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Rheumatology and functional genome analysis in East Asia

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Rheumatology & Autoimmunity 2022年第1期2卷 1-4页

作者： keishi Fujio Department of Allergy and Rheumatology Graduate School of MedicineThe University of TokyoTokyoJapan

Rheumatic diseases differ in severity and outcome across ethnic *** genetic predisposition is an important factor influencing the development of rheumatic diseases,genomic data to date have been accumulated mainly in ***,East Asia has become an influential center for genetic studies worldwide,and there is also a growing need for a functional genome database for East *** quantitative trait locus data for immune cell subsets can be extremely useful in interpreting the function of disease-associated genetic *** development of a functional genome database for East Asians is expected to make a significant contribution to the understanding and stratification of the pathogenesis of rheumatic diseases in this population in the future.

关键词： ethnicity expression quantitative trait locus functional genome analysis rheumatic diseases

Newly emerging standard chemotherapies for gastric cancer and clinical potential in elderly patients

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World Journal of Gastrointestinal Oncology 2009年第1期1卷 47-54页

作者： Shinichi Sakuramoto keishi Yamashita Masahiko Watanabe Department of Surgery Kitasato University Hospsital

With the increase in average life expectancy,the rate of occurrence of gastric cancer in elderly patients is also *** many clinical trials have been conducted to examine the effect of chemotherapy treatment on gastric cancer,age limits for eligible subjects have prevented the establishment of standards for chemotherapy in elderly patients with gastric *** of March 2009,evidence-based standard chemotherapy regimens were *** the Western world,debates centered on the ECF(Epirubicin/cisplatin/5FU) or DCF(Docetaxel/cisplatin/5-FU) regimens based on the phase □ randomized controlled trial at the Royal Marsden Hospital(RMH) or the V325 study,*** JCOG9912 and SPIRITS trials emerged from Japan indicating attractive regimens that include S-1 for advanced gastric cancer *** these active anticancer drugs,the trials that studied the eff icacy of adjuvant therapies or surgical approaches,such as the Int-116/MAGIC/ACTS-GC trials,have actually succeeded in demonstrating the benefits of adjuvant therapies in gastric cancer *** cases of gastric cancer in elderly patients,treatment policies should consider these studies while analyzing not only the therapeutic effects but also drug toxicity,individual general health conditions,and social factors to select treatments that emphasize quality of life.

关键词： Gastric cancer Elderly patients Chemotherapy Regimen comparison

An unusual enteropathy-associated T-cell lymphoma with MYC translocation arising in a Japanese patient:A case report

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World Journal of Gastroenterology 2012年第19期18卷 2434-2437页

作者： Kenji Okumura Masahiko Ikebe Tatsuro Shimokama Morishige Takeshita Nao Kinjo keishi Sugimachi Hidefumi Higashi Department of Surgery Nippon Steel Yawata Memorial HospitalKitakyushu 805-8508Japan Department of Pathology Nippon Steel Yawata Memorial HospitalKitakyushu 805-8508Japan Department of Pathology School of MedicineFukuoka UniversityFukuoka 814-0180Japan

Enteropathy-associated T-cell lymphoma(EATL) is a rare peripheral T-cell lymphoma classified into 2 types,with or without celiac disease,based on *** 2 EATL is less commonly associated with celiac disease,in which cells are characterized by being monomorphic and small-to *** are characterized by CD8 and CD56 expression and c-MYC oncogene locus *** present an atypical case of type 2 EATL in the jejunum,with human T-lymphotropic virus-1 that was CD4-CD8+ CD56-CD30-CD25-TIA-1+ and granzyme B+ on immunohistological *** also displayed translocation of chromosome 8p24(c-MYC),as determined by fluorescent in situ *** spreading and intraepithelial invasion by lymphoma with villous atrophy were detected adjacent to the mucosal *** lymphoma may be derived from intraepithelial CD8+ T cells,similar to celiac disease.

关键词： C-MYC 易位染色体 T细胞淋巴瘤病例报告空肠 C基因免疫组织化学染色

Segmental gastrectomy with radical lymph node dissection for early gastric cancer

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World Journal of Gastroenterology 2010年第41期16卷 5247-5251页

作者： Takeru Matsuda Kunihiko Kaneda Manabu Takamatsu keishi Aishin Masahide Awazu Akiko Okamoto Katsunori Kawaguchi Department of Surgery Kobe Kaisei HospitalKobe 657-0078 Japan

AIM: To describe a new surgical technique and evaluate the early results of segmental gastrectomy (SG) with modified D2 lymph node (LN) dissection for early gastric cancer (EGC). METHODS: Fourteen patients with EGC underwent SG with modified D2 dissection from 2006 to 2008. Their operative results and postoperative courses were compared with those of 17 patients who had distal gastrectomy (DG) for EGC during the same period. RESULTS: Operating time, blood loss, and hospital stay were similar between the 2 groups. Postoperative complications developed significantly more frequently in the DG group than in the SG group. Mean number of dissected LNs per each station in the SG group was comparable with that in the DG group. Postoperative recovery of body weight was significantly better in the SG group than in the DG group. The incidence of reflux esophagitis and gastritis after surgery was less frequent in the SG group than in the DG ***: SG with modified D2 LN dissection may be a new function-preserving gastrectomy that is feasible for treatment of EGC with possible LN involvement.

关键词： Gastrectomy Early diagnosis Gastric can-cer Lymph node Metastasis Gastrointestinal surgical procedures

Trend in gastric cancer:35 years of surgical experience in Japan

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World Journal of Gastroenterology 2011年第29期17卷 3390-3397页

作者： keishi Yamashita Shinichi Sakuramoto Masayuki Nemoto Tomotaka Shibata Hiroaki Mieno Natsuya Katada Shiroh Kikuchi Masahiko Watanabe Department of Surgery Kitasato University School of MedicineKitasato 1-15-1Minami-kuSagamiharaKanagawa 252-0374Japan

AIM:To investigate the trend in gastric cancer surgery in the context of rapid therapeutic advancement in Japan and East ***:A retrospective analysis was performed on 4163 patients who underwent gastric resection for gastric cancer with histological confirmation between 1971 and 2007 at the surgical unit in Kitasato University Hospital,to determine the trend in gastric cancer requiring ***:Gastric cancer requiring surgical resection increased in our hospital,but the incidence adjusted for population was constant during the observed ***,the ratio of diffuse type/intestinal type gastric cancer was unexpectedly unchanged,and that of advanced/early gastric cancer(EGC)was,however,markedly reduced,while the actual incidence of potentially curative advanced gastric cancer tended to *** incidence of EGC requiring surgery tended to increase as a whole,which is consistent with increased prevalence of endoscopic *** a result,overall survival and mortality of gastric cancer requiring gastric resection has recently markedly ***:In Japan,planned interventions may improve surgical gastric cancer mortality,but an unexpected trend of persistent existence of intestinal type cancer suggests the need for more robust medical intervention.

关键词：手术切除胃癌日本大学医院发病期间干预措施发病率死亡率

Prognostic factors associated with mortality in patients with gastric fundal variceal bleeding

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World Journal of Gastroenterology 2017年第3期23卷 496-504页

作者： keishi Komori Masaru Kubokawa Eikichi Ihara Kazuya Akahoshi Kazuhiko Nakamura Kenta Motomura Akihide Masumoto Department of Gastroenterology Aso Iizuka HospitalIizuka 820-8505Japan Department of Medicine and Bioregulatory Science Graduate School of Medical SciencesKyushu UniversityHigashi-kuFukuoka 812-8582Japan Department of Hepatology Aso Iizuka HospitalIizuka 820-8505Japan

AIM To determine the prognostic factors associated with mortality in patients with gastric fundal variceal (GFV) *** In total, 42 patients were endoscopically diagnosed with GFV bleeding from January 2000 to March 2014. We retrospectively reviewed the patients' medical records and assessed their history, etiology of liver cirrhosis, disease conditions, treatment options for GFV bleeding, medications administered before and after onset of GFV bleeding, blood test results(hemoglobin, albumin, and bilirubin concentrations), and imaging results(including computed tomography and abdominal ultrasonography). We also assessed the prognostic factors associated with short-term mortality(up to 90 d) and long-term mortality in all *** Multivariate analysis showed that prophylactic administration of antibiotics was an independent prognostic factor associated with decreases in short-term mortality (OR = 0.08, 95%CI: 0.01-0.52) and longterm mortality (OR = 0.27, 95%CI: 0.08-0.91) in patients with GFV bleeding. In contrast, concurrent hepatocellular carcinoma (HCC) and regular use of proton pump inhibitors (PPI) were independent prognostic factors associated with increases in shortterm mortality(HCC: OR = 15.4, 95%CI: 2.08-114.75; PPI: OR = 12.76, 95%CI: 2.13-76.52) and long-term mortality (HCC: OR = 7.89, 95%CI: 1.98-31.58; PPI: OR = 10.91, 95%CI: 2.86-41.65) in patients with GFV bleeding. The long-term overall survival rate was significantly lower in patients who regularly used PPI than in those who did not use PPI(P = 0.0074).CONCLUSION Administration of antibiotics is associated with decreased short- and long-term mortality, while concurrent HCC and regular PPI administration are associated with increased short- and long-term mortality.

关键词： Antibiotics Gastric varices Gastric fundus Proton pump inhibitors Hemorrhage

Advances in endoscopic therapy using grasping-type scissors forceps(with video)

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World Journal of Gastrointestinal Surgery 2021年第8期13卷 772-787页

作者： Kazuya Akahoshi keishi Komori Kazuaki Akahoshi Shinichi Tamura Shigeki Osada Yuki Shiratsuchi Masaru Kubokawa Endoscopy Center Aso Iizuka HospitalIizuka 820-8505Japan Department of Gastroenterology Aso Iizuka HospitalIizuka 820-8505Japan

Endoscopic submucosal dissection(ESD)is a globally accepted minimally invasive therapy for early-stage gastrointestinal tract *** numerous electrosurgical knives have been developed for ESD,technical difficulties and high complication rates(bleeding and perforation)have limited their use *** grasping-type scissors forceps[clutch cutter(CC)]is the first forceps-type resection device developed with reference to hemostatic *** aim was to allow easy and safe ESD throughout the gastro-intestinal tract,as a biopsy technique,using one *** CC can grasp the target tissue accurately and pull it away from the underlying muscle layer prior to energizing the tissue,for safe and effective incision and hemostasis during *** clinical studies showed that ESD using the CC(ESD-CC)is a safe(perforation rate:0%-3.6%;delayed bleeding rate:0%-4.2%),technically efficient(en-bloc resection rate:88.9%-100%),and single-device method for dissecting early-stage gastrointestinal tract *** ESD-CC technique is simple and easy to learn because it can be completed simply by repeating the grasp,pull,and coagulate and/or incise actions using an electrosurgical *** reported self-completion rate by nonexperts was significantly better with the CC than with conventional knives(61.7%vs 24.5%,respectively;P<0.001).Furthermore,the CC is used for other endoscopic therapies,such as endoscopic polypectomy for large pedunculated polyps,endoscopic myotomy for Zenker’s diverticulum,endoscopic treatment of buried bumper syndrome,and endoscopic necrosectomy for wall-off pancreatic *** initial reports using CC for these therapies have shown favorable *** this review,we describe the structural features of the CC,how to use the instrument,efficacies of ESD-CC,and other unique endoscopic therapies using the CC.

关键词： Grasping-type scissors forceps Clutch cutter Endoscopic submucosal dissection Endoscopic polypectomy Zenker’s diverticulum Buried bumper syndrome

Evaluation of Patient-Specific Quality Assurance for Carbon Ion Radiotherapy Using Full Energy Scanning Method at QST Hospital

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2022年第4期11卷 200-209页

作者： Asami Inomata Masashi Katsumata Sung Hyun Lee Yui Suzuki Takeo Nakajima Wataru Furuichi keishi Yamaoka Atsushi Yamamoto Hideyuki Mizuno Ryosuke Kohno Accelerator Engineering Corporation Chiba Japan Department of Accelerator and Medical Physics National Institutes for Quantum and Radiological Science and Technology Chiba Japan Department of Heavy Particle Medical Science Graduate School of Medical Science Yamagata University Yamagata Japan QST Hospital National Institutes for Quantum and Radiological Science and Technology Chiba Japan Department of Radiological Sciences International University of Health and Welfare Tochigi Japan

Purpose: Patient-specific QA (PSQA) measurements for carbon ion radiotherapy (CIRT) are critical components of processes designed to identify discrepancies between calculated and delivered doses. We report the results of PSQA conducted at the QST Hospital during the period from September 2017 to March 2018. Methods: We analyzed PSQA results for 1448 fields for 10 disease sites with various target volumes, target depths and number of energy layers. For the PSQA, all the planned beams were recalculated on a water phantom with treatment planning software. The recalculated dose distributions were compared with the measured distributions using a 2D ionization chamber array at three depths, including 95% of the area of the prescription dose. These recalculated dose distributions were evaluated using the 3%/3mm gamma index with a passing threshold of 90%. Results: The passing rates for prostate, head and neck, and bone and soft tissue were 96.8%, 99.3%, and 91.7%, respectively. Additionally, 94.7% of lung plans with low energy beams passed. Overall, the CIRT in the QST Hospital reached a high passing rate of more than 95%. Although the remaining 5% failed to pass, there was no dependence between measurement depth and disease sites in these failures. Conclusion: Using PSQA measurements, we confirmed consistency between the planned and delivered doses for CIRT using the full energy scanning method.

关键词： Carbon Ion Radiotherapy Full Energy Scanning Patient-Specific Quality Assurance Gamma Index

Vacuum Insulation and Achievement of 980 keV,185 A/m^2 H-Ion Beam Acceleration at JAEA for the ITER Neutral Beam Injector

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Plasma Science and Technology 2013年第2期15卷 179-183页

作者： Hiroyuki TOBARI Masaki TANIGUCHI Mieko KASHIWAGI Masayuki DAIRAKU Naotaka UMEDA Haruhiko YAMANAKA Kazuki TSUCHIDA Jumpei TAKEMOTO Kazuhiro WATANABE Takashi INOUE keishi SAKAMOTO Japan Atomic Energy Agency (JAEA) Mukouyama 801-1 Naka Ibaraki 311-1093 Japan

Abstract Vacuum insulation of -1 MV is a common issue for the HV bushing and the accel- erator for the ITER neutral beam injector （NBI）. The HV bushing as an insulating feedthrough has a five-stage structure and each stage consists of double-layered insulators. To sustain -1 MV in vacuum, reduction of electric field at several triple points existing around the double-layered insulators is a critical issue. To reduce electric field simultaneously at these points, three types of stress ring have been developed. In a voltage holding test of a full-scale mockup equipped with these stress rings, 120% of rated voltage was sustained and the voltage holding capability required in ITER was verified. In the MeV accelerator, whose target is the acceleration of a H- ion beam of 1 MeV, 200 A/mS, the gap between the grid support was extended to suppress breakdowns triggered by electric field concentration at the edge and corner of the grid support. This modi- fication improved the voltage holding capability in vacuum, and the MeV accelerator succeeded in sustaining -1 MV stably, b-~rthermore, it appeared that the H- ions beam was deflected and a part of the beam was intercepted at the acceleration grid, This causes high heat load on the grids and breakdowns during beam acceleration. To suppress the direct interception, a new grid was designed with proper aperture displacement based on a three dimensional beam trajectory analysis, As a result, 980 keV, 185 A/ms H- ion beam acceleration has been demonstrated, which is close to the ITER requirement.

关键词： neutral beam injector (NBI) negative ion beam HV bushing vacuum insu-lation