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Eosinophilic enteritis requiring differentiation from chronic enteropathy associated with SLCO2A1 gene:A case report

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World Journal of Gastroenterology 2023年第11期29卷 1757-1764页

作者： Kantaro Kimura keisuke Jimbo Nobuyasu Arai Masamichi Sato Mitsuyoshi Suzuki Takahiro Kudo Tomonori Yano Toshiaki Shimizu Department of Pediatrics Juntendo University Faculty of MedicineTokyo 113-8421Japan Department of Medicine Jichi Medical UniversityTochigi 329-0498Japan

BACKGROUND Eosinophilic gastrointestinal disease(EGID)is a disorder characterized by infiltration of eosinophils causing mucosal damage and dysfunction of the gastrointestinal *** endoscopic findings of eosinophilic enteritis(EoN),an EGID variant,are nonspecific and occasionally difficult to *** contrast,chronic enteropathy associated with SLCO2A1(CEAS)is a chronic persistent small intestinal disorder characterized by endoscopic findings such as multiple oblique and circular *** SUMMARY We report the case of a 10-year-old boy who had suffered abdominal pain and fatigue for the preceding 6 *** was referred to our institute for investigation of suspected gastrointestinal bleeding because of severe anemia with hypoproteinemia and positive fecal human *** upper and lower gastrointestinal endoscopic findings were normal;however,double-balloon small bowel endoscopy showed multiple oblique and circular ulcers with discrete margins and mild constriction of the intestinal lumen in the *** findings were highly consistent with CEAS,but urine prostaglandin metabolites were within normal limits,and no previously reported mutations in the SLCO2A1 gene were *** evaluation demonstrated moderate to severe eosinophilic infiltration localized to the small intestine suggesting a diagnosis of *** remission was maintained with montelukast and a partial elemental diet,but emergent surgery for bowel obstruction due to small intestinal stenosis was performed two years after the initial *** EoN should be considered in the differential diagnosis of CEAS-like small intestinal ulcerative lesions and normal urinary prostaglandin metabolite levels.

关键词： Anemia Chronic enteropathy associated with SLCO2A1 Double-balloon endoscopy Eosinophilic gastrointestinal disease Hypoproteinemia Case report

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An ever-increasing metabolic dysfunction-associated fatty liver disease-related hepatocellular carcinoma:what are problems and countermeasures?

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Hepatobiliary Surgery and Nutrition 2023年第6期12卷 941-944页

作者： Shigeo Shimose Tsubasa Tsutsumi Dan Nakano Tomoya Sano keisuke Amano Takumi Kawaguchi Division of Gastroenterology Department of MedicineKurume University School of MedicineKurumeJapan

Hepatocellular carcinoma(HCC)is the third leading cause of cancer deaths worldwide(1).HCC has been classified into viral or non-viral HCC according to the etiology and the incidence of viral HCC is *** contrast,the incidence of non-viral HCC is increasing and fatty liver is becoming a major etiology for the *** 2020,a new concept of fatty liver disease,metabolic dysfunction-associated fatty liver disease(MAFLD).

关键词： Hepatoma hepatic steatosis metabolic syndrome viral hepatitis lenvatinib(LEN)

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Degradation diagnosis of lithium-ion batteries using AC impedance technique in fixing the state of charge of an electrode

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Journal of Energy Chemistry 2021年第2期30卷 285-289,I0010页

作者： keisuke Ando Tomoyuki Matsuda Daichi Imamura E-Mobility Research Division Japan Automobile Research Institute2530 KarimaTsukubaIbaraki 305-0822Japan

A sustainable society requires an increase in electrified vehicles(xEVs) with a low environmental impact. Among various types of xEVs, battery electric vehicles (BEVs) with lithium-ion batteries(LIBs) have received co... 详细信息

关键词： Degradation diagnosis AC impedance dV/dQ curve analysis Lithium-ion battery Non-destructive analysis

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Unlocking the secrets of the invisible world:incredible deep optical imaging through in-silico clearing

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光:科学与应用(英文版) 2023年第8期12卷 1439-1440页

作者： Ting-Hui Xiao Yuqi Zhou keisuke Goda Henan Key Laboratory of Diamond Optoelectronic Materials and Devices School of Physics and MicroelectronicsZhengzhou UniversityZhengzhou 450052China Institute of Quantum Materials and Physics Henan Academy of SciencesZhengzhou 450046China Department of Chemistry School of ScienceThe University of TokyoTokyo 113-0033Japan institute of Technological Sciences Wuhan UniversityWuhan 430072China Department of Bioengineering University of CaliforniaLos AngelesCA 90095USA

In-silico clearing enables deep optical imaging of biological samples by correcting image blur caused by scattering and *** breakthrough method offers researchers unprecedented insights into three-dimensional biological systems,with enormous potential for advancing biology and medicine to better understand living organisms and human health.

关键词： clearing visible breakthrough

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Ore-forming mechanism for the Xiaoxinancha Au-rich Cu deposit in Yanbian,Jilin Province,China:Evidence from noble gas isotope geochemistry of fluid inclusions in minerals

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Science China Earth Sciences 2008年第2期51卷 216-228页

作者： keisuke Nagao HIROCHIKA Sumino Laboratory for Earthquake Chemistry Graduate School of Science The University of Tokyo Tokyo 7-3-1 Japan

The Xiaoxinancha Au-rich copper deposit is one of important Au-Cu deposits along the continental margin in Eastern China. The deposit consists of two sections: the Beishan mine (North), composed of altered rocks with veinlet-dissemination sulfides and melnicovite-dominated sulfide-quartz veins, and the Nanshan mine (South), composed of pyrrhotite-dominated sulfide-quartz veins and pure sulfide veins. The isotope compositions of noble gases extracted from fluid inclusions in ore minerals, i.e. ratios of 3He/4He, 20Ne/22Ne and40Ar/36Ar are in the ranges of 4.45―0.08 Ra, 10.2―8.8 and 306―430, respectively. Fluid inclusions in minerals from the Nanshan mine have higher 3He/4He and 20Ne/22Ne ratios whereas those from the Beishan mine have lower 3He/4He ratios. The analysis of origin, and evolution of the ore fluids and its relations with the ore-forming stages and the ages of mineralization suggests that the initial hydrothermal fluids probably come from the melts generated by partial melting of oceanic crust with the participation of fluids from the mantle (mantle-plume type)/aesthenosphere. This also corresponds to the continental margin settings during the subduction of Izanagi ocaneic plate towards the palaeo-Asian continent (123―102 Ma). The veinlet-dissemination ore bodies of the Beishan mine were formed through replacement and crystallization of the mixed fluids generated by mixing of the ascending high-temperature boiling fluid with young crustal fluid whereas the melnicovite-dominated sulfide-quartz veins were formed subsequently by filling of the high-temperature ore fluid in fissures. Pyrrhotite-dominated sulfide-quartz veins in the Nanshan mine were formed by filling-deposition-crystallization of the moderate-temperature ore fluids and the pure sulfide veins were formed later by filling-deposition-crystallization of ore substance-rich fluids after boiling of the moderate-temperature ore fluids. The metallogenic dynamic processes can be summarized as: (1) form

关键词： Au-rich Cu deposit fluid inclusion He-Ne-Ar isotopes ore-forming mechanism Xiaoxinancha Yanbian

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Numerical Investigation on Super-cooled Large Droplet Icing of Fan Rotor Blade in Jet Engine

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Journal of Thermal Science 2014年第5期23卷 432-437页

作者： keisuke Isobe Masaya Suzuki Makoto Yamamoto Graduate School of Mechanical Engineering Tokyo University of Science6-3-1 NiijukuKatsushika-kuTokyo125-8585Japan Aviation Program Group Japan Aerospace Exploration Agency(JAXA)7-44-1 Jindaiji Higashi-machiChofu-shiTokyo182-8522Japan Department of Mechanical Engineering Tokyo University of Science6-3-1 NiijukuKatsushika-kuTokyo125-8585Japan

Icing(or ice accretion) is a phenomenon in which super-cooled water droplets impinge and accrete on a *** is well known that ice accretion on blades and vanes leads to performance degradation and has caused severe *** various anti-icing and deicing systems have been developed,such accidents still ***,it is important to clarify the phenomenon of ice accretion on an aircraft and in a jet ***,flight tests for ice accretion are very expensive,and in the wind tunnel it is difficult to reproduce all climate conditions where ice accretion can ***,it is expected that computational fluid dynamics(CFD),which can estimate ice accretion in various climate conditions,will be a useful way to predict and understand the ice accretion *** the other hand,although the icing caused by super-cooled large droplets(SLD) is very dangerous,the numerical method has not been established *** is why SLD icing is characterized by splash and bounce phenomena of droplets and they are very complex in *** the present study,we develop an ice accretion code considering the splash and bounce phenomena to predict SLD icing,and the code is applied to a fan rotor *** numerical results with and without the SLD icing model are *** this study,the influence of the SLD icing model is numerically clarified.

关键词：喷气发动机数值模拟转子叶片结冰计算流体动力学雾滴冷却风机

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Insights into genetic variation and demographic history of sharpnose rays:examinations of three species of Telatrygon(Elasmobranchii,Dasyatidae)from the Indo-West Pacific

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Integrative Zoology 2022年第6期17卷 1063-1077页

作者： Jiwei QI Fanglei SHI Baowei ZHANG Xiao CHEN Jie XING keisuke FURUMITSU Joel B.CORUSH Atsuko YAMAGUCHI Jie ZHANG Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijingChina School of Life Science Anhui UniversityHefeiAnhuiChina College of Marine Sciences South China Agricultural UniversityGuangzhouChina East China Sea Centre of Standard and Metrology SOAShanghaiChina Faculty of Fisheries Nagasaki UniversityNagasakiJapan Illinois Natural History Survey University of Illinois Champaign-UrbanaChampaignIllinoisUSA State Key Laboratory of Marine Resource Utilization in South China Sea Hainan UniversityHaikouChina

Coastal and demersal chondrichthyans(sharks,rays,and skates)are expected to exhibit high levels of genetic differentiation in areas of complex *** genetic studies investigating the extent to which demographic history shapes the genetic structure of theseﬁshes are ***,we combined mitochondrial DNA(Cytb and ND2)and 8 nuclear microsatellite loci from 244 individuals to examine the population genetic structure and demographic history of the 3 Indo-West Paciﬁc species of sharpnose rays(Telatrygon zugei,Telatrygon biasa,and Trygon crozieri).High levels of genetic variation both within and between species were identiﬁ*** analysis partitioned haplotypes into 2 lineages supporting divergence of *** from *** and *** during the ***,microsatellite-based clustering analyses identiﬁed 4 genetic groups(*** from Japan,*** from coastal China,*** from Gulf of Thailand,and *** from the Andaman Sea).Measurements of genetic differentiation also support these 4 ***,Pleistocene demographic expansions were examined in all genetic *** climate oscillations and current hydrologic cycles in the Indo-West Paciﬁc appear to coincide with the hypothesis regarding speciation and the observed demographic history trends of the sharpnose *** the species group has,until recently,been thought to be one species,these results are critical for deﬁning management units and guiding conservation efforts to preserve stingray biodiversity.

关键词： conservation biodiversity of stingray demographic history genetic variation Indo-West Paciﬁc Telatrygon

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Precise analysis of compressive strain effects on electric power generation properties of a lead zirconate titanate piezoelectric ceramic

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Journal of Advanced Ceramics 2016年第1期5卷 35-39页

作者： Mitsuhiro OKAYASU keisuke WATANABE Graduate School of Natural Science and Technology Okayama University 3-1-1 Tsushimanaka Kita-kuOkayama 700-8530 Japan Graduate School of Science and Engineering Ehime University 3 Bunkyo-cho MatsuyamaEhime 790-8577 Japan

Electric power generation characteristics of lead zirconate titanate (PZT) piezoelectric ceramic have been examined during cyclic loading with different compressive strain value. A thin PZT ceramic plate attached to a thin brass plate was used. With an increasing compressive strain value in the PZT ceramic plate, the electric voltage increased, and the highest electric voltage was obtained for the sample with the high strain level (0.4%). The electric voltage decreased for the sample with more than 0.45% strain because of the failure in the PZT ceramic. The electric voltage was different depending on the strain condition, where the higher strain and the wider strain range (Δε) made the high electric voltage. Moreover, the electric voltage was attributed to the strain rate, where the higher strain rate made higher electric voltage due to high kinetic energy. The electric generation characteristics could be estimated with an operation of the strain value and strain ratio (εmin/εmax) especially for the sample loaded cyclically under the slow loading speed. This was affected by the linear correlation between the electric voltage and the strain value. Based upon the experimental work, suitable loading condition to make high electric voltage could be proposed.

关键词： energy harvesting piezoelectric ceramic cyclic loading electric power generation

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Lymphocyte-to-monocyte ratio is a short-term predictive marker of ulcerative colitis after induction of advanced therapy

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Gastroenterology Report 2022年第1期10卷 370-376页

作者： Natsuki Ishida Yusuke asai Takahiro Miyazu Satoshi Tamura Shinya Tani Mihoko Yamade Moriya Iwaizumi Yasushi Hamaya Satoshi Osawa Takahisa Furuta Ken Sugimoto First Department of Medicine Hamamatsu University School of MedicineHamamatsuShizuokaJapan Department of Endoscopic and Photodynamic Medicine Hamamatsu University School of MedicineHamamatsuShizuokaJapan Department of Laboratory Medicine Hamamatsu University School of MedicineHamamatsuShizuokaJapan Center for Clinical Research Hamamatsu University School of MedicineHamamatsuShizuokaJapan

Advanced therapies for patients with mild-to-severe ulcerative colitis(UC)may result in treatment *** examined whether the lymphocyte-to-monocyte ratio(L/M ratio)could predict the failure of advanced *** retrospective,observational,cohort study included 73 patients who were treated with advanced therapies at the Hamamatsu University School of Medicine(Shizuoka,Japan)between February 2011 and November *** patients were divided into the nonfailure and failure groups,and their leukocyte counts and ratios before induction were *** and multivariate analyses were performed to identify the prognostic *** therapies failed within 3 months in 15(20.5%)*** the L/M ratio was significantly lower in the failure group than in the non-failure group(P=0.004).Receiveroperating characteristic(ROC)curve analysis revealed that an L/M ratio of ≤3.417 was predictive of treatment failure;the area under the curve(AUC)was 0.747(95%CI,0.620–0.874).Kaplan–Meier analysis revealed that the failure-free rate was significantly lower in the group with an L/M ratio of≤3.417 than in the group with an L/M ratio of>3.417(log-rank test P=0.002).Cox proportional hazard regression analysis identified an L/M ratio of≤3.417 as an independent risk factor for failure within 3 months after the induction of advanced ***,ROC analysis of patients who did not receive immunomodulators also revealed that the cut-off L/M ratio was 3.417 and the AUC was 0.796(95%CI,0.666–0.925).In patients receiving advanced therapies for active UC,the L/M ratio can predict treatment failure within 3 months.L/M ratios could facilitate the transition from advanced therapies to subsequent treatments.

关键词： advanced therapy failure lymphocyte-to-monocyte ratio ulcerative colitis

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Precipitation of Icosahedral Quasicrystalline Phase, R-phase and Laves Phase in Ferritic Alloys

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材料热处理学报 2004年第5期25卷 229-233页

作者： keisuke Yamamoto Yoshisato Kimura Yoshinao Mishima Department of Materials Science and Engineering Tokyo Institute of Technology Yokohama JapanDepartment of Materials Science and Engineering Tokyo Institute of Technology Yokohama JapanDepartment of Materials Science and Engineering Tokyo Institute of Technology Yokohama Japan

Ferritic heat resistant steels involving precipitation of intermetallic phases have drawn a growing interest for the enhancement of creep strength, while the brittleness of the intermetallic phases may lower the toughness of the alloy. Therefore, it is necessary to optimize the dispersion characteristics of the intermetallics phase through microstructural control to minimize the trade-off between the strength and toughness. The effects of -Fe matrix substructures on the precipitation sequence, morphology, dispersion characteristics, and the stability of the intermetallic phases are investigated in Fe-Cr-W-Co-Si system. The precipitates of the Si-free Fe-10Cr-l.4W-4.5Co (at%) alloy aged at 873K are the R-phase but those of the Si-added Fe-10Cr-l.4W-4.5Co-0.3Si (at%) alloy are the icosahedral quasicrystalline phase. The precipitates in both the Si-free and Si-added alloys aged at 973K are the Laves phase. Matrix of the alloys is controlled by heat treatments as to provide three types of matrix substructures; ferrite, ferrite/martensite mixture and martensite. The hardening behavior of the alloys depends on the matrix substructures and is independent of the kinds of precipitates. In the alloys with ferrite matrix, the peak of hardness during aging at 873K shifts to longer aging time in comparison with that in the alloys with lath martensite matrix which contain numbers of nucleation sites.

关键词：过渡电子扫描仪准晶体 R相拉夫斯相铁素体钢

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