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Asian Journal of Pharmaceutical Sciences 2016年第1期11卷 68-69页

作者： Haruki Higashino keiko minami Makoto Kataoka Shinji Yamashita Faculty of Pharmaceutical Sciences Setsunan University

As one of the possible technologies to improve the oral absorption of poorly water-soluble drugs, supersaturable formulation, which enables to dissolve the drug to the higher concentration than their equilibrium solubility, is now attracting the attention (1)This include salt-formation, soliddispersion, co-crystallization or the use of amorphous *** supersaturation is a thermodynamically metastable state,supersaturated solution has a high potential to precipitate. Some pharmaceutical excipients.

关键词： Supersaturation Oral absorption Precipitation Re-dissolution HPMC

Anti-multiple myeloma drug-associated taste dysfunction: An analysis of the FAERS database

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Asian Journal of Pharmaceutical Sciences 2016年第1期11卷 140-141页

作者： Ayano Inoba Kaori Kadoyama keiko minami Akiko Tamon Masahiro Tsuda Toshiyuki Sakaeda Yasushi Okuno Center for Integrative Education in Pharmacy and Pharmaceutical Sciences Graduate School of Pharmaceutical SciencesKyoto UniversityKyoto 606-8501Japan School of Pharmaceutical Sciences Setsunan UniversityOsaka 572-8508Japan Kyoto Constella Technologies Co. LtdKyoto 604-8225Japan Kyoto Pharmaceutical University Kyoto 607-8414Japan Department of Clinical System Onco-Informatics Graduate School of MedicineKyoto UniversityKyoto 606-8501Japan

Multiple myeloma is an incurable disease in many patients;therefore, maintaining good quality of life (QOL) for the duration of the long-term treatment is important. Taste dysfunction is reported to occur in 30 to 70%of patients receiving cancer chemotherapy (1)This adverse event affects the appetite of patients;consequently, QOL of patients decreases.

关键词： Multiple myeloma Taste dysfunction FAERS Safety signal

Mapping urban building stocks for vulnerability assessment preliminary results

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International Journal of Digital Earth 2011年第S1期4卷 117-130页

作者： keiko Saito Robin Spence Department of Architecture University of CambridgeCambridgeUK Cambridge Architectural Research Ltd CambridgeUK Willis Research Fellow Willis Research Network

This paper discusses a methodology to collect building inventory data by combining image processing techniques,field work or tools such as Google Street View and applying statistical *** the methodology outlined in Marinescu(2002),a family of Gabor filters are first constructed,which are then applied to an optical high-resolution *** output from the processed image is segmented using Self-Organising *** paper examines the relationship between the segmented areas in the image and the building type distribution within each segmented area,by deriving the distribution from field *** relationship between the average number of buildings in these cells against the number of grid cells allocated to each segmentation cluster is also ***,using these results,the overall building inventory distribution for the whole of the case study site of Pylos is presented.

关键词： building inventory data collection remote sensing high-resolution optical satellite images Gabor filters Self-Organising Maps field data

Mineral Inclusions in Chromite from the Chromite Deposit in the Kudi Ophiolite,Tibet,Proto-Tethys

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Acta Geologica Sinica(English Edition) 2017年第2期91卷 469-485页

作者： LIU Jianguo HATTORI keiko WANG Jian College of Earth Sciences Jilin University Department of Earth and Environmental Sciences University of Ottawa

High-Al chromite from the Kudi chromitites contains a wide range of mineral inclusions. They include clinopyroxene, amphibole, phlogopite, olivine, orthopyroxene, apatite, base-metal sulfides, calcite and brucite. The modal abundance of inclusions vary greatly among different grains of chromite. The common inclusions are clinopyroxene and amphibole, which occur as monomineral or polymineral associated with other minerals. The shapes of these inclusions tend to follow the growth plane of host chromite. Mineral assemblages and textures demonstrate that some inclusions（olivine, clinopyroxene） are trapped during magmatic stage, and most of the inclusions（e.g., amphibole, phlogopite） are trapped during recrystallization of chromite. Sulfide inclusions are pentlandite, chalcopyrite and cubanite. They occur either as isolated grains or together with silicate minerals, and formed from the separation of sulfide-bearing liquid from silicate magma. The parental magma of chromitites contains Al2O3 15.0wt%–16.5wt%, TiO20.30wt%–1.05wt% based on calculation with the composition of chromite, similar to parental magma of high-Al chromitites from elsewhere and the estimated melt composition is comparable with that of MORB. Considering the high-Mg olivine in disseminated chromitite and abundant hydrous inclusions, we propose that Kudi chromitites formed beneath a volcanic front during the subduction initiation of Proto-Tethys.

关键词： chromitite volcanic front sub-arc Northern Kunlun Tibet Proto-Tethys

Redox Evolution of the Lithospheric Mantle beneath the North China Craton

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Acta Geologica Sinica(English Edition) 2016年第4期90卷 1539-1540页

作者： WANG Jian SONG Yue keiko HATTORI College of Earth Sciences Jilin University Department of Earth Sciences University of Ottawa

Objective The North China Craton （NCC） is a large Archean craton with a long geological history, yet very few studies have been carried out on the evolution of the redox conditions of its underlying mantle. Oxidation state of the mantle is critical in controlling the formation of metallic mineral deposits because metals can be readily released from the mantle to partial melt under oxidized conditions. In contrast, highly reduced and stable conditions are essential for the crystallization of diamond. The subcontinental lithospheric mantle （SCLM） beneath major cratons in the world has been stable since their formation and highly reduced in its oxidation state, but the SCLM below the NCC is different.

关键词： NCC Redox Evolution of the Lithospheric Mantle beneath the North China Craton

Measurements of the Ca II infrared triplet lines of young stellar objects

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Research in Astronomy and Astrophysics 2013年第10期13卷 1189-1201页

作者： Yoichi Itoh keiko Moto'oka Yoichi Itoh The Saga Prefecture Space & Science Museum 16351 Nagashima Takeo Takeo Saga 843-0021 Japan Nishi-Harima Astronomical Observatory Center for Astronomy University of Hyogo 407-2 Nishigaichi Sayo Hyogo 679-5313 Japan yitoh @nhao.jp

Equivalent widths and line widths of Ca II infrared triplet emission lines were measured in the high-resolution optical spectra of 39 young stellar *** found that the equivalent widths of the emission lines decrease with stellar *** has often been claimed that strong chromospheric activity is generated by a dynamo process caused by fast rotation of the ***,we found no clear correlation between the strength of the Ca II lines and the stellar rotation ***,we found that the objects with high mass accretion rates had stronger Ca II emission *** correlation supports the turbulent chromosphere model or the magnetic accretion theory for classical T Tauri *** also noticed that the equivalent widths of Ca II lines in transitional disk objects are one-tenth of those in classical T Tauri stars,even if the masses of the circumstellar disks are comparable.

关键词： stars:pre-main sequence stars:emission lines

In situ characterization of forearc serpentinized peridotite from the Sulu ultrahigh-pressure terrane: Behavior of fluid-mobile elements in continental subduction zone

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Geoscience Frontiers 2021年第4期12卷 110-121页

作者： Zhipeng Xie keiko Hattori Youpu Dong Jian Wang Department of Earth Sciences Kunming University of Science and TechnologyKunming 650093PR China Department of Earth and Environmental Sciences University of OttawaOttawa K1N 6N5Canada College of Earth Sciences Jilin UniversityChangchunJilin 130061PR China

Serpentinized peridotites in the Yangkou(YK),Suoluoshu(SLS) and Hujialin(HJL) areas in the Sulu ultrahighpressure terrane represent the relic of ancient subcontinental lithospheric mantle below the North China *** protoliths,harzburgite and dunite,were variably hydrated by aqueous fluids released from subducting Yangtze *** rocks are enriched in fluid-mobile elements(FME) including Sb(42–333 times the depleted mantle value) and Pb(30–476 times).The degrees of the FME enrichment are comparable to that of the Himalayan forearc serpentinites,and greater than forearc mantle serpentinites from Marianas,suggesting that the degrees of FME enrichment in the forearc serpentinites are greater in continental subduction zones than those in the oceanic subduction *** after olivine in the SLS serpentinite shows higher degrees of enrichment in Sb and As than those for antigorite after both olivine and orthopyroxene in the YK *** antigorite has highly enriched in Pb,U,Cs,and LREE,but not for the *** abundance of FME in two different species of serpentine reflects the different temperature of *** temperature lower than 300 ℃,formed lizardite at shallow depths of the mantle wedge incorporates elements that are fluid mobile at low temperatures,such as Sb and *** the temperature greater than 300 ℃,formed antigorite at a relatively deep mantle wedge incorporate more FME from the subducting continental slab(or fragments),including Pb,U,Cs,LREE as well as Sb and *** eventual breakdown of antigorite(600–700 ℃) in prograde metamorphism would discharge water as well as FME into the subducting channel and/or the overlying mantle.

关键词： Continental subduction channel Subcontinental lithospheric mantle Fluid-mobile element Serpentinite Antigorite Lizardite

Metabolomic Screening Applied to Rice FOX Arabidopsis Lines Leads to the Identification of a Gene-Changing Nitrogen Metabolism

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Molecular Plant 2010年第1期3卷 125-142页

作者： Doris Albinsky Miyako Kusano Mieko Higuchi Naomi Hayashi Makoto Kobayashi Atsushi Fukushima Masaki Mori Takanari Ichikawa keiko Matsui Hirofumi Kuroda Yoko Horii Yuko Tsumoto Hitoshi Sakakibara Hirohiko Hirochika minami Matsui Kazuki Saito RIKEN Plant Science Center Tsurumi-ku Yokohama 230-0045 Japan National Institute of Agrobiological Sciences Tsukuba 305-8602 Japan Graduate School of Pharmaceutical Sciences Chiba University Inage-ku Chiba 263-8522 Japan

Plant metabolomics developed as a powerful tool to examine gene functions and to gain deeper insight into the physiology of the plant cell. In this study, we screened Arabidopsis lines overexpressing rice full-length （FL） cDNAs （rice FOX Arabidopsis lines） using a gas chromatography-time-of-flight mass spectrometry （GC-TOF/MS）-based technique to identify rice genes that caused metabolic changes. This screening system allows fast and reliable identification of candi- date lines showing altered metabolite profiles. We performed metabolomic and transcriptomic analysis of a rice FOX Ara- bidopsis line that harbored the FL cDNA of the rice ortholog of the Lateral Organ Boundaries （LOB） Domain （LBD）/ Asymmetric Leaves2-1ike （ASL） gene of Arabidopsis, At-LBD37/ASL39. The investigated rice FOX Arabidopsis line showed prominent changes in the levels of metabolites related to nitrogen metabolism. The transcriptomic data as well as the results from the metabolite analysis of the Arabidopsis At-LBD37/ASL39-overexpressor plants were consistent with these findings. Furthermore, the metabolomic and transcriptomic analysis of the Os-LBD37/ASL39-overexpressing rice plants indicated that Os-LBD37/ASL39 is associated with processes related to nitrogen metabolism in rice. Thus, the combination of a metabolomics-based screening method and a gain-of-function approach is useful for rapid characterization of novel genes in both Arabidopsis and rice.

关键词： Metabolite profiling GC-TOF/MS rice FOX Arabidopsis lines transcript profiling LBD37/ASL39 nitrogenmetabolism.

Heat Shocking the Jedi Master: HSP90’s Role in Regulating Stomatal Cell Fate

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Molecular Plant 2020年第4期13卷 536-538页

作者： Aarthi Putarjunan keiko U.Torii Howard Hughes Medical Institute and Department of Molecular Biosciences The University of Texas at AustinAustinTX 78712USA

Plant stomata facilitate efficient gas exchange and control water loss in plants throughout the course of their *** stomatal pores plants take in CO2 from the atmosphere for photosynthesis,resulting in O2 and H2O being released back into the atmosphere,which makes life on Earth ***,the density and distribution of stomata on the epidermis of photosynthetic organs are critical for overall plant growth and *** the rise in global warming and harsher climatic conditions that threaten food security for future generations,understanding how stomatal density and distribution can be altered may serve as a valuable tool for the generation of crops that can withstand the adverse environmental conditions such as drought,flooding,extremes in temperature,and excessive salinity(Endo and Torii,2019).Temperature fluctuations constitute a critical environmental factor affecting the spatiotemporal development of plants,and seasonal fluctuations in temperature can greatly influence crop yield and productivity of agriculturally important plant species.

关键词： distribution crops salinity

The Role of Cyclic Nucleotide-Gated Ion Channels in Plant Immunity

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Molecular Plant 2011年第3期4卷 442-452页

作者： Wolfgang Moeder William Urquhart Huoi Ung keiko Yoshioka Department of Cell and Systems Biology University of Toronto 25 Willcocks Street Toronto ON M5S 3B2 Canada Center for the Analysis of Genome Evolution and Function (CAGEF) University of Toronto 25 Willcocks Street Toronto ON M5S 3B2 Canada

Since the first plant cyclic nucleotide-gated ion channel （CNGC）, HvCBT1, was identified as a calmodulin bind- ing protein, more than a decade has passed and a substantial amount of work has been done to understand the molecular nature and function of these channel proteins. Based on electrophysiological and heterologous expression analyses, plant CNGCs function as non-selective cation channels and, so far, their biological roles have been reported in defense responses, development, and ion homeostasis. Forward genetic approaches identified four AtCNGCs （AtCNGC2, 4, 11, and 12） to be involved in plant immunity, as null mutants for AtCNGC2, 4, 11, and 12 as well as a gain-of- function mutant for AtCNGC11 and 12 exhibited alterations in defense responses. Since ion flux changes have been reported as one of the early events upon pathogen recognition and also are an essential component for the activation of defense responses, the involvement of CNGCs in these ion flux changes has been suggested. However, the recent detailed characterization of null mutants suggested a more complex involvement of this channel family. In this review, we focus on the discoveries and character- ization of these CNGC mutants and discuss possible roles of CNGCs as components in plant immunity.

关键词： CNGC cyclic nucleotide-gated ion channel plant immunity DND1 DND2 HLM1 CPR22 ED51.