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World Journal of Orthopedics 2021年第11期12卷 945-953页

作者： Koichi Nakamura Kunihiro Asanuma Akira Shimamoto Shinji Kaneda keisuke yoshida Yumi Matsuyama Tomohito Hagi Tomoki Nakamura Motoshi Takao Akihiro Sudo Department of Orthopedic Surgery Mie University Graduate School of MedicineTsu 514-8507Mie PrefectureJapan Department of Thoracic and Cardiovascular Surgery Mie University Graduate School of MedicineTsu 514-8507Mie PrefectureJapan

BACKGROUND Multiple exostoses generally develop in the first decade of *** most frequently arise from the distal femur,proximal tibia,fibula,and proximal *** exostoses are rare,contributing to 1%-2% of all exostoses in hereditary multiple exostoses(HME).They are usually asymptomatic,but a few cases have resulted in severe thoracic *** caused by costal exostoses is rare,with only 13 previously reported *** report a new case of pneumothorax caused by costal *** SUMMARY A 17-year-old male with HME underwent surgery for removal of exostoses around his right *** months following the operation,he felt chest pain when he was playing the trumpet;however,he did not stop playing for a *** was referred to our hospital with a chief complaint of chest *** computed tomography(CT)scan revealed right pneumothorax and multiple exostoses in his right *** CT scan also revealed visceral pleura thickness and damaged lung tissues facing the exostosis of the seventh *** diagnosed that exostosis of the seventh rib induced *** exostosis resection was performed by video-assisted thoracoscopic surgery(VATS)2 wk after the *** patient’s postoperative course was uneventful,and there was no recurrence of pneumothorax for 2 *** Costal exostoses causing thoracic injuries should be resected regardless of *** must be considered in cases with apparently benign and relatively small exostoses or HME.

关键词： Costal exostosis Pneumothorax Video-assisted thoracoscopic surgery Hereditary multiple exostoses Case report Treatment

Primary Malignant Lymphoma of Prostate with Silent <i>MYD</i>88 Mutation

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Case Reports in Clinical Medicine 2014年第3期3卷 125-128页

作者： keisuke yoshida Riko Kitazawa Munenori Komoda Chihiro Ito Ryuma Haraguchi Sohei Kitazawa Department of Molecular Pathology Ehime University Graduate School of Medicine Toon City Japan

We present a case of primary malignant lymphoma of the prostate in a 77-year-old Japanese man. Immunohistochemical examinations revealed the presence of a non-GCB subtype of DLBCL (CD10 (-), Bcl-6 (-), MUM1 (+)), and genetic analysis disclosed a lack of typical codon 206 or 265 missense mutation in MYD88, suggesting that the case was of type3 (non-GCB andnon-ABC), a subtype of DLBCL. Three courses of chemotherapy (rituximab in combination with cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP)) were effective, and the patient has been free of the disease with no local or systemic recurrence for three years. Although the significance of silent mutation at hot spot of the highly oncogenic MYD88 gene in this case is unclear, a minute increase in translational efficiency by silent mutation may have contributed to the activation of MYD88.

关键词： Malignant Lymphoma Prostate MYD88

Synthesis of Heparan Sulfate Oligosaccharides and Glycopeptides

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Synthesis of Heparan Sulfate Oligosaccharides and Glycopepti...

日本东部内陆地区2011年大地震前后的应力状态与诱发地震

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作者：黄雪飞 Weizhun Yang Steven B.Dulaney Yongmei Xu 王鹏 Bo Yang keisuke yoshida Jian Liu Department of Chemistry 578 S. Shaw Lane Michigan State University College of Pharmacy Rm 1044 Genetic Medicine Building University of North Carolina 山东大学

＜正＞Heparan sulfates are highly sulfated polysaccharides exhibiting important functions in many biological *** backbone structures and sulfation patterns determine their biological *** nature,heparan sulfates exist as part of heparan sulfate proteoglycans with the glycan chain linked to the core protein backbone through a tetrasaccharide *** the ubiquitous presence of

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国际地震动态 2012年第4期33卷 7-12页

作者： keisuke yoshida Akira Hasegawa Tomomi Okada Takeshi Iinuma Yoshihiro Ito Youichi Asano 洪启宇 Research Center for Prediction of Earthquakes and Volcanic Eruptions Graduate School of ScienceTohoku UniversitySendaiJapan National Research Institute for Earth Science and Disaster Prevention TsukubaJapan 中国地震局地球物理研究所

通过反演震源机制数据,得到了东日本大地震前后日本东部内陆地区的应力场。地震前,在东北部(Tohoku),σ1轴呈EW方向,但在关东-东部(Kanto-Chubu)地区则呈NW-SE方向。地震后,在Tohoku北部和靠近磐城市(Iwaki City)的Tohoku东南部,应力场... 详细信息

通过反演震源机制数据,得到了东日本大地震前后日本东部内陆地区的应力场。地震前,在东北部(Tohoku),σ1轴呈EW方向,但在关东-东部(Kanto-Chubu)地区则呈NW-SE方向。地震后,在Tohoku北部和靠近磐城市(Iwaki City)的Tohoku东南部,应力场发生了变化,主应力取向大致等同于与地震相关的静应力变化取向。这说明地震前这些地区的差应力值小于1MPa。在Tohoku中部,虽然地震后加载的应力取向几乎逆转,但其应力场没有发生变化,说明那里的差应力值大大超过1MPa。在Kanto-Chubu,地震后加载了与背景应力方向近乎相同的应力,且应力场没有发生预期的变化。这可能就是Kanto-Chubu地区高地震活动水平的诱因。

关键词：应力状态内陆地区地震前诱发地震日本地震活动水平应力场地震后

单剂量二氯化镭－223(BAY 88－8223)在去势抵抗性前列腺癌骨转移日本患者中的药代动力学研究

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中华核医学与分子影像杂志 2017年第5期37卷 318-318页

作者： keisuke yoshida Tomohiro Kaneta Shoko Takano Madoka Sugiura Tsuyoshi Kawano Ayako Hino Tou Yamamoto Kazuya Shizukuishi Masato Kaneko Christian Zurth Tomio Inoue 华中科技大学同济医学院附属协和医院核医学科 Department of Radiology Yokohama City University

目的该非盲、非随机的一期临床研究旨在评估单剂量223Ra在去势抵抗性前列腺癌骨转移日本患者中的药代动力学和辐射剂量学表现。方法研究纳入6例经组织学或细胞学证实为前列腺Ⅳ期腺癌日本患者(平均年龄72.5岁, 范围65～79岁)。2～5 min... 详细信息

目的该非盲、非随机的一期临床研究旨在评估单剂量223Ra在去势抵抗性前列腺癌骨转移日本患者中的药代动力学和辐射剂量学表现。方法研究纳入6例经组织学或细胞学证实为前列腺Ⅳ期腺癌日本患者(平均年龄72.5岁, 范围65～79岁)。2～5 min内静脉缓慢推注单一剂量的223Ra, 组1剂量为50 kBq/kg, 组2剂量为100 kBq/kg。结果经静脉注射后, 223Ra以多相式从血液中快速清除。注射后24 h, 全身残留的223Ra为注射活度的85%。生物分布结果显示, 骨骼初始摄取为52%(范围41%～57%)。223Ra在骨骼中摄取的峰值时间为给药后2 h。给药24 h内, 在小肠中可以检测到有放射性, 其他器官未检测到放射性。223Ra的主要辐射剂量在成骨细胞中。通过计算发现, 成骨细胞和红骨髓中的吸收剂量分别为0.76 Gy/MBq和0.09 Gy/MBq。结论在去势抵抗性前列腺癌骨转移的日本患者中, 223Ra(静脉注射)可在骨组织中快速达到摄取峰值, 并在24 h内通过小肠, 而其他器官无明显放射性分布。本研究显示, 日本患者器官和组织中该药物的药代动力学和吸收辐射剂量与非日本患者的数据相似。临床试验注册号:NCT01565746。

关键词： 223Ra 去势抵抗性前列腺癌转移药代动力学

Coagulation and ablation of biological soft tissue byquantum cascade laser with peak wavelength of 5.7μm

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Journal of Innovative Optical Health Sciences 2014年第3期7卷 115-123页

作者： keisuke Hashimura Katsunori Ishii Naota Akikusa Tadataka Edamura Harumasa yoshida Kunio Awazu Medical Beam Physics Laboratory Division of Sustainable Energy and Environmental EngineeringGraduate School of Engineering Osaka UiniversityJapan Hamamatsu Photonics K.K.Japan Graduate School of Frontier Biosciences Osaka UniversityJapan The Center for Advanced Medical Engineering and Informatics Osaka University Japan

Molecules such as water,proteins and lipids that are contained in biological tissue absorb mid-infrared(MR)light,which allows such light to be used in laser surgical ***,amides and water exhibit strong absorption bands in the 5-7μm wavelength range,but at present there are no lasers in clinical use that can emit in this ***,the present study focused on thequantum cascade laser(QCL),which is a new type of semiconductor laser that can emit at MIRwavelengths and has recentiy achieved high output power.A high-power QCL with a peakwavelength of 5.7μm was evaluated for use as a laser scalpel for ablating biological soft *** interaction of the laser beam with chicken breast tissue was compared to a conventional CO_(2) laser,based on surface and cross-sectional *** QCL was found to have sufficient power to ablate soft tissue,and its coagulation,carbonization and ablation effects were similar to those forthe CO_(2) *** QCL also induced comparable photothermal effects because it acted as apseudo-continuous wave laser due to its low peak power.A QCL can therefore be used as an effective laser scalpel,and also offers the possibility of less invasive treatment by targeting specificabsorption bands in t he MIR region.

关键词： Quantum cascade laser mid-infrared wavelength CO,laser biological soft tissue laser-tissue interaction.

New insights into the roles for DYRK family in mammalian development and congenital diseases

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Genes & Diseases 2023年第3期10卷 758-770页

作者： Saishu yoshida Kiyotsugu yoshida Department of Biochemistry The Jikei University School of MedicineMinato-kuTokyo 1058461Japan

The dual-specificity tyrosine-regulated kinase (DYRK) family is evolutionarily conserved from invertebrate to mammals. DYRKs regulate cell proliferation, apoptosis, survival, and differentiation by modifying the protein activation state, cellular localization, and turnover. In contrast to several studies in cellular models, the available evidence regarding the in vivo roles of DYRKs in mammalian development is limited. This review summarizes the in vivo studies on Dyrks which provide insight into their roles in mammalian tissue development and congenital diseases. In vivo evidence obtained using knockout and genetically modified animals helps to understand and develop novel clinical therapies and drug for human congenital diseases, such as Down syndrome and neuronal disorders (associated with DYRK1A) and skeletal ciliopathies (associated with DYRK2).

关键词： Ciliopathies Development Down syndr ome DYRKS Embryogenesis

表面波等离子体暴露下铜表面的氧化特性(英文)

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材料与冶金学报 2011年第1期10卷 58-60,69页

作者：吉田圭佑妻鹿义治川添博光松野隆山田刚治竹内新日本鸟取大学 Nissin inc. 10-7 KameiTakarazukaHyogo665-0047Japan

Surface wave plasma(SWP) is a kind of low temperature plasma which can be utilized for material *** this research,argon and oxygen were used as a working gas for an SWP experiment and the influence of the plasma irradiation on a copper surface was ***,relation between the spatial characteristics of SWP and wetting characteristics was *** a result,it was found that spatial characteristics of the SWP affected the wetting characteristics and the oxidation characteristics.

关键词： surface wave plasma material surface reformation wetting characteristics

Visualizing the hepatic vascular architecture using superb microvascular imaging in patients with hepatitis C virus: A novel technique

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World Journal of Gastroenterology 2016年第26期22卷 6057-6064页

作者： Hidekatsu Kuroda Tamami Abe keisuke Kakisaka Yudai Fujiwara Yuichi yoshida Akio Miyasaka Kazuyuki Ishida Hideaki Ishida Tamotsu Sugai Yasuhiro Takikawa Division of Hepatology Department of Internal Medicine Iwate Medical University School of Medicine Department of Molecular Diagnostic Pathology Iwate Medical University Center of Diagnostic Ultrasound Akita Red Cross Hospital

AIM: To identify the hepatic vascular architecture of patients with hepatitis C virus (HCV) using superb microvascular imaging (SMI) and investigate the use of SMI in the evaluation of liver ***: SMI was performed in 100 HCV patients. SMI images were classified into five types according to the vascular pattern, and these patterns were compared with the fibrosis stage. Moreover, the images were analyzed to examine vascularity by integrating the number of SMI signals in the region of interest ROI [number of vascular trees (VT)]. The number of VT, fibrosis stage, serum parameters of liver function, and CD34 expression were ***: There was a significant difference between SMI distribution pattern and fibrosis stage (P < 0.001). The mean VT values in each of the fibrosis stages were as follows: 26.69 ± 7.08 in F0, 27.72 ± 9.32 in F1, 36.74 ± 9.23 in F2, 37.36 ± 5.32 in F3, and 58.14 ± 14.08 in F4. The VT showed excellent diagnostic ability for F4 [area under the receiver operator characteristic (AUROC): 0.911]. The VT was significantly correlated with the CD34 labeling index (r = 0.617, P < 0.0001).CONCLUSION: SMI permitted the detailed delineation of the vascular architecture in chronic liver disease. SMI appears to be a reliable tool for noninvasively detecting significant fibrosis or cirrhosis in HCV patients.

关键词： Superb microvascular imaging Number of vascular trees Chronic liver disease Ultrasound Liver fibrosis CD34