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Excessive portal flow causes graft failure in extremely small-for-size liver transplantation in pigs

World Journal of Gastroenterology 2005年第44期11卷 6954-6959页

作者： Hong-Sheng Wang Nobuhiro Ohkohchi Yoshitaka Enomoto Masahiro Usuda Shigehito Miyagi Takeshi Asakura Hiroo Masuoka Takashi Aiso keisuke fukushima Tomohiro Narita Hideyuki Yamaya Atsushi Nakamura Satoshi Sekiguchi Naoki Kawagishi Akira Sato Susumu Satomi Division of Advanced Surgical Science and Technology Department of Surgery

AIM： To evaluate the effects of a portocaval shunt on the decrease of excessive portal flow for the prevention of sinusoidal microcirculatory injury in extremely smallfor-size liver transplantation in pigs. METHODS： The right lateral lobe of pigs, i.e. the 25% of the liver, was transplanted orthotopically. The pigs were divided into two groups： graft without portocaval shunt （n = 11） and graft with portocaval shunt （n = 11）. Survival rate, portal flow, hepatic arterial flow, and histological findings were investigated. RESULTS： In the group without portocaval shunt, all pigs except one died of liver dysfunction within 24 h afcer transplantation. In the group with portocaval shunt, eight pigs survived for more than 4 d. The portal flow volumes before and after transplantation in the group without portocaval shunt were 118.2±26.9 mL/min/100 g liver tissue and 270.5±72.9 ml./min/100 g liver tissue, respectively. On the other hand, in the group with portocaval shunt, those volumes were 124.2±27.8 ml./ min/100 g liver tissue and 42.7±32.3 mL/min/100 g liver tissue, respectively （P〈0.01）. As for histological findings in the group without portocaval shunt, destruction of the sinusoidal lining and bleeding in the peri-portal areas were observed afl：er reperfusion, but these findings were not recognized in the group with portocaval shunt. CONCLUSION： These results suggest that excessive portal flow is attributed to post transplant liver dysfunction after extreme small-for-size liver transplantation caused by sinusoidal microcirculatory injury.

关键词： Hyperperfusion syndrome Liver regeneration Portocaval shunt Postoperative liver dysfunction Sinusoidal microcirculatory injury Small-for-size liver transplantation

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Numerical Investigations on Fluid Flow and Heat Transfer Characteristics of an Ultra-Thin Heat Pipe with Separated Wick Structures

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Frontiers in Heat and Mass Transfer 2024年第3期22卷 869-887页

作者： Yasushi Koito Akira fukushima Division of Industrial Fundamentals Faculty of Advanced Science and TechnologyKumamoto UniversityKumamoto860-8555Japan Department of Mechanical and Mathematical Engineering Graduate School of Science and TechnologyKumamoto UniversityKumamoto860-8555Japan

Thermal and fluid-flow characteristics were numerically analyzed for ultra-thin heat *** studies have been conducted for ultra-thin heat pipes with a centered wick structure,but this study focused on separated wick structures to increase the evaporation/condensation surface areas within the heat pipe and to reduce the concentration of heat flux within the wick structure.A mathematical heat-pipe model was made in the threedimensional coordinate system,and the model consisted of three regions:a vapor channel,liquid-wick,and container wall *** conservation equations for mass,momentum,and energy were solved numerically with boundary conditions by using a code developed by one of the *** numerical results with the separated wick structures were compared with those with the centered,which confirmed the effectiveness of the separation of the wick ***,the effectiveness of the separation was affected by the position of the separated wick structure.A simple equation was presented to determine the optimum position of the separated wick *** analyses were also conducted when the width of the heat pipe was increased with the cooled section,which clarified that the increase in the cooled-section width with the addition of wick structures wasmore effective than the increase in the cooled-section length.A 44%reduction in the total temperature difference of the heat pipe was obtained under the present numerical ***,a comparison wasmade between experimental results and numerical results.

关键词： Ultra-thin heat pipe vapor chamber heat transfer surface CFD thermal design

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Annular Supersonic Swirling Flows with Heterogeneous Condensation

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Journal of Thermal Science 2016年第6期25卷 518-525页

作者： Yusuke fukushima Shigeru MATSUO Norimasa SHIOMI Toshiaki SETOGUCHI Graduate School of Science & Engineering Saga University Department of Advanced Technology Fusion Saga University Department of Mechanical Engineering Saga University Institute of Ocean Energy Saga University

In recent years,separating and extracting technologies of condensate gas have been developed by combining a swirl flow with non-equilibrium condensation phenomena of condensate gas generated in a supersonic *** technology can reduce the size of the device and does not use ***,there are many unresolved problems for performance of the separation,extraction and operating *** it is necessary to research further in order to improve the performance of the *** the present study,the numerical study was carried out to clarify the effect of the heterogeneous condensation on the characteristics of the swirling flow field in a supersonic annular nozzle,and the differences between homogeneous condensation and heterogeneous condensation in the flow *** the results,it is found that the condensation flow with a swirl affects the position of sonic line,the generating position of condensate and the radial distribution ratio of liquid phase.

关键词： condensation supersonic heterogeneous condensate viscosity chemicals generating annular nozzle regardless

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A host lncRNA regulates the innate immune response to an RNA virus

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Cellular & Molecular Immunology 2019年第10期16卷 841-842页

作者： Kiyoharu fukushima Hiroshi Kida Department of Respiratory Medicine National Hospital Organization Osaka Toneyama Medical CenterOsakaJapan

TO THE EDITOR Recent studies have shown that more than 70%of the mammalian genome is transcribed into RNAs;however,most of these RNAs do not encode proteins and are thus called noncoding RNAs(ncRNAs).

关键词： immune EDIT innate

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Comparison of effects of six main gastrectomy procedures on patients’ quality of life assessed by Postgastrectomy Syndrome Assessment Scale-45

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World Journal of Gastrointestinal Surgery 2021年第5期13卷 461-475页

作者： Koji Nakada Yoshiyuki Kawashima Shinichi Kinami Ryoji fukushima Hiroshi Yabusaki Akiyoshi Seshimo Naoki Hiki keisuke Koeda Mikihiro Kano Yoshikazu Uenosono Atsushi Oshio Yasuhiro Kodera Department of Laboratory Medicine The Jikei University School of MedicineTokyo 105-8461Japan Department of Gastroenterological Surgery Saitama Cancer CenterSaitama 362-0806Japan Department of Surgical Oncology Kanazawa Medical UniversityKahoku-gun 920-0293IshikawaJapan Department of Surgery Teikyo University School of MedicineTokyo 173-8605Japan Department of Surgery Niigata Cancer Center HospitalNiigata 951-8566Japan Department of Gastrointestinal and Pediatric Surgery Tokyo Medical UniversityTokyo 160-0023Japan Department of Upper Gastrointestinal Surgery Kitasato University School of MedicineKanagawa 252-0374Japan Department of Medical Safety Science Iwate Medical UniversityIwate 028-3695Japan Department of Surgery Hiroshima City Asa Citizens HospitalHiroshima 731-0293Japan Department of Digestive Surgery Imamura General HospitalKagoshima 890-0064Japan Faculty of Letters Arts and SciencesWaseda UniversityTokyo 162-8644Japan Department of Gastroenterological Surgery Nagoya University Graduate School of MedicineNagoya 466-8550Japan

BACKGROUND The effects of various gastrectomy procedures on the patient’s quality of life(QOL)are not well ***,this nationwide multi-institutional crosssectional study using the Postgastrectomy Syndrome Assessment Scale-45(PGSAS-45),a well-established questionnaire designed to clarify the severity and characteristics of the postgastrectomy syndrome,was *** To compare the effects of six main gastrectomy procedures on the postoperative *** Eligible questionnaires retrieved from 2368 patients who underwent either of six gastrectomy procedures[total gastrectomy with Roux-en-Y reconstruction(TGRY;n=393),proximal gastrectomy(PG;n=193),distal gastrectomy with Roux-en-Y reconstruction(DGRY;n=475),distal gastrectomy with Billroth-I reconstruction(DGBI;n=909),pylorus-preserving gastrectomy(PPG;n=313),and local resection of the stomach(LR;n=85)]were *** the 19 main outcome measures of PGSAS-45,the severity and characteristics of postgastrectomy syndrome were compared for the aforementioned six gastrectomy procedures using analysis of *** TGRY and PG significantly impaired the QOL of postoperative *** QOL was excellent in LR(cardia and pylorus were preserved with minimal resection).In procedures removing the distal stomach,diarrhea subscale(SS)and dumping SS were less frequent in PPG than in DGBI and ***,there was no difference in the postoperative QOL between DGBI and *** most noticeable adverse effects caused by gastrectomy were mealrelated distress SS,dissatisfaction at the meal,and weight loss,with significant differences among the surgical *** Postoperative QOL greatly differed among six gastrectomy *** severity and characteristics of postgastrectomy syndrome should be considered to select gastrectomy procedures,overcome surgical shortcomings,and enhance postoperative care.

关键词： Gastrectomy Quality of life Postgastrectomy syndromes Patient reported outcome measures

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Specific targeting of lung ILC2s via NRP1 in pulmonary fibrosis

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Cellular & Molecular Immunology 2022年第8期19卷 869-871页

作者： Takuro Nii Kiyoharu fukushima Hiroshi Kida Department of Respiratory Medicine National Hospital Organization Osaka Toneyama Medical Center5-1-1 ToneyamaOsakaJapan Department of Respiratory Medicine and Clinical Immunology Osaka University Graduate School of Medicine2-2 YamadaokaSuitaOsakaJapan Laboratory of Host Defense World Premier Institute Immunology Frontier Research Center(WPI-IFReC)Osaka University3-1 YamadaokaSuitaOsakaJapan Department of Host Defense Research Institute for Microbial Diseases(RIMD)Osaka UniversityOsaka565-0871Japan Global Center for Medical Engineering and Informatics 2-2 YamadaokaSuitaOsakaJapan

Innate lymphoid cells are predominantly tissue-resident immune cells that have diverse functions similar to T-cell subsets and regulate tissue homeostasis and innate immunity without specific antigen recognition. Prev... 详细信息

关键词： ILC2s immunity homeostasis

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Hepatoid carcinoma of the pancreas mimicking neuroendocrine tumor

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Hepatobiliary Surgery and Nutrition 2018年第6期7卷 501-502页

作者： Kentaro fukushima Akira Kobayashi First Department of Surgery Shinshu University School of MedicineMatsumotoJapan

A 44-year-old man was admitted to our hospital for further investigation of a tumor in the pancreatic *** had no symptoms or chronic liver *** hormones,CEA,and CA19-9 were *** alpha-fetoprotein and des-gamma-carboxy p... 详细信息

关键词： admitted pancreas assessed

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Optimum sintering conditions for optical properties of translucent aluminum nitride ceramics

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Chinese Science Bulletin 2009年第5期54卷 842-845页

作者： KANECHIKA Yukihiro AZUMA Masanobu fukushima Hiroshi Tokuyama Corp. Graduate School of Engineering Hiroshima University

High translucency is one of the excellent properties of AlN ceramics because of its wide optical band gap energy of 6.2 eV. We have achieved success in producing AlN ceramic tube of 98% total visible light transmittance at 0.6 mm thick tube wall by applying an improved sintering technique. This AlN ceramic was produced by sintering at 1880℃ using Ca3Al2O6 as a sintering additive and in reduction atmosphere to remove the sintering additive from the final sintered material. After the sintering, the annealing with Al2O3 was carried out to improve the transmittance of AlN ceramics. The amount of metal impurities and carbon were 27ppm and 100ppm, respectively. It is noteworthy that the amount of oxygen in AlN ceramics after the annealing was 0.36wt% which was higher than the 0.07wt% of the as-sintered AlN ceramics. Therefore, total transmittance was improved by the oxygen doping. On the other hand, thermal conductivity of AlN after the annealing was lowered by 35% compared with that of as-sintered AlN. Positron Annihilation Lifetime (PAL) measurement was applied to investigation of a relationship between the total transmittance and lattice defects. The present PAL results confirms the presence of negatively charged atomic-size vacancies that is aluminum site vacancies and also sug-gests the increase in the concentration of the vacancies after the annealing compared with that of the as-sintered material. However, it can be concluded that there is no relation between aluminum site va-cancies and the light transmittance of AlN ceramics.

关键词：陶器阳电子湮没铝氮化物半透明性光学性能

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Revealing the diversity of neutrophil functions and subsets

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Cellular & Molecular Immunology 2021年第4期18卷 781-783页

作者： Kiyoharu fukushima Hiroshi Nabeshima Hiroshi Kida Department of Respiratory Medicine National Hospital Organization Osaka Toneyama Medical CenterOsakaJapan Department of Respiratory Medicine and Clinical immunology Osaka University Graduate School of MedicineOsakaJapan Laboratory of Host Defense World Premier Institute Im m unology Frontier Research Center(WPIIFReC)Osaka UniversityOsakaJapan Fujii Memorial Research Institute Otsuka Pharmaceutical CompanyLtdShigaJapan

Several recent studies have shown that diverse neutrophil subsets exhibit distinct phenotypic and functional properties in terms of disease onset and progression.1,2 In a study published in Nature Immunology,Sas et al.3 discovered a new neutrophil subset that promotes neuronal survival and axonal regeneration in the central nervous system(CNS).

关键词： neutrophil Immunology

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Physical and mechanical properties of municipal solid waste incineration residues with cement and coal fly ash using X-ray Computed Tomography scanners

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Frontiers of Structural and Civil Engineering 2019年第3期13卷 640-652页

作者： Toshifumi MUKUNOKI Ta Thi HOAI Daisuke fukushima Teppei KOMIYA Takayuki SHIMAOKA Faculty of Advanced Science and Technology Graduate School of Kumamoto UniversityKumamoto city 860-8555Japan Graduate school of Science and Technology Kumamoto UniversityKumamoto city 860-8555Japan Faculty of Geology VNU University of ScienceVietnam National University Hanoi334 Nguyen TraiHanoiVietnam Water and Material Cycles System Faculty of EngineeringKyushu UniversityFukuoka city 819-0395Japan

A significant volume of Municipal Solid Waste incineration bottom ash and fly ash (i.e.,incineration residues) are commonly disposed as ***,reclamation of landfill sites to create a new land space after their closure becomes an important goal in the current fewer and fewer land availability scenario in many narrow *** objective of this study is to reclaim incineration residue materials in the landfill site by using cement and coal fly ash as stabilizers aiming at performing quality check as new developed materials before future ***,physical and mechanical properties of these new materials should be initially examined at the micro scale,which is the primary fundamental for construction at larger *** research examines quantitative influences of using the combination of cement and coal fly ash at different ratio on the internal structure and ability of strength enhancement of incineration residues when suffering from *** of industrial and micro-focus X-ray computed tomography (CT) scanners combined with an image analysis technique were utilized to characterize and visualize the behavior and internal structure of the incineration residues-cement-coal fly ash mixture under the series of unconfined compression test and curing period *** types of cement solidified incineration residues in term of different curing period (i.e.,7,14,28 days) and coal fly ash addition content (i.e.,0%,9%,18%) were scanned before and after unconfined compression *** was shown that incineration residues solidified by cement and coal fly ash showed an increase in compression strength and deformation modulus with curing time and coal fly ash ***-dimension computed tomography images observation and analysis confirmed that solidified incineration residues including incineration bottom and fly ash as well as cement and coal fly ash have the deliquescent ***,it was studied that stabilized parts play a more im

关键词： mechanical property municipal solid waste incineration residues coal fly ash unconfined compression test image analysis X-Ray Computed Tomography scanners

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