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Shear wave velocity is a useful marker for managing nonalcoholic steatohepatitis

World Journal of Gastroenterology 2010年第23期16卷 2918-2925页

作者： Akihiko Osaki Tomoyuki Kubota Takeshi Suda Masato Igarashi keisuke nagasaki Atsunori Tsuchiya Masahiko Yano Yasushi Tamura Masaaki Takamura Hirokazu Kawai Satoshi Yamagiwa Toru Kikuchi Minoru Nomoto Yutaka Aoyagi Department of Gastroenterology and Hepatology Graduate School of Medical and Dental SciencesNiigata University Department of Homeostatic Regulation and Development Graduate School of Medical and Dental SciencesNiigata University Department of Laboratory Medicine Niigata University Medical and Dental Hospital

AIM:To investigate whether a noninvasive measurement of tissue strain has a potential usefulness for management of nonalcoholic steatohepatitis(NASH).METHODS:In total 26 patients,23 NASHs and 3 normal controls were enrolled in this *** was staged based on Brunt *** a region of interest(ROI),a shear wave was evoked by implementing an acoustic radiation force impulse(ARFI),and the propagation velocity was quantif ***:Shear wave velocity(SWV) could be reproducibly quantified at all ROIs in all subjects except for 4 NASH cases,in which a reliable SWV value was not calculated at several *** average SWV of 1.34 ± 0.26 m/s in fibrous stage 0-1 was significantly slower than 2.20 ± 0.74 m/s and 2.90 ± 1.01 m/s in stages 3 and 4,respectively,but was not significantly different from 1.79 ± 0.78 m/s in stage *** a cutoff value was set at 1.47 m/s,receiver operating characteristic analysis showed significance to dissociate stages 3 and 4 from stage 0-1(P=0.0092) with sensitivity,specificity and area under curve of 100%,75% and 94.2%,*** addition,the correlation between SWV and hyaluronic acid was significant(P<0.0001),while a tendency toward negative correlation was observed with serum albumin(P=0.053).CONCLUSION:The clinical implementation of ARFI provides noninvasive repeated evaluations of liver stiffness at an arbitrary position,which has the potential to shed new light on NASH management.

关键词： Nonalcoholic steatohepatitis Ultrasound Liver stiffness measurement Shear wave velocity Acoustic radiation force impulse

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Estimates of the Isovariant Borsuk–Ulam Constants of Connected Compact Lie Groups

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Acta Mathematica Sinica,English Series 2018年第10期34卷 1485-1500页

作者： Ikumitsu nagasaki Department of Mathematics Kyoto Prefectural University of Medicine

The isovariant Borsuk Ulam constant cc of a compact Lie group G is defined to be the supremum of c ∈ R such that the inequalityc（dim V - dim V^C） ≤ dim W - dim W^Gholds whenever there exists a G-isovariant map f ： S（V） → S（W） between G-representation spheres. In this paper, we shall discuss some properties of cG and provide lower estimates of cG of connected compact Lie groups, which leads us to some Borsuk-Ulam type results for isovariant maps. We also introduce and discuss the generalized isovariant Borsuk-Ulam constant c^-G for more general smooth G-actions on spheres. The result is considerably different from the case of linear actions.

关键词： Isovariant map Borsuk-Ulam type theorem Borsuk Ulam constant transformation groups representation theory

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A Hopf Type Classification Theorem for Isovariant Maps from Free G-manifolds to Representation Spheres

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Acta Mathematica Sinica,English Series 2011年第4期27卷 685-700页

作者： Ikumitsu nagasaki Fumihiro USHITAKI Department of Mathematics Kyoto Prefectural University of Medicine Nishitakatsukasa-cho Taishogun Kita-ku Kyoto 603-8334 Japan Department of Mathematics Faculty of Science Kyoto Sangyo University Kamigamo Motoyama Kita-ku Kyoto 603-8555 Japan

An isovariant map is an equivariant map preserving the isotropy subgroups. In this paper, we develop an isovariant version of the Hopf classification theorem; namely, an isovariant homotopy classification result of G-isovariant maps from free G-manifolds to representation spheres under a certain dimensional condition, the so-called Borsuk-Ulam inequality. In order to prove it, we use equivariant obstruction theory and the multidegree of an isovariant map.

关键词： Hopf classification theorem Borsuk Ulam theorem isovariant map multidegree finitegroup action

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Periodical shedding of cloud cavitation from a single hydrofoil in high-speed cryogenic channel flow

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Journal of Thermal Science 2009年第1期18卷 58-64页

作者： Yutaka ITO Koichi SETO Takao nagasaki Tokyo Institute of Technology

In order to explain criteria for periodical shedding of the cloud cavitation, flow patterns of cavitation around a piano-convex hydrofoil were observed using a cryogenic cavitation tunnel of a blowdown type. Two hydrofoils of similarity of 20 and 60 mm in chord length with two test sections of 20 and 60 mm in width were prepared. Working fluids were water at ambient temperature, hot water and liquid nitrogen. The parameter range was varied between 0.3 and 1.4 for cavitation number, 9 and 17 m/sec for inlet flow velocity, and -8° and 8° for the flow incidence angle, respectively. At incidence angle 8°, that is, the convex surface being suction surface, periodical shedding of the whole cloud cavitation was observed on the convex surface under the specific condition with cavitation number and inlet flow velocity, respectively, 0.5, 9 m/sec for liquid nitrogen at 192℃ and 1.4, 11 m/sec for water at 88℃, whereas under the supercavitation condition, it was not observable. Periodical shedding of cloud cavitation occurs only in the case that there are both the adverse pressure gradient and the slow flow region on the hydrofoil.

关键词： cloud cavitation cryogen visualization hydrofoil

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Gray zone lymphoma effectively treated with cyclophosphamide,doxorubicin,vincristine,prednisolone,and rituximab chemotherapy:A case report

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World Journal of Clinical Cases 2022年第17期10卷 5708-5716页

作者： Nobumasa Hojo Makoto nagasaki Yasuha Mihara Department of General Medicine National Hospital Organization Hamada Medical CenterHamada City 697-8511ShimaneJapan Department of Pathology National Hospital Organization Hamada Medical CenterHamada City 697-8511ShimaneJapan Clinical Resident National Hospital Organization Hamada Medical CenterHamada City 697-8511ShimaneJapan

BACKGROUND B-cell lymphoma,unclassifiable,with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma(BCLu-DLBCL/cHL),also referred to as gray zone lymphoma(GZL),is known to share features with cHL and ***,GZL is often difficult to *** is no consensus regarding the optimal therapeutic *** reported cases of GZL have been in Caucasian and Hispanic individuals,and its incidence is lower in African-American and Asian populations,including the Japanese *** SUMMARY A 69-year-old female presented at our hospital with a growing mass on the right side of her *** elastic,soft mass measuring 9 cm×6 cm was palpable in the right cervical *** analyses showed pancytopenia,increased serum lactate dehydrogenase levels,and markedly increased levels of soluble interleukin-2 *** computed tomography(CT)and fluorodeoxyglucose positron emission tomography(PET)/CT revealed multiple lesions throughout her *** was diagnosed with GZL based on the characteristic pathological findings,the immunophenotype[CD20+,PAX5+,OCT2+/BOB1(focal+),CD30+,CD15-],and the strong positive expression of neoplastic programmed cell death protein ligand 1(PD-L1)in her lymphoma *** lymphoma was stage IV according to the Lugano classification and high-risk according to the International Prognostic Index for aggressive non-Hodgkin *** patient received cyclophosphamide,doxorubicin,vincristine,prednisolone,and rituximab(R-CHOP)chemotherapy because the tumor cells were CD20+.She has remained in complete remission for 3 *** GZL was diagnosed based on histopathology and immunophenotyping with ancillary PD-L1 positivity.R-CHOP chemotherapy was an effective treatment.

关键词： Classical Hodgkin lymphoma Diffuse large B-cell lymphoma Gray zone lymphoma Programmed cell death protein ligand 1 R-CHOP Case report

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A Blowdown Cryogenic Cavitation Tunnel and CFD Treatment for Flow Visualization around a Foil

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Journal of Thermal Science 2005年第4期14卷 346-351页

作者： Yutaka ITO Kazuya SAWASAKI Naoki TANI Takao nagasaki Toshio NAGASHIMA Tokyo Institute of Technology G3-334259Nagatsuta-choMidori-kuYokohama226-8502Japan Honda Motor Co.Ltd. 2-1-1Minami-AoyamaMinato-kuTokyo107-8556Japan Japan Aerospace Exploration Agency 2-1-1SengenTsukuba305-8505Japan University of Tokyo 7-3-1HongoBunkyo-kuTokyo113-8656Japan

Cavitation is one of the major problems in the development of rocket engines. There have been few experimental studies to visualize cryogenic foil cavitation. Therefore a new cryogenic cavitation tunnel of blowdown type was built. The foil shape is “piano-convex”. This profile was chosen because of simplicity, but also of being similar to the one for a rocket inducer impeller. Working fluids were water at room temperature, hot water and liquid nitrogen. In case of Angle of Attack （AOA）=8°, periodical cavity departure was observed in the experiments of both water at 90℃ and nitrogen at -190℃ under the same velocity 10 m/sec and the same cavitation number 0.7. The frequencies were observed to be 110 and 90 Hz, respectively, and almost coincided with those of vortex shedding from the foil. Temperature depression due to the thermodynamic effect was confirmed in both experiment and simulation especially in the cryogenic cavitation.

关键词： cavitation tunnel cryogen CFD visualization simulation foil.

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Synthesis and Binding Properties of Novel Cyclodextrin Dimers Linked at C-6 by the Shortest Bridge-a Sulfur Atom

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Chinese Chemical Letters 1997年第6期8卷 475-476页

作者： De Qi YUAN Kahee FUJITA Yuji OKABE (Faculty of Pharmaceutical Sciences, nagasaki University, Bunkyo-machi 14-1, nagasaki 852, Japan ) nagasaki UNIV FAC PHARMACEUT SCINAGASAKI 852JAPAN

Three cyclodextrin dimers bridged at C-6 by the shortest tether - a sulfur atom are synthesized by reacting cyclodextrin tosylates with Na2S and their binding properties are evaluated

关键词： ppm

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Operational efficiencies and costs of an arm roll forwarder: A case study at Nasu in Tochigi Prefecture, Japan

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Journal of Forestry Research 2013年第3期24卷 577-583页

作者： Kazuhiro Aruga Yuto Otsuka Chikara Nakahata Reiko Yamaguchi Masashi Saito Mayu nagasaki Department of Forest Science Faculty of Agriculture Utsunomiya University350 Mine Utsunomiya 321-8505 Japan Frontier Agriscience and Technology Center Faculty of Agriculture Shinshu UniversityNagano 399-4598 Japan Japan Wood Energy Co. Ltd.Tokyo 198-0036

We investigated a developed arm roll forwarder at Nasu in Tochigi Prefecture, Japan. An arm roll forwarder can only load a steel container that has been fully loaded with logs beforehand, and can later unload such a container. Such a forwarder can shorten the loading and untoading times and improve operational efficiency. We examined two operation systems with an arm roll forwarder and a forwarder. In the first system the loading was done with a grapple-loader. In the second system the loading was done with a processor. The loading times of an arm roll forwarder were significantly tess than those of a forwarder. Because the optimal cycle times （excluding the waiting times for an arm roll for- warder） were significantly reduced, the costs of using an arm roll for- warder are lower, although the loading capacity was small and the hourly operation cost was high. The maximum operational efficiencies varied depending on forwarding distances. The second operation system with an arm roll forwarder exhibited the best operational efficiency within a 1,580-m forwarding distance, and beyond that distance it exhibited the highest operational efficiency when a forwarder was used. Similarly, the cost of operation of the system with an arm roll forwarder was the lowest within a 1,130-m forwarding distance, and beyond that distance the cost was the lowest when using the forwarder. Therefore, the arm roll for- warder is effective within a certain forwarding distance.

关键词： arm roll forwarder steel container operational efficiency cost forwarding distance

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Assessment of Flow Drive by Use of Ion Bernstein Wave on Heliotron J and EAST Devices

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Plasma Science and Technology 2006年第1期8卷 125-128页

作者： YukiTORII HiroyukiOKADA Tetsuo WATARI Hiroki KITAGAWA YasuhiroSUZUKI MasayukiYOKOYAMA 赵燕平 Kazunobu nagasaki Institute of Advanced Energy Kyoto UniversityUjiJapan National Institute for Fusion Science TokiJapan Graduate School of Energy Science Kyoto UniversityKyotoJapan Institute of Plasma Physics Chinese Academy of SciencesHefei 230031China

The possibility of driving poloidal flows by use of ion Bernstein wave is assessed for Heliotron J and EAST devices by means of ray tracing analysis. Sheared poloidal flow is expected to suppress plasma turbulences due to the decorrelation of the waves. In Heliotron J and EAST plasma, the rays of Ion Bernstein Wave travel into the central region with oscillations along the magnetic lines of force and their power is absorbed by ions at the cyclotron resonance layers. The momentum input has been estimated by calculating the momentum change of rays and the poloidal flow has been estimated using neoclassical viscosities. The wave momentum changes its sign as it propagates inward, depositing sheared momentum to the plasma, and therefore causes sheared poloidal flows.

关键词： Heliotron J EAST ion Bernstein wave

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New tomographic reconstruction technique based on Laplacian eigenfunction

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Plasma Science and Technology 2020年第10期22卷 5-9页

作者： Yasuhiro SUZUKI Shishir PUROHIT Satoshi OHDACHI Satoshi YAMAMOTO Kazunobu nagasaki National Institute for Fusion Science Toki 509-5292Japan The Graduate University for Advanced Studies SOKENDAIToki 509-5292Japan Institute for Plasma Research Gandhinagar 382428India Graduate School of Frontier Science The University of TokyoKashiwa 277-8561.Japan Naka Fusion Institute National Institutes for Quantum and Radiological Science and TechnologyNaka 311-0193Japan Institute of Advanced Energy Kyoto UniversityUji 611-0011Japan

This letter proposes a new tomographic reconstruction procedure based on the Laplacian eigenfunction(LEF) patterns, which are independent of the plasma cross-section and do not require the flux surface information. The process is benchmarked for the experimental data of Heliotron J plasma and the results are compared with the least-squares approximation by a Phillips–Tikhonov(PT)-type regularization, which is widely used as the standard technique for tomographic reconstruction. The reconstruction based on the LEF is found to be capable of determining the magnetic axis at different time locations efficiently in comparison with the PT-type regularization.

关键词： tomography Laplacian eigenfunction Heliotron J soft x-ray

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