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Morphological changes of doxorubicin-loaded liposomes observed by atomic force microscopy

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Asian Journal of Pharmaceutical Sciences 2016年第1期11卷 60-61页

作者： Naoki Takahashi Keisuke Ueda Kenjirou Higashi keiji yamamoto Kunikazu Moribe Graduate School of Pharmaceutical Sciences Chiba University

Liposomes, closed vesicles composed of lipid bilayers, have been widely used as pharmaceutical carriers. Liposomal formulations containing doxorubicin (DOX) of an anticancer drug are developed to reduce toxic side effects and to improve drug accumulation at tumor tissues. An encapsulation of DOX into the inner water phase of liposomes results in the formations of fibrous DOX bundles and the elongation of the liposomes [1].In this study, atomic force microscopy (AFM).

关键词： Liposome Doxorubicin Atomic force microscopy

Stabilization mechanism of nitrazepam supersaturated state in nitrazepam/Eudragit~?EPO/saccharin solution revealed by NMR measurements

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Asian Journal of Pharmaceutical Sciences 2016年第1期11卷 58-59页

作者： Harunobu Kanaya Keisuke Ueda Kenjirou Higashi keiji yamamoto Kunikazu Moribe Graduate School of Pharmaceutical Science Chiba University

Aminoalkyl methacrylate copolymer,Eudragit?E PO(EPO),has been used as a polymeric carrier for solid dispersion to significantly enhance the drug ***,the improvement of the drug dissolution by the drug/EPO solid dispersion is limited only in acidic solution due to the pHdependant solubility of basic EPO with its tertiary amino *** previously reported that the blending of saccharin(SAC)in the drug/EPO solid dispersion led to the supersaturation formation of drug even at neutral pH[1].

关键词： Solid dispersion Supersaturation NMR relaxation time 2D-NOESY

Higher levels of the lipophilic antioxidants coenzyme Q_(10) and vitamin E in long-lived termite queens than in short-lived workers

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Insect Science 2024年第1期31卷 201-210页

作者： Eisuke Tasaki Yorihiro yamamoto Yoshihito Iuchi Department of Biological Chemistry Graduate School of Sciences and Technology for InnovationYamaguchi UniversityYamaguchiJapan School of Bioscience and Biotechnology Tokyo University of TechnologyHachiojiTokyoJapan

Termite queens and kings live longer than nonreproductive *** molecular mechanisms contributing to their long lifespan have been investigated;however,the underlying biochemical explanation remains *** Q(CoQ),a component of the mitochondrial electron transport chain,plays an essential role in the lipophilic antioxidant defense *** beneficial effects on health and longevity have been well studied in several ***,we demonstrated that long-lived termite queens have significantly higher levels of the lipophilic antioxidant CoQ_(10) than *** chromatography analysis revealed that the levels of the reduced form of CoQ_(10) were 4 fold higher in the queen's body than in the worker's *** addition,queens showed 7 fold higher levels of vitamin E,which plays a role in antilipid peroxidation along with CoQ,than ***,the oral administration of CoQ_(10) to termites increased the CoQ_(10) redox state in the body and their survival rate under oxidative *** findings suggest that CoQ_(10) acts as an efficient lipophilic antioxidant along with vitamin E in long-lived termite *** study provides essential biochemical and evolutionary insights into the relationship between CoQ_(10) concentrations and termite lifespan extension.

关键词： antioxidant defense system coenzyme Q termite queens vitamin E

Mission of the National Cancer Center Hospital in Japan to promote clinical trials for precision medicine

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Cancer Biology & Medicine 2024年第1期21卷 1-3页

作者： Kazuaki Shimada Kenichi Nakamura Noboru yamamoto Department of Hepatobiliary and Pancreatic Surgery National Cancer Center HospitalTokyo 104-0045Japan Clinical Research Support Offce National Cancer Center HospitalTokyo 104-0045Japan Department of Experimental Therapeutics National Cancer Center HospitalTokyo 104-0045Japan

Precision medicine is a growing field *** its potential benefit to many patients,several major obstacles must be overcome before precision medicine can be more widely used in clinical *** main obstacles are associated... 详细信息

关键词： clinical Cancer overcome

Unveiling the challenges encountered by newly graduated nurses during night shifts:A descriptive qualitative study

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International Journal of Nursing Sciences 2024年第4期11卷 447-456页

作者： Naomi Kisanuki Miyuki Takase Masako yamamoto School of Nursing Yasuda Women’s UniversityHiroshimaJapan

Objectives:Newly graduated nurses commence night shifts during a phase of heightened vulnerability to reality shock,exacerbating the challenges faced by these ***,this study aimed to identify the challenges experienced by newly graduated nurses when undertaking night shifts in order to help identify a strategy for supporting their adaptation to these ***:Semi-structured personal interviews were used to collect *** newly graduated nurses were selected to participate in the study by purposive sampling method from November 2021 to March 2022 in one of four general hospitals situated in the southwestern region of ***-structured interviews were analyzed by using thematic ***:The analysis revealedﬁve central themes and nine subthemes:challenges in task efﬁciency(task organization challenges,challenges in time-constrained task performance),challenges in responding to patients’changing conditions(challenges in responding to patients’irregular conditions,challenges in responding to nighttime changes in patients’behaviors),challenges in independent practice(challenges in engaging in independent nursing practice,challenges in dealing with unexpected events),challenges in establishing collaborative relationships(challenges in working closely with other staff,challenges in establishing collaborative relationships during night shifts with limited resources),challenges in adapting to shift work(challenges in managing physical conditions for shift work).Conclusions:Newly graduated nurses often encounter challenges in performing their tasks during the transition *** working night shifts,they face additional hurdles unique to nocturnal ***ﬁndings underscore the necessity for these graduates to develop night shift-speciﬁc readiness to effectively navigate the demands inherent in such work schedules.

关键词： Challenge Newly graduated nurses Patient care management Qualitative research Shift work schedule Night shifts

A new electric field mill array with each of the mill’s rotor controlled precisely by a GPS module:Equipment and initial results

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Earth and Planetary Physics 2024年第2期8卷 423-435页

作者： Kozo Yamashita Hironobu Fujisaka DaoHong Wang Hiroyuki Iwasaki Kazuo yamamoto Koichiro Michimoto Masashi Hayakawa Department of Production Systems Engineering and Sciences Komatsu UniversityNu 1-3 Shicho-machiKomatsuIshikawa 923-8511Japan Fujisaka Technology Office 1058-5 Yoshizawa-choOhta-shiGunma 373-0019Japan Department of Electrical Electronic and Computer EngineeringGifu University1-1 YanagidoGifu CityGifu 501-1193Japan Cooperative Faculty of Education Gunma University4-2-Aramaki-machiMaebashiGunma 371-8510Japan Department of Electrical and Electronic Engineering Chubu University1200 Matsumoto-choKasugaiAichi 487-8501Japan Independent Researcher Kosenba Town 2-44-11-406Kawagoe CitySaitama350-0036Japan Advanced Wireless&Communications Research Center The University of Electro-Communications1-5-1 ChofugaokaChofuTokyo 182-8585Japan

We have newly designed an electrostatic sensor,called an electric field mill(EFM),to simplify the estimation of the charge position and charge amount transferred by lightning *** is necessary for this remote estimation of the transferred charge to measure electric field changes caused by charge loss at the time of a lightning strike at multiple *** multiple-station measurement of electric field changes,not only speed but also phase for exposure and shielding of the sensing plates inside each EFM of the array should be synchronized to maintain the sensitivities of the deployed ***,there is no such EFM with specified speed and phase control performance of the rotary ***,we developed a new EFM in which the rotary mechanism was controlled consistently to within 3%error by a GPS *** EFMs had been distributed in the Hokuriku area of Japan during the winter season of 2022-2023 for a test *** we describe the design and a simple calibration method for our new EFM *** analysis method based on the assumption of a simple monopole charge structure is also *** validation,locations of assumed point charges were compared with three-dimensional lightning mapping data estimated by radio observations in the MF-HF *** results indicated the validity to estimate transferred charge amounts and positions of winter cloud-to-ground lightning discharges with our new EFM array.

关键词： lightning electrostatic field electric field mill electric field change

External defects and severity level evaluation of potato using single and multispectral imaging in near infrared region Author links open overlay panel

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Information Processing in Agriculture 2024年第1期11卷 80-90页

作者： Dimas Firmanda Al Riza Slamet Widodo Kazuya yamamoto Kazunori Ninomiya Tetsuhito Suzuki Yuichi Ogawa Naoshi Kondo Laboratory of Biosensing Engineering Graduate School of AgricultureKyoto UniversityKitashirakawaKyoto 6068267Japan Department of Biosystems Engineering Faculty of Agricultural TechnologyUniversitas BrawijayaJl.VeteranMalang 65145Indonesia Department of Mechanical and Biosystem Engineering Bogor Agricultural UniversityJl.Raya Darmaga Kampus IPB DarmagaBogor 16680Indonesia Technology Development Department Shibuya Seiki Co.Ltd.66Takaoka-choMatsuyamaEhime 7918036Japan

Non-invasive potato defects detection has been demanded for sorting and grading *** on the classification of the defects has been available,however,investigation on the severity level calculation is *** the detection of the common scab,it has been found that imaging in the infrared region provide an interesting characteristic that could distinguish defected area to normal ***,investigations on this wavelength range is interesting to add more knowledge and for *** this research,the multispectral image has been obtained and investigated especially at three wavelengths(950,1150,1600 nm).Image pre-processing and pseudo-color conversion techniques were explored to enhance the contrast between defects,normal background skin area and soil *** show that external defects,such as common scab and some mechanical damage types,appear brighter in the near infrared region,especially at 1600 nm against the normal skin *** has been found that pseudo-color images conversion provides more information regarding type if surface characteristics compared to grayscale single *** segmentation using pseudo-color images after multiplication operation pre-processing could be used for common scab and mechanical damage detection excluding soil deposits with a Dice Sorensen coefficient of *** addition,image segmentation using single image at 1600 nm shown relatively better results with Dice Sorensen coefficient of 0.72 with note that thick soil deposits will also be *** severity level evaluation had an R2 correlation of 0.84 against standard measurements of severity.

关键词： Multispectral imaging Pseudo-color Common scab External defects Near infrared

Propensity score matching analysis for clinical impact of braided-type versus laser-cut-type covered self-expandable metal stents for endoscopic ultrasound-guided hepaticogastrostomy

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Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 181-185页

作者： Mitsuki Tomita Takeshi Ogura Akitoshi Hakoda Saori Ueno Atsushi Okuda Nobu Nishioka Yoshitaro yamamoto Hiroki Nishikawa 2nd Department of Internal Medicine Osaka Medical and Pharmaceutical UniversityOsakaJapan Endoscopy Center Osaka Medical and Pharmaceutical UniversityOsakaJapan

Background:To prevent stent migration during endoscopic ultrasound-guided hepaticogastrostomy(EUS-HGS),intra-scope channel release technique is important,but is unfamiliar to non-expert *** self-expandable metal stent(SEMS)is an additional factor to prevent stent ***,no compara-tive studies of laser-cut-type and braided-type during EUS-HGS have been *** aim of this study was to compare the distance between the intrahepatic bile duct and stomach wall after EUS-HGS among laser-cut-type and braided-type ***:To evaluate stent anchoring function,we measured the distance between the hepatic parenchyma and stomach wall before EUS-HGS,one day after EUS-HGS,and 7 days after ***,propensity score matching was performed to create a propensity score for using laser-cut-type group and braided-type ***:A total of 142 patients were enrolled in this *** them,24 patients underwent EUS-HGS using a laser-cut-type SEMS,and 118 patients underwent EUS-HGS using a braided-type ***-HGS using the laser-cut-type SEMS was mainly performed by non-expert endoscopists(n=21);EUS-HGS using braided-type SEMS was mainly performed by expert endoscopists(n=98).The distance after 1 day was significantly shorter in the laser-cut-type group than that in the braided-type group[2.00(1.70-3.75)vs.6.90(3.72-11.70)mm,P<0.001].In addition,this distance remained significantly shorter in the laser-cut-type group after 7 *** these results were similar after propensity score matching analysis,the distance between hepatic parenchyma and stomach after 7 days was increased by 4 mm compared with the distance after 1 day in the braided-type *** the other hand,in the laser-cut-type group,the distance after 1 day and 7 days was almost the ***:EUS-HGS using a laser-cut-type SEMS may be safe to prevent stent migration,even in non-expert hands.

关键词： Endoscopic ultrasound-guided hepaticogastrostomy Endoscopic ultrasound-guided biliary drainage Endoscopic retrograde cholangiopancreatography

The evolution of cancer genomic medicine in Japan and the role of the National Cancer Center Japan

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Cancer Biology & Medicine 2024年第1期21卷 29-44页

作者： Teruhiko Yoshida Yasushi Yatabe Ken Kato Genichiro Ishii Akinobu Hamada Hiroyuki Mano Kuniko Sunami Noboru yamamoto Takashi Kohno Department of Genetic Medicine and Services National Cancer Center HospitalTokyo 104-0045Japan Department of Diagnostic Pathology National Cancer Center HospitalTokyo 104-0045Japan Clinical Research Support Offce Clinical Research Coordinating SectionBiobank Translational Research Support SectionNational Cancer Center HospitalTokyo 104-0045Japan Department of Pathology and Clinical Laboratories National Cancer Center Hospital EastChiba 277-8577Japan Division of Molecular Pharmacology National Cancer Center Research InstituteTokyo 104-0045Japan National Cancer Center Research Institute Tokyo 104-0045Japan Department of Laboratory Medicine National Cancer Center HospitalTokyo 104-0045Japan Department of Experimental Therapeutics National Cancer Center HospitalTokyo 104-0045Japan Division of Genome Biology National Cancer Center Research InstituteTokyo 104-0045Japan

The journey to implement cancer genomic medicine(CGM)in oncology practice began in the 1980s,which is considered the dawn of genetic and genomic cancer *** the time,a variety of activating oncogenic alterations and their functional significance were unveiled in cancer cells,which led to the development of molecular targeted therapies in the 2000s and *** CGM is still a relatively new discipline and it is difficult to predict to what extent CGM will benefit the diverse pool of cancer patients,the National Cancer Center(NCC)of Japan has already contributed considerably to CGM advancement for the conquest of *** back at these past achievements of the NCC,we predict that the future of CGM will involve the following:1)A biobank of paired cancerous and non-cancerous tissues and cells from various cancer types and stages will be *** quantity and quality of these samples will be compatible with omics *** biobank samples will be linked to longitudinal clinical information.2)New technologies,such as whole-genome sequencing and artificial intelligence,will be introduced and new bioresources for functional and pharmacologic analyses(e.g.,a patient-derived xenograft library)will be systematically deployed.3)Fast and bidirectional translational research(bench-to-bedside and bedside-to-bench)performed by basic researchers and clinical investigators,preferably working alongside each other at the same institution,will be implemented;4)Close collaborations between academia,industry,regulatory bodies,and funding agencies will be established.5)There will be an investment in the other branch of CGM,personalized preventive medicine,based on the individual's genetic predisposition to cancer.

关键词： Cancer genomic medicine biobank patient-derived xenograft multi-gene panel test whole genome sequencing