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KDM2B promotes cell viability by enhancing DNA damage response in canine hemangiosarcoma

Journal of Genetics and Genomics 2021年第7期48卷 618-630页

作者： Kevin Christian Montecillo Gulay keisuke aoshima Yuki Shibata Hironobu Yasui Qin Yan Atsushi Kobayashi Takashi Kimura Laboratory of Comparative Pathology Department of Clinical SciencesFaculty of Veterinary MedicineHokkaido UniversitySapporoHokkaido 060-0818 Japan Laboratory of Radiation Biology Department of Applied Veterinary SciencesFaculty of Veterinary MedicineHokkaido UniversitySapporoHokkaido 060-0818 Japan Department of Pathology Yale School of MedicineNew HavenCT 06510USA

Epigenetic regulators have been implicated in tumorigenesis of many types of cancer;however,their roles in endothelial cell cancers such as canine hemangiosarcoma(HSA)have not been studied.In this study,we find that lysine-specific demethylase 2 b(KDM2 B)is highly expressed in HSA cell lines compared with normal canine endothelial cells.Silencing of KDM2 B in HSA cells results in increased cell death in vitro compared with the scramble control by inducing apoptosis through the inactivation of the DNA repair pathways and accumulation of DNA damage.Similarly,doxycycline-induced KDM2 B silencing in tumor xenografts results in decreased tumor sizes compared with the control.Furthermore,KDM2 B is also highly expressed in clinical cases of HSA.We hypothesize that pharmacological KDM2 B inhibition can also induce HSA cell death and can be used as an alternative treatment for HSA.We treat HSA cells with GSK-J4,a histone demethylase inhibitor,and find that GSK-J4 treatment also induces apoptosis and cell death.In addition,GSK-J4 treatment decreases tumor size.Therefore,we demonstrate that KDM2 B acts as an oncogene in HSA by enhancing the DNA damage response.Moreover,we show that histone demethylase inhibitor GSK-J4 can be used as a therapeutic alternative to doxorubicin for HSA treatment.

关键词： DNA repair Epigenetics Hemangiosarcoma KDM2B Oncogene

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Investigation and prediction of enteral nutrition problems after percutaneous endoscopic gastrostomy

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World Journal of Gastroenterology 2009年第11期15卷 1367-1372页

作者： Shiro Yokohama Masaru aoshima Yukiomi Nakade Junya Shindo Junichi Maruyama Masashi Yoneda Department of Gastroenterology Asahikawa Rehabilitation HospitalAsahikawa078-8801Japan Division of Gastro-enterology Department of Internal MedicineAichi Medical University School of MedicineAichi 480-1195Japan Department of Rehabilitation Asahikawa Rehabilitation HospitalAsahikawa 078-8801Japan Department of Internal Medicine Asahikawa Rehabilitation HospitalAsahikawa 078-8801Japan

AIM:To investigate and predict enteral nutrition problems after percutaneous endoscopic gastrostomy (PEG). METHODS:We retrospectively analyzed data for 252 out of 285 patients who underwent PEG at our hospital from 1999 to 2008.Enteral nutrition problems after PEG were defined as:(1)patients who required ≥1 mo after surgery to switch to complete enteral nutrition,or who required additional parenteral alimentation continuously;or(2)patients who abandoned switching to enteral nutrition using the gastrostoma and employed other nutritional methods. We attempted to identify the predictors of problem cases by using a logistic regression analysis that examined the patients’backgrounds and the specific causes that led to their problems. RESULTS:Mean age of the patients was 75 years,and in general,their body weight was low and their overall condition was markedly poor.Blood testing revealed that patients tended to be anemic and malnourished.A total of 44 patients(17.5%)were diagnosed as having enteral nutrition problems after PEG.Major causes ofthe problems included pneumonia,acute enterocolitis (often Clostridium difficile-related),paralytic ileus and biliary tract infection.A multivariate analysis identified the following independent predictors for problem cases:(1)enteral nutrition before gastrectomy(a risk reduction factor);(2)presence of esophageal hiatal hernia;(3)past history of paralytic ileus;and(4) presence of chronic renal dysfunction. CONCLUSION:Enteral nutrition problems after PEG occurred at a comparatively high rate.Patient background analysis elucidated four predictive factors for the problem cases.

关键词：经皮内镜下胃造瘘术全肠内营养营养问题预测因素 Logistic回归分析麻痹性肠梗阻慢性肾功能不全聚乙二醇

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Facile and Scalable Synthesis of a Highly Hydroxylated Water-Soluble Fullerenol as a Single Nanoparticle

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Nano Research 2011年第2期4卷 204-215页

作者： Ken Kokubo Shogo Shirakawa Naoki Kobayashi Hisae aoshima Takumi Oshima Division of Applied Chemistry Graduate School of Engineering Osaka University Suita Osaka 565-0871 Japan Vitamin C60 BioResearch Corporation 1-3-19 Yaesu Chuo-ku Tokyo 103-0028 Japan

水溶性的 polyhydroxylated fullerene，即 fullerenol 与 44 个氢氧根组和 8 个第二等的界限水分子一起， C60 (哦)

关键词：水溶性多羟基合成纳米可扩展扫描探针显微镜简便相转移催化剂

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Surface modification of stratum corneum for drug delivery and skin care by microplasma discharge treatment

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Plasma Science and Technology 2019年第6期21卷 1-8页

作者： J KRISTOF T aoshima M BLAJAN K SHIMIZU Graduate School of Science and Technology Shizuoka University 432-8561 Hamamatsu Japan Department of Electrical and Electronic Engineering Shizuoka University 432-8561 Hamamatsu Japan Organization for Innovation and Social Collaboration Shizuoka University 432-8561 Hamamatsu Japan

Human skin is the largest organ and also the main barrier that prevents foreign substances from entering the body.The surface properties of the skin are relevant for transdermal drug delivery and cosmetics.Yucatan micropig skin is used as a substitute for human skin.A microplasma electrode is used for surface modification of the skin epidermal layer of the Yucatan micropig.Microplasma dielectric barrier discharge has a thin dielectric as a barrier (~50 μm) and a frequency of 25 kHz.The surface properties of the epidermal layer were characterized by the measurement of the contact angle of the water droplet.The effects of different gases such as air,nitrogen,oxygen,helium or argon were compared.The change of the contact angle is temporal and it is returned to its initial state after several hours.Among the gases used for plasma ignition,oxygen and argon were the most effective for skin treatment.The distance of the skin from the electrode and the treatment time played a crucial roles in the increasing water contact angle.Changes of surface atomic concentration were determined by x-ray photoelectron spectroscopy.After microplasma treatment,the oxygen and nitrogen concentration increased at the skin surface.

关键词： microplasma contact angle skin stratum corneum XPS

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神秘小镇大冒险

神秘小镇大冒险

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1000年

作者： John aoshima

来源：畅想之星图书光盘版（南... 评论

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Inhibitory effect of angiotensinⅡreceptor antagonist on hepatic stellate cell activation in non-alcoholic steatohepatitis

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World Journal of Gastroenterology 2006年第2期12卷 322-326页

作者： Shiro Yokohama Yoshihiko Tokusashi Kimihide Nakamura Yosui Tamaki Satoshi Okamoto Mituyoshi Okada Kazunobu Aso Takenao Hasegawa Masaru aoshima Naoyuki Miyokawa Masakazu Haneda Masashi Yoneda Second Department of Medicine Asahikawa Medical CollegeAsahikawaJapan Department of Surgical Pathology Asahikawa Medical CollegeAsahikawaJapan Health Care Administration Center Obihiro University of Agriculture and Veterinary MedicineObihiroJapan Department of Gastroenterology Dokkyo University School of MedicineMibuJapan

AIM: To investigate the efficacy of angiotensinⅡreceptor antagonist on hepatic stellate cells (HSCs) activation in the patients with non-alcoholic steatohepatitis (NASH). METHODS: Seven patients with NASH were prescribed losartan, a selective angiotensinⅡtype 1 receptor antagonist (50 mg/d) for 48 wk. Liver biopsies were performed both at the entry and end of the study in all patients. Quiescent and activated HSCs were identified by double immunostaining using anti-p75 andα-smooth muscle actin antibodies, and the number of each phenotype was counted. Similarly, the liver specimens obtained from the eight patients with non-alcoholic fatty liver (NAFL) were also examined as controls. RESULTS: In NASH hepatic tissues, activated HSCs were dominantly distributed as compared with those in NAFL. The 48-wk losartan treatment induced a remarkable decrease in activated HSCs and a mild increase in quiescent phenotypes. CONCLUSION: Our data suggest the crucial involvement of HSCs in anti-fibrotic effect of angiotensinⅡreceptor antagonist on patients with NASH.

关键词： NASH NAFLD 肝纤维化 HSC 血管紧张素

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联合国教科文组织驻北京办事处贺信

联合国教科文组织驻北京办事处贺信

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“民族文化与全球化”学术研讨会

作者： Y.aoshima 联合国教科文组织北京办事处

＜正＞尊敬的各位领导、学者和来宾们: 我很荣幸能够为“民族文化与全球化”研讨会的胜利召开致以诚挚的祝贺。此外,我也要借此机会为中国民族学会和云南大学在全球化的今天能够认识到文化多样性的价值并为之做出的努力表示祝贺。

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长空气间隙的冲击闪络特性及大气因素的校正

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高压电器 1979年第3期 43-50页

作者： AIHARA·HARADA·aoshima·ITO 王勇武日

棒一棒及棒一板类长空气间隙的闪络电压,随着冲击电压的波形、极性、间隙距离及大气条件等因素的不同而改变。本文是对正、负极性各种冲击波形下闪络特性的分析处理及其所测得的结果。这些闪络特性,是在日本电力工业中央研究所(CRIEPI... 详细信息

棒一棒及棒一板类长空气间隙的闪络电压,随着冲击电压的波形、极性、间隙距离及大气条件等因素的不同而改变。本文是对正、负极性各种冲击波形下闪络特性的分析处理及其所测得的结果。这些闪络特性,是在日本电力工业中央研究所(CRIEPI)等许多试验室中测得的。在闪络电压及上面所提到的诸因素间,得到了新的通用关系式,由此式可确定在各种试验条件下的闪络电压。

关键词：冲击闪络电压间隙距离波头时间长空气间隙间隙(电器) 闪络特性

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