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Clinical applications of 5-aminolevulinic acid-mediated fluorescence for gastric cancer

World Journal of Gastroenterology 2015年第29期21卷 8769-8775页

作者： Tsutomu Namikawa Tomoaki Yatabe keiji inoue Taro Shuin Kazuhiro Hanazaki Department of Surgery Kochi Medical School Nankoku Department of Anesthesiology Kochi Medical School Nankoku Department of Urology Kochi Medical School Nankoku

5-aminolevulinic acid(ALA) is a naturally occurring amino acid that is a protoporphyrin IX(Pp IX) precursor and a next-generation photosensitive substance. After exogenous administration of ALA, Pp IX specifically accumulates in cancer cells owing to the impaired metabolism of ALA to Pp IX in mitochondria, which results in a red fluorescence following irradiation with blue light and the formation of singlet oxygen. Fluorescence navigation by photodynamic diagnosis(PDD) using ALA provides good visualization and detection of gastric cancer lesions and is a potentially valuable diagnostic tool for gastric cancer for evaluating both the surgical resection margins and extension of the lesion. Furthermore, PDD using ALA might be used to detect peritoneal metastases during preoperative staging laparoscopy, where it could provide useful information for the selection of a therapeutic approach. Another promising application for this modality is in the evaluation of lymph node metastases. Photodynamic therapy(PDT) using ALA to cause selective damage based on the accumulation of a photosensitizer in malignant tissue is expected to be a non-invasive endoscopic treatment for superficial early gastric cancer. ALA has the potential to be used not only as a diagnostic agent but also as a therapeutic drug, resulting in a new strategy for cancer diagnosis and therapy. Here, we review the current use of PDD and PDT in gastric cancer and evaluate its future potential beyond conventional modalities combined with a light energy upconverter, a light-emitting diode and nearinfrared rays as light sources.

关键词： Fluorescence imaging 5-aminolevulinic acid Photodynamic diagnosis Photodynamic therapy Gastric cancer

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Case of plasmablastic lymphoma of the sigmoid colon and literature review

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World Journal of Gastroenterology 2015年第24期21卷 7598-7603页

作者： Tomoko Haramura Masashi Haraguchi Junji Irie Shinichiro Ito Hirotaka Tokai Kazumasa Noda Masachika Kitajima Shigeki Minami keiji inoue Yuya Sasaki Koichi Oshima Susumu Eguchi Department of Surgery Nagasaki Harbor Medical Center City Hospital Department of Pathology Nagasaki Harbor Medical Center City Hospital Department of Pathology Kurume University Department of Surgery Nagasaki University Graduate School of Biomedical Sciences

Plasmablastic lymphoma(PBL) is a rare form of nonHodgkin's lymphoma that is associated with human immunodeficiency virus(HIV) infection. Although PBL is most commonly observed in the oral cavity of HIV-positive patients, it can also be observed at extra-oral sites in HIV-negative patients. This report represents an unusual case of HIV-negative PBL that occurred in the sigmoid colon. This patient had a history of systemic lupus erythematosus and an underlying immunosuppressive state from long term steroid therapy. The lymphoma cells were positive for CD138, kappa light chain restriction and Epstein-Barr virus and negative for CD20/L26, CD3, CD79 a, UCHL1(CD45RO) and cytokeratin(AE1/AE3). The patient died approximately 2 mo after the operation. In the present paper, we review cases of PBL of the colon in HIVnegative patients.

关键词： Plasmablastic lymphoma Sigmoid colon Humanimmunodeficiency virus-negative Immunosuppressive state Extra-oral site

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5-ALA-mediated photodynamic treatment Induces caspase-dependent and-Independent cell death in human histiocytic lymphoma cell line U937

5-ALA-mediated photodynamic treatment Induces caspase-depend...

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21st IUBMB and 12th FAOBMB International Congress of Biochemistry and Molecular Biology

作者： Kozo Utsuml Masataka Uchida Hirofumi Fujita Toshihiko Utsumi keiji inoue Junzo Sasaki Okayama University Graduate School of Medicine DentistryPharmaceutical Sciences Graduate School of Medicine Yamaguchi University Medical School Kochi University

＜正＞The photodynamic treatment（PDT） using 5-aminolevulinic acid（ALA） is one of the new therapeutic modalities for malignant *** mechanism of cell damage induced by ALA-mediated PDT is not fully *** treatment of human histiocytic lymphoma U937 cell line cultures by ALA-based PDT resulted in apoptotic cell death,chromatin condensation,phos-

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Continued Diagnostic Difficulties in Preoperatively Differentiating Lipiodized Oil and Residual Metallic Material: A Case Report

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Case Reports in Clinical Medicine 2016年第4期5卷 125-129页

作者： Masashi Haraguchi Shinichiro Ito Kohei Kotera Aya Fukushima Toshio Fukuda Hirotaka Tokai Kazumasa Noda Masataka Hirabaru Toshiyuki Adachi Nobuhiro Tada keiji inoue Shinya Onizuka Shigeki Minami Department of Surgery Nagasaki Harbor Medical Center City Hospital Nagasaki Japan Department of Obstetrics and Gynecology Nagasaki Harbor Medical Center City Hospital Nagasaki Japan Department of Radiology Nagasaki Harbor Medical Center City Hospital Nagasaki Japan

Retained foreign objects in the abdomen and pelvis are serious clinical problems yet the imaging required can present difficulties. Prolonged retention of lipiodized oil used for hysterosalpingography over years is very rare. However, lipiodized oil had previously been misdiagnosed as residual metallic material. We are reporting a case in which the latest computed tomography (CT) equipment seemed inadequate for obtaining a clear pre-operative diagnosis. Here, we describe the case of a 33-year-old Japanese female whose pelvis had contained retained lipiodized oil that had been suspected as residual metallic material. The preoperative diagnosis was very difficult and included three-dimensional computed tomography (3D-CT) of unclear results despite expectations of resolution. By laparoscopic surgery, we removed a cyst of approximately 2 cm containing a yellowish oily fluid. Postoperatively, we demonstrated that the fluid was lipiodized oil. A postoperative experiment to attempt distinguishing lipiodized oil from metal through gemstone spectral CT imaging did not offer clarity either. Distinguishing between retained lipiodized oil and metallic material in the abdominal cavity may still present unexpected difficulties even with the latest medical equipments.

关键词： Lipiodized Oil Hysterosalpingography Residual Metallic Material

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Non-prosthetic treatment using segmental osteotomy and bone grafting in a patient with cleft lip and palate

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Plastic and Aesthetic Research 2022年第1期9卷 654-660页

作者： Atsuhiro inoue Michiko Tsuji Yoshiyuki Baba keiji Moriyama Department of Maxillofacial Orthognathics Graduate School of Medical and Dental SciencesTokyo Medical and Dental University1-5-45 YushimaBunkyo-kuTokyo 113-8549Japan Division of Pedodontics and Orthodontics Department of Surgical SpecialtiesNational Center for Child Health and Development2-10-1 OkuraSetagaya-kuTokyo 157-8535Japan

This case report aimed to present the course of surgically combined comprehensive orthodontic treatment of a male adult with cleft lip and palate,showing a left alveolar cleft,lateral deviation of the major segment of the maxilla,and palatal transposition of the lateral ***,the midline of the upper central incisors was shifted by 7.0 mm to the right,the right lateral incisor showed palatal transposition,and the residual alveolar cleft was 6.5 *** Le Fort I osteotomy of the major segment,and simultaneous bone grafting into the extended alveolar bone and former cleft region were performed at 18 years and 4 months of ***,midline correction,alignment of the right lateral incisor,and cleft closure were achieved;no further prosthetic treatment was required.

关键词： Cleft lip and palate palatal transposition segmental Le Fort I osteotomy bone grafting

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Bounded derived categories of very simple manifolds

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Science China Mathematics 2011年第8期54卷 1741-1750页

作者： OGUISO keiji Department of Mathematics Graduate School of ScienceOsaka University Korea Institute for Advanced Study

A non-representable cohomological functor of finite type of the bounded derived category of coherent sheaves of a compact complex manifold of dimension greater than one with no proper closed subvariety is given explic... 详细信息

关键词： derived category cohomological functor very simple manifold

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A simple remark on a flat projective morphism with a Calabi-Yau fiber

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Science China Mathematics 2011年第8期54卷 1751-1756页

作者： OGUISO keiji Department of Mathematics Graduate School of ScienceOsaka University Korea Institute for Advanced Study

If a K3 surface is a fiber of a flat projective morphisms over a connected noetherian scheme over the complex number field,then any smooth connected fiber is also a K3 *** this,Professor Nam-Hoon Lee asked if the same is true for higher dimensional Calabi-Yau *** shall give an explicit negative answer to his question in each dimension greater than or equal to three as well as a proof of his initial observation.

关键词： flat projective morphism Hilbert scheme Calabi-Yau manifold

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Circuit Implementation of Power Converter for High-Speed Switching Operations

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Chinese Journal of Electrical Engineering 2018年第3期4卷 47-52页

作者： keiji Wada Department of Electronics Engineering and Computer Science Tokyo Metropolitan UniversityTokyo Japan

Recently,high di/dt and dv/dt switching operations of power converter circuits has been discussed for realizing a high-efficiency power converter *** this case,parasitic inductances of the bus bar between a DC capacitor and power devices may cause issues of overshoot voltage and electromagnetic interference(EMI)***,it is necessary to design the bus bar geometry while considering the minimization and optimization of the parasitic inductance of bus *** paper discusses a relationship between bus bar geometry and switching *** addition,the bus bar analysis is based on the PEEC method,and the bus bar geometry is designed by considering the stray inductance with using an inductance-map ***,this paper also presents a design procedure of acceptable stray inductance based on a standardization *** should be noted that the stray inductance is designed not for minimization,but optimization,and it is shown not as an absolute value(H),but as a percentage value(%).Finally,the oscillation waveforms under turn-off operation will be discussed depending on the bus bar geometry.

关键词： Bus bar inductance bus bar geometry circuit implementation EMI switching characteristics

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Synthesis,structure and mechanical properties of Zr-Cu-based bulk metallic glass composites

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International Journal of Minerals,Metallurgy and Materials 2010年第2期17卷 208-213页

作者： Akihisa inoue Institute for Materials Research Tohoku University

The unusual glass-forming ability（GFA） of the Zr48Cu36Ag8Al8 alloy and the high ductility of the Zr48Cu36Ag8Al8 metallic glass-matrix composites containing Ta powder were *** bulk metallic glass rod with a diameter of 25 mm was successfully synthesized using copper mold casting for the Zr48Cu36Ag8Al8 *** GFA of this alloy was found to be related to a large supercooled liquid region and a quaternary eutectic point with low melting *** bulk metallic glass matrix composites were prepared by introducing extra Ta particles into the Zr48Cu36Ag8Al8 *** composites consist of Ta particles homogenously distributed in the Zr48Cu36Ag8Al8 metallic glass *** optimum content of Ta powder is 10at%for the composite with the highest plasticity,which shows a plastic strain of 31%.

关键词： bulk metallic glass composites glass forming ability Zr-Cu-based alloy plastic strain

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Stress Dependence of Transformation Plastic Behavior

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材料热处理学报 2004年第5期25卷 208-213页

作者： Tatsuo inoue Fukuyama University Fukuyama/Himshima Japan

Transformation plasticity is known to play an important role in the course of heat treatment processes, and so affect the results of heat treatment simulations, which means that the transformation plasticity coefficient is necessary to be identifies. The authors developed a new method by use of four-point bending system of a beam to identify transformation plasticity coefficient taking advantage of its easiness and high accuracy compared with other conventional methods like tension test, etc., and identified the coefficient for four kinds of steels; plane carbon steel, Cr-steel, Cr-Mo steel and bearing steel. In this paper, further experimental data are presented for the steels if the coefficient Kp during pearlite transformation depend on the applied stress. Obtained results reveals that the stress dependence of Kp is rather trivial except for uncertain tendency detected in plane carbon steel. The relation between the Kp and carbon content included is discussed in comparison with other data referred from references.

关键词：相变塑性四点弯曲试验应力关系金属热机械性能

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