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Case Report: Asymptomatic Osteosarcoma

Case Reports in Clinical Medicine 2015年第12期4卷 369-375页

作者： Reiko Yamaguchi Seiichi Matsumoto keisuke ae Taisuke Tanizawa Tabu Gokita Keiko Hayakawa Yuki Funauchi Munehisa Kito Hirotada Ishii Noriko Motoi Department of Orthopaedic Surgery Cancer Institute Hospital Tokyo Japan Ishii Orthopaedic Clinic Tokyo Japan Division of Pathology Cancer Institute Hospital Tokyo Japan

Osteosarcomas are primary malignant tumors that are characterized by the production of osteoid or immature bone. However they are the most common primary malignant tumor of bone in adolescents and young adults, the diagnosis of osteosarcoma is often delayed. It is because of the rarity of population, the variety of findings, nonspecific symptoms and so on. A 46-year-old male patient had left knee pain for 3 months without any symptoms in his right knee. At a nearby clinic, X-ray of his healthy side was taken by chance. The irregular bone formation was however seen in the metaphysis of the distal femur with spreading into the soft tissues. No abnormal findings were pointed out at his left side knee. A diagnosis of pleomorphic sarcoma was made by incisional biopsy. Pulmonary CT showed multiple nodules which were considered as multiple lung metastases. He was diagnosed as right femoral sarcoma, clinical stage IV (T1N0M1a) by TNM classification. He underwent preoperative chemotherapy, followed by limb-saving operation. No preoperative complaints were found in his left knee. Final diagnosis of surgically resected specimen was osteoblastic osteosarcoma which showed neoplastic osteoid formation within pleomorphic malignant cells. However, osteosarcomas occurred in adult populations are sometimes occurred as a secondary neoplasms, he had a history of diabetes but no other medical history, such as radiation therapy for a solid cancer, Paget’s disease, other benign bone lesions or inherited conditions. As far as our knowledge, we believe that this is a first case report of asymptomatic incidental osteosarcoma.

关键词： Incidental Osteosarcoma Asymptomatic Osteosarcoma De Novo Osteosarcoma

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Life-threatening stress-induced cardiomyopathy combined with acute adrenal crisis

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Journal of Geriatric Cardiology 2017年第6期14卷 423-424页

作者： ae-Young Her Yong Hoon Kim Division of Cardiology Department of Internal Medicine Kangwon National University School of Medicine Chuncheon South Korea

Stress-induced cardiomyopathy, also known as Takotsubo cardiomyopathy and left ventricular apical ballooning syndrome, is characterized by transient systolic dysfunction of the apical and mid-segments of the left ventricle with the abscence of coronary occlusion, This disease typically occurs in postmenopausal women of an advanced age after emotional or physical stress. Although the prognosis is generally favorable, acute fatal complications have been reported in a small subset of patients. Some patients died with acute cardiac complications, on the other hand, other patients died with underlying critical illness which triggered stress-induced cardiomyopathy.

关键词： Adrenal crisis Cardiomyopathy

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Synthesis, characterization and electrocatalytic studies of palladium–manganese oxyhydroxide nanocomposite towards direct ethylene glycol fuel cell

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Chinese Science Bulletin 2014年第27期59卷 3413-3419页

作者： Ramanujam Kannan ae Rhan Kim Dong Jin Yoo R&D Education Center for Specialized Graduate School of Hydrogen and Fuel Cells Engineering Chonbuk National University Chonju Joellabuk-do 561-756 Korea Department of Energy Storage/Conversion Engineering Hydrogen and Fuel Cell Research Center Graduate SchoolChonbuk National University Chonju Joellabuk-do 561-756Korea Department of Chemistry Chonbuk National UniversityChonju Joellabuk-do 561-756 Korea

The palladium nanoparticle grafted manganese oxyhydroxide nanorod(MON) electrocatalyst has been synthesized and tested for the electrooxidation of ethylene glycol(EG) in an alkaline medium. The MON was prepared using the hydrothermal method and the Pd nanoparticles were coated on the MON using an in situ reduction method. The nanocatalyst thus prepared was characterized by powder X-ray diffraction, scanning electron microscopy, high resolution transmission electron microscopy, energy dispersive X-ray spectroscopy and electrochemical methods. The microscopic studies confirm the formation of MON and reveal that the Pd nanoparticles were grafted uniformly on the MON. In the voltammetric studies, the Pd/MON catalyst exhibited a six-fold improved peak current for ethylene glycol electrooxidation compared with the C/Pd. The EG electrooxidation reaction performances of the Pd/MON nanocatalyst in the alkaline solutions containing different quantities of EG were tested through cyclic voltammetry. The catalytic removal of the poisonous intermediates formed during electrooxidation of EG was explained. The present study shows that MON can act as an active support for the Pd nanocatalyst.

关键词：钯纳米粒子氢氧化锰乙二醇化学研究燃料电池纳米复合合成高分辨透射电子显微镜

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Prediction of Typhoon Tracks Using Dynamic Linear Models

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Advances in Atmospheric Sciences 2003年第3期20卷 379-384页

作者： Keon-Tae SOHN H.Joe KWON ae-Sook SUH Pusan KongjuMeteorological Research Institute//KMA National UniversityPusan609-735KoreaNational UniversityKonju314-701KoreaSeoul156-010Korea

This paper presents a study on the statistical forecasts of typhoon tracks. Numerical models have their own systematic errors, like a bias. In order to improve the accuracy of track forecasting, a statistical model called DLM (dynamic linear model) is applied to remove the systematic error. In the analysis of typhoons occurring over the western North Pacific in 1997 and 2000, DLM is useful as an adaptive model for the prediction of typhoon tracks.

关键词： typhoon track forecast systematic error dynamic linear model

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X region mutations of hepatitis B virus related to clinical severity

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World Journal of Gastroenterology 2016年第24期22卷 5467-5478页

作者： Hong Kim Seoung-ae Lee Bum-Joon Kim Department of Biomedical Sciences Microbiology and Immunology Liver Research Institute and Cancer Research Institute College of Medicine Seoul National University

Chronic hepatitis B virus (HBV) infection remains a major health problem, with more than 240 million people chronically infected worldwide and potentially 650000 deaths per year due to advanced liver diseases including liver cirrhosis and hepatocellular carcinoma (HCC). HBV-X protein (HBx) contributes to the biology and pathogenesis of HBV via stimulating virus replication or altering host gene expression related to HCC. The HBV X region contains only 465 bp encoding the 16.5 kDa HBx protein, which also contains several critical cis-elements such as enhancer II, the core promoter and the microRNA-binding region. Thus, mutations in this region may affect not only the HBx open reading frame but also the overlapped cis-elements. Recently, several types of HBx mutations significantly associated with clinical severity have been described, although the functional mechanism in most of these cases remains unsolved. This review article will mainly focus on the HBx mutations proven to be significantly related to clinical severity via epidemiological studies.

关键词： Hepatitis B virus infection Hepatitis B virus-X protein mutation Hepatocellular carcinoma Clinical severity

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Spatio-temporal variability in sea surface wind stress near and off the east coast of Korea

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Acta Oceanologica Sinica 2005年第1期24卷 107-114页

作者： NAM SungHyun KIM Young Ho PARK Kyung-ae KIM Kuh Ocean Laboratory/RIO School of Earth and Environmental Sciences Seoul National University Seoul 151-742 KoreaOcean Laboratory/RIO School of Earth and Environmental Sciences Seoul National University Seoul 151-742 KoreaOcean Laboratory/RIO School of Earth and Environmental Sciences Seoul National University Seoul 151-742 KoreaOcean Laboratory/RIO School of Earth and Environmental Sciences Seoul National University Seoul 151-742 Korea

Sea surface wind stress variabilities near and off the east coast of Korea, are examined using 7 kinds of wind datasets from measurements at 2 coastal (land) stations and 2 ocean buoys,satellite scatterometer (QuikSCAT), and global reanalyzed products (ECMWF,NOGAPS,and NCEP/NCAR). Temporal variabilities are analyzed at 3 frequency bands; synoptic (2-20 d), intra-seasonal (20-90 d),and seasonal (>90 d).Synoptic and intra-seasonal variations are predominant near and off the Donghae City due to the passage of the mesoscale weather system. Seasonal variation is caused by southeastward wind stress during Asian winter monsoon. The sea surface wind stress from reanalyzed *** and KMA-B measurements off the coast show good agreement in the magnitude and direction,which are strongly aligned with the alongshore *** the land-based sites,wind stresses are much weaker by factors of 3-10 due to the mountainous landmass on the east parts of Korea *** first EOF modes(67%-70%) of wind stresses from reanalyzed and QuikSCAT data have similar structures of the strong southeastward wind stress in winter along the coast but show different curl structures at scales less than 200 km due to the orographic *** second EOF modes (23%-25%) show southwestward wind stress in every September along the east coast of the North Korea

关键词： sea surface wind stress spatio-temporal variability monsoon seasonal intra-seasonal synoptic band orographic effect

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Fast-track program vs traditional care in surgery for gastric cancer

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World Journal of Gastroenterology 2014年第2期20卷 578-583页

作者： Zhi-Xing Chen ae-Huey Jennifer Liu Ying Cen Department of Burns and Plastic Surgery West China HospitalSichuan University

AIM:To systematically review the evidence for the effectiveness of fast-track program vs traditional care in laparoscopic or open surgery for gastric ***:PubMed,Embase and the Cochrane library databases were electronically searched for published studies between January 1995 and April 2013,and only randomized trials were *** references of relevant studies were manually searched for further studies that may have been *** terms included"gastric cancer","fast track"and"enhanced recovery".Five outcome variables were considered most suitable for analysis:postoperative hospital stay,medical cost,duration to first flatus,C-reactive protein(CRP)level and *** hospital stay was calculated from the date of operation to the date of *** effects model was used for ***:Compared with traditional care,fasttrack program could significantly decrease the postoperative hospital stay[weighted mean difference(WMD)=-1.19,95%CI:-1.79--0.60,P=0.0001,fixed model],duration to first flatus(WMD=-6.82,95%CI:-11.51--2.13,P=0.004),medical costs(WMD=-2590,95%CI:-4054--1126,P=0.001),and the level of CRP(WMD=-17.78,95%CI:-32.22--3.35,P=0.0001)in laparoscopic surgery for gastric *** open surgery for gastric cancer,fast-track program could also significantly decrease the postoperative hospital stay(WMD=-1.99,95%CI:-2.09--1.89,P=0.0001),duration to first flatus(WMD=-12.0,95%CI:-18.89--5.11,P=0.001),medical cost(WMD=-3674,95%CI:-5025--2323,P=0.0001),and the level of CRP(WMD=-27.34,95%CI:-35.42--19.26,P=0.0001).Furthermore,fast-track program did not significantly increase the incidence of complication(RR=1.39,95%CI:0.77-2.51,P=0.27,for laparoscopic surgery;and RR=1.52,95%CI:0.90-2.56,P=0.12,for open surgery).CONCLUSION:Our overall results suggested that compared with traditional care,fast-track program could result in shorter postoperative hospital stay,less medical costs,and lower level of CRP,with no more complicatio

关键词： Fast-track program Traditional care Gastric cancer Meta-analysis Laparoscopic and open surgery

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Corticoreticular tract lesion in children with developmental delay presenting with gait dysfunction and trunk instability

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Neural Regeneration Research 2017年第9期12卷 1465-1471页

作者： Yong Min Kwon Jessica Rose ae Ryoung Kim Su Min Son Department of Physical Medicine and Rehabilitation College of Medicine Yeungnam University Department of Orthopedic Surgery College of Medicine Stanford University

The corticoreticular tract （CRT） is known to be involved in walking and postural control. Using diffusion tensor tractography （DTT）, we investigated the relationship between the CRT and gait dysfunction, includ- ing trunk instability, in pediatric patients. Thirty patients with delayed development and 15 age-matched, typically-developed （TD） children were recruited. Fifteen patients with gait dysfunction （bilateral trunk instability） were included in the group A, and the other 15 patients with gait dysfunction （unilateral trunk instability） were included in the group B. The Growth Motor Function Classification System, Functional Ambulation Category scale, and Functional Ambulation Category scale were used for measurement of functional state. Fractional anisotropy, apparent diffusion coefficient, fiber number, and tract integrity of the CRT and corticospinal tract were measured. Diffusion parameters or integrity of corticospinal tract were not significantly different in the three study groups. However, CRT results revealed that both CRTs were disrupted in the group A, whereas CRT disruption in the hemispheres contralateral to clinical mani- festations was observed in the group B. Fractional anisotropy values and fiber numbers in both CRTs were decreased in the group A than in the group TD. The extents of decreases of fractional anisotropy values and fiber numbers on the ipsilateral side relative to those on the contralateral side were greater in the group B than in the group TD. Functional evaluation data and clinical manifestations were found to show strong correlations with CRT status, rather than with corticospinal tract status. These findings suggest that CRT status appears to be clinically important for gait function and trunk stability in pediatric patients and DTT can help assess CRT status in pediatric patients with gait dysfunction.

关键词： nerve regeneration corticoreticular tract corticospinal tract gait trunk diffusion tensor Trunk Control Measurement Scale Functional Ambulation Category Growth Motor Function Classification System cerebral palsy motor neural regeneration

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Statistical estimations for Plasmodium vivax malaria in South Korea

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Asian Pacific Journal of Tropical Medicine 2015年第3期8卷 169-175页

作者： Youngsaeng Lee Hyeongap Jang Jeong ae Rhee Jeong-Soo Park Department of Statistics Chonnam National University JW LEE Center for Global Medicine College of MedicineSeoul National University Department of Preventive Medicine Chonnam National University

Objective:To calculate the numbers of weekly infections and prevalence of malaria,and to predict future trend of malaria incidences in South ***:Weekly incidences of malaria for 13 years from the period 2001-2013 in South Korea were *** backcalculation equations were used with incubation period *** maximum likelihood estimation for Poisson model was also *** confidence intervals of the estimates were obtained by a bootstrap method.A regression model for time series of malaria incidences over13 years was fitted by the non-linear least squares method,and used to predict ***:The estimated infection curve is narrower and more concentrated in the summer than in the incidence *** started around the 19 th week and was over around the41 st *** maximum weekly infection 110 was obtained at the 29 th *** prevalence at the first week was around 496 persons,the minimum number was 366 at 22 nd week,and the maximum prevalence was 648 at 34 th *** drops in late spring with people that falling ill and had had long incubation periods and rose in the summer with new *** future forecast based on the regression model was that an increase at year 2014 compared to 2013 may reach a peak(at maximum about 70 weekly cases) at year *** a decreasing trend after ***:This work shows that back-calculation methods could work well in estimating the infection rates and the prevalence of *** obtained results can be useful in establishing an efficient preventive program for malaria *** method presented here can be used in other countries where incidence data and incubation period are available.

关键词： Back calculation Incidence Incubation period Infection Poisson model Prevalence Regression model

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Long-term clinical outcome between beta-blocker with ACEI or ARB in patients with NSTEMI who underwent PCI with drug-eluting stents

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Journal of Geriatric Cardiology 2019年第3期16卷 280-290页

作者： Yong Hoon Kim ae-Young Her Eun-Seok Shin Myung Ho Jeong Division of Cardiology Department of Internal MedicineKangwon National University School of MedicineChuncheonSouth Korea Division of Cardiology Department of Internal MedicineUlsan Medical CenterUlsan HospitalUlsanSouth Korea Chonnam National University Hospital GwangjuSouth Korea

Background Because limited comparative data are available,we decided to compare 2-year major clinical outcomes between beta-blockers (BB) with angiotensin converting enzyme inhibitors (ACEI) and BB with angiotensin receptor blockers (ARB) therapy in patients with non-ST-segment elevation myocardial infarction (NSTEMI) after percutaneous coronary intervention (PCI) with drug-eluting stents (DES).Methods A total 11,288 NSTEMI patients who underwent PCI with DES were enrolled and they were divided into two groups,the BB with ACEI group (n = 7600) and the BB with ARB group (n = 3688).The major clinical endpoint was the occurrence of major adverse cardiac events (MACE) defined as all-cause death,recurrent myocardial infarction (re-MI),total revascularization [target lesion revascularization (TLR),target vessel revascularization (TVR),non-TVR] rate during the 2-year follow-up *** After propensity score-matched (PSM) analysis,two PSM groups (3317 pairs,n = 6634,C-statistic = 0.695) were *** the cumulative incidences of all-cause death,cardiac death,TLR,and non-TVR were similar between the two groups,MACE (HR = 0.832,95% CI: 0.704?0.982,P = 0.030),total revascularization rate (HR = 0.767,95% CI: 0.598?0.984,P = 0.037),and TVR rate (HR = 0.646,95% CI: 0.470?0.888,P = 0.007) were significantly lower in the BB with ACEI group after *** In this study,we suggest that the combination of BB with ACEI may be beneficial for reducing the cumulative incidences of MACE,total revascularization rate,and TVR rather than the BB with ARB after PCI with DES in NSTEMI patients.

关键词： Angiotensin converting enzyme inhibitor Angiotensin receptor blocker Beta-blocker Myocardial infarction

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