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Human CD4^- CD8^- Invariant Natural Killer T Cells Promote IgG Secretion from B Cells Stimulated by Cross-Linking of Their Antigen Receptors

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World Journal of Vaccines 2016年第2期6卷 34-41页

作者： Tomomitsu Miyasaka Yurie Watanabe Yukiko Akahori Namiko Miyamura Keiko Ishii Yuki Kinjo Yoshitsugu Miyazaki Tian-Yi Liu Yasushi Uemura Kazuyoshi kawakami Department of Medical Microbiology Mycology and Immunology Tohoku University Graduate School of Medicine Sendai Japan Department of Chemotherapy and Mycoses National Institute of Infectious Diseases Tokyo Japan Division of Immunology Aichi Cancer Center Research Institute (ACCRI) Nagoya Japan Key Laboratory of Cancer Center Chinese PLA General Hospital Beijing China Division of Cancer Immunotherapy Exploratory Oncology Research & Clinical Trial Center National Cancer Center (NCC) Kashiwa Japan

Immunoglobulin (Ig) M production can be induced by the interaction of thymus-independent type-2 (TI-2) antigen (Ag) with B cell Ag receptors (BCRs) without the involvement of conventional T cells;for IgG production through the same process, however, a second signal is required. Previous studies have reported that invariant natural killer T (iNKT) cells may be responsible for the second signal involved in IgG production. In the present study, we addressed whether human iNKT cells could participate in the production of Ig against TI-2 Ag in vitro. Two major distinct subsets of human iNKT cells, CD4+ CD8β- (CD4) and CD4- CD8β- [double negative (DN)] cells, were generated from peripheral blood monocytes from a healthy volunteer. BCR engagement, triggered by anti-IgM antibody stimulation, examined here as a model of BCR engagement triggered by TI-2 Ag, induced abundant IgM production by B cells. Both CD4 and DN iNKT cells reduced IgM production and conversely enhanced IgG production in a dose-dependent manner. In addition, IgG production by CD19+CD27- (naïve) and CD19+CD27+ (memory) B cells was predominantly promoted by DNiNKT cells rather than CD4 iNKT cells;nevertheless, IgM production by both B cell subsets was similarly reduced by either subset of iNKT cells. These results suggest that the DN iNKT subsets may preferentially promote Ig class switching by B cells upon stimulation with TI-2 Ag.

关键词： Invariant Natural Killer T Cells TI-2 Antigen B Cells IgM IgG

自组织生长CdSe-ZnSe量子点的光致发光

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中国科学（A辑） 2000年第4期30卷 342-346页

作者：郑宏 K.Okamoto H.C.Ko Y.kawakami Sg.Fujita 中国科学院长春物理研究所中国科学院激发态物理开放实验室长春130021 Venture Business Laboratory Department of Electronic Science and Engineering

利用不同温度下的光致发光和时间分辨光谱研究了生长在GaAs( 1 1 0 )衬底上的CdSe ZnSe自组织量子点的发光特性 ,发现浸润层量子阱的激子发光淬灭比量子点的淬灭过程快得多 ,量子点的激子辐射复合寿命远大于浸润层量子阱的激子复合寿命 ... 详细信息

利用不同温度下的光致发光和时间分辨光谱研究了生长在GaAs( 1 1 0 )衬底上的CdSe ZnSe自组织量子点的发光特性 ,发现浸润层量子阱的激子发光淬灭比量子点的淬灭过程快得多 ,量子点的激子辐射复合寿命远大于浸润层量子阱的激子复合寿命 .根据不同尺寸的量子点复合寿命的差异。

关键词：自组织生长光致发光硒化镉硒化锌量子点

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呼吸系统疾病的基因因素

中华结核和呼吸杂志 1997年第Z1期20卷 15-15页

作者： Yoshikazu kawakami 蔡柏蔷(译) FirstDepartmentofMedicine SchoolofMedicineHokkaidoUniversitySapporo060Japan

Recent advances in endoscopic ultrasonography-guided biliary interventions

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World Journal of Gastroenterology 2015年第32期21卷 9494-9502页

作者： Kazumichi Kawakubo Hiroshi kawakami Masaki Kuwatani Shin Haba Shuhei Kawahata Yoko Abe Yoshimasa Kubota Kimitoshi Kubo Hiroyuki Isayama Naoya Sakamoto Department of Gastroenterology and Hepatology Hokkaido University Graduate School of Medicine Department of Gastroenterology Graduate School of Medicine The University of Tokyo

Interventional endoscopic ultrasonography(EUS) based on EUS-guided fine-needle aspiration has rapidly spread as a minimally invasive procedure. Especially in patients with failed endoscopic retrograde cholangiopancreatography, EUS-guided biliary intervention is reported to be useful as salvage therapy. EUS-guided biliary interventions are carried out using three techniques: EUS-guided bilioenteric anastomosis, EUS-guided rendezvous procedure, and EUS-guided antegrade treatment. Although interventional EUS is not yet a standardized procedure, there have been recent advances in this field that address various biliary diseases. Here, we summarize the indications, techniques, clinical results of previous studies, and future perspectives.

关键词： Endosonography-guided biliary intervention Choledo

Usefulness of vonoprazan,a potassium ion-competitive acid blocker,for primary eradication of Helicobacter pylori

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2016年第4期7卷 550-555页

作者： Shinya Yamada Takumi kawakami Yoshikazu Nakatsugawa Takahiro Suzuki Hideki Fujii Naoya Tomatsuri Hideki Nakamura Hideki Sato Yusuke Okuyama Hiroyuki Kimura Norimasa Yoshida Department of Gastroenterology Japanese Red Cross Kyoto Daiichi Hospital

AIM To investigate usefulness of triple therapy with vonoprazan,a potassium ion-competitive acid blocker and antibiotics,for Helicobacter pylori(***) *** The *** eradication rate was examined in 2507 patients(2055 undergoing primary eradication and 452 undergoing secondary eradication,excluding patients with subtotal gastrectomy) at the Japanese Red Cross Kyoto Daiichi Hospital from March 2013 to September *** patients treated from March 2013 to February 2015,a proton pump inhibitor(PPI) was used to reduce acid secretion,while vonoprazan was used after March *** success rates of the 2 regimens(PPI + amoxicillin + clarithromycin/metronidazole,or vonoprazan + amoxicillin + clarithromycin/metronidazole) were *** The success rate of primary *** eradication was significantly higher in the vonoprazan *** stratified by the underlying disease,a significant increase of the *** eradication rate was observed in patients with chronic gastritis.A significantly lower *** eradication rate was observed in younger patients compared to older patients in the PPI group,but there was no difference according to age in the vonoprazan *** the otherhand,the success rate of secondary eradication was similar at approximately 90% in both *** Vonoprazan is very useful for primary eradication of ***,and may become a first-line acid secretion inhibitor instead of PPIs.

关键词： Helicobacter pylori Eradication Vonoprazan Chronic gastritis Potassium ion-competitive acid blocker

Development of Adsorption Steam Generator without the Fossil Fuels Consumption

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Journal of Energy and Power Engineering 2014年第4期8卷 589-595页

作者： Tsuguhiko Nakagawa Takahiro Nishi Yu Notoji Yoshiaki kawakami Masayuki Tanino Yoshio Abe Kasumi Ito Kenji Marumo Toshiyuki Aoyama Yoshinori Itaya Kouichi Nakaso Jun Fukai Department of System Engineering Okayama Prefectural University Okayama 719-1197 Japan Multidiscipline Laboratory Takasago Thermal Engineering Co. Ltd Kanagawa 243-0213 Japan Project Department of Environment and Energy Solution ThyssenKrupp Otto Tokyo 107-0052 Japan Department of Production Engineering Morimatsu Industry Co. Ltd. Gifu 501-0413 Japan Department of Engineering Gifu University Gifu 501-1193 Japan Faculty of Engineering Kyushu University Fukuoka 819-0395 Japan

Reducing CO2 emissions and restraining dependence on nuclear power generation are serious concerns in the prevention of global warming since the Great East Japan Earthquake. To do so, it is necessary to use and expand natural renewable energy source such as solar energy and to promote energy conservation. However, in high-latitude regions, it is difficult to directly and effectively use solar power due to on insufficient amount of solar radiation. If steam can be generated from warm water at less than 373 K, it is possible to obtain steam by solar water heaters from weak solar radiation and industrial waste warm water without the consumption of any fossil fuels. In this study, the authors have been developing a system which generates steam over 423 K from warm water at less than 373 K using an adsorption heat pump with zeolite. Therefore, bench-scale equipment which generates steam continuously and the experimental results are mentioned.

关键词： Steam generation heat pump solar thermal utilization energy conservation.

Practical Use of Gemcitabine and Cisplatin Combination Therapy as First-Line Treatment for Japanese Patients with Advanced Biliary Tract Cancer

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Journal of Cancer Therapy 2013年第6期4卷 1068-1073页

作者： Hisato kawakami Isamu Okamoto Wataru Okamoto Masayuki Takeda Shinya Ueda Toshihiro Kudo Shin-ichi Nishina Yasuhito Fujisaka Masaki Miyazaki Junji Tsurutani Takayasu Kurata Kazuhiko Nakagawa Department of Medical Oncology Faculty of Medicine Kinki University Osaka Japan

Gemcitabine and cisplatin combination therapy (GC) is accepted as a standard treatment for advanced biliary tract cancer (BTC). However, little information is available regarding such treatment in the clinical practice setting in Japan. We retrospectively examined the clinical data of patients with unresectable or recurrent BTC who received GC as first-line treatment. The regimen consisted of cisplatin (25 mg/m2) and gemcitabine (1000 mg/m2) administered intravenously on days 1 and 8 of repeated 3-week cycles. Twenty patients were analyzed. A total of 148 cycles of GC was administered, with a median of 8 and a range of 1 to 18 cycles. Treatment delay and dose reduction were noted in 35 (24%) and 41 (28%) of the 148 cycles, respectively. The major adverse events of grade 3 or 4 included neutropenia (50%), leukopenia (45%), anemia (30%), and thrombocytopenia (15%). Nonhematologic toxicities included nausea (10%), appetite loss (10%), and fatigue (10%). Median progression-free and overall survival times were 6.9 and 12.3 months, respectively. Gallbladder cancer showed a significantly higher response rate than did other types of BTC (chi-squaretest, P = 0.002). GC was thus effective and well tolerated as first-line chemotherapy for Japanese patients with advanced BTC in the clinical practice setting.

关键词： Gemcitabine Cisplatin Chemotherapy Biliary Tract Cancer

Churg-Strauss综合征的初始皮肤症状与多重单一神经病变一致

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世界核心医学期刊文摘（皮肤病学分册） 2005年第11期1卷 25-26页

作者： kawakami T. Soma Y. Kawasaki K. 王琼 Dr.Department of Dermatology St. Marianna University School of Medicine 2-16-1 Sugao Kawasaki Kanagawa 216-8511 Japan

Background: Churg-Strauss syndrome (CSS), also known as allergic granulomatous angiitis, is a rare entity that is characterized by systemic vasculitis in patients with a history of asthma. Patients with CSS show a marked peripheral blood eosinophilia, but the pathogenesis remains unknown. Observations: A retrospective review was performed in 9 cases of CSS in whom cutaneous findings were present as an initial manifestation. All 9 patients had purpura and petechiae as well as severe pain and paresthesias of the lower extremities. Four patients (44%) used leukotriene receptor antagonists to treat their asthma, and 3 (75%) of them developed CSS within 3 months. Five patients (56%) were positive for perinuclear antineutrophil cytoplasmic antibodies before therapy, but in all 5 the levels of perinuclear antineutrophil cytoplasmic antibody normalized. Serum IgE levels were elevated in all patients before treatment but decreased after treatment. Histologically, all patients demonstrated leukocytoclastic vasculitis and eosinophilic infiltration. Eight biopsy specimens (73%) revealed marked eosinophilia around the nerve fibers in the dermis. Palisading granulomas in association with vessel-based changes were present in 4 (36%) of 11 biopsy specimens. Conclusions: These characteristic cutaneous clinical patterns that are consistent with the presence of mononeuropathy multiplexes in the lower extremities may help physicians establish an earlier diagnosis. Both eosinophils and IgE, as well as perinuclear antineutrophil cytoplasmic antibodies to some degree, likely participate in skin lesion development in CSS. Furthermore, there appears to be a correlation between treatment with leukotriene receptor antagonists and the onset of CSS in some cases.

关键词： Strauss 皮肤症状栅栏状肉芽肿系统性血管炎血嗜酸性粒细胞初发症状哮喘病史组织学检查感觉异常活检标本

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中速柴油机用(轴承)锡基镀覆层的开发

内燃机配件 2004年第6期 1-8页

作者： Hideo Tsuji Yuichi Tomita Naohisa kawakami lan Kerr John Harrison 张乐山日本大同金属有限公司大同工业轴承欧洲有限分公司成都圣三强铁路配件有限公司

0概述不断提高功率和缩小体积,是现代四冲程柴油机的发展趋势.这种情况,同更加严酷的运转和环境条件一起,进一步加重了发动机各种零件的负荷.同时受经济因素支配,这些零件的使用寿命和大修周期也更长.支承曲轴和连杆的滑动轴承处在极高... 详细信息

0概述不断提高功率和缩小体积,是现代四冲程柴油机的发展趋势.这种情况,同更加严酷的运转和环境条件一起,进一步加重了发动机各种零件的负荷.同时受经济因素支配,这些零件的使用寿命和大修周期也更长.支承曲轴和连杆的滑动轴承处在极高的发动机工作温度中,并因此受到更加严峻条件的影响.

关键词：覆层镀覆零件轴承曲轴连杆高功率中速柴油机发动机大修周期