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Journal of Sustainable Bioenergy Systems 2013年第3期3卷 179-185页

作者： Masahide Yasuda keisuke takeo Hayato Nagai Takuya Uto Toshifumi Yui Tomoko Matsumoto Yasuyuki Ishii Kazuyoshi Ohta Center for Collaborative Research and Community Cooperation University of Miyazaki Miyazaki Japan Department of Animal and Grassland Sciences Faculty of Agriculture University of Miyazaki Miyazaki Japan Department of Applied Chemistry Faculty of Engineering University of Miyazaki Miyazaki Japan Department of Biochemistry and Applied Biosciences Faculty of Agriculture University of Miyazaki Miyazaki Japan

Napiegrass (Pennisetum purpureum Schumach) was treated with a low-moisture anhydrous ammonia (LMAA) pretreatment by adding an equal weight of water and keeping it under atmospheric ammonia gas at room temperature for four weeks. After the removal of ammonia and washing with water, a simultaneous saccharification and fermentation (SSF) was conducted for the LMAA-pretreated napiergrass (1.33 g) in a buffer solution (8 mL) using a mixture of a cellulase (80 mg) and a xylanase (53 mg) as well as the cell suspension (0.16 mL) of Saccharomyces cerevisiae. Ethanol and xylose resulted in 91.2% and 62.9% yields, respectively. The SSF process was scaled up using LMAA-pretreated napiergrass (100.0 g) to give ethanol (77.2%) and xylose (52.8%). After the removal of ethanol, the pentose fermentation of the SSF solution (40 mL), which contained 1.00 g of xylose, using cell suspension of Escherichia coli KO11 (70 mL) gave 86.3% yield of ethanol. Total ethanol yield reached 68.9% based on xylan (21.4 wt%) and glucan (39.7 wt%) of the LMAA-pretreated napiergrass.

关键词： LMAA SSF Cellulase Xylanase Saccharomyces cerevisiae Escherichia coli KO11

Stage at diagnosis of colorectal cancer through diagnostic route:Who should be screened?

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World Journal of Gastroenterology 2024年第10期30卷 1368-1376页

作者： Nobukazu Agatsuma Takahiro Utsumi Yoshitaka Nishikawa Takahiro Horimatsu Takeshi Seta Yukitaka Yamashita Yukari Tanaka Takahiro Inoue Yuki Nakanishi Takahiro Shimizu Mikako Ohno Akane Fukushima takeo Nakayama Hiroshi Seno Department of Gastroenterology and Hepatology Kyoto University Graduate School of MedicineKyoto 606-8507Japan Department of Gastroenterology and Hepatology Japanese Red Cross Wakayama Medical CenterWakayama 640-8558Japan Department of Health Informatics Kyoto University School of Public HealthKyoto 606-8501Japan Institute for Advancement of Clinical and Translational Science(iACT) Kyoto University HospitalKyoto 606-8507Japan Medical Support Section Medical Affairs DivisionKyoto University HospitalKyoto 606-8507Japan

BACKGROUND Colorectal cancer(CRC)is a global health concern,with advanced-stage diagnoses contributing to poor *** efficacy of CRC screening has been well-established;nevertheless,a significant proportion of patients remain unscreened,with>70%of cases diagnosed outside *** identifying specific subgroups for whom CRC screening should be particularly recommended is crucial owing to limited resources,the association between the diagnostic routes and identification of these subgroups has been less *** the Japanese cancer registry,the diagnostic routes for groups discovered outside of screening are primarily categorized into those with comorbidities found during hospital visits and those with CRC-related *** To clarify the stage at CRC diagnosis based on diagnostic *** We conducted a retrospective observational study using a cancer registry of patients with CRC between January 2016 and December 2019 at two *** diagnostic routes were primarily classified into three groups:Cancer screening,follow-up,and *** early-stage was defined as Stages 0 or *** and univariate logistic regressions were exploited to determine the odds of early-stage diagnosis in the symptomatic and cancer screening groups,referencing the follow-up *** adjusted covariates were age,sex,and tumor *** Of the 2083 patients,715(34.4%),1064(51.1%),and 304(14.6%)belonged to the follow-up,symptomatic,and cancer screening groups,*** the 2083 patients,CRCs diagnosed at an early stage were 57.3%(410 of 715),23.9%(254 of 1064),and 59.5%(181 of 304)in the follow-up,symptomatic,and cancer screening groups,*** symptomatic group exhibited a lower likelihood of early-stage diagnosis than the follow-up group[P<0.001,adjusted odds ratio(aOR),0.23;95%confidence interval(95%CI):0.19-0.29].The likelihood of diagnosis at an early stage was similar between the follow-up and cancer screening gro

关键词： Colorectal neoplasms Cancer registry Diagnostic route Cancer screening Stage at diagnosis

On the extension of L^2 holomorphic functions VII： Hypersurfaces with isolated singularities

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Science China Mathematics 2017年第6期60卷 1083-1088页

作者： OHSAWA takeo Graduate School of Mathematics Nagoya University Nagoya 464-8602 Japan

An extension theorem for holomorphic functions with L^2 growth condition is strengthened for the case of the extension from hypersurfaces with isolated singularities.

关键词： L^2 holomorphic hypersurface isolated singularity

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Anticipation phenomenon in familial adenomatous polyposis:an analysis of its origin

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World Journal of Gastroenterology 2000年第3期6卷 335-338页

作者： takeo Iwama Joji Utsunomiya Department of Surgery Kyoundo HospitalSasaki Institute KandaSurugadai 1-8Chiyoda-KuTokyo 101-0062Japan Institute for Advanced Medical Sciences Hyogo Medical College Mukogawa 1-1NisinomiyaHyogo 663-8131Japan

AIM To analyze the origin of the anticipationphenomenon,which means earlier death insuccessive generation in familial *** The study subjects were 2161patients with familial adenomatous polyposisand their 7465 first-degree relatives who weremembers of 750 families registered at ourPolyposis *** ages at death andcumulative mortality rates in the parent,theproband,and the child generations werecompared for both all subjects and the *** In the patients over 5 years of age,the mean age at death was 50.9 years for theparent,42.3 years for the proband,and 33.3years for the child generations,respectively(P<0.001).The deceased rates in the threegenerations were 90.7%,51.3% and 23.1% ofthe patients,respectively,and this differencewas the main cause of the anticipation measuredby parent-child paring *** cumulativemortality rates for all subjects failed to showanticipation,however the cumulative mortalityrates for the patients showed the *** anticipation phenomenon was shown by anyparent-child pairing methods for the *** important causes of theanticipation were different proportion of causesof death between generations(P<0.001),and alow proportion of detected or deceased patients (P<0.001)in the child *** Anticipation in familialadenomatous polyposis may be caused byparent-child paring methods as well as severalintergenerational biases.

关键词： familial adenomatous apolyposis (FAP) anticipation phenomenon intergenerational bias child generations hereditary disorder mortality

CONTRIBUTION OF MACROSCOPIC DIMENSION EFFECT TO PIEZOELFCTRICITY IN POLYVINYLIDENE FLUORIDE

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Chinese Journal of Polymer Science 1987年第4期5卷 292-297页

作者：闻建勋,takeo FURUKAWA Shanghai Institute of Organic Chemistry Academia Sinica Shanghai The Institute of Physical and Chemical Research Japan

In this paper, we have studied the piezoelectricity in the poled uniaxially drawn polyvinylidene fluoride. The piezoelectric constants d31, d32, d33αand Young's moduli 1/s11 and 1/s22have been determined as a function of the remanent polarization Pr. The piezoelectric constants of the samples show a strong in-plane anisotropy. Such an anisotropy is mostly attributable to different Poisson's ratio. It is found that the piezoelectric activity mainly arises from macroscopic dimensional change.

关键词： Piezoelectricity Pyroelectricity Polyvinylidene fluoride.

STUDIES ON THE CHAIN STRUCTURAL EFFECT OF PVDF AND VDF (52)/TrFE(48) COPOLYMER BY MEANS OF THE METHOD OF DIELECTRIC RELAXATION

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Chinese Journal of Polymer Science 1994年第1期12卷 12-21页

作者：张兴元 FURUKAWA takeo Department of Materials Science and Engineering University of Science and Technology of China Hefei 230026 Department of Chemistry Science University of Tokyo Japan

Through improvements on a fully commercial and automatic system measuring frequency andtemperature spectra of the complex elastic, dielectric, and piezoelectric constants of polymerfilms, the precision for measuring complex dielectric constants achieved 2‰ from original 1%.The complex dielectric constants of PVDF, VDF （95 ）/VF （5）, VDF （52）/TrFE （48） and VDF（47. 5）/TrFE（47. 5）/HeFP （5） over a range of-120-140℃, 10-2-10;Hz were measured bythe described system. The diminution of chain regularity due to 5mol% vinyl fluoride in the chainof PVDF led to disappearing of α-relaxation and increase in T;（3℃） of VDF （95）/VF （5）.Because of the spatial impediment of 5mol% HeFP in copolymer chain, the Curie point of VDF（52）/TrFE（48） decreased by 30℃ and T;by 3℃. The behavior of dielectric relaxation indicatedthat 5mol% vinyl fluoride and HeFP made the relaxation strength of noncrystalline regionreduced, the activation energy of local relaxation increased and the relaxation time prolonged respectively.

关键词： Polyvinylidene fluoride VDF(52)/TrFE(48) Chain structure effect Dielectric relaxation

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A two-step surface-based 3D deep learning pipeline for segmentation of intracranial aneurysms

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Computational Visual Media 2023年第1期9卷 57-69页

作者： Xi Yang Ding Xia Taichi Kin takeo Igarashi The University of Tokyo 7 Chome-3-1 HongoBunkyo CityTokyo 113-8654Japan Jilin University No.2699Qianjin RoadChangchunChina

The exact shape of intracranial aneurysms is critical in medical diagnosis and surgical *** voxel-based deep learning frameworks have been proposed for this segmentation task,their performance remains *** this study,we offer a two-step surface-based deep learning pipeline that achieves significantly better *** proposed model takes a surface model of an entire set of principal brain arteries containing aneurysms as input and returns aneurysm surfaces as output.A user first generates a surface model by manually specifying multiple thresholds for time-of-flight magnetic resonance angiography *** system then samples small surface fragments from the entire set of brain arteries and classifies the surface fragments according to whether aneurysms are present using a point-based deep learning network(PointNet++).Finally,the system applies surface segmentation(SO-Net)to surface fragments containing *** conduct a direct comparison of the segmentation performance of our proposed surface-based framework and an existing voxel-based method by counting voxels:our framework achieves a much higher Dice similarity(72%)than the prior approach(46%).

关键词： intracranial aneurysm(IA)segmentation point-based 3D deep learning medical image segmentation

Future perspectives on cell therapy for autism spectrum disorder

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BIOCELL 2022年第4期46卷 873-879页

作者： MAKOTO NABETANI takeo MUKAI Department of Pediatrics Yodogawa Christian HospitalOsaka533-0024Japan Department of Cell Processing and Transfusion The Institute of Medical ScienceThe University of TokyoTokyo108-8639Japan

Autism spectrum disorder(ASD)is a complex neurodevelopmental condition characterized by impairments in social communication,abnormal to absent verbal communication,the presence of repetitive stereotypic verbal and nonverbal behaviors and restricted interests,with onset early in *** showed cognitive and behavioral characteristics of ASD by impairment of communication,cognition,perception,motor skills,executive function,theory of mind and emotion ***,pathogenesis of immune pathology in the brains of individuals with ASD has been *** therapeutic approaches in the viewpoints of immune modulation and microglial function are logical for novel treatments for individuals with *** therapies such as umbilical cord blood cells and mesenchymal stromal cells for ASD will be a challenging and encouraging field in the future clinical study with progress of biotechnological science.

关键词： Autism ASD Cell therapy Umbilical cord blood cells MSC Mesenchymal stromal cells

Recent trends from the results of clinical trials on gastric cancer surgery

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Cancer Communications 2019年第1期39卷 106-112页

作者： Takashi Kiyokawa takeo Fukagawa Department of Surgery Teikyo University School of Medicine2-11-1 KagaItabashi-KuTokyo 173-8606Japan

The Japan Clinical Oncology Group has recently conducted large scale clinical trials with findings that have revealed pivotal strategies for the treatment of resectable gastric cancer *** findings include the fact that D3 lymphadenectomy does not improve survival rates when compared to D2 lymphadenectomy,and it is not recommended for resectable gastric ***,a transhiatal approach is recommended,instead of the left thoraco-abdominal approach,for the treatment of adenocarcinoma of the esophago-gastric junction or gastric cardia which has invaded≤3 cm of the *** with splenectomy and bursectomy had been recommended as a part of the D2 ***,the results of the recent clinical trials revealed that splenectomy should be avoided in total gastrectomy with D2 lymphadenectomy for proximal gastric cancer and that bursectomy should be avoided in gastrectomy with D2 lymphadenectomy for resectable gastric *** splenectomy and bursec-tomy were found to be unable to improve survival,but instead increased operative *** trials revealed that the above-mentioned invasive and aggressive procedures did not provide sufficient survival benefits and that gastric cancer surgery may be trending from an“invasive to less invasive”and“aggressive to more conservative”approach.

关键词： Gastric cancer Japanese Gastric Cancer Association Randomized clinical trials Para-aortic lymph nodes D2 lymphadenectomy D3 lymphadenectomy Left thoraco-abdominal approach Hiatal approach Splenectomy Bursectomy

Breast cancer resistance protein(BCRP/ABCG2):its role in multidrug resistance and regulation of its gene expression

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Chinese Journal of Cancer 2012年第2期31卷 73-99页

作者： takeo Nakanishi Douglas D.Ross Department of Membrane Transport and Biopharmaceutics Kanazawa University School of Pharmaceutical SciencesKanazawa 920-1192Japan University of Maryland Greenebaum Cancer Center the Departments of Medicine Pathology and Pharmacology and Experimental TherapeuticsUniversity of Maryland School of Medicineand the Baltimore VA Medical CenterBaltimoreMaryland 21201USA

Breast cancer resistance protein(BCRP)/ATP-binding cassette subfamily G member 2(ABCG2) is an ATP-binding cassette(ABC) transporter identified as a molecular cause of multidrug resistance(MDR) in diverse cancer *** physiologically functions as a part of a self-defense mechanism for the organism;it enhances elimination of toxic xenobiotic substances and harmful agents in the gut and biliary tract,as well as through the blood-brain,placental,and possibly blood-testis *** recognizes and transports numerous anticancer drugs including conventional chemotherapeutic and targeted small therapeutic molecules relatively new in clinical ***,BCRP expression in cancer cells directly causes MDR by active efflux of anticancer *** BCRP is also known to be a stem cell marker,its expression in cancer cells could be a manifestation of metabolic and signaling pathways that confer multiple mechanisms of drug resistance,self-renewal(stemness),and invasiveness(aggressiveness),and thereby impart a poor ***,blocking BCRP-mediated active efflux may provide a therapeutic benefit for *** the precise molecular mechanisms for BCRP gene expression may lead to identification of a novel molecular target to modulate BCRP-mediated *** evidence suggests that BCRP gene transcription is regulated by a number of trans-acting elements including hypoxia inducible factor 1α,estrogen receptor,and peroxisome proliferator-activated ***,alternative promoter usage,demethylation of the BCRP promoter,and histone modification are likely associated with drug-induced BCRP overexpression in cancer ***,PI3K/AKT signaling may play a critical role in modulating BCRP function under a variety of *** biological events seem involved in a complicated *** the events would be an essential first step to developing a method to modulate BCRP function to aid patients with *** review will present a sy

关键词：多重耐药性基因表达调控组蛋白修饰乳腺癌过氧化物酶体增殖物激活受体分子机制多药耐药肿瘤细胞

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