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Usefulness of Y-shaped sheaths in CT angiography for examination of liver tumors

World Journal of Gastroenterology 2010年第37期16卷 4704-4708页

作者： Toru Ishikawa Kazuo Higuchi Tomoyuki Kubota Kei-ichi Seki Terasu Honma Toshiaki Yoshida Takeo Nemoto keiko takeda Tomoteru Kamimura Department of Gastroenterology and Hepatology Saiseikai Niigata Second Hospital Department of Radiology Saiseikai Niigata Second Hospital

AIM: To conduct a single-stage, combined computed tomography (CT) arterial portography (CTAP) and CT arteriography (CTA) imaging operation, we used Y-shaped sheaths with 2 valves, which allowed the insertion of 2 catheters simultaneously. METHODS: Of 1254 patients who underwent abdominal angiography for transarterial embolization and/or intraarterial chemotherapy in our department from May 2002 to November 2009, 664 patients in whom Y-shaped sheaths with 2 valves were used underwent CT angiography using a combination of CTA and CTAP. The Seldinger method was used to insert a 10 cm Y-shaped short sheath with 2 valves into the femoral artery. Under radiographic guidance, a 3.2 French (Fr) catheter was placed in the celiac artery or proper hepatic artery, and a second 3.2 Fr catheter was then placed distal to the inferior pancreaticoduodenal artery of the superior mesenteric artery. CTAP was then performed followed by CTA 10 min later. Photographs were taken during the early and late phases of the ***: Insertion of 3.2 Fr catheters was not possible in 6 of 664 (0.9%) patients with strong curvature of the femoral artery and 4 of 664 (0.6%) patients with strong curvature of the abdominal aorta. In addition, performing CTAP and CTA as a single-stage combined intervention was not possible in 14 of 664 (2.1%) patients whose right hepatic artery originated from the superior mesenteric artery and in 8 of 664 (1.2%) patients whose left hepatic artery branched from the left gastric artery. There were no sheath-related complications such as those related to arterial dissection or hemostasis. CONCLUSION: Although transfers to and from the CT room were necessary for anatomically variant patients, CT angiography using the Y-shaped sheath for combined CTAP and CTA was considered useful.

关键词： Computed tomography angiography Interventional radiology Liver tumors

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CT-maximum intensity projection is a clinically useful modality for the detection of gastric varices

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World Journal of Gastroenterology 2005年第47期11卷 7515-7519页

作者： Toru Ishikawa Takashi Ushiki Ken-ichi Mizuno Tadayuki Togashi Kouji Watanabe Kei-ichi Seki Hironobu Ohta Toshiaki Yoshida keiko takeda Tomoteru Kamimura Department of Gastroenterology Saiseikai Niigata Second HospitalNiigataJapan Department of Radiology Saiseikai Niigata Second HospitalNiigataJapan

AIM： To evaluate the efficacy of CT-maximum intensity projection （CT-MIP） in the detection of gastric varices and their infiowing and outflowing vessels in patients with gastric varices scheduled to undergo balloonoccluded retrograde transvenous obliteration （B-RTO）. METHODS： Sixteen patients with endoscopically confirmed gastric varices were included in this study. All patients were evaluated with CT-MIP using threedimensional reconstructions, before and after B-RTO. RESULTS： CT-MIP clearly depicted gastric varices in 16 patients （100%）, the left gastric vein in 6 （32.5%）, the posterior gastric vein in 12 （75.0%）, the short gastric veins in 13 （81.3%）, gastrorenal shunts in 16 （100%）, the hemiazygos vein （HAZV） in 4 （25.0%）, the pericardiophrenic vein （PCPV） in 9 （56.3%）, and the left inferior phrenic vein in 9 patients （56.3%）. Although flow direction itself cannot be determined from CT-MIP, this modality provided clear images of the inflowing and the outflowing vessels. Moreover, in one patient, short gastric veins were not seen on conventional angiographic portography images of the spleen, but were clearly revealed on CT-MIP. CONCLUSION： We suggest that CT-MIP should be considered as a routine method for detecting and diagnosing collateral veins in patients with gastric varices scheduled for B-RTO. Furthermore, CT-MIP is more useful than endoscopy in verifying the early therapeutic effects of B-RTO.

关键词： Gastric varices CT-MIP, Portal hypertension

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Angiotensin-Ⅱ administration is useful for the detection of liver metastasis from pancreatic cancer during pharmacoangiographic computed tomography

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World Journal of Gastroenterology 2007年第22期13卷 3080-3083页

作者： Toru Ishikawa Takashi Ushiki Hiroteru Kamimura Tadayuki Togashi Atsunori Tsuchiya Kouji Watanabe Kei-ichi Seki Hironobu Ohta Toshiaki Yoshida keiko takeda Tomoteru Kamimura Department of Gastroenterology and Hepatology Saiseikai Niigata Second Hospital Niigata Japan Department of Radiology Saiseikai Niigata Second Hospital Niigata Japan

AIM: To improve the preoperative diagnosis of liver metastasis from pancreatic cancer, we estimated computed tomography during arterial angiography (CTA) with/without administration of angiotensin-Ⅱ (AT-Ⅱ). METHODS: Thirty-fi ve patients with pancreatic cancer were examined in this study. After conventional CTA was performed, pharmacoangiographic CTA was performed with a 1-3 microgram/5 mL solution of angiotensin Ⅱ injected through a catheter into the celiac artery during spiral computed tomography. We prospectively analyzed the relative region of interest (ROI) ratio of tumor to liver with/without AT-Ⅱ. RESULTS: In all patients, the relative ratio of each computed tomography (CT) number in the ROI was larger at pharmacoangiographic CT than at conventional angiographic CT. Administration of angiotensin-Ⅱ enhanced the metastatic liver tumor as compared with normal tissue. Intratumoral blood flow increased in all patients with malignant tumors due to the pressure effect of AT-Ⅱ. Furthermore, the metastatic lesions in the liver of three patients were represented by only pharmacoangiographic CT, not by conventional CT and conventional CT angiography. In even peripheral and central areas of metastatic liver tumor, the lesions were enhanced after administration of AT-Ⅱ. CONCLUSION: These results support that high detection rate of liver metastasis revealed by pharmacoangiographic CT suggests the improvement of diagnosis on preoperative staging. Moreover, chemotherapy under AT-Ⅱ induced hypertension may have a better effect on the treatment of metastatic liver tumors.

关键词： Angiotensin Ⅱ Phamacoangiographic CT Pancreatic cancer

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Health 2017年第4期9卷 657-668页

作者： Yuko takeda Mitsumi Ono Hideyuki Kanda Sachiko Hara keiko takeda Department of Community Health and Gerontological Nursing Faculty of Medicine Shimane University Izumo Japan Department of Environmental Medicine and Public Health Faculty of Medicine Shimane University Izumo Japan Department of Nursing Faculty of Health and Welfare Kawasaki University of Medical Welfare Okayama Japan

The elderly people are prone to be affected by quality of life (QOL) by nocturia becoming the multiple times. A purpose of this study was to determine it about a factor associated with the night urination. This survey was conducted in 2015 as a cross-sectional study. Anonymous, self-administered questionnaires were used to prevent individuals from being identified. The analysis subjects were 699 elderly people with the nocturia which belonged to club of the aged 65 years or older. Those with nocturia were placed in the Nocturia-1 group if they reported experiencing nocturia once per night or in the Nocturia- ≥ 2 group if they reported experiencing nocturia two or more times per night. We analyzed the relationships between the characteristics, lower urinary tract symptoms, and opportunities to go outdoors in the Nocturia-1 and Nocturia- ≥ 2 groups based on sex using the χ2 test. In addition, to investigate the factors that influence the change from nocturia once per night to two or more times per night, we performed logistic regression analysis using the χ2 test on the characteristics and lower urinary tract symptoms that showed significant differences separately for men and women. Among the men, factors with a significant positive relation-ship were age, diabetes mellitus, lower back pain, daytime frequency, and urinary urgency. Among the women, factors with a significant positive relationship were age, requiring support 1-requiring long-term care 2, urinary urgency, and feeling of incomplete emptying. It was suggested that the life of elderly people improved by nocturia not increasing.

关键词： Elderly Nocturia Quality of Life

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Investigation of HO_(2) uptake mechanisms onto multiple-component ambient aerosols collected in summer and winter time in Yokohama,Japan

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Journal of Environmental Sciences 2024年第3期137卷 18-29页

作者： Jun Zhou Yukiko Fukusaki Kentaro Murano Tania Gautam Yu Bai Yoshimi Inomata Hiroaki Komatsu Mayuko takeda Bin Yuan Min Shao Yosuke Sakamoto Yoshizumi Kajii Institute for Environmental and Climate Research Jinan UniversityGuangzhou 511443China Guangdong-Hongkong-Macao Joint Laboratory of Collaborative Innovation forEnvironmental Quality Guangzhou 511443China Graduate School of Global Environmental Studies Kyoto UniversityKyoto606-8501Japan Yokohama Environmental Science Research Institute Yokohama Kanagawa 221–0024Japan Department of Chemistry University of AlbertaAlbertaEdmonton T6G 2G2Canada Graduate School of Human and Environmental Studies Kyoto UniversityKyoto 606-8501Japan Kanagawa Environmental Research Center Kanagawa 254-0014Japan Center for Regional Environmental Research National Institute for Environmental StudiesIbaraki305-8506Japan

The heterogeneous loss of HO_(2)radicals onto ambient aerosols plays an important role in tropospheric ***,sparse investigation of the dominating parameters controlling the HO_(2)uptake coefficients onto ambient aerosols(γHO_(2))has largely hindered the application of the measuredγHO_(2)to the global spatial *** we induced an offine method using LFP-LIF technique to measure the kinetics of HO_(2)uptake onto ambient aerosols collected in summertime and wintertime in Yokohama city,a regional urban site near Tokyo,*** controlling the dominating parameters which infuenceγHO_(2),we were able to investigate the detailed HO_(2)uptake *** characterized the chemical composition of the collected ambient aerosols,including organics,inorganics,transition metals ions,*** modeledγHO_(2)using different *** show thatγHO_(2)increased with the increase in RH,and the aerosol states(“dry”or wet/aqueous)have large effects onγHO_(2).With fixed RH and aerosol chemical composition,γHO_(2)was highly dependent on pH and inversely correlated with[HO_(2)]_*** combing the measuredγHO_(2)values with the modeled ones,we found that both the HO_(2)self-reaction and transition metal-catalyzed reactions should be accounted for to yield a single parameterization to predictγHO_(2),and different chemical compositions may have collective effects onγHO_(2).Results may serve for extending theγHO_(2)values measured at one observation site to different environmental conditions,which will help us to achieve more accurate modeling results concerning secondary pollutant formation(i.e.,ozone).

关键词： HO_(2)uptake kinetics Offine method Impacting factors Mechanism

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How Effective Is Cervical Ripening Using the Controlled-Release Dinoprostone Vaginal Delivery System for Primiparas with Unruptured Membranes?

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Open Journal of Obstetrics and Gynecology 2024年第8期14卷 1185-1196页

作者： Yoshino Kinjyo Yukiko Chinen Tadatsugu Kinjo Shuko Chinen keiko Mekaru Department of Obstetrics and Gynecology Graduate School of Medicine University of the Ryukyus Okinawa Japan

Background: Labor induction has a low success rate, especially in primiparas with unruptured membranes. Previous studies focused on pregnant women with unruptured membranes, but none specifically targeted primiparas. Aims: To compare the effectiveness of a controlled-release dinoprostone vaginal delivery system for cervical dilatation (PROPESS) with that of mechanical dilation for labor induction in primiparous women with unruptured membranes. Materials and Methods: We retrospectively analyzed the data of 90 primiparas with unruptured membranes (41 and 49 in the PROPESS and mechanical dilation groups, respectively). The primary outcome was the cesarean section (CS) rate. The secondary outcomes were the prevalence of vaginal delivery within 12 or 24 h after the initial insertion, oxytocin usage rate, chorioamnionitis, additional use of mechanical dilation in the PROPESS group, and neonatal outcomes. Results: The CS rate was significantly lower in the PROPESS group than in the mechanical dilation group (p = 0.02). A total of 13 patients (31.7%) delivered within 24 h with PROPESS alone, indicating a significantly higher rate of delivery within 24 h in the PROPESS group (p = 0.02). Fewer patients required additional oxytocin in the PROPESS group than in the mechanical dilation group (p = 0.001). However, 14 (34%) patients in the PROPESS group required additional mechanical cervical dilation, resulting in a longer time to delivery than mechanical dilation. Conclusions: PROPESS significantly reduced CS rates and increased delivery rates 24 h after the initial insertion in primiparas with unruptured membranes compared to mechanical dilatation. However, failure to respond to PROPESS resulted in an overall longer delivery time than that of the conventional mechanical dilation group;therefore, identifying predictors of response to PROPESS is necessary.

关键词： PROPESS Labor Induction Primiparas Cervical Ripening Unruptured Membranes

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Direct Correlation among Telomere Length, Cellular Aging, and Rejuvenation Effects of Honey Child Powder

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Journal of Biosciences and Medicines 2024年第7期12卷 55-70页

作者： Naofumi Shiomi keiko Watanabe Yuki Fujiwara Takae Yamasaki Hideto Matsuyama Research Center for Membrane and Film Technology Kobe University Kobe Japan School of Human Sciences Kobe College Nishinomiya Japan Department of Chemical Science and Engineering Kobe University Kobe Japan

Purpose: Telomere length (TL) is an indicator of age;however, hormonal influences complicate individual aging. It remains unclear whether TL shortening is a direct factor in both individual and cellular aging. Therefore, we examined the direct relationship between TL and cellular senescence at the cellular level. Methods: Telomerase activity, TL, and gene expression were measured in cultured human lung-, fetal-, and skin-derived fibroblasts, human skin keratinocytes, and telomerase reverse transcriptase (TERT) gene-immortalized cells using detection kits, Cawthon’s method, and reverse transcription-quantitative polymerase chain reaction, respectively. Novel substances that elongate telomeres were screened to confirm cell rejuvenation effects. Results: Long-term cell culture of TIG-1-20 normal human fibroblasts resulted in TL shortening, decreased division rate, and senescence progression, whereas in OUMS-36T-2 cells, TL elongation via TERT gene transfer increased the division rate, reduced endoplasmic reticulum stress, and upregulated genes associated with young individuals, indicating that cellular rejuvenation occurs via TL elongation. In addition, a honey child powder (HCP) extract was found through screening, and the HCP extract strongly suppressed the menin gene, resulting in increased telomerase activity and extended cell lifespan. Upon addition of the HCP extract to skin fibroblasts, gene expression of moisturizing components, including collagen, hyaluronic acid, and elastin, increased, and exhibited a rejuvenating effect with an increase in elastin amount. Conclusions: TL elongation or shortening is involved in cell proliferation rate and cellular aging, and TL elongation rejuvenates cells. In addition, HCP extract has a rejuvenating effect on cells and is expected to be a rejuvenating compound.

关键词： Telomere Cellular Aging Telomerase Reverse Transcriptase Gene Rejuvenation Honey Child Powder

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Perinatal Morbidity, Mortality, and Neurodevelopmental Outcomes of Neonates with Fetal Growth Restriction

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Open Journal of Obstetrics and Gynecology 2024年第3期14卷 321-333页

作者： Natsuki Tamashiro Shuko Chinen Yoshino Kinjyo Yukiko Chinen Tadatsugu Kinjo keiko Mekaru Department of Obstetrics and Gynecology Graduate School of Medicine University of the Ryukyus Nishihara Japan

Objective: This study aimed to assess perinatal morbidity, mortality rates, and neurodevelopmental outcomes in the management of fetal growth restriction (FGR) at a single tertiary institute. Methods: Among 2465 deliveries between 2013 and 2019, 109 cases of FGR were reviewed retrospectively for causes, indications for pregnancy termination, perinatal death, overall neonatal outcomes, and long-term prognosis. Results: Excluding FGR due to congenital anomalies (n = 17), the mortality rate was 3.3% (3/92). One neonate delivered at 23 weeks developed cerebral palsy (1.1%). Retinopathy of prematurity occurred in four neonates (4.3%). Neurodevelopmental disorders were present in six neonates (6.5%), all of whom were delivered at 32 - 38 weeks. Significantly lower gestational age at delivery, lower birth weight, and higher umbilical artery resistance indices were observed in neonates with neurodevelopmental disorders. Conclusions: Intact survival before 27 weeks of gestation at delivery with FGR is uncommon. Neurodevelopmental disorders may still develop after delivery at 32 - 38 weeks;consideration should be given to the timing of delivery usingfetal ductus venosus Doppler waveforms measurements to reduce neurodevelopmental disorders.

关键词： Fetal Death Fetal Growth Retardation Neurodevelopmental Disorders Perinatal Mortality Umbilical Artery Doppler Velocimetry

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Development and Evaluation of 3D Delivery Animation Software Designed to Improve the Mother’s and Spouse’s Satisfaction with Delivery

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Health 2024年第5期16卷 439-458页

作者： Ayako Sasaki Sachi Chikazawa Nojima Kumiko Tomita Takako Hatakeyama keiko Imoto Yasufumi Imoto Nobutane Faculty of Nursing Osaka Medical and Pharmaceutical University Takatsuki Japan Imoto Ladies Clinic Echizen Japan

Purpose: To clarify the effectiveness of 3-D delivery animation software for the mother’s and husband’s satisfaction with delivery. Subjects and Method: We independently developed a software application used to display the pelvic region and explain the labor process. The study involved a collaboration with hospital staff who recruited 18 primiparous and 18 multiparous mothers who were hospitalized for delivery at Facility A. The midwife explained the process of delivery using the “Delivery Animation Software”. A self-administered, anonymous questionnaire was distributed and analyzed separately for primiparous and multiparous mothers and their husbands. Results: 1) For both primiparous and multiparous couples, both mothers and their husbands gained a significantly higher level of understanding after delivery than during pregnancy. 2) The Self-Evaluation Scale for Experience of Delivery results were as follows: “I did my best for the baby even if it was painful” was selected more often for “birth coping skills”;“reliable medical staff” was selected more often for “physiological birth process”;“the birth progressed as I expected” was selected frequently by primiparous mothers;and “the birth progressed smoothly” was selected often by multiparous mothers. 3) In terms of husbands’ satisfaction with the delivery, “I was satisfied with the delivery”, “I was given an easy-to-understand explanation”, and “They explained the process to me” was selected of primiparous and multiparous fathers. 4) All primiparous and multiparous mothers positively evaluated whether the delivery animation was helpful in understanding the process of delivery. Conclusion: The delivery animation was effective in improving the understanding and satisfaction of both the mothers and their husbands.

关键词： Mother Spouse Satisfaction 3D Delivery Animation Software

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A Case Report of Kissing Molars Class II

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Open Journal of Stomatology 2024年第5期14卷 249-254页

作者： Toshiyuki Inou Keiichi Uchida keiko Kaneko Anna Fuji Nina Wakimoto Tatsuo Takaya Hiroyuki Kitamura Hiroshi Mori Yuji Kurihara Department of Oral Diagnostics and Comprehensive Dentistry Matsumoto Dental University Hospital Shiojiri Japan Department of Oral and Maxillofacial Surgery School of Dentistry Matsumoto Dental University Shiojiri Japan

Kissing molars (KMs) is a condition of occlusal molar surfaces in a single follicular space with roots extending in opposite directions. Here, we have reported a case of KMs in a 58-year-old woman. The patient complained of pain in the right mandibular molar region and was diagnosed with KMs consisting of the right mandibular second and third molars. Because of the patient’s pain having subsided at the time of the visit and her unwillingness to undergo tooth extraction, the patient was followed up. KMs is classified into three classes (I-III) and is either true-KMs or pseudo-KMs and presents with or without cystic variants of dental follicles. The presents as true-KMs class II without a cystic variant. With reference to the literature and based on our analysis, the mean age of patients affected by this specific case of KMs is 31.7 years and unilateral KMs is relatively more common (85.7%). Histopathological findings of dentigerous cysts are more often indicated (42.9%). The treatment policy for KMs should therefore be based on the classification of KMs. Importantly, the focus should be on preserving the first and second molars as much as possible. The treatment approach, such as the employment of surgical removal or orthodontics, should be determined by considering the associated factors such as the crowns, tissues, and age of the patient.

关键词： Kissing Molars Mandibular Second Molar Mandibular Third Molar Cone-Beam Computed Tomography

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