxanes

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World Journal of Gastrointestinal Oncology 2015年第11期7卷 285-291页

作者： Hironori Yamaguchi Joji Kitayama Hironori Ishigami Shinsuke Kazama Hiroaki Nozawa Kazushige Kawai keisuke Hata Tomomichi Kiyomatsu Toshiaki Tanaka Junichiro Tanaka Takeshi nishikawa Kensuke Otani Koji Yasuda Soichiro Ishihara Eiji Sunami Toshiaki Watanabe Department of Surgical Oncology the University of Tokyo

The effect of chemotherapy on peritoneal carcinomatosis(PC) of gastric cancer remains ***,the intraperitoneal(IP) administration of taxanes [e.g.,paclitaxel(PTX) and docetaxel(DOC)] during the perioperative period has shown promising ***,we summarized the rationale and methodology for using IP chemotherapy with taxanes and reviewed the clinical *** administered taxanes remain in the IP space at an extremely high concentration for 48-72 *** drug directly infiltrates peritoneal metastatic nodules from the surface and then produces antitumor effects,making it ideal for IP *** are two types of perioperative IP chemotherapy with taxanes: neoadjuvant intraperitoneal and systemic chemotherapy and sequential perioperative intraperitoneal chemotherapy(SPIC).In SPIC,patients receive neoadjuvant IP chemotherapy and the same regimen of IP chemotherapy after cytoreductive surgery(CRS) until disease ***,a taxane dissolved in 500-1000 m L of saline at ordinary temperature is administered through an IP access port on an outpatient *** to phase Ⅰ?studies,the recommended doses(RD) are as follows: IP DOC,45-60 mg/m2; IP PTX [without intravenous(IV) PTX],80 mg/m2; and IP PTX(with IV PTX),20 mg/*** Ⅱ studies have reported a median survival time of 14.4-24.6 mo with a 1-year overall survival of 67%-78%.A phase Ⅲ study comparing S-1 in combination with IP and IV PTX to S-1 with IV cisplatin started in *** prognosis of patients who underwent CRS was better than that of those who did not; however,this was partly due to selection *** several phase Ⅱ studies have shown promising results,a randomized controlled study is needed to validate the effectiveness of IP chemotherapy with taxanes for PC of gastric cancer.

关键词： Taxane Paclitaxel Docetaxel Carcinoma Gastric canc

Activated Carbons Containing Dispersed Metal Oxide Particles for Removal of Methyl Mercaptan in Air

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Materials Sciences and Applications 2011年第1期2卷 49-52页

作者： Hisashi Tamai Miki Nakamori Masayoshi nishikawa Takeshi Shiono 不详

Activated carbons containing dispersed metal oxide particles were prepared by carbonization of phenol resin containing metal compounds followed by steam activation. Acetylacetonates of Fe, Mn and V, and Cu nitrate were used as the sources of metals. The removal of a small amount of methyl mercaptan (CH3SH) in air with these activated carbons was tested in a flow system. Compared with activated carbons without metal oxides, the carbons exhibited high activity for the removal of CH3SH in air. In particular, activated carbon obtained from Novolac containing 5 wt% Cu showed excellent behavior over a long time.

关键词： Activated Carbon Methyl Mercaptan Adsorption Metal Oxide Oxidation

Development of Epstein-Barr virus-associated gastric cancer:Infection,inflammation,and oncogenesis

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World Journal of Gastroenterology 2022年第44期28卷 6249-6257页

作者： Hisashi Iizasa Andy Visi Kartika Sintayehu Fekadu Shunpei Okada Daichi Onomura Afifah Fatimah Azzahra Ahmad Wadi Mosammat Mahmuda Khatun Thin Myat Moe Jun nishikawa Hironori Yoshiyama Department of Microbiology Shimane University Faculty of MedicineIzumo 693-8501ShimaneJapan Faculty of Medicine Muslim University of IndonesiaMakassar 90231Indonesia Department of Medical Microbiology and Parasitology Hawassa UniversityCollege of Medicine and Health ScienceHawassa 1560Ethiopia Faculty of Laboratory Science Yamaguchi University Graduate School of MedicineUbe 755-8505Japan

Epstein-Barr virus(EBV)-associated gastric cancer(EBVaGC)cells originate from a single-cell clone infected with ***,more than 95%of patients with gastric cancer have a history of Helicobacter pylori(***)infection,and *** is a major causative agent of gastric ***,it has long been argued that *** infection may affect the development of EBVaGC,a subtype of gastric *** gastrointestinal inflammation,a symptom of *** infection,is observed in the gastric mucosa of ***,it remains unclear whether *** infection is a cofactor for gastric carcinogenesis caused by EBV infection or whether *** and EBV infections act independently on gastric cancer *** has been reported that EBV infection assists in the oncogenesis of gastric cancer caused by *** *** contrast,several studies have reported that *** infection accelerates tumorigenesis initiated by EBV *** reviewing both clinical epidemiological and experimental data,we reorganized the role of *** and EBV infections in gastric cancer formation.

关键词： Helicobacter pylori Epstein-Barr virus Epstein-Barr virus-associated gastric cancer Coreceptor Inflammation Oncogenesis

Refractory ulcerative colitis accompanied with cytomegalovirus colitis and multiple liver abscesses: A case report

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World Journal of Gastroenterology 2005年第33期11卷 5241-5244页

作者： Takuya Inoue Ichiro Hirata Yutaro Egashira Kumi Ishida Ken Kawakami Eijiro Morita Naoko Murano Shingo Yasumoto Mitsuyuki Murano Ken Toshina Takashi nishikawa Norihiro Hamamoto Ken Nakagawa Ken-Ichi Katsu The Second Department of Internal Medicine Osaka Medical College 2-7 DaigakuchoTakatsuki City Osaka 569-8686 Japan Department of Pathology Osaka Medical College Takatsuki City Osaka 569-8686 Japan The Second Department of Internal Medicine Osaka Medical College 2-7 Daigakucho Takatsuki City Osaka 569-8686 Japan

Various hepato-biliary complications are an increased incidence in patients with inflammatory bowel disease,and portal bacteremia is well documented in patients with ulcerative colitis (UC). However, few reports mention UC in association with liver abscesses. Recently, there are several reports describing cytomegalovirus (CMV) infection in association with disease exacerbation and steroid refractoriness in patients with UC. Here we present a case of refractory UC accompanied with multiple liver abscesses and CMV colitis. The patient, a 72-year-old male, with a five-year history of repeated admissions to our hospital for UC, presented with an exacerbation of his *** performed on admission suggested that his UC was exacerbated, then he was given prednisolone and mesalazine orally, and betamethasone ***, he had exacerbated symptoms. Repeat sigmoidoscopy revealed multiple longitudinal ulcers and pseudopolyps in the rectosigmoid colon. Although immunohistochemical staining of biopsy specimens and the serum testing for antigenemia were negative on admission and after the repeat sigmoidoscopy, they became histologically positive for CMV. Nonetheless, the patient developed spiking fevers, soon after ganciclovir was administered. Laboratory studies revealed an increased white cell count with left shift, and Enterococcus fecalis grew in blood cultures. An abdominal computed tomography (CT) scan was obtained and the diagnosis of liver abscesses associated with UC was made, based on CT results. The hepatic abscesses were successfully treated with intravenous meropenem for 6 wk, without further percutaneous drainage. To our knowledge, this is the first reported case of multiple liver abscesses that develop during UC exacerbation complicated by CMV colitis.

关键词： Uver abscess Ulcerative colitis Cytomegalovirusinfection Inflammatory bowel disease

Carbon footprinting of carbon capture and -utilization technologies: discussion of the analysis of Carbon XPRIZE competition team finalists

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Clean Energy 2021年第4期5卷 587-599页

作者： Sylvia Sleep Raghav Munjal Michael Leitch Marcius Extavour Adriana Gaona Shah Ahmad Emily nishikawa Vaidehi Pitre Peter Psarras Andrea Ramirez Heather L.MacLean Joule A.Bergerson Department of Chemical and Petroleum Engineering University of CalgaryCalgaryABCanada XPRIZE Foundation Culver CityCAUSA Department of Civil&Mineral Engineering University of TorontoTorontoONCanada Department of Agricultural Food&Nutritional ScienceUniversity of AlbertaEdmontonABCanada Department of Chemical and Biomolecular Engineering University of PennsylvaniaPhiladelphiaPAUSA Department of Engineering Systems and Services Delft University of TechnologyDelftCNThe Netherlands

Life cycle assessments(LCAs)of early-stage technologies can provide valuable insights about key drivers of emissions and aid in prioritizing research into further emissions-reduction *** this potential value,further development of LCA methods is required to handle the increased uncertainty,data gaps,and confidentially of early-stage *** study presents a discussion of the life cycle carbon footprinting of technologies competing in the final round of the NRG COSIA Carbon XPRIZE competition-a US$20 million competition for teams to demonstrate the conversion of CO_(2) into valuable products at the scale of a small industrial pilot using consistent deployment conditions,boundaries,and methodological *** competition allowed the exploration of how LCA can be used and further improved when assessing disparate and early-stage *** intensity estimates are presented for two conversion pathways:(i)CO_(2) mineralization and(ii)catalytic conversion(including thermochemical,electrochemical,photocatalytic and hybrid process)of CO_(2),aggregated across teams to highlight the range of emissions intensities demonstrated at the pilot for individual life cycle stages.A future scenario is also presented,demonstrating the incremental technology and deployment conditions that would enable a team to become carbon-avoiding relative to an incumbent process(*** emissions relative to a reference pathway producing a comparable product).By considering the assessment process across a diverse set of teams,conversion pathways and products,the study presents generalized insights about opportunities and challenges facing carbon capture and-utilization technologies in their next phases of deployment from a life cycle perspective.

关键词： CCUS life cycle assessment carbon footprinting carbon capture and utilization

Long-lasting responses after discontinuation of nivolumab treatment for reasons other than tumor progression in patients with previously treated,advanced non-small cell lung cancer

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Cancer Communications 2019年第1期39卷 665-669页

作者： Hideharu Kimura Tomoyuki Araya Taro Yoneda Hiroki Shirasaki Koji Kurokawa Tamami Sakai Hayato Koba Yuichi Tambo Shingo nishikawa Takashi Sone Kazuo Kasahara Respiratory Medicine Kanazawa University HospitalTakara-machi 13-1KanazawaIshikawa 920-8641Japan Respiratory Medicine National Hospital Organization Kanazawa Medical CenterKanazawaIshikawa 920-8650Japan Respiratory Medicine Komatsu Municipal HospitalKomatsuIshikawa 923-8560Japan Respiratory Medicine Fukui-ken Saiseikai HospitalFukuiFukui 918-8503Japan Respiratory Medicine Ishikawa Prefectural Central HospitalKanazawaIshikawa 920-8530Japan Internal Medicine Keiju Medical CenterNanaoIshikawa 926-8605Japan Regional Respiratory Symptomatology Kanazawa University Graduate School of Medical ScienceKanazawaIshikawa 920-8641Japan

Dear Editor,Nivolumab,an inhibitor of programmed cell death 1(PD-1),is an immune checkpoint inhibitor(ICI)that enhances T cell functions by preventing negative regulation of cancer immunity,and it has shown clinically significant efficacy and tolerability in various types of *** on the results of randomized phase III trials comparing nivolumab with docetaxel[1,2],nivolumab is now used in clinical practice for patients with previously treated advanced non-small cell lung cancer(NSCLC).Fur-thermore,the most recent Japan Lung Cancer Society guidelines include nivolumab monotherapy in the sys-temic treatment strategy for previously treated,locally advanced or metastatic NSCLC[3].However,ICIs induce characteristic immune-related adverse events(irAEs),which are not seen with conventional cytotoxic agents or molecular targeted *** can occur in any organ system,most typically the skin,lung,and gastrointesti-nal,hepatic,and endocrine systems.

关键词： nivolumab patients lung

Influence of Wheelchair Cushions Fabricated by Therapists on Stability, Comfort, and Functionality

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Open Journal of Therapy and Rehabilitation 2020年第1期8卷 1-11页

作者： Takeshi Oshikawa Seigo Koura nishikawa Chihoko Kazuho Nagao Kentaro Higashi Department of Rehabilitation Nishikyusyu University Saga Japan Social Welfare Corporation Kanjikai Japan

“Ease of comfort” and “functionality” are important factors that have been cited to improve wheelchair seating. The ability to maintain balance and posture while seated in a wheelchair improves stability, comfort, and functionality and is a prerequisite for daily activities. In this study, the authors used a sitting position measuring device to scientifically verify differences in sitting posture, comfort, and functionality depending on the presence or absence of cushions and the type of cushion in elderly individuals who used wheelchairs. Results suggested that a cushion fabricated by a therapist was more useful than a commercially available air cushion. While a commercially available air cushion was the most suitable, the therapist’s self-made cushion could be expected to demonstrate the same or better applicability than an air cushion.

关键词： Wheelchair Sitting Stability Cushion Comfort Functionality

Systematic Relationship between Sr Content and the Lattice Constants in Sr Substituted Hydroxyapatite Thin Films

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Journal of Crystallization Process and Technology 2017年第1期7卷 1-10页

作者： Hiroaki nishikawa Ayaka Saito Akiko Miyake Yuichiro Tashiro Yoshiya Hashimoto Faculty of Biology-Oriented Science and Technology Kindai University Kinokawa Japan Graduate School of Biology-Oriented Science and Technology Kindai University Kinokawa Japan Department of Removable Prosthodontics and Occlusion Osaka Dental University Hirakata Japan Department of Biomaterials Osaka Dental University Hirakata Japan

To increase the biocompatibility of hydroxyapatite (HA), Ca10(PO4)6(OH)2, the Sr substitution of Ca into the HA structure was effected to yield Ca10-xSrx(PO4)6(OH)2(Sr-HA). For medical and dental applications, it is important that Sr-HA is prepared as a thin film so that the Sr fully substitutes the Ca sites in the HA structure and does not form segregated impurities consisting of Sr compounds. If the segregated Sr forms different amounts of different impurities, the dissolution of the Sr into the living body will not be reproducible across different samples. To confirm the Sr substitution into the Ca site in the HA structure, the systematic variation in the lattice constants of the Sr-HA with Sr content was evaluated as the first step. The a- and c-axis lengths were found to exhibit a linear relationship with the Sr content for six samples with different Sr contents, indicating that the prepared Sr-HA thin films likely possessed partial Sr substitution into the Ca sites of the HA structure. This result is an important first step in the accurate evaluation of the biological effects of Sr-HA thin films.

关键词： Sr Substituted Hydroxyapatite X-Ray Diffraction Lattice Constant Pulsed Laser Deposition Technique

TREATMENT OF CENTRAL NERVOUS SYSTEM LYMPHOMAS WITH TEMOZOLOMIDE-PRELIMINARY RESULTS WITH MGMT PROMOTOR METHYLATION STATUS

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TREATMENT OF CENTRAL NERVOUS SYSTEM LYMPHOMAS WITH TEMOZOLOM...